AU2001284643A1 - De-agglomerator for breath-actuated dry powder inhaler - Google Patents
De-agglomerator for breath-actuated dry powder inhalerInfo
- Publication number
- AU2001284643A1 AU2001284643A1 AU2001284643A AU2001284643A AU2001284643A1 AU 2001284643 A1 AU2001284643 A1 AU 2001284643A1 AU 2001284643 A AU2001284643 A AU 2001284643A AU 2001284643 A AU2001284643 A AU 2001284643A AU 2001284643 A1 AU2001284643 A1 AU 2001284643A1
- Authority
- AU
- Australia
- Prior art keywords
- dry powder
- agglomerator
- chamber
- swirl chamber
- breath
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Description
DE-AGGLOMERATOR FOR BREATH-ACTUATED DRY POWDER INHALER
Cross-Reference to Related Applications
The present application claims priority to co-pending provisional U.S. patent application serial no. 60/213,668, filed June 23, 2000 (entitled "Breath-Actuated Dry Powder Inhaler"), provisional U.S. patent application serial no. 60/213,667, filed June 23, 2000 (entitled "Pre-Metered Dose Magazine for Breath-Actuated Dry Powder Inhaler"), and co-pending provisional U.S. patent application serial no. 60/213,382, filed June 23, 2000 (entitled "De-Agglomerator for Breath- Actuated Dry Powder Inhaler"). Each of these co-pending applications is assigned to the assignee of the present disclosure and incorporated herein by reference.
Field of the Invention
The invention relates to a breath-actuated dry powder inhaler for administering dry powder medicament, or a dry powder composition of medicament mixed with a suitable carrier agent, e.g., lactose, to a patient. More particularly, the present disclosure relates to a de-agglomerator for a breath-actuated dry powder inhaler and a method of de- agglomerating a dry powder medicament or a dry powder composition of medicament and a suitable carrier.
Background of the Invention
Metered dose medicament inhalers are well known for dispensing medicament to the lungs of a patient. Some previous inhalers have comprised a pressurized aerosol dispensing container, wherein the aerosols contain gas propellants in which the powdered medicament is suspended. Upon actuation, the aerosol contents are expelled, through a metering valve, and into the lungs of the patient. However, it is now known that some aerosol propellants, including those used in metered dose inhalers, can cause depletion of the ozone layer in the atmosphere. In addition, such aerosol systems are not suitable for all patients.
Several types of non-aerosol, breath actuated dry powder inhalers have therefore been provided. For example, U.S. Patent No. 5,503,144 to Bacon, which is assigned to the assignee of the present disclosure and incorporated herein by reference, shows a breath- actuated dry-powder inhaler. The device includes a dry powder reservoir for containing a dry powdered medicament, a metering chamber for removal of the powdered medicament from the reservoir in discrete amounts, and an air inlet for entraining the removed powdered medicament through a mouth piece upon patient inhalation.
Regardless of whether an aerosol or non-aerosol inhaler is used, it is of utmost importance that particles of the dispensed dry powder medicament be small enough to ensure the adequate penetration of the medicament into the bronchial region of a patient' s lungs during inhalation. However, because the dry powder medicament is composed of very small particles, and often provided in a composition including a carrier such as lactose, non-defined agglomerates or aggregates of the medicament form at random prior to being dispensed. It has therefore been found preferably to provide breath-actuated dry powder inhalers with means for breaking down the agglomerates of medicament or medicament and carrier before inhalation of the medicament.
Accordingly, there is desired an improved dry powder inhaler and, in particular, an improved breath-actuated dry powder inhaler. There is also desired a de-agglomerator for a breath-actuated dry powder inhaler and method for breaking down agglomerates of medicament, or medicament and carrier, before inlialation of the medicament by a patient.
Summary of the Invention
The present disclosure accordingly provides a de-agglomerator for use with a breath-actuated dry powder inhaler for breaking up aggregates and micronizing particles of dry powder prior to inhalation of the powder by a patient. The de-agglomerator includes an inner wall defining a swirl chamber extending along an axis from a first end to a second end, a dry powder supply port, an inlet port, and an outlet port.
The supply port is in the first end of the swirl chamber for providing fluid communication between a dry powder delivery passageway of an inhaler and the first end
of the swirl chamber. The inlet port is in the inner wall of the swirl chamber adjacent to the first end of the swirl chamber and provides fluid communication between a region exterior to the de-agglomerator and the swirl chamber. The outlet port provides fluid communication between the second end of the swirl chamber and a region exterior to the de-agglomerator.
A breath induced low pressure at the outlet port causes air flows into the swirl chamber through the dry powder supply port and the inlet port. The air flows collide with each other and with the wall of the swirl chamber prior to exiting through the outlet port, such that any powder entrained in the air flows is broken down and micronized. The de- agglomerator further includes vanes at the first end of the swirl chamber for creating additional collisions and impacts of entrained powder.
