AU2001250783A1 - Benzamides and related inhibitors of factor xa - Google Patents
Benzamides and related inhibitors of factor xaInfo
- Publication number
- AU2001250783A1 AU2001250783A1 AU2001250783A AU5078301A AU2001250783A1 AU 2001250783 A1 AU2001250783 A1 AU 2001250783A1 AU 2001250783 A AU2001250783 A AU 2001250783A AU 5078301 A AU5078301 A AU 5078301A AU 2001250783 A1 AU2001250783 A1 AU 2001250783A1
- Authority
- AU
- Australia
- Prior art keywords
- factor
- benzamides
- compounds
- related inhibitors
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
- C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
- C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
- C07C317/40—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Abstract
Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18574600P | 2000-02-29 | 2000-02-29 | |
US60185746 | 2000-02-29 | ||
US09663420 | 2000-09-15 | ||
US09/663,420 US6844367B1 (en) | 1999-09-17 | 2000-09-15 | Benzamides and related inhibitors of factor Xa |
PCT/US2001/006247 WO2001064642A2 (en) | 2000-02-29 | 2001-02-28 | Benzamides and related inhibitors of factor xa |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001250783A1 true AU2001250783A1 (en) | 2001-09-12 |
Family
ID=26881428
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001250783A Abandoned AU2001250783A1 (en) | 2000-02-29 | 2001-02-28 | Benzamides and related inhibitors of factor xa |
AU2001245353A Abandoned AU2001245353A1 (en) | 2000-02-29 | 2001-02-28 | Benzamides and related inhibitors of factor xa |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001245353A Abandoned AU2001245353A1 (en) | 2000-02-29 | 2001-02-28 | Benzamides and related inhibitors of factor xa |
Country Status (10)
Country | Link |
---|---|
US (13) | US6376515B2 (en) |
EP (1) | EP1259485B1 (en) |
AT (1) | ATE311366T1 (en) |
AU (2) | AU2001250783A1 (en) |
CA (1) | CA2401778C (en) |
DE (1) | DE60115394T2 (en) |
DK (1) | DK1259485T3 (en) |
ES (1) | ES2254385T3 (en) |
HK (1) | HK1051539A1 (en) |
WO (2) | WO2001064643A2 (en) |
Families Citing this family (220)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6822267B1 (en) * | 1997-08-20 | 2004-11-23 | Advantest Corporation | Signal transmission circuit, CMOS semiconductor device, and circuit board |
ATE311366T1 (en) * | 2000-02-29 | 2005-12-15 | Millennium Pharm Inc | BENZAMIDE AND SIMILAR FACTOR XA INHIBITORS |
AU776053B2 (en) | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
TWI288745B (en) | 2000-04-05 | 2007-10-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
AU2001280438A1 (en) | 2000-07-27 | 2002-02-13 | Eli Lilly And Company | Substituted heterocyclic amides |
CA2424522C (en) | 2000-11-22 | 2009-12-29 | Yamanouchi Pharmaceutical Co., Ltd. | Substituted benzene derivatives or salts thereof |
EP1379506A2 (en) * | 2000-11-28 | 2004-01-14 | Eli Lilly And Company | Substituted carboxamides |
US7067539B2 (en) | 2001-02-08 | 2006-06-27 | Schering Corporation | Cannabinoid receptor ligands |
US7507767B2 (en) | 2001-02-08 | 2009-03-24 | Schering Corporation | Cannabinoid receptor ligands |
US7312235B2 (en) * | 2001-03-30 | 2007-12-25 | Millennium Pharmaceuticals, Inc. | Benzamide inhibitors of factor Xa |
US7365205B2 (en) | 2001-06-20 | 2008-04-29 | Daiichi Sankyo Company, Limited | Diamine derivatives |
SE0102764D0 (en) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
AUPR738301A0 (en) * | 2001-08-30 | 2001-09-20 | Starpharma Limited | Chemotherapeutic agents |
US7868204B2 (en) * | 2001-09-14 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
US6897220B2 (en) * | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
CN101851173A (en) | 2001-09-14 | 2010-10-06 | 梅特希尔基因公司 | Inhibitors of histone deacetylase |
