AU2001292235A1 - Polymeric micelle containing cisplatin enclosed therein and use thereof - Google Patents

Polymeric micelle containing cisplatin enclosed therein and use thereof

Info

Publication number
AU2001292235A1
AU2001292235A1 AU2001292235A AU9223501A AU2001292235A1 AU 2001292235 A1 AU2001292235 A1 AU 2001292235A1 AU 2001292235 A AU2001292235 A AU 2001292235A AU 9223501 A AU9223501 A AU 9223501A AU 2001292235 A1 AU2001292235 A1 AU 2001292235A1
Authority
AU
Australia
Prior art keywords
enclosed
polymeric micelle
micelle containing
containing cisplatin
poly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001292235A
Inventor
Kazunori Kataoka
Nobuhiro Nishiyama
Teruo Okano
Masayuki Yokoyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Todai TLO Ltd
Original Assignee
Ct For Advanced Science & Tech
Center for Advanced Science and Technology Incubation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct For Advanced Science & Tech, Center for Advanced Science and Technology Incubation Ltd filed Critical Ct For Advanced Science & Tech
Publication of AU2001292235A1 publication Critical patent/AU2001292235A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/44—Polyester-amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/40—Polyamides containing oxygen in the form of ether groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0233—Polyamines derived from (poly)oxazolines, (poly)oxazines or having pendant acyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Nanotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Materials For Medical Uses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Lubricants (AREA)

Abstract

Provided is a complex comprising cisplatin encapsulated therein in a form in which a chlorine ion thereof is ligand-exchanged with a carboxyl anion of a block copolymer comprising poly(ethylene glycol)-poly(glutamic acid). This complex can be a medicinal preparation to which a novel dosage form decreased in toxicity can be applied.
AU2001292235A 2000-09-26 2001-09-26 Polymeric micelle containing cisplatin enclosed therein and use thereof Abandoned AU2001292235A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000292218 2000-09-26
JP2000-292218 2000-09-26
PCT/JP2001/008337 WO2002026241A1 (en) 2000-09-26 2001-09-26 Polymeric micelle containing cisplatin enclosed therein and use thereof

Publications (1)

Publication Number Publication Date
AU2001292235A1 true AU2001292235A1 (en) 2002-04-08

Family

ID=18775184

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001292235A Abandoned AU2001292235A1 (en) 2000-09-26 2001-09-26 Polymeric micelle containing cisplatin enclosed therein and use thereof

Country Status (13)

Country Link
US (1) US7125546B2 (en)
EP (1) EP1329221B1 (en)
JP (1) JP4257697B2 (en)
KR (1) KR100780585B1 (en)
CN (1) CN100344293C (en)
AT (1) ATE330619T1 (en)
AU (1) AU2001292235A1 (en)
CY (1) CY1105342T1 (en)
DE (1) DE60121016T2 (en)
DK (1) DK1329221T3 (en)
ES (1) ES2263659T3 (en)
PT (1) PT1329221E (en)
WO (1) WO2002026241A1 (en)