The present disclosure also provides a method of de-agglomerating dry powder from a breath-actuated dry powder inhaler, prior to inhalation of the dry powder by a patient. The method includes directing a first breath-actuated air flow for entraining a dry powder from an inhaler into a first end of a chamber extending longitudinally between the first end and a second end, the first air flow directed in a longitudinal direction.
A second breath-actuated airflow is directed in a substantially transverse direction into the first end of the chamber such that the air flows collide and substantially combine. Then, a portion of the combined air flows is deflected in a substantially longitudinal direction towards a second end of the chamber, and a remaining portion of the combined air flows is directed in a spiral path towards the second end of the chamber. All the combined air flows and any dry powder entrained therein are then delivered from the second end of the chamber to a patient's mouth.
The de-agglomerator and method of de-agglomerating according to the present disclosure, therefore, ensure that particles of dry powder are small enough for adequate penetration of the powder into a bronchial region of a patient's lungs during inhalation of the dry powder by the patient.
Further features and advantages of the presently disclosed de-agglomerator and method of de-agglomerating will become more readily apparent to those having ordinary skill in the art to which the present disclosure relates from the following detailed description and attached drawings.
Brief Description of the Drawings
So that those having ordinary skill in the art will more readily understand how to construct a de-agglomerator in accordance with the present disclosure, a preferred embodiment is described in detail below with reference to the drawing figures wherein:
FIG. 1 is an exploded isometric view of a de-agglomerator according to the present disclosure;
FIG. 2 is a side elevation view of the de-agglomerator of FIG. 1;
FIG. 3 is a top plan view of the de-agglomerator of FIG. 1;
FIG. 4 is a bottom plan view of the de-agglomerator of FIG. 1 ;
FIG. 5 is a sectional view of the de-agglomerator of FIG. 1 taken along line 5 - 5 of FIG. 2; and
FIG. 6 is a sectional view of the de-agglomerator of FIG. 1 taken along line 6 — 6 of FIG. 3.
Description of the Preferred Embodiment
Referring to FIGS. 1 through 6, the present disclosure provides a de-agglomerator 10 for breaking down agglomerates of medicament, or medicament and carrier, before inhalation of the medicament by a patient. Although not shown, the de-agglomerator 10 is for use with a breath-actuated dry powder inhaler including a dry powder delivery passageway and a dry powder reservoir for exposing a predetermined amount of dry powder to the dry powder delivery passageway. Preferably, the dry powder delivery passageway of the inhaler will include a venturi adjacent the dry powder reservoir such
that an air flow passing therethrough will entrain dry powder in the reservoir. Examples of breath-actuated dry powder inhalers utilizing the presently disclosed de-agglomerator 10 are shown in co-pending provisional U.S. patent application serial no. 60/213,668, filed June 23, 2000 (entitled "Breath-Actuated Dry Powder Inhaler"), provisional U.S. patent application serial no. 60/213,669, filed June 23, 2000 (entitled "Pre-Metered Dose
Magazine for Breath-Actuated Dry Powder Inhaler"). Both co-pending applications are assigned to the assignee of the present disclosure and have been incorporated herein by reference.
In general, the presently disclosed de-agglomerator 10 includes an inner wall 12 defining a swirl chamber 14 extending along an axis A from a first end 18 to a second end 20. The swirl chamber 14 includes circular cross-sectional areas arranged transverse to the axis A, that decrease from the first end 18 to the second end 20 of the swirl chamber 14, such that any air flow traveling from the first end of the swirl chamber to the second end will be constricted and at least in part collide with the inner wall 12 of the chamber. Preferably, the cross-sectional areas of the swirl chamber 14 decrease monotonically. In addition, the inner wall 12 is preferably convex, i.e., arches inwardly towards the axis A, as shown best in FIG. 6.
As shown in FIGS. 1, 3 and 6, the de-agglomerator 10 also includes a dry powder supply port 22 in the first end 18 of the swirl chamber 14 for providing fluid communication between a dry powder delivery passageway of an inhaler and the first end 18 of the swirl chamber 14. Preferably, the dry powder supply port 22 faces in a direction substantially parallel with the axis A such that an air flow, illustrated by arrow 1 in FIG. 6, entering the chamber 14 through the supply port 22 is at least initially directed parallel with respect to the axis A of the chamber.
Referring to FIGS. 1 through 6, the de-agglomerator 10 additionally includes at least one inlet port 24 in the inner wall 12 of the swirl chamber 14 adjacent to or near the first end 18 of the chamber providing fluid communication between a region exterior to the de-agglomerator and the first end 18 of the swirl chamber 14. Preferably, the at least one inlet port comprises two diametrically opposed inlet ports 24, 25 that extend in a
direction substantially transverse to the axis A and substantially tangential to the circular cross-section of the swirl chamber 14. As a result, air flows, illustrated by arrows 2 and 3 in FIGS. 1 and 5, entering the chamber 14 through the inlet ports are at least initially directed transverse with respect to the axis A of the chamber and collide with the air flow 1 entering through the supply port 22 to create turbulence. The combined air flows, illustrated by arrow 4 in FIGS. 5 and 6, then collide with the inner wall 12 of the chamber 14, form a vortex, and create additional turbulence as they move towards the second end 20 of the chamber.
