AU2001255458A1 - Improved electrospray and other lc/ms interfaces - Google Patents
Improved electrospray and other lc/ms interfacesInfo
- Publication number
- AU2001255458A1 AU2001255458A1 AU2001255458A AU5545801A AU2001255458A1 AU 2001255458 A1 AU2001255458 A1 AU 2001255458A1 AU 2001255458 A AU2001255458 A AU 2001255458A AU 5545801 A AU5545801 A AU 5545801A AU 2001255458 A1 AU2001255458 A1 AU 2001255458A1
- Authority
- AU
- Australia
- Prior art keywords
- interfaces
- improved electrospray
- electrospray
- improved
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0013—Miniaturised spectrometers, e.g. having smaller than usual scale, integrated conventional components
- H01J49/0018—Microminiaturised spectrometers, e.g. chip-integrated devices, Micro-Electro-Mechanical Systems [MEMS]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
- G01N30/7273—Desolvation chambers
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
- H01J49/044—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for preventing droplets from entering the analyzer; Desolvation of droplets
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/84—Preparation of the fraction to be distributed
- G01N2030/8423—Preparation of the fraction to be distributed using permeable separator tubes
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55147400A | 2000-04-18 | 2000-04-18 | |
US09551474 | 2000-04-18 | ||
US09/655,577 US6396057B1 (en) | 2000-04-18 | 2000-09-06 | Electrospray and other LC/MS interfaces |
US09655577 | 2000-09-06 | ||
PCT/US2001/012635 WO2001080283A1 (en) | 2000-04-18 | 2001-04-18 | Improved electrospray and other lc/ms interfaces |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001255458A1 true AU2001255458A1 (en) | 2001-10-30 |
Family
ID=27069783
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001255458A Abandoned AU2001255458A1 (en) | 2000-04-18 | 2001-04-18 | Improved electrospray and other lc/ms interfaces |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1282910B1 (en) |
AU (1) | AU2001255458A1 (en) |
WO (1) | WO2001080283A1 (en) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6610978B2 (en) * | 2001-03-27 | 2003-08-26 | Agilent Technologies, Inc. | Integrated sample preparation, separation and introduction microdevice for inductively coupled plasma mass spectrometry |
US6902937B2 (en) | 2001-07-13 | 2005-06-07 | Air Liquide America, L.P. | Method for the determination of low-concentration anions in the presence of an excess of another anion |
JP2006507921A (en) | 2002-06-28 | 2006-03-09 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | Method and apparatus for fluid dispersion |
US20100022414A1 (en) | 2008-07-18 | 2010-01-28 | Raindance Technologies, Inc. | Droplet Libraries |
US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
EP2127736A1 (en) | 2003-04-10 | 2009-12-02 | The President and Fellows of Harvard College | Formation and control of fluidic species |
EP1658133A1 (en) | 2003-08-27 | 2006-05-24 | President And Fellows Of Harvard College | Electronic control of fluidic species |
US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
US9477233B2 (en) | 2004-07-02 | 2016-10-25 | The University Of Chicago | Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets |
US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
AU2006335290A1 (en) | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
EP4190448A3 (en) | 2006-05-11 | 2023-09-20 | Bio-Rad Laboratories, Inc. | Microfluidic devices |
WO2008021123A1 (en) | 2006-08-07 | 2008-02-21 | President And Fellows Of Harvard College | Fluorocarbon emulsion stabilizing surfactants |
WO2008097559A2 (en) | 2007-02-06 | 2008-08-14 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
US8528589B2 (en) | 2009-03-23 | 2013-09-10 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
US10520500B2 (en) | 2009-10-09 | 2019-12-31 | Abdeslam El Harrak | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
US10837883B2 (en) | 2009-12-23 | 2020-11-17 | Bio-Rad Laboratories, Inc. | Microfluidic systems and methods for reducing the exchange of molecules between droplets |
EP2534267B1 (en) | 2010-02-12 | 2018-04-11 | Raindance Technologies, Inc. | Digital analyte analysis |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
EP2622103B2 (en) | 2010-09-30 | 2022-11-16 | Bio-Rad Laboratories, Inc. | Sandwich assays in droplets |
EP2673614B1 (en) | 2011-02-11 | 2018-08-01 | Raindance Technologies, Inc. | Method for forming mixed droplets |
EP3736281A1 (en) | 2011-02-18 | 2020-11-11 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
DE202012013668U1 (en) | 2011-06-02 | 2019-04-18 | Raindance Technologies, Inc. | enzyme quantification |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
US11193176B2 (en) | 2013-12-31 | 2021-12-07 | Bio-Rad Laboratories, Inc. | Method for detecting and quantifying latent retroviral RNA species |
US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3013620A1 (en) * | 1979-05-25 | 1980-12-04 | Hewlett Packard Co | SAMPLE INPUT DEVICE FOR MASS SPECTROMETER |
USRE34757E (en) * | 1988-04-05 | 1994-10-18 | Battelle Memorial Institute | Combined electrophoresis-electrospray interface and method |
US4958529A (en) * | 1989-11-22 | 1990-09-25 | Vestec Corporation | Interface for coupling liquid chromatography to solid or gas phase detectors |
CA2062629C (en) * | 1992-03-10 | 1999-06-15 | John Barry French | Apparatus and method for liquid sample introduction |
US5306910A (en) * | 1992-04-10 | 1994-04-26 | Millipore Corporation | Time modulated electrified spray apparatus and process |
US5681752A (en) * | 1995-05-01 | 1997-10-28 | The Regents Of The University Of California | Method and apparatus for determining the size and chemical composition of aerosol particles |
US5838002A (en) * | 1996-08-21 | 1998-11-17 | Chem-Space Associates, Inc | Method and apparatus for improved electrospray analysis |
WO1998035376A1 (en) * | 1997-01-27 | 1998-08-13 | California Institute Of Technology | Mems electrospray nozzle for mass spectroscopy |
ATE476751T1 (en) * | 2001-03-29 | 2010-08-15 | Wisconsin Alumni Res Found | PIEZOELECTRICALLY CHARGED DROPLETS SOURCE |
-
2001
- 2001-04-18 AU AU2001255458A patent/AU2001255458A1/en not_active Abandoned
- 2001-04-18 WO PCT/US2001/012635 patent/WO2001080283A1/en active Application Filing
- 2001-04-18 EP EP01928622.8A patent/EP1282910B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1282910A1 (en) | 2003-02-12 |
WO2001080283A1 (en) | 2001-10-25 |
EP1282910B1 (en) | 2017-04-05 |
EP1282910A4 (en) | 2007-07-11 |
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