AU2001263155A1 - Methods and compositions for interaction trap assays - Google Patents

Methods and compositions for interaction trap assays

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Publication number
AU2001263155A1
AU2001263155A1 AU2001263155A AU6315501A AU2001263155A1 AU 2001263155 A1 AU2001263155 A1 AU 2001263155A1 AU 2001263155 A AU2001263155 A AU 2001263155A AU 6315501 A AU6315501 A AU 6315501A AU 2001263155 A1 AU2001263155 A1 AU 2001263155A1
Authority
AU
Australia
Prior art keywords
compositions
methods
interaction trap
trap assays
assays
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001263155A
Inventor
J. Keith Joung
Jeffrey Miller
Carl O Pabo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
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Massachusetts Institute of Technology
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Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of AU2001263155A1 publication Critical patent/AU2001263155A1/en
Abandoned legal-status Critical Current

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1055Protein x Protein interaction, e.g. two hybrid selection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2001263155A 2000-05-16 2001-05-16 Methods and compositions for interaction trap assays Abandoned AU2001263155A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20450900P 2000-05-16 2000-05-16
US60/204,509 2000-05-16
PCT/US2001/015718 WO2001088197A2 (en) 2000-05-16 2001-05-16 Methods and compositions for interaction trap assays

Publications (1)

Publication Number Publication Date
AU2001263155A1 true AU2001263155A1 (en) 2001-11-26

Family

ID=22758190

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001263155A Abandoned AU2001263155A1 (en) 2000-05-16 2001-05-16 Methods and compositions for interaction trap assays

Country Status (3)

Country Link
US (2) US20030044787A1 (en)
AU (1) AU2001263155A1 (en)
WO (1) WO2001088197A2 (en)

Families Citing this family (215)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020061512A1 (en) * 2000-02-18 2002-05-23 Kim Jin-Soo Zinc finger domains and methods of identifying same
CN100463962C (en) * 2001-12-07 2009-02-25 图尔金株式会社 Phenotypic screen of chimeric proteins
US20020094519A1 (en) * 2002-03-07 2002-07-18 Agencourt Bioscience Corporation Detection of protein interactions
US7825227B2 (en) * 2002-05-09 2010-11-02 Prolexys Pharmaceuticals, Inc. Method for purification of a protein complex and identification of its components
EP1570058A1 (en) * 2002-12-09 2005-09-07 Toolgen, Inc. Regulatory zinc finger proteins
US20050037409A1 (en) * 2003-07-29 2005-02-17 Kauvar Lawrence M. Translocation tagging
US20120196370A1 (en) 2010-12-03 2012-08-02 Fyodor Urnov Methods and compositions for targeted genomic deletion
JP4555292B2 (en) 2003-08-08 2010-09-29 サンガモ バイオサイエンシズ インコーポレイテッド Methods and compositions for targeted cleavage and recombination
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
US7407776B2 (en) 2003-09-19 2008-08-05 Sangamo Biosciences, Inc. Engineered zinc finger proteins for regulation of gene expression
US7504216B2 (en) 2004-02-02 2009-03-17 University Of Massachusetts Bacterial counterselectable hybrid systems
US20070077575A1 (en) * 2004-03-05 2007-04-05 Mcallister William T Use of rna polymerase as an information-dependent molecular motor
AU2005287278B2 (en) * 2004-09-16 2011-08-04 Sangamo Biosciences, Inc. Compositions and methods for protein production
JP4564926B2 (en) * 2005-01-25 2010-10-20 エワ ユニバーシティ−インダストリー コラボレーション ファウンデーション Deletion IgE-dependent histamine-releasing factor having histamine secretion ability, HRF-binding peptide and method of using the same
AU2006272634B2 (en) 2005-07-26 2013-01-24 Sangamo Therapeutics, Inc. Targeted integration and expression of exogenous nucleic acid sequences
ATE427956T1 (en) * 2005-10-11 2009-04-15 Johnson & Johnson Consumer Fr CKROX PEPTIDES AND THEIR ANALOGUES FOR THE TREATMENT OF SKIN AGING