Referring to FIGS. 1-3 and 6, the de-agglomerator 10 includes vanes 26 at the first end 18 of the swirl chamber 14 extending at least in part radially outwardly from the axis A of the chamber. Each of the vanes 26 has an oblique surface 28 facing at least in part in a direction transverse to the axis A of the chamber. The vanes 26 are sized such that at least a portion 4 A of the combined air flows 4 collide with the oblique surfaces 28, as shown in FIG. 6. Preferably, the vanes comprise four vanes 26, each extending between a hub 30 aligned with the axis A and the wall 12 of the swirl chamber 14.
As shown in FIGS. 1 through 6, the de-agglomerator 10 further includes an outlet port 32 providing fluid communication between the second end 20 of the swirl chamber 14 and a region exterior to the de-agglomerator. The outlet port 32 acts as a mouthpiece for a patient using an inhaler incorporating the de-agglomerator 10. A breath induced low pressure at the outlet port 32 causes the air flow 1 through the supply port 22 and the air flows 2, 3 through the inlet ports and draws the combined air flow 4 through the swirl chamber 14. The combined air flow 4 then exits the de-agglomerator through the outlet port 32. Preferably the outlet port 32 extends substantially transverse to the axis A, such that the air flow 4 will collide with an inner wall of the outlet port 32 and create further turbulence.
During use of the de-agglomerator 10 in combination with a breath-actuated dry powder inhaler including a dry powder delivery passageway and a dry powder reservoir for exposing a predetermined amount of dry powder to the delivery passageway, patient inhalation at the outlet port 32 causes air flows 1, 2, 3 to enter through, respectively, the
dry powder supply port 22 and the inlet ports. Although not shown, the air flow 1 through the supply port 22 entrains the dry powder into the swirl chamber 14. The air flow 1 and entrained dry powder are directed by the supply port 22 into the chamber in a longitudinal direction, while the air flows 2, 3 from the inlet ports are directed in a transverse direction, such that the air flows collide and substantial combine.
A portion of the combined air flow 4 and the entrained dry powder then collide with the oblique surfaces 28 of the vanes 26 causing particles and any agglomerates of the dry powder to impact against the oblique surfaces and collide with each other. The geometry of the swirl chamber 14 causes the combined air flow 4 and the entrained dry powder to follow a turbulent, spiral path, or vortex, through the chamber. As will be appreciated, the decreasing cross-sections of the swirl chamber 14 continuously changes the direction and increases the velocity of the spiraling combined air flow 4 and entrained dry powder. Thus, particles and any agglomerates of the dry powder constantly impact against the wall 12 of the swirl chamber 14 and collide with each other, resulting in a mutual grinding or shattering action between the particles and agglomerates. In addition, particles and agglomerates deflected off the oblique surfaces 28 of the vanes 26 cause further impacts and collisions. The constant impacts and collisions cause any agglomerates to break into additional particles, and cause the particles to be substantially micronized.
Upon exiting the swirl chamber 14, the direction of the combined air flow 4 and the entrained dry powder is again changed to a transverse direction with respect to the axis A, through the outlet port 32. The combined air flow 4 and the entrained dry powder retain a swirl component of the flow, such that the air flow 4 and the entrained dry powder spirally swirls through the outlet port 32. Since the micronized powder and any remaining agglomerates maintain the swirl imparted from swirl chamber 14, the swirling flow causes additional impacts in the outlet port 32 so as to result in further breaking up of any remaining agglomerates prior to being inhaled by a patient.
The de-agglomerator according to the present disclosure, therefore, ensures that particles of the dry powder are small enough for adequate penetration of the powder into a bronchial region of a patient's lungs during inhalation.
As shown in FIGS. 1 through 6, the de-agglomerator is preferably assembly from two pieces: a cup-like base 40 and a cover 42. The base 40 and the cover 42 are connected to form the swirl chamber 14. The cup-like base 40 includes the wall 12 and the second end 20 of the chamber and defines the outlet port 32. The base 40 also includes the inlet ports of the swirl chamber 14. The cover 42 forms the vanes 26 and defines the supply port 22.
The base 40 and the cover 42 of the de-agglomerator are preferably manufactured from a plastic such as polypropylene, acetal or moulded polystyrene, but may be manufactured from metal or another suitable material. Preferably, the cover 42 includes an anti-static additive, so that dry powder will not cling to the vanes 26. The base 40 and the cover 42 are then connected in a manner that provides an air tight seal between the parts. For this purpose heat or cold sealing, laser welding or ultra sonic welding could be used, for example.