RU2004117907A (en) | 2001-11-14 | 2006-01-10 | Шеринг Корпорейшн (US) | CANNABINOID RECEPTOR LIGANDS |
EP1314733A1 (en) | 2001-11-22 | 2003-05-28 | Aventis Pharma Deutschland GmbH | Indole-2-carboxamides as factor Xa inhibitors |
US7030141B2 (en) * | 2001-11-29 | 2006-04-18 | Christopher Franklin Bigge | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade |
WO2003050088A1 (en) | 2001-12-07 | 2003-06-19 | Eli Lilly And Company | Substituted heterocyclic carboxamides with antithrombotic activity |
US20050026929A1 (en) * | 2002-04-23 | 2005-02-03 | Axys Pharmaceuticals, Inc. | Novel phenyl derivatives as inducers of apoptosis |
MXPA04012704A (en) | 2002-06-19 | 2005-03-23 | Schering Corp | Cannabinoid receptor agonists. |
AR040336A1 (en) | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | PIPERIDINE COMPOUND, USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND PROCEDURE TO PREPARE SUCH COMPOUND |
GB0215293D0 (en) * | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
US7307088B2 (en) * | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
PL376479A1 (en) | 2002-10-18 | 2005-12-27 | F.Hoffmann-La Roche Ag | 4-piperazinyl benzenesulfonyl indoles with 5-ht6 receptor affinity |
GB0226930D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
AU2003302238A1 (en) | 2002-12-03 | 2004-06-23 | Axys Pharmaceuticals, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
TWI299664B (en) | 2003-01-06 | 2008-08-11 | Osi Pharm Inc | (2-carboxamido)(3-amino)thiophene compounds |
US7696225B2 (en) * | 2003-01-06 | 2010-04-13 | Osi Pharmaceuticals, Inc. | (2-carboxamido)(3-Amino) thiophene compounds |
EP1591443B1 (en) | 2003-02-07 | 2010-08-25 | Daiichi Sankyo Company, Limited | Pyrazole derivative |
TW200505902A (en) | 2003-03-20 | 2005-02-16 | Schering Corp | Cannabinoid receptor ligands |
WO2004087696A1 (en) * | 2003-04-03 | 2004-10-14 | Merck Patent Gmbh | Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor xa inhibitors for the treatment of thromboses |
MXPA05010444A (en) * | 2003-04-03 | 2005-11-04 | Merck Patent Gmbh | Pyrrolidino-1, 2-dicarboxy -1-(phenylamide) -2-(4-(3-oxo- morpholino -4-yl)- phenylamide) derivatives and related compounds for use as inhibitors of coagulation factor xa in the treatment of thrombo-embolic diseases. |
TWI372050B (en) | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
PL1651612T3 (en) | 2003-07-22 | 2012-09-28 | Astex Therapeutics Ltd | 3,4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators |
RU2370494C2 (en) | 2003-09-19 | 2009-10-20 | Астразенека Аб | Quinazoline derivatives |
US7868205B2 (en) * | 2003-09-24 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
SE0302573D0 (en) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
WO2005049604A2 (en) * | 2003-09-30 | 2005-06-02 | Eli Lilly And Company | Antithrombotic aromatic ethers |
WO2005046683A1 (en) | 2003-10-07 | 2005-05-26 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
EP1678161B1 (en) * | 2003-10-09 | 2009-12-30 | Millennium Pharmaceuticals, Inc. | Thioether-substituted benzamides as inhibitors of factor xa |
EP1706403B9 (en) * | 2003-12-22 | 2012-07-25 | K.U.Leuven Research & Development | Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment |
PL1706385T3 (en) | 2003-12-23 | 2011-03-31 | Astex Therapeutics Ltd | Pyrazole derivatives as protein kinase modulators |
US20050165015A1 (en) * | 2004-01-23 | 2005-07-28 | Ncube Mghele V. | Vanilloid receptor ligands and their use in treatments |
JP2007523905A (en) * | 2004-02-18 | 2007-08-23 | アストラゼネカ アクチボラグ | Compound |
WO2005080359A1 (en) * | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Benzamide derivatives and their use as glucokinae activating agents |
US7253204B2 (en) * | 2004-03-26 | 2007-08-07 | Methylgene Inc. | Inhibitors of histone deacetylase |