JP5551432B2 (en) 2006-05-25 2014-07-16 サンガモ バイオサイエンシーズ, インコーポレイテッド Methods and compositions for gene inactivation
EP2213731B1 (en) 2006-05-25 2013-12-04 Sangamo BioSciences, Inc. Variant foki cleavage half-domains
PL2049663T3 (en) 2006-08-11 2015-08-31 Dow Agrosciences Llc Zinc finger nuclease-mediated homologous recombination
AU2007319881B2 (en) 2006-11-13 2012-05-17 Sangamo Therapeutics, Inc. Zinc finger nuclease for targeting the human glucocorticoid receptor locus
HUE029238T2 (en) 2006-12-14 2017-02-28 Dow Agrosciences Llc Optimized non-canonical zinc finger proteins
US7932030B2 (en) * 2007-04-05 2011-04-26 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College System for pulling out regulatory elements using yeast
CA2684378C (en) 2007-04-26 2016-11-29 Sangamo Biosciences, Inc. Targeted integration into the ppp1r12c locus
AU2008275649B2 (en) 2007-07-12 2013-09-05 Sangamo Therapeutics, Inc. Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT 8) gene expression
BRPI0817560B1 (en) 2007-09-27 2022-09-20 Dow Agrosciences Llc ENGINEERED ZINC FINGER PROTEINS (ZFP) TARGETING 5-ENOLPIRUVYL SHIKYMATE-3-PHOSPHATE SYNTHASE, ZINC FINGER NUCLEASE (ZFN) GENES, VECTOR, AS WELL AS METHODS FOR INTRODUCTION OF A TRANSGENE INTO A CELL GENOME PLANT, TO EXPRESS THE PRODUCT OF A TRANSGENE IN A PLANT CELL, FOR DELETION OF AN EPSPS GENE SEQUENCE FROM AN EPSPS GENE LOCU IN THE GENOME OF A PLANT CELL, AND TO MODULATE EXPRESSION OF AN EPSPS GENE
CN101883863B (en) 2007-09-27 2018-01-23 桑格摩生物科学股份有限公司 The rapid in vivo identification of biologically active nucleases
US11235026B2 (en) 2007-09-27 2022-02-01 Sangamo Therapeutics, Inc. Methods and compositions for modulating PD1
US8563314B2 (en) 2007-09-27 2013-10-22 Sangamo Biosciences, Inc. Methods and compositions for modulating PD1
JP2011500082A (en) 2007-10-25 2011-01-06 サンガモ バイオサイエンシーズ, インコーポレイテッド Methods and compositions for targeted integration
JP2011518555A (en) 2008-04-14 2011-06-30 サンガモ バイオサイエンシーズ, インコーポレイテッド Linear donor constructs for targeted integration
WO2009146179A1 (en) * 2008-04-15 2009-12-03 University Of Iowa Research Foundation Zinc finger nuclease for the cftr gene and methods of use thereof
JP2011521643A (en) 2008-05-28 2011-07-28 サンガモ バイオサイエンシーズ, インコーポレイテッド Composition for linking a DNA binding domain and a cleavage domain
JP5763530B2 (en) 2008-06-10 2015-08-12 サンガモ バイオサイエンシーズ, インコーポレイテッド Methods and compositions for the generation of Bax- and Bak-deficient cell lines
CA2734235C (en) 2008-08-22 2019-03-26 Sangamo Biosciences, Inc. Methods and compositions for targeted single-stranded cleavage and targeted integration
CA2741119C (en) 2008-10-29 2019-02-12 Sangamo Biosciences, Inc. Methods and compositions for inactivating glutamine synthetase gene expression
WO2010065123A1 (en) 2008-12-04 2010-06-10 Sangamo Biosciences, Inc. Genome editing in rats using zinc-finger nucleases
ES2654923T3 (en) 2008-12-17 2018-02-15 Dow Agrosciences Llc Directed integration in Zp15 location
EP2393506B1 (en) 2009-02-04 2018-03-28 Sangamo Therapeutics, Inc. Methods and compositions for treating neuropathies
CA2755192C (en) 2009-03-20 2018-09-11 Sangamo Biosciences, Inc. Modification of cxcr4 using engineered zinc finger proteins
WO2010117464A1 (en) 2009-04-09 2010-10-14 Sangamo Biosciences, Inc. Targeted integration into stem cells
US8772008B2 (en) 2009-05-18 2014-07-08 Sangamo Biosciences, Inc. Methods and compositions for increasing nuclease activity
EP2449135B1 (en) 2009-06-30 2016-01-06 Sangamo BioSciences, Inc. Rapid screening of biologically active nucleases and isolation of nuclease-modified cells
CA2766123A1 (en) 2009-07-08 2011-01-13 Cellular Dynamics International, Inc. Modified ips cells having a mutant form of human immunodeficiency virus (hiv) cellular entry gene
JP5866283B2 (en) 2009-07-28 2016-02-17 サンガモ バイオサイエンシーズ, インコーポレイテッド Methods and compositions for treating trinucleotide repeat disease