It should be understood that the foregoing detailed description and preferred embodiment is only illustrative of de-agglomerator according to the present disclosure. Various alternatives and modifications to the presently disclosed de-agglomerator can be devised by those skilled in the art without departing from the spirit and scope of the present disclosure. For example, the de-agglomerator can be provided as a single piece through blow molding. In addition, the de-aggregator can be modified to be used with any inhaler and, in particular, any breath-actuated dry powder inhaler. Accordingly, the present disclosure is intended to embrace all such alternatives and modifications that fall within the spirit and scope of a de-agglomerator and a method of de-agglomerating as recited in the appended claims.
Claims (22)
1. A de-agglomerator for use with a breath-actuated dry powder inhaler including a dry powder delivery passageway and a dry powder reservoir for exposing a predetermined amount of dry powder to the dry powder delivery passageway, the de- agglomerator comprising: an inner wall defining a swirl chamber extending along an axis from a first end to a second end; a dry powder supply port in the first end of the swirl chamber for providing fluid communication between a dry powder delivery passageway of an inhaler and the first end of the swirl chamber; at least one inlet port in the inner wall of the swirl chamber adjacent to the first end of the swirl chamber providing fluid communication between a region exterior to the de-agglomerator and the first end of the swirl chamber; an outlet port providing fluid communication between the second end of the swirl chamber and a region exterior to the de-agglomerator; and vanes at the first end of the swirl chamber extending at least in part radially outwardly from the axis of the chamber, each of the vanes having an oblique surface facing at least in part in a direction transverse to the axis; whereby a breath induced low pressure at the outlet port causes air flows into the swirl chamber through the dry powder supply port and the inlet port.
2. A de-agglomerator according to claim 1, wherein the vanes comprise four vanes extending from a hub aligned with the axis to the wall of the swirl chamber.
3. A de-agglomerator according to claim 1, wherein the swirl chamber includes cross-sectional areas arranged transverse to the axis, the cross-sectional areas decreasing from the first end to the second end of the swirl chamber.
4. A de-agglomerator according to claim 3, wherein the cross-sectional areas of the swirl chamber decrease monotonically.
5. A de-agglomerator according to claim 1, wherein the inner wall of the swirl chamber is convex.
6. A de-agglomerator according to claim 1, wherein the dry powder supply port faces in a direction substantially parallel to the axis.
7. A de-agglomerator according to claim 1, wherein the outlet port extends substantially transverse to the axis.
8. A de-agglomerator according to claim 1, wherein the at least one inlet port extends in a direction substantially transverse to the axis.
9. A de-agglomerator according to claim 8, wherein the swirl chamber includes generally circular cross-sectional areas coaxially arranged about the axis, and the at least one inlet port extends substantially tangential to the circular cross-sectional areas.
10. A de-agglomerator according to claim 9, wherein the at least one inlet port comprises two diametrically opposed inlet ports.
11. A de-agglomerator according to claim 1 , wherein the vanes include an antistatic additive.
12. A de-agglomerator according to claim 1, assembled from a cup-like base closed with a cover, wherein the base defines the inner wall, the second end of the chamber and the outlet port, the cover defines the first end of the chamber, the vanes and the supply port, and the inlet port is defined by both the base and the cover.
13. A breath-actuated dry powder inhaler including a de-agglomerator according to claim 1, and further comprising: a dry powder delivery passageway providing fluid communication between a region exterior to the inhaler and the dry powder supply port of the de-agglomerator; and a dry powder reservoir for exposing a predetermined amount of dry powder to the dry powder delivery passageway; whereby an air flow through the dry powder delivery passageway and the dry powder supply port will entrain dry powder from the dry powder reservoir into the swirl chamber.
14. An inhaler according to claim 13, wherein the dry powder delivery passageway includes a venturi adjacent the dry powder reservoir.
15. An inhaler according to claim 13, further including dry powder in the dry powder reservoir.
16. An inhaler according to claim 13, wherein the dry powder comprises a medicament composition having at least one active agent medicament adhered to a particulate carrier.
17. A method of de-agglomerating dry powder from a breath-actuated dry powder inhaler prior to inhalation of the dry powder by a patient, comprising: directing a first breath-actuated air flow for entraining a dry powder from an inhaler into a first end of a chamber extending longitudinally between the first end and a second end, the first air flow directed in a longitudinal direction; directing a second breath-actuated airflow in a substantially transverse direction into the first end of the chamber such that the air flows collide and substantially combine; deflecting a portion of the combined air flows in a substantially longitudinal direction towards a second end of the chamber; directing the remaining portion of the combined air flows in a spiral path towards the second end of the chamber; and delivering all the combined air flows and any dry powder entrained therein from the second end of the chamber to a patient's mouth.
18. A method according to claim 17, wherein the second breath-actuated air flow is directed tangentially into the first end of the chamber.