US7625949B2 (en) | 2004-04-23 | 2009-12-01 | Roche Palo Alto Llc | Methods for treating retroviral infections |
US7166738B2 (en) | 2004-04-23 | 2007-01-23 | Roche Palo Alto Llc | Non-nucleoside reverse transcriptase inhibitors |
TW200600086A (en) * | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
US7696352B2 (en) * | 2004-06-18 | 2010-04-13 | Millennium Pharmaceuticals, Inc. | Factor Xa inhibitors |
AU2005257999B2 (en) | 2004-06-18 | 2011-12-08 | Millennium Pharmaceuticals, Inc. | Factor Xa inhibitors |
AR050279A1 (en) | 2004-08-03 | 2006-10-11 | Wyeth Corp | INDAZOLS AS USEFUL LXR MODULATORS IN THE PREPARATION OF MEDICINES PUT THE TREATMENT OF CARDIOVASCULAR DISEASES AND THROUGH TH1 AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AS ACTIVE PRINCIPLE. |
BRPI0515897A (en) * | 2004-09-24 | 2008-08-12 | Astrazeneca Ab | compound, use thereof, pharmaceutical composition, and method for pain therapy in a warm-blooded animal, and for the preparation of a compound |
GB0422556D0 (en) * | 2004-10-11 | 2004-11-10 | Syngenta Participations Ag | Novel insecticides |
JP2008516935A (en) | 2004-10-16 | 2008-05-22 | アストラゼネカ アクチボラグ | Process for producing phenoxybenzamide compound |
GB0423044D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
GB0423043D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
AU2005299771A1 (en) | 2004-10-21 | 2006-05-04 | High Point Pharmaceuticals, Llc | Bissulfonamide compounds as agonists of GalR1, compositions, and methods of use |
MX2007005113A (en) | 2004-11-03 | 2007-06-26 | Hoffmann La Roche | Dicarboxamide derivatives and their use as factor xa inhibitors. |
ES2339138T3 (en) | 2004-11-24 | 2010-05-17 | Eli Lilly And Company | DERIVATIVES OF USEFUL AROMATIC ETERS AS INHIBITORS OF THROMBIN. |
ES2330461T3 (en) * | 2004-11-29 | 2009-12-10 | Eli Lilly And Company | ANTHROMBOTIC DIAMIDS. |
JP2008524246A (en) | 2004-12-16 | 2008-07-10 | タケダ サン ディエゴ インコーポレイテッド | Histone deacetylase inhibitor |
SI1841765T1 (en) * | 2004-12-21 | 2009-08-31 | Gilead Sciences Inc | IMIDAZO?á4,5-C?åPYRIDINE COMPOUND AND METHOD OF ANTIVIRAL TREATMENT |
US8110573B2 (en) | 2004-12-30 | 2012-02-07 | Astex Therapeutics Limited | Pyrazole compounds that modulate the activity of CDK, GSK and aurora kinases |
KR20070107022A (en) | 2005-01-07 | 2007-11-06 | 신타 파마슈티칼스 코프. | Compounds for inflammation and immune-related uses |
CA2594477C (en) | 2005-01-21 | 2016-07-12 | Astex Therapeutics Limited | Pharmaceutical compounds |
AR054425A1 (en) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | PIPERIDIN ADDITION SALTS 4-IL-ACID AMID 4- (2,6-DICLORO-BENZOILAMINO) 1H-PIRAZOL-3-CARBOXILICO. |
US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
CN101146532B (en) | 2005-01-21 | 2012-05-09 | 阿斯泰克斯治疗有限公司 | Pharmaceutical compounds |
JP4900238B2 (en) * | 2005-02-02 | 2012-03-21 | 味の素株式会社 | New benzamidine compounds |
US7576099B2 (en) | 2005-02-28 | 2009-08-18 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
US7264402B2 (en) * | 2005-03-10 | 2007-09-04 | Corning Cable Systems Llc | Multi-fiber optic receptacle and plug assembly |
EP1858865B1 (en) | 2005-03-10 | 2009-09-16 | Pfizer Inc. | Substituted n-sulfonylaminophenylethyl-2-phenoxy acetamide compounds |
JP2008540574A (en) | 2005-05-11 | 2008-11-20 | タケダ サン ディエゴ インコーポレイテッド | Histone deacetylase inhibitor |
EP1891069A1 (en) * | 2005-05-24 | 2008-02-27 | AstraZeneca AB | 2-phenyl substituted imidazol [4,5b]pyridine/ pyrazine and purine derivatives as glucokinase modulators |
TW200714597A (en) * | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
EP1902032A1 (en) | 2005-06-22 | 2008-03-26 | Astex Therapeutics Limited | Pharmaceutical compounds |
EP1933832A2 (en) | 2005-06-23 | 2008-06-25 | Astex Therapeutics Limited | Pharmaceutical combinations comprising pyrazole derivatives as protein kinase modulators |
