AU2001284268A1 - Synthons for oligonucleotide synthesis - Google Patents

Synthons for oligonucleotide synthesis

Info

Publication number
AU2001284268A1
AU2001284268A1 AU2001284268A AU8426801A AU2001284268A1 AU 2001284268 A1 AU2001284268 A1 AU 2001284268A1 AU 2001284268 A AU2001284268 A AU 2001284268A AU 8426801 A AU8426801 A AU 8426801A AU 2001284268 A1 AU2001284268 A1 AU 2001284268A1
Authority
AU
Australia
Prior art keywords
synthons
oligonucleotide synthesis
trivalent phosphorus
phosphorus multimer
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001284268A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nitto Denko Avecia Inc
Original Assignee
Avecia Biotechnology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avecia Biotechnology Inc filed Critical Avecia Biotechnology Inc
Publication of AU2001284268A1 publication Critical patent/AU2001284268A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)

Abstract

The present invention relates to phosphoramidite compounds, especially to a trivalent phosphorus multimer, a method of utilizing a trivalent phosphorus multimer to prepare an oligonucleotide, and a method of preparing a trivalent phosphorus multimer. In addition, the invention relates to a solid support that is derivatized with a trivalent phosphorus multimer and a method of preparing the same.
AU2001284268A 2000-09-07 2001-09-06 Synthons for oligonucleotide synthesis Abandoned AU2001284268A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23068500P 2000-09-07 2000-09-07
US60/230,685 2000-09-07
PCT/GB2001/003973 WO2002020543A2 (en) 2000-09-07 2001-09-06 Synthons for oligonucleotide synthesis

Publications (1)

Publication Number Publication Date
AU2001284268A1 true AU2001284268A1 (en) 2002-03-22

Family

ID=22866178

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001284268A Abandoned AU2001284268A1 (en) 2000-09-07 2001-09-06 Synthons for oligonucleotide synthesis

Country Status (10)

Country Link
US (1) US20030229218A1 (en)
EP (1) EP1317466B1 (en)
JP (1) JP2004508379A (en)
KR (1) KR20030081303A (en)
CN (1) CN1471537A (en)
AT (1) ATE289610T1 (en)
AU (1) AU2001284268A1 (en)
CA (1) CA2421489A1 (en)
DE (1) DE60109047T2 (en)
WO (1) WO2002020543A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0209539D0 (en) * 2002-04-26 2002-06-05 Avecia Ltd Monomer Polymer and process
WO2005027962A1 (en) * 2003-09-18 2005-03-31 Isis Pharmaceuticals, Inc. 4’-thionucleosides and oligomeric compounds
JP4628686B2 (en) * 2004-02-25 2011-02-09 独立行政法人科学技術振興機構 3'-terminal nucleoside unit containing phosphoramidite
JP5195757B2 (en) * 2007-08-31 2013-05-15 富士通株式会社 Dimer amidite for nucleic acid synthesis and nucleic acid synthesis method
KR100886139B1 (en) * 2007-11-13 2009-02-27 주식회사 삼천리제약 Method for preparing oligonucleotide
EP3004131B1 (en) 2013-06-05 2020-07-22 AM Chemicals Llc Phosphoramidite building blocks for sugar-conjugated oligonucleotides
WO2018035380A1 (en) 2016-08-17 2018-02-22 Solstice Biologics, Ltd. Polynucleotide constructs
US11597744B2 (en) 2017-06-30 2023-03-07 Sirius Therapeutics, Inc. Chiral phosphoramidite auxiliaries and methods of their use
WO2019158007A1 (en) * 2018-02-13 2019-08-22 深圳华大生命科学研究院 Method and system for synthesizing oligonucleotide
US11166976B2 (en) 2018-11-08 2021-11-09 Aligos Therapeutics, Inc. S-antigen transport inhibiting oligonucleotide polymers and methods
EP3805242A1 (en) * 2019-10-07 2021-04-14 Sterna Biologicals GmbH & Co. KG Method for the production of a catalytically active dna molecule having improved activity and its use in a method of treating asthma
EP4089099A1 (en) 2020-01-08 2022-11-16 Nitto Denko Corporation Nucleic acid synthesis method using segment-type amidite

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0173356B1 (en) * 1980-02-29 1990-09-19 University Patents, Inc. Process for preparing modified inorganic polymers
EP0090789A1 (en) * 1982-03-26 1983-10-05 Monsanto Company Chemical DNA synthesis
US5449769A (en) * 1989-03-06 1995-09-12 Gen-Probe Incorporated Method and reagent for sulfurization of organophosphorous compounds
US5218088A (en) * 1989-11-02 1993-06-08 Purdue Research Foundation Process for preparing dithiophosphate oligonucleotide analogs via nucleoside thiophosphoramidite intermediates
DE69232032T3 (en) * 1991-12-24 2012-09-13 Isis Pharmaceutical, Inc. ANTISENSE OLIGONUCLEOTIDE
WO1994000472A2 (en) * 1992-06-30 1994-01-06 Research Corporation Technologies, Inc. Trivalent synthesis of oligonucleotides containing stereospecific alkylphosphonates and arylphosphonates
US6087491A (en) * 1993-01-08 2000-07-11 Hybridon, Inc. Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
US5856464A (en) * 1995-06-07 1999-01-05 Lajolla Pharmaceutical Company Selective capping solution phase oligonucleotide synthesis
JP4151751B2 (en) * 1999-07-22 2008-09-17 第一三共株式会社 New bicyclonucleoside analogues

Also Published As

Publication number Publication date
US20030229218A1 (en) 2003-12-11
DE60109047D1 (en) 2005-03-31
EP1317466B1 (en) 2005-02-23
WO2002020543A3 (en) 2002-08-08
KR20030081303A (en) 2003-10-17
EP1317466A2 (en) 2003-06-11
DE60109047T2 (en) 2006-04-06
WO2002020543A2 (en) 2002-03-14
ATE289610T1 (en) 2005-03-15
JP2004508379A (en) 2004-03-18
CN1471537A (en) 2004-01-28
CA2421489A1 (en) 2002-03-14

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