AU2002219135A1 - Substituted 2-anilino-benzimidazoles and the use thereof as NHE-inhibitors - Google Patents

Substituted 2-anilino-benzimidazoles and the use thereof as NHE-inhibitors

Info

Publication number
AU2002219135A1
AU2002219135A1 AU2002219135A AU1913502A AU2002219135A1 AU 2002219135 A1 AU2002219135 A1 AU 2002219135A1 AU 2002219135 A AU2002219135 A AU 2002219135A AU 1913502 A AU1913502 A AU 1913502A AU 2002219135 A1 AU2002219135 A1 AU 2002219135A1
Authority
AU
Australia
Prior art keywords
nhe
benzimidazoles
anilino
inhibitors
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002219135A
Inventor
Markus Bleich
Michael Gekle
Uwe Heinelt
Armin Hofmeister
Hans-Jochen Lang
Klaus Wirth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Publication of AU2002219135A1 publication Critical patent/AU2002219135A1/en
Assigned to SANOFI-AVENTIS DEUTSCHLAND GMBH reassignment SANOFI-AVENTIS DEUTSCHLAND GMBH Request for Assignment Assignors: AVENTIS PHARMA DEUTSCHLAND GMBH
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2002219135A 2000-12-05 2001-11-22 Substituted 2-anilino-benzimidazoles and the use thereof as NHE-inhibitors Abandoned AU2002219135A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10060292 2000-12-05
DE10060292A DE10060292A1 (en) 2000-12-05 2000-12-05 Use of substituted benzimidazoles for the manufacture of a medicament for the treatment of diseases which can be influenced by inhibition of the Na + / H + exchanger and medicament containing them
PCT/EP2001/013586 WO2002046169A1 (en) 2000-12-05 2001-11-22 Substituted 2-anilino-benzimidazoles and the use thereof as nhe-inhibitors

Publications (1)

Publication Number Publication Date
AU2002219135A1 true AU2002219135A1 (en) 2002-06-18

Family

ID=7665784

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002219135A Abandoned AU2002219135A1 (en) 2000-12-05 2001-11-22 Substituted 2-anilino-benzimidazoles and the use thereof as NHE-inhibitors

Country Status (24)