EP2027113A1 (en) * | 2005-07-09 | 2009-02-25 | AstraZeneca AB | Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes |
AU2006268406C1 (en) * | 2005-07-09 | 2011-02-24 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
JP2009500442A (en) * | 2005-07-09 | 2009-01-08 | アストラゼネカ アクチボラグ | 2-Heterocyclyloxybenzoylaminoheterocyclyl compounds as modulators of glucokinase for treating type 2 diabetes |
CN101263121A (en) * | 2005-07-14 | 2008-09-10 | 塔克达圣地亚哥公司 | Histone deacetylase inhibitors |
US9202182B2 (en) * | 2005-08-11 | 2015-12-01 | International Business Machines Corporation | Method and system for analyzing business architecture |
DE602006016313D1 (en) | 2005-09-16 | 2010-09-30 | Arrow Therapeutics Ltd | BIPHENYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEPATITIS C |
EP1940781A1 (en) | 2005-10-19 | 2008-07-09 | F.Hoffmann-La Roche Ag | Phenyl-acetamide nnrt inhibitors |
NZ567992A (en) | 2005-11-08 | 2011-05-27 | Millennium Pharm Inc | Pharmaceutical salts and polymorphs of N-(5-chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxy-benzamide, a factor Xa inhibitor |
TW200738621A (en) * | 2005-11-28 | 2007-10-16 | Astrazeneca Ab | Chemical process |
US8399442B2 (en) | 2005-12-30 | 2013-03-19 | Astex Therapeutics Limited | Pharmaceutical compounds |
JP2009525955A (en) * | 2006-01-13 | 2009-07-16 | タケダ サン ディエゴ インコーポレイテッド | Histone deacetylase inhibitor |
AU2007221207A1 (en) | 2006-02-28 | 2007-09-07 | Merck Sharp & Dohme Corp. | Inhibitors of histone deacetylase |
TW200745049A (en) * | 2006-03-23 | 2007-12-16 | Astrazeneca Ab | New crystalline forms |
WO2007112367A2 (en) * | 2006-03-27 | 2007-10-04 | Portola Pharmaceuticals, Inc. | Potassium channel modulators and platelet procoagulant activity |
JP2009531385A (en) | 2006-03-31 | 2009-09-03 | グラクソ グループ リミテッド | Piperazine derivatives as growth hormone secretagogue (GHS) receptor agonists |
AU2007234843B2 (en) | 2006-04-07 | 2013-07-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
TW200808769A (en) * | 2006-04-18 | 2008-02-16 | Astrazeneca Ab | Therapeutic compounds |
EP2016072B1 (en) | 2006-05-05 | 2014-07-16 | Millennium Pharmaceuticals, Inc. | Factor xa inhibitors |
EP2049119A2 (en) | 2006-06-29 | 2009-04-22 | Astex Therapeutics Limited | Pharmaceutical combinations of 1-cyclopropyl-3-[3-(5-morphoolin-4-ylmethyl-1h-benzoimidazol-2-yl)-1h-1-pyrazol-4-yl]-urea |
EP2043635A2 (en) * | 2006-06-29 | 2009-04-08 | Astex Therapeutics Limited | Pharmaceutical combinations |
PL2038275T3 (en) * | 2006-07-07 | 2010-08-31 | Gilead Sciences Inc | Novel pyridazine compound and use thereof |
TW200825063A (en) * | 2006-10-23 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
CL2007003061A1 (en) * | 2006-10-26 | 2008-08-01 | Astrazeneca Ab | COMPOUNDS DERIVED FROM 3,5-DIOXI-BENZAMIDA; PREPARATION PROCESS; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO TREAT A MEDIUM DISEASE THROUGH GLK, SUCH AS TYPE 2 DIABETES. |
EP2077995B1 (en) | 2006-11-02 | 2012-02-08 | Millennium Pharmaceuticals, Inc. | Methods of synthesizing pharmaceutical salts of a factor xa inhibitor |
CA2669311C (en) | 2006-11-13 | 2011-09-20 | Pfizer Products Inc. | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof |
CN105193799A (en) * | 2006-12-08 | 2015-12-30 | 米伦纽姆医药公司 | Unit dose formulations and methods of treating thrombosis with an oral factor Xa inhibitor |
US20100094009A1 (en) * | 2006-12-21 | 2010-04-15 | Mccabe James | Novel crystalline compound useful as glk activator |
EP2114930A2 (en) * | 2007-01-05 | 2009-11-11 | Millennium Pharmaceuticals, Inc. | Factor xa inhibitors |
UY30892A1 (en) * | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | AKT ACTIVITY INHIBITORS |