19. A method according to claim 17, wherein a third breath-actuated airflow is directed in a substantially transverse direction into the first end of the chamber such that the third air flow collides and substantially combines with the first and the second air flows.
20. A method according to claim 17, wherein the combined air flows and any dry powder entrained therein are delivered from the second end of the chamber to a patient's mouth in a substantially transverse direction.
21. A method according to claim 17, wherein the combined air flows are constricted between the first end and the second end of the chamber.
22. A method according to claim 17, wherein the combined air flows are monotonically constricted between the first end and the second end of the chamber.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21338200P | 2000-06-23 | 2000-06-23 | |
US21366800P | 2000-06-23 | 2000-06-23 | |
US21366700P | 2000-06-23 | 2000-06-23 | |
US60/213,668 | 2000-06-23 | ||
US60/213,667 | 2000-06-23 | ||
US60/213,382 | 2000-06-23 | ||
PCT/US2001/020091 WO2001097889A2 (en) | 2000-06-23 | 2001-06-23 | De-agglomerator for breath-actuated dry powder inhaler |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2001284643A1 true AU2001284643A1 (en) | 2002-03-21 |
AU2001284643B2 AU2001284643B2 (en) | 2004-09-09 |
Family
ID=27395855
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001284643A Ceased AU2001284643B2 (en) | 2000-06-23 | 2001-06-23 | De-agglomerator for breath-actuated dry powder inhaler |
AU8464301A Pending AU8464301A (en) | 2000-06-23 | 2001-06-23 | De-agglomerator for breath-actuated dry powder inhaler |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU8464301A Pending AU8464301A (en) | 2000-06-23 | 2001-06-23 | De-agglomerator for breath-actuated dry powder inhaler |
Country Status (19)
Country | Link |
---|---|
US (2) | US6748947B2 (en) |
EP (2) | EP2189176B1 (en) |
JP (1) | JP4511785B2 (en) |
KR (1) | KR100503235B1 (en) |
AR (2) | AR028747A1 (en) |
AT (1) | ATE460955T1 (en) |
AU (2) | AU2001284643B2 (en) |
CA (1) | CA2407051C (en) |
CY (1) | CY1110161T1 (en) |
DE (1) | DE60141579D1 (en) |
DK (2) | DK1294421T3 (en) |
ES (2) | ES2559760T3 (en) |
GB (1) | GB2366740A (en) |
PE (1) | PE20020067A1 (en) |
PT (2) | PT2189176E (en) |
SI (1) | SI1294421T1 (en) |
TW (1) | TWI224511B (en) |
UY (1) | UY26793A1 (en) |
WO (1) | WO2001097889A2 (en) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
PE20020067A1 (en) * | 2000-06-23 | 2002-02-05 | Norton Healthcare Ltd | DEAGGLOMERATOR FOR BREATH-ACTUATED DRY POWDER INHALER |
US20040211419A1 (en) * | 2001-05-10 | 2004-10-28 | Eason Stephen William | Inhalers |
WO2003026559A2 (en) | 2001-09-28 | 2003-04-03 | Kurve Technology, Inc | Nasal nebulizer |
CA2479751C (en) | 2002-03-20 | 2008-06-03 | Trent Poole | Inhalation apparatus |
AU2003249623A1 (en) * | 2002-05-09 | 2003-12-12 | Kurve Technology, Inc. | Particle dispersion chamber for nasal nebulizer |
EP1386630B1 (en) * | 2002-07-31 | 2006-05-17 | CHIESI FARMACEUTICI S.p.A. | Powder inhaler |
AU2003285246A1 (en) * | 2002-12-02 | 2004-06-23 | The Governors Of The University Of Alberta | Device and method for deagglomeration of powder for inhalation |
GB0303870D0 (en) * | 2003-02-20 | 2003-03-26 | Norton Healthcare Ltd | Pre-metered dose magazine for breath-actuated dry powder inhaler |
CA2562386C (en) | 2004-04-21 | 2014-11-18 | Innovata Biomed Limited | Inhaler |
GB0409197D0 (en) | 2004-04-24 | 2004-05-26 | Innovata Biomed Ltd | Device |
BRPI0514263B8 (en) | 2004-08-20 | 2021-05-25 | Mannkind Corp | method for the synthesis of n-protected bis-3,6-[4-aminobutyl]-2,5-diketopiperazine n-protected |
DK2314298T3 (en) | 2004-08-23 | 2015-06-15 | Mannkind Corp | Microparticles comprising diketopiperazinsalte for drug delivery |
GB0427028D0 (en) * | 2004-12-09 | 2005-01-12 | Cambridge Consultants | Dry powder inhalers |
FR2885820B1 (en) * | 2005-05-18 | 2007-06-22 | Rexam Dispensing Systems Sas | ROOM NOZZLE TOURBILLONNAIRE |