NZ598053A (en) 2009-08-11 2014-01-31 Sangamo Biosciences Inc Organisms homozygous for targeted modification
RU2568056C2 (en) 2009-10-22 2015-11-10 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Constructed proteins with zinc fingers directed towards genes of plants involved in biosynthesis of fatty acids
US8956828B2 (en) 2009-11-10 2015-02-17 Sangamo Biosciences, Inc. Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
AU2011207769B2 (en) 2010-01-22 2015-05-28 Corteva Agriscience Llc Targeted genomic alteration
CA2788560A1 (en) 2010-02-08 2011-08-11 Sangamo Biosciences, Inc. Engineered cleavage half-domains
CA2788850C (en) 2010-02-09 2019-06-25 Sangamo Biosciences, Inc. Targeted genomic modification with partially single-stranded donor molecules
JP5952263B2 (en) 2010-04-26 2016-07-13 サンガモ バイオサイエンシーズ, インコーポレイテッド Genome editing of the ROSA locus using zinc finger nuclease
LT2566972T (en) 2010-05-03 2020-03-10 Sangamo Therapeutics, Inc. Compositions for linking zinc finger modules
CA2798988C (en) 2010-05-17 2020-03-10 Sangamo Biosciences, Inc. Tal-effector (tale) dna-binding polypeptides and uses thereof
CA3157027A1 (en) 2010-07-21 2012-01-26 Sangamo Therapeutics, Inc. Methods and compositions for modification of a t-cell receptor gene
JP2013537410A (en) 2010-07-23 2013-10-03 シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー Genome editing using targeted endonucleases and single-stranded nucleic acids
EP2622090B1 (en) 2010-09-27 2019-06-19 Sangamo Therapeutics, Inc. Compositions for inhibiting viral entry into cells
EP2627665B1 (en) 2010-10-12 2015-12-16 The Children's Hospital Of Philadelphia Methods and compositions for treating hemophilia B
JP2014513520A (en) 2010-12-29 2014-06-05 シグマ−アルドリッチ・カンパニー、エルエルシー Cells with perturbed expression of proteins involved in ADME and toxicological processes
US9267123B2 (en) 2011-01-05 2016-02-23 Sangamo Biosciences, Inc. Methods and compositions for gene correction
EP2707714B1 (en) * 2011-05-09 2019-10-09 Whitehead Institute For Biomedical Research Chaperone interaction assays and uses thereof
ES2671733T3 (en) 2011-06-30 2018-06-08 Sigma Aldrich Co. Llc Cells deficient in CMP-N-acetylneuraminic hydroxylase and / or glycoprotein alpha-1,3-galactosyl transferase
AU2012286901B2 (en) 2011-07-25 2016-10-27 Sangamo Therapeutics, Inc. Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (CFTR) gene
JP6185916B2 (en) 2011-09-21 2017-08-23 サンガモ セラピューティクス, インコーポレイテッド Methods and compositions for controlling transgene expression
AU2012328682B2 (en) 2011-10-27 2017-09-21 Sangamo Therapeutics, Inc. Methods and compositions for modification of the HPRT locus
AU2012340213B2 (en) 2011-11-16 2017-12-07 Sangamo Therapeutics, Inc. Modified DNA-binding proteins and uses thereof
JP6262665B2 (en) 2012-01-11 2018-01-17 シグマ−アルドリッチ・カンパニー、エルエルシー Production of recombinant proteins with simple glycoforms
US10570378B2 (en) 2012-02-28 2020-02-25 Sigma-Aldrich Co. Llc Targeted histone acetylation
KR102084539B1 (en) 2012-02-29 2020-03-04 상가모 테라퓨틱스, 인코포레이티드 Methods and compositions for treating huntington's disease
CN102660642A (en) * 2012-04-24 2012-09-12 西北农林科技大学 Screening system for screening zinc finger protein
UA115875C2 (en) 2012-05-02 2018-01-10 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Targeted modification of malate dehydrogenase
BR112014027813A2 (en) 2012-05-07 2017-08-08 Dow Agrosciences Llc methods and compositions for nuclease-mediated directed transgene integration
US10883119B2 (en) 2012-07-11 2021-01-05 Sangamo Therapeutics, Inc. Methods and compositions for delivery of biologics
US10648001B2 (en) 2012-07-11 2020-05-12 Sangamo Therapeutics, Inc. Method of treating mucopolysaccharidosis type I or II
EP3816281A1 (en) 2012-07-11 2021-05-05 Sangamo Therapeutics, Inc. Methods and compositions for the treatment of lysosomal storage diseases
RS60838B1 (en) 2012-08-29 2020-10-30 Sangamo Therapeutics Inc Methods and compositions for treatment of a genetic condition