WO2008112938A2 (en) * | 2007-03-13 | 2008-09-18 | New England Medical Center Hospitals, Inc. | Composition and method for the treatment of diseases affected by a peptide receptor |
GB0704932D0 (en) | 2007-03-14 | 2007-04-25 | Astex Therapeutics Ltd | Pharmaceutical compounds |
WO2008127682A2 (en) * | 2007-04-13 | 2008-10-23 | Millennium Pharmaceuticals, Inc. | Combination anticoagulant therapy with a compound that acts as a factor xa inhibitor |
PT2146705E (en) * | 2007-05-02 | 2014-05-23 | Portola Pharm Inc | Combination therapy with a compound acting as a platelet adp receptor inhibitor |
UA99466C2 (en) | 2007-07-06 | 2012-08-27 | Гилиад Сайенсиз, Инк. | Crystalline pyridazine compound |
HUE052423T2 (en) | 2007-09-28 | 2021-04-28 | Alexion Pharma Inc | Antidotes for factor xa inhibitors and methods of using the same |
UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
AU2009278929B2 (en) | 2008-08-04 | 2012-07-05 | Astrazeneca Ab | Pyrazolo [3,4] pyrimidin-4-yl derivatives and their uses to treat diabetes and obesity |
MX2011004907A (en) | 2008-11-14 | 2011-07-29 | Portola Pharm Inc | Antidotes for factor xa inhibitors and methods of using the same in combination with blood coagulating agents. |
PE20120003A1 (en) * | 2009-01-30 | 2012-02-12 | Glaxosmithkline Llc | N - {(1S) -2-AMINO-1 - [(3-FLUOROPHENYL) METHYL) ETHYL HYDROCHLORIDE} -5-CHLORO-4- (4-CHLORO-1-METHYL-1H-PIRAZOL-5-IL) - CRYSTALLINE 2-THIOPHENOCARBOXAMIDE |
GB0902434D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Chemical process |
GB0902406D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Crystalline polymorphic form |
WO2010105243A1 (en) | 2009-03-13 | 2010-09-16 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
WO2010117729A1 (en) | 2009-03-30 | 2010-10-14 | Portola Pharmaceuticals, Inc. | Antidotes for factor xa inhibitors and methods of using the same |
CA2758071C (en) | 2009-04-06 | 2018-01-09 | Agios Pharmaceuticals, Inc. | Pyruvate kinase m2 modulators, therapeutic compositions and related methods of use |
AR076221A1 (en) * | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | DERIVED FROM PIRAZOL [4,5-E] PYRIMIDINE AND ITS USE TO TREAT DIABETES AND OBESITY |
AR076220A1 (en) | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | DERIVATIVES OF PIRAZOL [4,5 - E] PYRIMIDINE |
IN2012DN00471A (en) | 2009-06-29 | 2015-06-05 | Agios Pharmaceuticals Inc | |
JP6163304B2 (en) | 2009-07-15 | 2017-07-12 | ポートラ ファーマシューティカルズ, インコーポレイテッド | Unit dose formulations of factor Xa inhibitor antidote and methods of use thereof |
US20110086853A1 (en) * | 2009-10-08 | 2011-04-14 | William Brown | Therapeutic Compounds |
EP2491145B1 (en) | 2009-10-21 | 2016-03-09 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
EP2513058B1 (en) | 2009-12-17 | 2016-11-09 | Millennium Pharmaceuticals, Inc. | Methods of synthesizing factor xa inhibitors |
CA2784921A1 (en) | 2009-12-17 | 2011-07-14 | Millennium Pharmaceuticals, Inc. | Salts and crystalline forms of a factor xa inhibitor |
US8742120B2 (en) * | 2009-12-17 | 2014-06-03 | Millennium Pharmaceuticals, Inc. | Methods of preparing factor xa inhibitors and salts thereof |
EA015918B1 (en) * | 2010-03-03 | 2011-12-30 | Дмитрий Геннадьевич ТОВБИН | URETHANES, UREAS, AMIDES AND RELATED INHIBITORS OF Xa FACTORS |
JP2013528174A (en) | 2010-05-28 | 2013-07-08 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | Oligobenzamide compounds and their use |
ES2547890T3 (en) | 2010-07-07 | 2015-10-09 | Ardelyx, Inc. | Compounds and methods to inhibit phosphate transport |
JP5827328B2 (en) | 2010-07-07 | 2015-12-02 | アーデリクス,インコーポレーテッド | Compounds and methods for inhibiting phosphate transport |
WO2012054110A2 (en) | 2010-07-07 | 2012-04-26 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