WO2007007110A1 (en) * | 2005-07-13 | 2007-01-18 | Cipla Limited | Inhaler device |
US8763605B2 (en) | 2005-07-20 | 2014-07-01 | Manta Devices, Llc | Inhalation device |
US7803404B2 (en) | 2005-09-14 | 2010-09-28 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces |
US7987845B2 (en) * | 2006-01-31 | 2011-08-02 | Oriel Therapeutics, Inc. | Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods |
BRPI0707991B8 (en) | 2006-02-22 | 2021-05-25 | Mannkind Corp | methods of preparing a dry powder medicine with an improved pharmaceutical property, said dry powder and using an effective amount of the dry powder |
GB0611656D0 (en) * | 2006-06-13 | 2006-07-19 | Cambridge Consultants | Dry powder inhalers |
CA2681299C (en) * | 2007-03-21 | 2015-02-17 | Cipla Limited | Multi-dose inhaler device |
US11224704B2 (en) | 2007-07-06 | 2022-01-18 | Manta Devices, Llc | Dose delivery device for inhalation |
JP5528336B2 (en) * | 2007-07-06 | 2014-06-25 | マンタ デバイシス,エルエルシー | Delivery device and related method |
EP2020249A1 (en) | 2007-08-01 | 2009-02-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Inhalator |
DE102007056263A1 (en) * | 2007-11-22 | 2009-05-28 | Siegfried Generics International Ag | Dosing device for inhaling a powdery substance |
DK2082769T3 (en) * | 2008-01-24 | 2015-08-31 | Vectura Delivery Devices Ltd | inhaler |
US9358352B2 (en) | 2008-06-13 | 2016-06-07 | Mannkind Corporation | Dry powder drug delivery system and methods |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
AU2009257311B2 (en) | 2008-06-13 | 2014-12-04 | Mannkind Corporation | A dry powder inhaler and system for drug delivery |
DK2300083T3 (en) | 2008-06-20 | 2013-07-22 | Mannkind Corp | INTERACTIVE DEVICE AND PROCEDURE FOR REAL-TIME PROFILING INHALATION TESTS |
TWI494123B (en) | 2008-08-11 | 2015-08-01 | Mannkind Corp | Use of ultrarapid acting insulin |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
US8550074B2 (en) * | 2009-01-15 | 2013-10-08 | Manta Devices, Llc | Delivery device and related methods |
CN102438602B (en) * | 2009-03-04 | 2016-04-13 | 曼金德公司 | The dried powder delivery system improved |
US8538707B2 (en) | 2009-03-11 | 2013-09-17 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
GB0910537D0 (en) | 2009-06-18 | 2009-07-29 | Ivax Pharmaceuticals Ireland | Inhaler |
KR101875969B1 (en) | 2009-06-12 | 2018-07-06 | 맨카인드 코포레이션 | Diketopiperazine microparticles with defined specific surface areas |
WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
GB0919465D0 (en) | 2009-11-06 | 2009-12-23 | Norton Healthcare Ltd | Airflow adaptor for a breath-actuated dry powder inhaler |
AU2014201778B2 (en) * | 2009-11-06 | 2017-03-30 | Norton Healthcare Limited | Airflow adaptor for a breath-actuated dry powder inhaler |
WO2011116293A2 (en) | 2010-03-19 | 2011-09-22 | Manta Devices, Llc | Delivery device and related methods |
ES2625858T3 (en) | 2011-04-01 | 2017-07-20 | Mannkind Corporation | Blister pack for pharmaceutical cartridges |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
US11103659B2 (en) | 2011-07-06 | 2021-08-31 | Manta Devices, Llc | Delivery device and related methods |
CA2846899C (en) | 2011-09-07 | 2019-12-03 | Syphase, Llc | Dry powder inhalation device |
JP6018640B2 (en) | 2011-10-24 | 2016-11-02 | マンカインド コーポレイション | Analgesic composition effective for alleviating pain, and dry powder and dry powder drug delivery system comprising the composition |
US9649454B2 (en) | 2012-05-03 | 2017-05-16 | Manta Devices, Llc | Delivery device and related methods |
ES2624294T3 (en) | 2012-07-12 | 2017-07-13 | Mannkind Corporation | Dry powder drug delivery systems |
EP2911690A1 (en) | 2012-10-26 | 2015-09-02 | MannKind Corporation | Inhalable influenza vaccine compositions and methods |
EP2970149B1 (en) | 2013-03-15 | 2019-08-21 | MannKind Corporation | Microcrystalline diketopiperazine compositions and methods |