WO2014039513A2 (en) 2012-09-04 2014-03-13 The Trustees Of The University Of Pennsylvania Inhibition of diacylglycerol kinase to augment adoptive t cell transfer
UA118090C2 (en) 2012-09-07 2018-11-26 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Fad2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
JP6775953B2 (en) 2012-09-07 2020-10-28 ダウ アグロサイエンシィズ エルエルシー FAD3 performance locus and corresponding target site-specific binding proteins capable of inducing targeted cleavage
UA119135C2 (en) 2012-09-07 2019-05-10 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Engineered transgene integration platform (etip) for gene targeting and trait stacking
DK2906684T3 (en) 2012-10-10 2020-09-28 Sangamo Therapeutics Inc T-CELL MODIFIING COMPOUNDS AND USES THEREOF
JP2016500254A (en) 2012-12-05 2016-01-12 サンガモ バイオサイエンシーズ, インコーポレイテッド Methods and compositions for the regulation of metabolic diseases
KR20150096696A (en) 2012-12-13 2015-08-25 다우 아그로사이언시즈 엘엘씨 Precision gene targeting to a particular locus in maize
ES2768291T3 (en) 2013-02-14 2020-06-22 Univ Osaka Method for isolating a specific genomic region using a molecule that specifically binds to an endogenous DNA sequence
WO2014130955A1 (en) 2013-02-25 2014-08-28 Sangamo Biosciences, Inc. Methods and compositions for enhancing nuclease-mediated gene disruption
JP6346266B2 (en) 2013-03-21 2018-06-20 サンガモ セラピューティクス, インコーポレイテッド Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
WO2014165612A2 (en) 2013-04-05 2014-10-09 Dow Agrosciences Llc Methods and compositions for integration of an exogenous sequence within the genome of plants
WO2014182700A1 (en) 2013-05-10 2014-11-13 Sangamo Biosciences, Inc. Delivery methods and compositions for nuclease-mediated genome engineering
EP2997146A4 (en) 2013-05-15 2017-04-26 Sangamo BioSciences, Inc. Methods and compositions for treatment of a genetic condition
WO2015031619A1 (en) 2013-08-28 2015-03-05 Sangamo Biosciences, Inc. Compositions for linking dna-binding domains and cleavage domains
EP3058072B1 (en) 2013-10-17 2021-05-19 Sangamo Therapeutics, Inc. Delivery methods and compositions for nuclease-mediated genome engineering
EP3057432B1 (en) 2013-10-17 2018-11-21 Sangamo Therapeutics, Inc. Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
AU2014341927B2 (en) 2013-11-04 2017-12-14 Corteva Agriscience Llc Optimal maize loci
EP3065540B1 (en) 2013-11-04 2021-12-15 Corteva Agriscience LLC Optimal maize loci
NZ718117A (en) 2013-11-04 2017-09-29 Dow Agrosciences Llc Optimal soybean loci
WO2015066634A2 (en) 2013-11-04 2015-05-07 Dow Agrosciences Llc Optimal soybean loci
BR112016010175A2 (en) 2013-11-11 2017-10-03 Sangamo Biosciences Inc GENETIC REPRESSOR, ITS USES, AND PHARMACEUTICAL COMPOSITION
PT3068881T (en) 2013-11-13 2019-05-31 Childrens Medical Center Nuclease-mediated regulation of gene expression
JP6535684B2 (en) 2013-12-09 2019-06-26 サンガモ セラピューティクス, インコーポレイテッド Methods and compositions for genome manipulation
RS60514B1 (en) 2014-02-03 2020-08-31 Sangamo Therapeutics Inc Methods and compositions for treatment of a beta thalessemia
EP3110454B1 (en) 2014-02-24 2020-11-18 Sangamo Therapeutics, Inc. Methods and compositions for nuclease-mediated targeted integration
CN106661569B (en) 2014-03-04 2020-09-11 西格马—奥尔德里奇有限责任公司 Antiviral cells and uses thereof
JP6594891B2 (en) 2014-03-18 2019-10-23 サンガモ セラピューティクス, インコーポレイテッド Methods and compositions for modulating zinc finger protein expression
WO2015164748A1 (en) 2014-04-24 2015-10-29 Sangamo Biosciences, Inc. Engineered transcription activator like effector (tale) proteins
NZ725542A (en) 2014-05-08 2024-02-23 Sangamo Biosciences Inc Methods and compositions for treating huntington’s disease
US9574211B2 (en) 2014-05-13 2017-02-21 Sangamo Biosciences, Inc. Methods and compositions for prevention or treatment of a disease
EP3151846A4 (en) 2014-06-05 2017-12-27 Sangamo BioSciences, Inc. Methods and compositions for nuclease design
WO2016005449A1 (en) 2014-07-08 2016-01-14 Vib Vzw Means and methods to increase plant yield