EP2590965B1 (en) | 2010-07-07 | 2016-04-20 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
AR082803A1 (en) | 2010-09-01 | 2013-01-09 | Portola Pharm Inc | METHODS AND FORMULATIONS FOR THE TREATMENT OF THROMBOSIS WITH BETRIXABAN AND A GLICOPROTEIN P INHIBITOR |
TW201221128A (en) | 2010-09-01 | 2012-06-01 | Portola Pharm Inc | Crystalline forms of a factor Xa inhibitor |
JP5837091B2 (en) | 2010-12-17 | 2015-12-24 | アジオス ファーマシューティカルズ, インコーポレイテッド | Novel N- (4- (azetidine-1-carbonyl) phenyl)-(hetero-) arylsulfonamide derivatives as modulators of pyruvate kinase M2 (PKM2) |
ES2569712T3 (en) | 2010-12-21 | 2016-05-12 | Agios Pharmaceuticals, Inc. | PKM2 bicyclic activators |
TWI549947B (en) | 2010-12-29 | 2016-09-21 | 阿吉歐斯製藥公司 | Therapeutic compounds and compositions |
EP2665751A1 (en) | 2011-01-19 | 2013-11-27 | Bayer Intellectual Property GmbH | Binding proteins to inhibitors of coagulation factors |
GB201104267D0 (en) | 2011-03-14 | 2011-04-27 | Cancer Rec Tech Ltd | Pyrrolopyridineamino derivatives |
RU2675656C2 (en) | 2011-05-03 | 2018-12-21 | Аджиос Фармасьютикалз, Инк. | Pyruvate kinase activators for use in therapy |
AU2012250690B2 (en) | 2011-05-03 | 2017-06-08 | Agios Pharmaceuticals, Inc | Pyruvate kinase activators for use in therapy |
JP5934782B2 (en) | 2011-05-04 | 2016-06-15 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Amino-pyridine-containing spleen tyrosine kinase (Syk) inhibitors |
CN102827170A (en) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | Active treatment compositions and use method thereof |
CN102827073A (en) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | Therapeutically active compositions and application methods thereof |
US20150224091A1 (en) | 2011-08-31 | 2015-08-13 | Portola Pharmaceuticals, Inc. | Prevention and treatment of thrombosis in medically ill patients |
ES2583853T3 (en) | 2011-10-03 | 2016-09-22 | Respivert Limited | 1-Pirazolyl-3- (4 - ((2-anilinopyrimidin-4-yl) oxy) naphthalen-1-yl) ureas as inhibitors of p38 MAP kinase |
EP2578582A1 (en) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors |
WO2013078277A1 (en) | 2011-11-23 | 2013-05-30 | The Board Of Regents Of The University Of Texas System | Oligo-benzamide compounds and their use in treating cancers |
US8835493B2 (en) | 2011-11-23 | 2014-09-16 | Board Of Regents, The University Of Texas System | Oligo-benzamide compounds for use in treating cancers |
US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
NZ700928A (en) | 2012-04-24 | 2017-06-30 | Vertex Pharma | Dna-pk inhibitors |
GB201214750D0 (en) | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
GB201215357D0 (en) | 2012-08-29 | 2012-10-10 | Respivert Ltd | Compounds |
GB201216018D0 (en) | 2012-09-07 | 2012-10-24 | Cancer Rec Tech Ltd | Pharmacologically active compounds |
US9163021B2 (en) | 2012-10-04 | 2015-10-20 | Pfizer Limited | Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors |
US20140346397A1 (en) | 2012-12-27 | 2014-11-27 | Portola Pharmaceuticals, Inc. | Compounds and methods for purification of serine proteases |
US9200268B2 (en) * | 2012-12-27 | 2015-12-01 | Portola Pharmaceuticals, Inc. | Compounds and methods for purification of serine proteases |
FR3000895B1 (en) | 2013-01-11 | 2017-02-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies Sa | USE OF ANTIDOTES OF COAGULATION INHIBITORS INDICATED IN THE PREVENTION OR TREATMENT OF THROMBOEMBOLIC PATHOLOGIES |
LT3527563T (en) | 2013-03-12 | 2021-12-10 | Vertex Pharmaceuticals Incorporated | Dna-pk inhibitors |
US20160016934A1 (en) | 2013-03-14 | 2016-01-21 | Respivert Limited | Kinase inhibitors |
EP3019480B1 (en) | 2013-07-11 | 2020-05-06 | Agios Pharmaceuticals, Inc. | 2,4- or 4,6-diaminopyrimidine compounds as idh2 mutants inhibitors for the treatment of cancer |
