AU2001253181A1 - Expression system for efficiently producing clinically effective lysosomal enzymes (glucocerebrosidase) - Google Patents

Expression system for efficiently producing clinically effective lysosomal enzymes (glucocerebrosidase)

Info

Publication number
AU2001253181A1
AU2001253181A1 AU2001253181A AU5318101A AU2001253181A1 AU 2001253181 A1 AU2001253181 A1 AU 2001253181A1 AU 2001253181 A AU2001253181 A AU 2001253181A AU 5318101 A AU5318101 A AU 5318101A AU 2001253181 A1 AU2001253181 A1 AU 2001253181A1
Authority
AU
Australia
Prior art keywords
glucocerebrosidase
expression system
efficiently producing
clinically effective
lysosomal enzymes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001253181A
Inventor
Susan L. Berent
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exegenics Inc
Original Assignee
Cytoclonal Pharmaceutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytoclonal Pharmaceutics Inc filed Critical Cytoclonal Pharmaceutics Inc
Publication of AU2001253181A1 publication Critical patent/AU2001253181A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2001253181A 2000-04-06 2001-04-06 Expression system for efficiently producing clinically effective lysosomal enzymes (glucocerebrosidase) Abandoned AU2001253181A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19559800P 2000-04-06 2000-04-06
US60195598 2000-04-06
PCT/US2001/011144 WO2001077307A2 (en) 2000-04-06 2001-04-06 Expression system for efficiently producing clinically effective lysosomal enzymes (glucocerebrosidase)

Publications (1)

Publication Number Publication Date
AU2001253181A1 true AU2001253181A1 (en) 2001-10-23

Family

ID=22722012

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001253181A Abandoned AU2001253181A1 (en) 2000-04-06 2001-04-06 Expression system for efficiently producing clinically effective lysosomal enzymes (glucocerebrosidase)

Country Status (6)

Country Link
US (1) US20030215435A1 (en)
EP (1) EP1272620A2 (en)
AU (1) AU2001253181A1 (en)
CA (1) CA2405120A1 (en)
IL (1) IL152110A0 (en)
WO (1) WO2001077307A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7723296B2 (en) * 2001-01-18 2010-05-25 Genzyme Corporation Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof
US7855063B2 (en) 2003-04-16 2010-12-21 Yeda Research And Development Co. Ltd. Partially deglycosylated glucocerebrosidase polypeptide and crystals thereof
US8889127B2 (en) * 2004-07-01 2014-11-18 Icahn School Of Medicine At Mount Sinai Targeted protein replacement for the treatment of lysosomal storage disorders
ES2391657T3 (en) 2006-02-07 2012-11-28 Shire Human Genetic Therapies, Inc. Stabilized protein compositions that have a free thiol moiety
US8962273B2 (en) * 2007-05-11 2015-02-24 Genzyme Corporation Methods of producing a secreted protein
FR2926563B1 (en) * 2008-01-21 2013-04-26 Biomerieux Sa METHOD FOR DETECTION AND / OR IDENTIFICATION OF DIFFICULT CLOSTRIDIUM
US8962564B2 (en) 2010-11-08 2015-02-24 Amicus Therapeutics, Inc. Variant, recombinant beta-glucocerebrosidase proteins with increased stability and increased retained catalytic activity
PL2753346T3 (en) 2011-09-07 2020-10-19 Mount Sinai School Of Medicine Ceramidase and cell differentiation
CN102517301B (en) * 2011-12-16 2013-09-25 西南大学 Transcription activator IE1
SI2854910T1 (en) 2012-06-01 2020-09-30 Icahn School Of Medicine At Mount Sinai Ceramide levels in the treatment and prevention of infections
DK2968479T3 (en) 2013-03-14 2019-08-12 Icahn School Med Mount Sinai THERAPEUTIC SURE CERAMIDASE COMPOSITIONS AND METHODS FOR PREPARING AND USING THEREOF

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5879680A (en) * 1987-12-23 1999-03-09 The United States Of America As Represented By The Department Of Health And Human Services Cloned DNA for synthesizing unique glucocerebrosidase
EP0393143A4 (en) * 1987-12-23 1991-09-11 Us Commerce Cloned dna for synthesizing unique glucocerebrosidase
US5236838A (en) * 1988-12-23 1993-08-17 Genzyme Corporation Enzymatically active recombinant glucocerebrosidase
WO1990007573A1 (en) * 1988-12-23 1990-07-12 Genzyme Corporation Enzymatically active recombinant glucocerebrosidase
US5549892A (en) * 1988-12-23 1996-08-27 Genzyme Corporation Enhanced in vivo uptake of glucocerebrosidase
CA2179394A1 (en) * 1993-12-23 1995-06-29 Kostas Iatrou Methods of expressing proteins in insect cells and methods of killing insects
DE69637875D1 (en) * 1995-09-14 2009-04-30 Virginia Tech Intell Prop Production of lysosomal enzymes in plant expression systems
IL150314A0 (en) * 1999-12-30 2002-12-01 Maxygen Aps Improved lysosomal enzymes and lysosomal enzyme activators

Also Published As

Publication number Publication date
IL152110A0 (en) 2003-07-31
WO2001077307A3 (en) 2002-03-21
US20030215435A1 (en) 2003-11-20
EP1272620A2 (en) 2003-01-08
CA2405120A1 (en) 2001-10-18
WO2001077307A2 (en) 2001-10-18

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