CN114848614A (en) | 2013-07-18 | 2022-08-05 | 曼金德公司 | Heat stable dry powder pharmaceutical compositions and methods |
CA2920488C (en) | 2013-08-05 | 2022-04-26 | Mannkind Corporation | Insufflation apparatus and methods |
US20160243320A1 (en) | 2013-10-07 | 2016-08-25 | Teva Branded Pharmaceutical Products R&D, Inc. | Dry powder inhaler |
GB201321717D0 (en) * | 2013-12-09 | 2014-01-22 | Pharmachemie Bv | Inhalable Medicaments |
GB201321712D0 (en) | 2013-12-09 | 2014-01-22 | Pharmachemie Bv | Dry Powder Inhaler |
WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
US11147936B2 (en) | 2014-05-02 | 2021-10-19 | Manta Devices, Llc | Dose delivery device with cover connected to dose chamber seal |
WO2015191259A1 (en) | 2014-06-13 | 2015-12-17 | Microdose Therapeutx Inc. | Medical device communication |
WO2016014153A1 (en) * | 2014-07-23 | 2016-01-28 | Microdose Therapeutx, Inc. | Dry powder nebulizer |
AR102057A1 (en) | 2014-08-28 | 2017-02-01 | Microdose Therapeutx Inc | DOCILITY MONITORING MODULE FOR A BREATHERED INHALER |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
DE102014017065B3 (en) * | 2014-11-20 | 2015-11-19 | Klaus-Dieter Beller | Powder container for powder inhalers |
US10058661B2 (en) | 2014-12-04 | 2018-08-28 | Norton (Waterford) Limited | Inhalation monitoring system and method |
MA41378A (en) * | 2015-01-20 | 2017-11-28 | Teva Branded Pharmaceutical Prod R & D Inc | DRY POWDER INHALER CONSISTING OF FLUTICASONE PROPIONATE AND SALMETEROL XINAFOATE |
US9937305B2 (en) | 2015-06-03 | 2018-04-10 | Microdose Therapeutx, Inc. | Medical device notification system |
GB201700727D0 (en) | 2017-01-16 | 2017-03-01 | Teva Pharma | Inhalers and airflow adaptors therefor |
JP2020515366A (en) | 2017-03-28 | 2020-05-28 | コンセントリクス ファーマシューティカルズ,インコーポレイテッド | Device and method for delivering dry powder drug |
ES2921305T3 (en) * | 2017-10-09 | 2022-08-23 | Pearl Therapeutics Inc | drug delivery systems |
CN111437473B (en) * | 2020-04-16 | 2023-03-24 | 宁波诺丁汉大学 | Powder inhalation device |
CN113750331B (en) * | 2021-08-18 | 2022-08-16 | 华中科技大学 | Dry powder inhaler |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3795244A (en) * | 1973-02-02 | 1974-03-05 | Syntex Corp | Inhalation device |
IE50472B1 (en) * | 1979-10-30 | 1986-04-30 | Riker Laboratories Inc | Breath actuated devices for administering powdered medicaments |
US4739754A (en) * | 1986-05-06 | 1988-04-26 | Shaner William T | Suction resistant inhalator |
GB9027234D0 (en) | 1990-12-15 | 1991-02-06 | Harris Pharma Ltd | An inhalation device |
US6055980A (en) | 1991-05-20 | 2000-05-02 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
DE69233690T2 (en) * | 1991-07-02 | 2008-01-24 | Nektar Therapeutics, San Carlos | Delivery device for nebulous drugs |
RU2111020C1 (en) * | 1992-12-18 | 1998-05-20 | Шеринг Корпорейшн | Powdered drug inhaler |
GB9306703D0 (en) * | 1993-03-31 | 1993-05-26 | Fisons Plc | Inhalation device |
DE4440734A1 (en) * | 1994-11-15 | 1996-05-23 | Bayer Ag | Separation system for a powder inhaler |
CN101398871B (en) * | 1995-02-13 | 2011-05-18 | 英特特拉斯特技术公司 | Systems and methods for secure transaction management and electronic rights protection |
CA2146954C (en) * | 1995-04-12 | 2008-06-17 | Arthur Slutsky | Breath activated nicotine inhalers |
CA2241880A1 (en) * | 1996-01-03 | 1997-07-17 | Glaxo Group Limited | Inhalation device |
GB2318737B (en) * | 1996-10-30 | 2000-06-14 | Bespak Plc | Improved inhalers |
GB9626233D0 (en) * | 1996-12-18 | 1997-02-05 | Chawla Brinda P S | Medicament packaging and deliveery device |
GB9626263D0 (en) * | 1996-12-18 | 1997-02-05 | Innovata Biomed Ltd | Powder inhaler |
SE9700937D0 (en) * | 1997-03-14 | 1997-03-14 | Astra Ab | Powder inhales I |
CA2212430A1 (en) * | 1997-08-07 | 1999-02-07 | George Volgyesi | Inhalation device |
GB9720283D0 (en) | 1997-09-25 | 1997-11-26 | Norton Healthcare Ltd | Inhaler spacer |
US6073629A (en) * | 1997-09-25 | 2000-06-13 | Norton Healthcare Ltd. | Inhaler spacer |