WO2015003355A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
EA201300843A1 (en) * | 2013-08-01 | 2015-04-30 | Арсений Валерьевич Айбушев | CARBAMOILPHENYL DERIVATIVES FOR STOPPING, PREVENTION AND PREVENTION OF BLEEDING OR STRENGTHENING OF THE HEMOSTASIS SYSTEM |
GB201314452D0 (en) | 2013-08-13 | 2013-09-25 | Ostara Biomedical Ltd | Embryo implantation |
CA2926950C (en) | 2013-10-10 | 2022-10-11 | Eastern Virginia Medical School | 4-((2-hydroxy-3-methoxybenzyl)amino) benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase |
PT3424920T (en) | 2013-10-17 | 2020-07-07 | Vertex Pharma | Co-crystals of (s)-n-methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as dna-pk inhibitors |
US9636298B2 (en) | 2014-01-17 | 2017-05-02 | Methylgene Inc. | Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs |
MX371353B (en) | 2014-02-14 | 2020-01-27 | Respivert Ltd | Aromatic heterocyclic compounds as antiinflammatory compounds. |
NZ723859A (en) | 2014-03-14 | 2023-01-27 | Servier Lab | Pharmaceutical compositions of therapeutically active compounds and their uses |
DE102014108210A1 (en) | 2014-06-11 | 2015-12-17 | Dietrich Gulba | rodenticide |
CN107073082B (en) | 2014-08-20 | 2021-04-30 | 博尔托拉制药公司 | Lyophilized formulations of factor XA antidotes |
GB201501302D0 (en) | 2015-01-27 | 2015-03-11 | Ostara Biomedical Ltd | Embryo implantation |
DK3307271T3 (en) | 2015-06-11 | 2023-10-09 | Agios Pharmaceuticals Inc | METHODS OF USING PYRUVATE KINASE ACTIVATORS |
AU2016295693B2 (en) | 2015-07-17 | 2020-05-21 | Sunshine Lake Pharma Co., Ltd. | Substituted quinazoline compounds and preparation and uses thereof |
GB201514021D0 (en) | 2015-08-07 | 2015-09-23 | Arner Elias Set Jeno | Novel Pyridines and their use in the treatment of cancer |
GB201517523D0 (en) | 2015-10-05 | 2015-11-18 | Ostara Biomedical Ltd | Methods and compositions for managing reproduction |
WO2017066566A1 (en) | 2015-10-15 | 2017-04-20 | Agios Pharmaceuticals, Inc | Combination therapy for treating malignancies |
PT3362066T (en) | 2015-10-15 | 2021-11-16 | Celgene Corp | Combination therapy for treating malignancies |
WO2017091757A1 (en) | 2015-11-24 | 2017-06-01 | Portola Pharmaceuticals, Inc. | Isotopically enriched betrixaban |
AU2017208555B2 (en) | 2016-01-22 | 2021-03-18 | Janssen Pharmaceutica Nv | New 6-membered heteroaromatic substituted cyanoindoline derivatives as NIK inhibitors |
KR20180100441A (en) | 2016-01-22 | 2018-09-10 | 잔센파마슈티카엔.브이. | A novel substituted cyanoindoline derivative as an NIK inhibitor |
ES2884119T3 (en) | 2016-02-24 | 2021-12-10 | Alexion Pharma Inc | Freeze-Dried Formulas for Factor Xa Antidote |
RU2698202C2 (en) * | 2016-06-01 | 2019-08-23 | Закрытое акционерное общество "ФАРМА ВАМ" | METHOD FOR PRODUCING DIRECT FACTOR Xa INHIBITOR |
KR102373215B1 (en) | 2016-06-17 | 2022-03-10 | 포톨라 파마슈티컬스, 인코포레이티드 | Preparation of Factor Xa Derivatives |
US20190119299A1 (en) | 2016-06-30 | 2019-04-25 | Janssen Pharmaceutica Nv | Cyanoindoline derivatives as nik inhibitors |
JP6936815B2 (en) | 2016-06-30 | 2021-09-22 | ヤンセン ファーマシューティカ エヌ.ベー. | Heteroaromatic derivatives as NIK inhibitors |
CR20220309A (en) | 2016-09-02 | 2022-09-16 | Cyclerion Therapeutics Inc | Fused bicyclic sgc stimulators |
KR20190062485A (en) | 2016-09-27 | 2019-06-05 | 버텍스 파마슈티칼스 인코포레이티드 | Methods of treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors |
WO2018069936A1 (en) | 2016-10-13 | 2018-04-19 | Mylan Laboratories Limited | Polymorphs and solid dispersion of betrixaban and methods for the preparation thereof |
US11161815B2 (en) | 2017-02-07 | 2021-11-02 | Oblique Therapeutics Ab | Hydrocarbylsulfonyl-substituted pyridines and their use in the treatment of cancer |
JP2020507625A (en) | 2017-02-07 | 2020-03-12 | オブリーク セラピューティクス アーベー | Heteroarylsulfonyl-substituted pyridines and their use in the treatment of cancer |