BR112017000925B1 (en) 2014-07-14 2023-10-10 Washington State University METHOD OF REPRODUCTION OF PIGS, METHOD OF GENERATING A PIG WITHOUT ANY FUNCTIONAL SPERMATOGONE CELLS, METHOD OF PRODUCING A RECEIVING MALE AND METHOD OF PRODUCING PIGS
WO2016011381A1 (en) 2014-07-18 2016-01-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Reducing cxcr4 expression and/or function to enhance engraftment of hematopoietic stem cells
WO2016014794A1 (en) 2014-07-25 2016-01-28 Sangamo Biosciences, Inc. Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
US9757420B2 (en) 2014-07-25 2017-09-12 Sangamo Therapeutics, Inc. Gene editing for HIV gene therapy
WO2016019144A2 (en) 2014-07-30 2016-02-04 Sangamo Biosciences, Inc. Gene correction of scid-related genes in hematopoietic stem and progenitor cells
CN113699113A (en) 2014-09-16 2021-11-26 桑格摩治疗股份有限公司 Methods and compositions for nuclease-mediated genome engineering and correction in hematopoietic stem cells
US10889834B2 (en) 2014-12-15 2021-01-12 Sangamo Therapeutics, Inc. Methods and compositions for enhancing targeted transgene integration
US20180002379A1 (en) 2015-01-21 2018-01-04 Sangamo Therapeutics, Inc. Methods and compositions for identification of highly specific nucleases
CA2981077A1 (en) 2015-04-03 2016-10-06 Dana-Farber Cancer Institute, Inc. Composition and methods of genome editing of b-cells
US10179918B2 (en) 2015-05-07 2019-01-15 Sangamo Therapeutics, Inc. Methods and compositions for increasing transgene activity
SG10202112057QA (en) 2015-05-12 2021-12-30 Sangamo Therapeutics Inc Nuclease-mediated regulation of gene expression
US9957501B2 (en) 2015-06-18 2018-05-01 Sangamo Therapeutics, Inc. Nuclease-mediated regulation of gene expression
JP6954890B2 (en) 2015-07-13 2021-10-27 サンガモ セラピューティクス, インコーポレイテッド Delivery methods and compositions for nuclease-mediated genomic genetic engineering
WO2017023570A1 (en) 2015-08-06 2017-02-09 The Curators Of The University Of Missouri Pathogen-resistant animals having modified cd163 genes
EA037993B1 (en) 2015-09-23 2021-06-21 Сангамо Терапьютикс, Инк. Htt repressors and uses thereof
EP3380622A4 (en) 2015-11-23 2019-08-07 Sangamo Therapeutics, Inc. Methods and compositions for engineering immunity
US11352631B2 (en) 2015-12-18 2022-06-07 Sangamo Therapeutics, Inc. Targeted disruption of the T cell receptor
SG10202005640UA (en) 2015-12-18 2020-07-29 Sangamo Therapeutics Inc Targeted disruption of the mhc cell receptor
BR112018014288A2 (en) 2016-01-15 2018-12-18 Univ Minnesota methods and compositions for the treatment of neurological disease
EP3411056A4 (en) 2016-02-02 2019-10-02 Sangamo Therapeutics, Inc. Compositions for linking dna-binding domains and cleavage domains
US11421218B2 (en) 2016-03-23 2022-08-23 Dana-Farber Cancer Institute, Inc. Methods for enhancing the efficiency of gene editing
EP3484870B1 (en) 2016-07-13 2022-11-16 Vertex Pharmaceuticals Incorporated Methods, compositions and kits for increasing genome editing efficiency
EP3487992A4 (en) 2016-07-21 2020-03-18 Maxcyte, Inc. Methods and compositions for modifying genomic dna
CA3031818A1 (en) 2016-07-27 2018-02-01 Case Western Reserve University Compounds and methods of promoting myelination
US11193136B2 (en) 2016-08-09 2021-12-07 Vib Vzw Cellulose synthase inhibitors and mutant plants
RS62758B1 (en) 2016-08-24 2022-01-31 Sangamo Therapeutics Inc Regulation of gene expression using engineered nucleases
EP3964573A1 (en) 2016-08-24 2022-03-09 Sangamo Therapeutics, Inc. Engineered target specific nucleases
CA3035534A1 (en) 2016-09-07 2018-03-15 Sangamo Therapeutics, Inc. Modulation of liver genes
EP3757120B8 (en) 2016-10-04 2022-06-15 Precision Biosciences, Inc. Co-stimulatory domains for use in genetically-modified cells
KR20190060829A (en) 2016-10-20 2019-06-03 상가모 테라퓨틱스, 인코포레이티드 Methods and compositions for the treatment of Fabry disease