US5954047A (en) * | 1997-10-17 | 1999-09-21 | Systemic Pulmonary Development, Ltd. | Methods and apparatus for delivering aerosolized medication |
JP4253124B2 (en) | 1997-12-02 | 2009-04-08 | デュラ・ファーマシューティカルズ・インコーポレイテッド | Dry powder inhaler |
US6237591B1 (en) * | 1998-11-02 | 2001-05-29 | Dura Pharmaceuticals, Inc. | Turbine dry powder inhaler |
JPH11299891A (en) | 1998-04-21 | 1999-11-02 | Unisia Jecs Corp | Inhalation type medicine administration device |
AU4194199A (en) * | 1998-05-20 | 1999-12-06 | Recording Industry Association Of America | Data disc modulation for minimizing pirating |
JP3739955B2 (en) * | 1999-01-11 | 2006-01-25 | 株式会社日立製作所 | Inhaler |
US6367471B1 (en) * | 1999-11-01 | 2002-04-09 | Sheffield Pharmaceuticals, Inc. | Internal vortex mechanism for inhaler device |
TWI224515B (en) * | 2000-06-23 | 2004-12-01 | Norton Healthcare Ltd | Pre-metered dose magazine for breath-actuated dry powder inhaler |
PE20020067A1 (en) * | 2000-06-23 | 2002-02-05 | Norton Healthcare Ltd | DEAGGLOMERATOR FOR BREATH-ACTUATED DRY POWDER INHALER |
US7003674B1 (en) * | 2000-07-31 | 2006-02-21 | Western Digital Ventures, Inc. | Disk drive employing a disk with a pristine area for storing encrypted data accessible only by trusted devices or clients to facilitate secure network communications |
US6681768B2 (en) * | 2001-06-22 | 2004-01-27 | Sofotec Gmbh & Co. Kg | Powder formulation disintegrating system and method for dry powder inhalers |
-
2001
- 2001-06-22 PE PE2001000607A patent/PE20020067A1/en active IP Right Grant
- 2001-06-22 TW TW090115328A patent/TWI224511B/en not_active IP Right Cessation
- 2001-06-22 AR ARP010102990A patent/AR028747A1/en active IP Right Grant
- 2001-06-23 JP JP2002503371A patent/JP4511785B2/en not_active Expired - Fee Related
- 2001-06-23 EP EP10002414.0A patent/EP2189176B1/en not_active Expired - Lifetime
- 2001-06-23 CA CA002407051A patent/CA2407051C/en not_active Expired - Lifetime
- 2001-06-23 DK DK01963716.4T patent/DK1294421T3/en active
- 2001-06-23 ES ES10002414.0T patent/ES2559760T3/en not_active Expired - Lifetime
- 2001-06-23 ES ES01963716T patent/ES2343511T3/en not_active Expired - Lifetime
- 2001-06-23 SI SI200130968T patent/SI1294421T1/en unknown
- 2001-06-23 US US09/888,281 patent/US6748947B2/en not_active Expired - Lifetime
- 2001-06-23 EP EP01963716A patent/EP1294421B1/en not_active Expired - Lifetime
- 2001-06-23 PT PT100024140T patent/PT2189176E/en unknown
- 2001-06-23 AT AT01963716T patent/ATE460955T1/en active
- 2001-06-23 KR KR10-2002-7014844A patent/KR100503235B1/en active IP Right Grant
- 2001-06-23 DE DE60141579T patent/DE60141579D1/en not_active Expired - Lifetime
- 2001-06-23 DK DK10002414.0T patent/DK2189176T3/en active
- 2001-06-23 AU AU2001284643A patent/AU2001284643B2/en not_active Ceased
- 2001-06-23 PT PT01963716T patent/PT1294421E/en unknown
- 2001-06-23 AU AU8464301A patent/AU8464301A/en active Pending
- 2001-06-23 WO PCT/US2001/020091 patent/WO2001097889A2/en active IP Right Grant
- 2001-06-25 UY UY26793A patent/UY26793A1/en not_active IP Right Cessation
- 2001-06-25 GB GB0115520A patent/GB2366740A/en not_active Withdrawn
-
2004
- 2004-04-30 US US10/837,004 patent/US6871646B2/en not_active Expired - Lifetime
-
2007
- 2007-12-19 AR ARP070105726A patent/AR064449A2/en active IP Right Grant
-
2010
- 2010-06-04 CY CY20101100498T patent/CY1110161T1/en unknown
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6748947B2 (en) | De-agglomerator for breath-actuated dry powder inhaler | |
AU2001284643A1 (en) | De-agglomerator for breath-actuated dry powder inhaler | |
CA2398815C (en) | Dry powder inhaler | |
JP2006507876A (en) | Apparatus and method for deagglomerating powder for inhalation | |
US6983748B2 (en) | Dry powder inhaler | |
JP5016486B2 (en) | Powder inhaler with low agglomeration | |
JP2002537077A (en) | Slow spray type metered dose inhaler | |
WO2008017575A1 (en) | An inhaler and a method of dispensing medication to a person |