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US7332527B2 (en) * 2003-05-16 2008-02-19 Board Of Regents Of The University Of Nebraska Cross-linked ionic core micelles
CA2548457C (en) * 2003-12-10 2010-08-24 Toudai Tlo, Ltd. Coordination complex of diaminocyclohexaneplatinum(ii) with block copolymer containing poly(carboxylic acid) segment and antitumor agent comprising the same
US20080241073A1 (en) * 2004-07-05 2008-10-02 Kanagawa Academy Of Science And Technology Polymeric Micelle Type Mri Imaging Agent
EP2348096A3 (en) * 2005-01-04 2011-11-09 Intezyne Technologies Inc. Synthesis of hybrid block copolymers and uses thereof
WO2006090924A1 (en) * 2005-02-28 2006-08-31 The University Of Tokyo Block copolymer having peptide ligand
EP1867673B1 (en) * 2005-03-18 2011-11-16 The University of Tokyo Coordination compound composed of diaminocyclohexane platinum (ii) and block copolymer and anti-cancer agent comprising the same
CN1332716C (en) * 2005-05-25 2007-08-22 北京市海格里斯科技有限公司 High molecular antineoplastic cisplatin medicine and preparation method thereof
EP2474310B1 (en) * 2005-06-09 2013-08-21 NanoCarrier Co., Ltd. Method for producing polymerized coordination compounds of platinum complex
KR20080064827A (en) 2005-10-05 2008-07-09 도쿄 씨알오 가부시키가이샤 Biocompatible block copolymer, use thereof, and production method thereof
CA2631704A1 (en) 2005-12-05 2007-06-14 Nitto Denko Corporation Polyglutamate-amino acid conjugates and methods
JPWO2007088651A1 (en) * 2006-02-01 2009-06-25 国立大学法人 東京大学 Combination use of TGF-β signal inhibitor and antitumor agent
US20080181852A1 (en) * 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
CN101674852A (en) * 2007-04-10 2010-03-17 日东电工株式会社 Multi-functional polyglutamate drug carriers
ES2432641T3 (en) * 2007-04-30 2013-12-04 Intezyne Technologies Inc. Hybrid micelles of block copolymer with mixed stereochemistry for encapsulation of hydrophobic agents
CN101678123B (en) 2007-05-09 2014-07-16 日东电工株式会社 Compositions that include a hydrophobic compound and a polyamino acid conjugate
JP2010528122A (en) * 2007-05-09 2010-08-19 日東電工株式会社 Polymer combined with platinum drug
JP2010526917A (en) * 2007-05-09 2010-08-05 日東電工株式会社 Polyglutamate complex and polyglutamate-amino acid complex having plural kinds of drugs
WO2009006311A2 (en) * 2007-06-29 2009-01-08 Wisconsin Alumni Research Foundation Structuring effect of cholesterol in peg-phospholipid micelles, drug delivery of amphotericin b, and combination antifungals
FR2922452B1 (en) * 2007-10-19 2010-01-22 Coatex Sas FORMULATIONS OF ORGANOPLATINIC COMPOUNDS IN THE PRESENCE OF ASSOCIATIVE POLYMERS, PRODUCTS OBTAINED AND USES THEREOF
CA2713571C (en) * 2008-01-28 2015-06-16 Nanocarrier Co., Ltd. Pharmaceutical composition or combination drug
US20090232762A1 (en) * 2008-03-11 2009-09-17 May Pang Xiong Compositions for delivery of therapeutic agents
DK2305275T3 (en) * 2008-06-24 2013-10-07 Nanocarrier Co Ltd Liquid composition comprising cisplatin coordinating compound
US8961949B2 (en) * 2008-06-26 2015-02-24 Japan Science And Technology Agency Polymer-metal complex composite having MRI contrast ability and MRI contrasting and/or antitumor composition using the same
JP5804453B2 (en) * 2009-05-14 2015-11-04 国立大学法人 東京大学 Crystalline polyol fine particles and preparation method thereof
WO2011007824A1 (en) * 2009-07-15 2011-01-20 国立大学法人東京大学 Antitumor composition and method for treating tumors
JP2011105792A (en) * 2009-11-12 2011-06-02 Japan Science & Technology Agency Block copolymer, block copolymer-metal complex composite material, and hollow structure carrier using the same
CN102091025B (en) * 2009-12-14 2012-07-11 中国科学院化学研究所 Anti-tumor injectable hydrogel as well as preparation method and application thereof
EA201290506A1 (en) * 2009-12-16 2013-03-29 Брихэм Энд Уимен'З Хоспитал, Инк. PARTICLES FOR DELIVERY OF A SET OF AGENTS
ES2385995B2 (en) 2011-01-10 2013-05-21 Universidade De Santiago De Compostela NANOCAPPSULES WITH POLYMER COVER
TWI568453B (en) * 2011-11-22 2017-02-01 原創生醫股份有限公司 A drug carrier with chelating complex micelles and the application thereof
CN102604082B (en) * 2012-02-15 2013-12-11 中国科学院长春应用化学研究所 Cis-platinum coordination compound and preparation method thereof
CN103055324B (en) * 2013-01-31 2015-04-01 中国科学院长春应用化学研究所 Compound of co-carried cis-platinum and adriamycin, micelle and preparation method of micelle
AU2016374759B2 (en) * 2015-12-22 2021-04-01 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of sulfoxide derivative-coordinated platinum(II) complex
KR101978673B1 (en) 2017-11-03 2019-05-15 경상대학교산학협력단 Composition for prevention, improvement or treatment of liver cancer or stomach cancer comprising sinensetin as active ingredient
CN112121176B (en) * 2019-06-24 2022-07-01 山东华铂凯盛生物科技有限公司 Cisplatin particle composition, preparation method and application
WO2023005953A1 (en) * 2021-07-27 2023-02-02 嘉兴清准医药科技有限公司 Drug loading monomolecular nano polymer, prodrug, micelle, drug delivery system, preparation method, and use

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US5384333A (en) * 1992-03-17 1995-01-24 University Of Miami Biodegradable injectable drug delivery polymer
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Also Published As

Publication number Publication date
JP4257697B2 (en) 2009-04-22
DK1329221T3 (en) 2006-10-23
US20030170201A1 (en) 2003-09-11
KR20030038768A (en) 2003-05-16
PT1329221E (en) 2006-10-31
WO2002026241A1 (en) 2002-04-04
JPWO2002026241A1 (en) 2004-02-05
ATE330619T1 (en) 2006-07-15
EP1329221A1 (en) 2003-07-23
CN1476330A (en) 2004-02-18
EP1329221B1 (en) 2006-06-21
ES2263659T3 (en) 2006-12-16
KR100780585B1 (en) 2007-11-29
CN100344293C (en) 2007-10-24
CY1105342T1 (en) 2010-03-03
DE60121016T2 (en) 2006-12-21
DE60121016D1 (en) 2006-08-03
US7125546B2 (en) 2006-10-24
EP1329221A4 (en) 2004-01-21

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