US11020492B2 (en) 2016-10-31 2021-06-01 Sangamo Therapeutics, Inc. Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
US11504389B2 (en) 2016-12-01 2022-11-22 Sangamo Therapeutics, Inc. Tau modulators and methods and compositions for delivery thereof
ES2968892T3 (en) 2016-12-08 2024-05-14 Univ Case Western Reserve Methods and compositions to increase the production of functional myelin
WO2018140478A1 (en) 2017-01-24 2018-08-02 Sigma-Aldrich Co. Llc Viral resistant cells and culture systems
US20210047633A1 (en) * 2017-03-29 2021-02-18 Editas Medicine, Inc. Selection methods
WO2018195418A1 (en) 2017-04-20 2018-10-25 Oregon Health & Science University Human gene correction
RU2019139045A (en) 2017-05-03 2021-06-03 Сангамо Терапьютикс, Инк. METHODS AND COMPOSITIONS FOR MODIFICATION OF THE TRANSMEMBRANE CONDUCTIVITY REGULATOR GENE IN CYSTIC FIBROSIS (CFTR)
EP4029943A1 (en) 2017-05-08 2022-07-20 Precision Biosciences, Inc. Nucleic acid molecules encoding an engineered antigen receptor and an inhibitory nucleic acid molecule and methods of use thereof
AU2018279829B2 (en) 2017-06-09 2024-01-04 Editas Medicine, Inc. Engineered Cas9 nucleases
US11512287B2 (en) 2017-06-16 2022-11-29 Sangamo Therapeutics, Inc. Targeted disruption of T cell and/or HLA receptors
JP2020529834A (en) 2017-06-30 2020-10-15 プレシジョン バイオサイエンシズ,インク. Genetically modified T cells containing modified introns of the T cell receptor alpha gene
GB201712733D0 (en) * 2017-08-08 2017-09-20 Snipr Tech Ltd Methods & cells
JP2020537515A (en) 2017-10-03 2020-12-24 ジュノー セラピューティクス インコーポレイテッド HPV-specific binding molecule
EP4269560A3 (en) 2017-10-03 2024-01-17 Precision Biosciences, Inc. Modified epidermal growth factor receptor peptides for use in genetically-modified cells
EP3704238B1 (en) 2017-11-01 2024-01-03 Precision Biosciences, Inc. Engineered nucleases that target human and canine factor viii genes as a treatment for hemophilia a
KR20200079539A (en) 2017-11-09 2020-07-03 상가모 테라퓨틱스, 인코포레이티드 Genetic modification of cytokine-inducible SH2-containing protein (CISH) gene
EA202091709A1 (en) 2018-01-17 2020-11-10 Вертекс Фармасьютикалз Инкорпорейтед DNA PC INHIBITORS
MA51619A (en) 2018-01-17 2021-04-14 Vertex Pharma DNA-DEPENDENT KINASE PROTEIN INHIBITORS
MA51623A (en) 2018-01-17 2021-04-14 Vertex Pharma QUINOXALINONE COMPOUNDS, COMPOSITIONS, METHODS AND KITS FOR INCREASING GENOME EDITING EFFICIENCY
WO2019157324A1 (en) 2018-02-08 2019-08-15 Sangamo Therapeutics, Inc. Engineered target specific nucleases
MA52656A (en) 2018-04-05 2021-02-17 Editas Medicine Inc PROCESSES FOR THE PRODUCTION OF CELLS EXPRESSING A RECOMBINANT RECEIVER AND ASSOCIATED COMPOSITIONS
JP2021520211A (en) 2018-04-05 2021-08-19 ジュノー セラピューティクス インコーポレイテッド T cells expressing recombinant receptors, related polynucleotides, and methods
CN112313246A (en) 2018-04-18 2021-02-02 桑格摩生物治疗股份有限公司 Zinc finger protein compositions for modulating Huntingtin (HTT)
US11690921B2 (en) 2018-05-18 2023-07-04 Sangamo Therapeutics, Inc. Delivery of target specific nucleases
CN108802357B (en) * 2018-06-27 2021-03-30 中南民族大学 Bioluminescent probe for immunoblot analysis and application thereof
AU2019326408A1 (en) 2018-08-23 2021-03-11 Sangamo Therapeutics, Inc. Engineered target specific base editors
EP4234570A3 (en) 2018-09-18 2023-12-13 Sangamo Therapeutics, Inc. Programmed cell death 1 (pd1) specific nucleases
EP3898661A1 (en) 2018-12-21 2021-10-27 Precision BioSciences, Inc. Genetic modification of the hydroxyacid oxidase 1 gene for treatment of primary hyperoxaluria
AU2020205717A1 (en) 2019-01-11 2021-08-12 Acuitas Therapeutics, Inc. Lipids for lipid nanoparticle delivery of active agents
CN112805026A (en) 2019-02-06 2021-05-14 桑格摩生物治疗股份有限公司 Methods for treating mucopolysaccharidosis type I
BR112021019448A2 (en) 2019-04-02 2021-11-30 Sangamo Therapeutics Inc Methods for treating beta-thalassemia
MX2021012110A (en) 2019-04-03 2022-01-06 Prec Biosciences Inc Genetically-modified immune cells comprising a microrna-adapted shrna (shrnamir).