Country Link
US (2) US6686384B2 (en)
EP (1) EP1341770B1 (en)
JP (1) JP4323803B2 (en)
KR (1) KR20030070045A (en)
CN (1) CN1478081A (en)
AR (1) AR032778A1 (en)
AT (1) ATE329906T1 (en)
AU (1) AU2002219135A1 (en)
BR (1) BR0115936A (en)
CA (1) CA2430412A1 (en)
CZ (1) CZ20031538A3 (en)
DE (2) DE10060292A1 (en)
EE (1) EE200300193A (en)
HR (1) HRP20030449A2 (en)
HU (1) HUP0400967A3 (en)
IL (1) IL156161A0 (en)
MX (1) MXPA03004932A (en)
NO (1) NO20032490L (en)
NZ (1) NZ526250A (en)
PL (1) PL366305A1 (en)
RU (1) RU2272031C2 (en)
SK (1) SK6822003A3 (en)
WO (1) WO2002046169A1 (en)
ZA (1) ZA200303932B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2243226C2 (en) * 1999-06-22 2004-12-27 НьюроСёрч А/С New derivatives of benzimidazole and pharmaceutical compositions containing thereof
DE10163239A1 (en) * 2001-12-21 2003-07-10 Aventis Pharma Gmbh Substituted imidazolidines, process for their preparation, their use as medicaments or diagnostic agents, and medicaments containing them
US20030187045A1 (en) * 2001-12-21 2003-10-02 Uwe Heinelt Substituted imidazolidines, process for their preparation, and their use as a medicament or diagnostic
DE10304294A1 (en) * 2003-02-04 2004-08-12 Aventis Pharma Deutschland Gmbh N-Substituted (benzoimidazol-2-yl) -phenyl, process for their preparation, their use as medicament or diagnostic agent and medicament containing them
DE10304374A1 (en) * 2003-02-04 2004-08-05 Aventis Pharma Deutschland Gmbh Novel substituted 2-aminoimidazoles, process for their preparation, their use as medicament or diagnostic agent and medicament containing them
US20050054705A1 (en) * 2003-02-04 2005-03-10 Aventis Pharma Deutschland Gmbh N-substituted (benzoimidazol-2-yl) phenylamines, process for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
DE10341240A1 (en) 2003-09-08 2005-04-07 Aventis Pharma Deutschland Gmbh Substituted thienoimidazoles, process for their preparation, their use as medicament or diagnostic agent, and medicament containing them
GB0401334D0 (en) * 2004-01-21 2004-02-25 Novartis Ag Organic compounds
US7470712B2 (en) * 2004-01-21 2008-12-30 Bristol-Myers Squibb Company Amino-benzazoles as P2Y1 receptor inhibitors
US7429608B2 (en) 2005-01-20 2008-09-30 Amgen Inc. Benzo[d]imidazol analogs as vanilloid receptor ligands and their use in treatments
TWI370820B (en) * 2005-04-27 2012-08-21 Takeda Pharmaceutical Fused heterocyclic compounds
EP1896427A2 (en) * 2005-06-21 2008-03-12 NeuroSearch A/S Novel 2-(phenylamino)benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels
PE20070335A1 (en) * 2005-08-30 2007-04-21 Novartis Ag SUBSTITUTE BENZIMIDAZOLES AND METHODS FOR THEIR PREPARATION
US20100056515A1 (en) * 2006-10-25 2010-03-04 Kazuyoshi Aso Benzimidazole compounds
US20120088737A2 (en) * 2009-10-02 2012-04-12 Ajinomoto Co., Inc Novel acyl guanidine derivatives
US8604217B2 (en) 2009-11-12 2013-12-10 Selvita S.A. Compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine kinases and a serine/threonine kinases modulating agent
JP2013510824A (en) * 2009-11-12 2013-03-28 セルビタ エス．エー． Compounds for modulating or controlling serine / threonine kinases, methods for their preparation, pharmaceutical compositions, use of compounds, methods and serine / threonine kinase modulators
CN102060780B (en) 2010-12-27 2014-11-05 雅本化学股份有限公司 Preparation method of 2-(N-substituted).-aminobenzimidazole derivative
CN103435554A (en) * 2013-09-06 2013-12-11 中国药科大学 2-phenylaminobenzimidazole compound and application thereof
US9951027B2 (en) * 2014-02-11 2018-04-24 Bayer Pharma Aktiengesellschaft Benzimidazol-2-amines as MIDH1 inhibitors
CN105061324B (en) * 2015-08-14 2017-09-12 广西师范大学 A kind of dihydrobenzo imdazole derivatives of 2 aryl 1,3 and its synthetic method and application
CN109331014B (en) * 2018-10-29 2021-06-04 南方医科大学南方医院 Application of benzimidazole derivative in preparation of heart failure treatment drugs
CN112675169A (en) * 2020-12-23 2021-04-20 南京景瑞康分子医药科技有限公司 Application of ITM-1B4 in preparation of drugs for preventing and/or treating tumors
WO2024028893A1 (en) * 2022-08-01 2024-02-08 Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act (Act Xxi Of 1860) Substituted benzimidazoles for treating viral diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1171904A (en) 1965-10-21 1969-11-26 Unilever Ltd Anilinobenzimidazoles having Antibacterial Properties
DE4328869A1 (en) 1993-08-27 1995-03-02 Hoechst Ag Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
DE19548812A1 (en) * 1995-12-27 1997-07-03 Hoechst Ag Use of inhibitors of the cellular Na · + · / H · + · exchanger (NHE) for the manufacture of a medicament for respiratory stimulation
EA002357B1 (en) 1995-12-28 2002-04-25 Фудзисава Фармасьютикал Ко., Лтд. Benzimidazole derivatives
WO1998008818A1 (en) 1996-08-26 1998-03-05 Genetics Institute, Inc. Inhibitors of phospholipase enzymes

Also Published As

Publication number Publication date
HRP20030449A2 (en) 2005-04-30
SK6822003A3 (en) 2003-11-04
MXPA03004932A (en) 2003-09-10
EE200300193A (en) 2003-08-15
CA2430412A1 (en) 2002-06-13
US20020132842A1 (en) 2002-09-19
WO2002046169A1 (en) 2002-06-13
BR0115936A (en) 2003-10-28
AR032778A1 (en) 2003-11-26
US6958357B2 (en) 2005-10-25
NO20032490D0 (en) 2003-06-02
US20030191170A1 (en) 2003-10-09
EP1341770A1 (en) 2003-09-10
ZA200303932B (en) 2004-04-15
JP4323803B2 (en) 2009-09-02
PL366305A1 (en) 2005-01-24
JP2004517086A (en) 2004-06-10
DE50110181D1 (en) 2006-07-27
IL156161A0 (en) 2003-12-23
RU2272031C2 (en) 2006-03-20
CN1478081A (en) 2004-02-25
CZ20031538A3 (en) 2003-09-17
NO20032490L (en) 2003-07-22
HUP0400967A2 (en) 2004-08-30
DE10060292A1 (en) 2002-06-20
NZ526250A (en) 2004-11-26
HUP0400967A3 (en) 2004-10-28
KR20030070045A (en) 2003-08-27
ATE329906T1 (en) 2006-07-15
US6686384B2 (en) 2004-02-03
EP1341770B1 (en) 2006-06-14

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Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application