EP3947646A1 (en) 2019-04-05 2022-02-09 Precision BioSciences, Inc. Methods of preparing populations of genetically-modified immune cells
WO2020219726A1 (en) 2019-04-23 2020-10-29 Sangamo Therapeutics, Inc. Modulators of chromosome 9 open reading frame 72 gene expression and uses thereof
US20220184131A1 (en) 2019-05-01 2022-06-16 Juno Therapeutics, Inc. Cells expressing a recombinant receptor from a modified tgfbr2 locus, related polynucleotides and methods
KR20220016474A (en) 2019-05-01 2022-02-09 주노 쎄러퓨티크스 인코퍼레이티드 Cells expressing chimeric receptors from modified CD247 loci, related polynucleotides and methods
WO2020252381A2 (en) 2019-06-13 2020-12-17 Allogene Therapeutics, Inc. Anti-talen antibodies and uses thereof
US20220273715A1 (en) 2019-07-25 2022-09-01 Precision Biosciences, Inc. Compositions and methods for sequential stacking of nucleic acid sequences into a genomic locus
JP2022544825A (en) 2019-08-20 2022-10-21 プレシジョン バイオサイエンシズ,インク. Lymphocyte-depleting administration regimens for cellular immunotherapy
WO2021035170A1 (en) 2019-08-21 2021-02-25 Precision Biosciences, Inc. Compositions and methods for tcr reprogramming using fusion proteins
JP2022551286A (en) 2019-10-02 2022-12-08 サンガモ セラピューティクス, インコーポレイテッド Zinc finger protein transcription factors for repressing α-synuclein expression
CN114728037A (en) 2019-10-02 2022-07-08 桑格摩生物治疗股份有限公司 Zinc finger protein transcription factor for prion disease treatment
WO2021087305A1 (en) 2019-10-30 2021-05-06 Precision Biosciences, Inc. Cd20 chimeric antigen receptors and methods of use for immunotherapy
TW202132565A (en) 2019-11-01 2021-09-01 美商聖加莫治療股份有限公司 Gin recombinase variants
CA3160096A1 (en) 2019-12-06 2021-06-10 Bruce J. Mccreedy Jr. Methods for cancer immunotherapy
AR121118A1 (en) 2020-01-22 2022-04-20 Sangamo Therapeutics Inc ZINC FINGER PROTEIN TRANSCRIPTION FACTORS TO REPRESS TAU EXPRESSION
WO2021158915A1 (en) 2020-02-06 2021-08-12 Precision Biosciences, Inc. Recombinant adeno-associated virus compositions and methods for producing and using the same
WO2021202513A1 (en) 2020-03-31 2021-10-07 Elo Life Systems Modulation of endogenous mogroside pathway genes in watermelon and other cucurbits
WO2021224416A1 (en) 2020-05-06 2021-11-11 Cellectis S.A. Methods to genetically modify cells for delivery of therapeutic proteins
US20230212613A1 (en) 2020-05-06 2023-07-06 Cellectis S.A. Methods for targeted insertion of exogenous sequences in cellular genomes
US20230183664A1 (en) 2020-05-11 2023-06-15 Precision Biosciences, Inc. Self-limiting viral vectors encoding nucleases
US20230181641A1 (en) 2020-05-13 2023-06-15 Juno Therapeutics, Inc. Process for producing donor-batched cells expressing a recombinant receptor
JP2023531531A (en) 2020-06-26 2023-07-24 ジュノ セラピューティクス ゲーエムベーハー Engineered T Cells Conditionally Expressing Recombinant Receptors, Related Polynucleotides, and Methods
US11976019B2 (en) 2020-07-16 2024-05-07 Acuitas Therapeutics, Inc. Cationic lipids for use in lipid nanoparticles
EP4192875A1 (en) 2020-08-10 2023-06-14 Precision BioSciences, Inc. Antibodies and fragments specific for b-cell maturation antigen and uses thereof
WO2022046760A2 (en) 2020-08-25 2022-03-03 Kite Pharma, Inc. T cells with improved functionality
JP2023542705A (en) 2020-09-25 2023-10-11 サンガモ セラピューティクス, インコーポレイテッド Zinc finger fusion proteins for nucleobase editing
US20230365995A1 (en) 2020-10-07 2023-11-16 Precision Biosciences, Inc. Lipid nanoparticle compositions
WO2022087527A1 (en) 2020-10-23 2022-04-28 Elo Life Systems, Inc. Methods for producing vanilla plants with improved flavor and agronomic production
EP4240756A1 (en) 2020-11-04 2023-09-13 Juno Therapeutics, Inc. Cells expressing a chimeric receptor from a modified invariant cd3 immunoglobulin superfamily chain locus and related polynucleotides and methods
US20240000051A1 (en) 2020-11-16 2024-01-04 Pig Improvement Company Uk Limited Influenza a-resistant animals having edited anp32 genes
WO2022165111A1 (en) 2021-01-28 2022-08-04 Precision Biosciences, Inc. Modulation of tgf beta signaling in genetically-modified eukaryotic cells
US20240141311A1 (en) 2021-04-22 2024-05-02 North Carolina State University Compositions and methods for generating male sterile plants
WO2023064872A1 (en) 2021-10-14 2023-04-20 Precision Biosciences, Inc. Combinations of anti-bcma car t cells and gamma secretase inhibitors
WO2023070003A1 (en) 2021-10-19 2023-04-27 Precision Biosciences, Inc. Gene editing methods for treating alpha-1 antitrypsin (aat) deficiency
WO2023081900A1 (en) 2021-11-08 2023-05-11 Juno Therapeutics, Inc. Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods
TW202328201A (en) 2021-11-09 2023-07-16 美商安進公司 Method of producing an antibody peptide conjugate
WO2023091910A1 (en) 2021-11-16 2023-05-25 Precision Biosciences, Inc. Methods for cancer immunotherapy
WO2023105244A1 (en) 2021-12-10 2023-06-15 Pig Improvement Company Uk Limited Editing tmprss2/4 for disease resistance in livestock
WO2023122722A1 (en) 2021-12-22 2023-06-29 Sangamo Therapeutics, Inc. Novel zinc finger fusion proteins for nucleobase editing
WO2023131616A1 (en) 2022-01-05 2023-07-13 Vib Vzw Means and methods to increase abiotic stress tolerance in plants
WO2023131637A1 (en) 2022-01-06 2023-07-13 Vib Vzw Improved silage grasses
WO2023144199A1 (en) 2022-01-26 2023-08-03 Vib Vzw Plants having reduced levels of bitter taste metabolites
WO2023168397A1 (en) 2022-03-04 2023-09-07 Sigma-Aldrich Co. Llc Metabolic selection via the asparagine biosynthesis pathway
WO2024013514A2 (en) 2022-07-15 2024-01-18 Pig Improvement Company Uk Limited Gene edited livestock animals having coronavirus resistance
WO2024073686A1 (en) 2022-09-30 2024-04-04 Sigma-Aldrich Co. Llc Metabolic selection via the serine biosynthesis pathway
WO2024073692A1 (en) 2022-09-30 2024-04-04 Sigma-Aldrich Co. Llc Metabolic selection via the glycine-formate biosynthesis pathway
WO2024100604A1 (en) 2022-11-09 2024-05-16 Juno Therapeutics Gmbh Methods for manufacturing engineered immune cells

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE316573T1 (en) * 1992-10-30 2006-02-15 Gen Hospital Corp INTERACTING TRAP SYSTEM FOR ISOLATION OF PROTEINS
CA2217545A1 (en) * 1995-04-11 1996-10-17 Marc Vidal Reverse two-hybrid systems
US5925523A (en) * 1996-08-23 1999-07-20 President & Fellows Of Harvard College Intraction trap assay, reagents and uses thereof
AU4159697A (en) * 1996-08-23 1998-03-06 President And Fellows Of Harvard College Interaction trap assay, reagents and uses thereof
ATE289353T1 (en) * 1996-12-11 2005-03-15 Bristol Myers Squibb Co PROKARYOTIC TWO-HYBRID SYSTEM
US5885779A (en) 1997-09-09 1999-03-23 University Of British Columbia Repressed trans-activator system for characterization of protein-protein interactions
US6326150B1 (en) 1997-09-16 2001-12-04 Fox Chase Cancer Center Yeast interaction trap assay
AU760908B2 (en) 1997-11-27 2003-05-22 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Identification and characterization of interacting molecules by automated interaction mating
US20020061512A1 (en) 2000-02-18 2002-05-23 Kim Jin-Soo Zinc finger domains and methods of identifying same

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