CA3051538A1 (en) | 2017-02-07 | 2018-08-16 | Oblique Therapeutics Ab | Heterocyclylsulfonyl-substituted pyridines and their use in the treatment of cancer |
MX2019009356A (en) | 2017-02-07 | 2019-09-19 | Oblique Therapeutics Ab | Sulfinylpyridines and their use in the treatment of cancer. |
WO2018229796A2 (en) | 2017-06-14 | 2018-12-20 | Mylan Laboratories Limited | A process for betrixaban hydrochloride and betrixaban maleate salt |
EP3651752A1 (en) | 2017-07-11 | 2020-05-20 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
EA202090871A1 (en) | 2017-10-06 | 2020-07-03 | Форма Терапьютикс, Инк. | INHIBITION OF UBIKVITIN-SPECIFIC PEPTIDASE 30 |
PT3786160T (en) | 2017-10-27 | 2022-08-19 | Boehringer Ingelheim Int | Pyridine derivatives and therapeutic uses thereof as trpc6 inhibitors |
KR102596598B1 (en) | 2018-04-26 | 2023-11-03 | 화이자 인코포레이티드 | 2-Amino-pyridine or 2-amino-pyrimidine derivatives as cyclin-dependent kinase inhibitors |
GB201807014D0 (en) | 2018-04-30 | 2018-06-13 | Univ Leeds Innovations Ltd | Factor xlla inhibitors |
US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
GB201810581D0 (en) | 2018-06-28 | 2018-08-15 | Ctxt Pty Ltd | Compounds |
EP4218934A1 (en) | 2018-10-05 | 2023-08-02 | Forma Therapeutics, Inc. | Inhibiting ubiquitin-specific protease 30 (usp30) |
LT3986890T (en) | 2019-06-18 | 2023-12-11 | Pfizer Inc. | Benzisoxazole sulfonamide derivatives |
CR20220316A (en) | 2019-12-06 | 2022-10-07 | Vertex Pharma | Substituted tetrahydrofurans as modulators of sodium channels |
TWI794742B (en) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | Antiviral compounds |
WO2022211680A1 (en) * | 2021-03-30 | 2022-10-06 | Общество С Ограниченной Ответственностью "Фармадиол" | Process for producing the anticoagulant n-(5-chloropyridin-2-yl)-2-({4-[ethanimidoyl(methyl)amino]benzoyl}amino)-5-methylbenzamide hydrochloride |
EP4070658A1 (en) | 2021-04-06 | 2022-10-12 | BIORoxx GmbH | Use of anticoagulant active compounds as rodenticide |
JP2024512771A (en) | 2021-04-16 | 2024-03-19 | ギリアード サイエンシーズ, インコーポレイテッド | How to prepare carbanucleosides using amides |
GB202107722D0 (en) | 2021-05-28 | 2021-07-14 | Lunac Therapeutics Ltd | Factor XIIA Inhibitors |
AR126073A1 (en) | 2021-06-04 | 2023-09-06 | Vertex Pharma | N-(HYDROXYALKYL(HETERO)ARYL)TETRAHYDROFURAN CARBOXAMIDES AS SODIUM CHANNEL MODULATORS |
Family Cites Families (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2095619A (en) | 1937-10-12 | Aryl oxides | ||
CH479557A (en) * | 1961-09-11 | 1969-10-15 | Wander Ag Dr A | Process for the preparation of new polybasic compounds |
GB1047245A (en) * | 1963-02-15 | |||
JPS6033389B2 (en) * | 1979-02-22 | 1985-08-02 | 日産化学工業株式会社 | Heterocyclic ether phenoxy fatty acid derivative, its production method, and herbicide containing the derivative |
GB2095239B (en) | 1981-02-27 | 1985-03-06 | Torii & Co Ltd | Novel amidine compounds |
US4500714A (en) * | 1981-10-15 | 1985-02-19 | Chugai Seiyaku Kabushiki Kaisha | 3-Substituted-ureido-N-pyridyl benzamides |
US4588587A (en) | 1983-03-01 | 1986-05-13 | Pennsylvania Hospital | Method of treatment to inhibit metastasis |
JPS59181257A (en) | 1983-03-31 | 1984-10-15 | Chugai Pharmaceut Co Ltd | Ureidobenzamide derivative |
JPS648675A (en) | 1987-06-30 | 1989-01-12 | Mitsubishi Electric Corp | Formation of schottky gate |
JP2668231B2 (en) | 1987-12-29 | 1997-10-27 | 大日精化工業株式会社 | Electrophotographic photoreceptor |
AU606808B2 (en) * | 1988-06-29 | 1991-02-14 | Otsuka Pharmaceutical Factory, Inc. | Arylcarboxamide substituted by alkylphosphonates, process for preparing the same and a pharmaceutical composition containing the same |
JPH0418675A (en) | 1990-05-11 | 1992-01-22 | Ricoh Co Ltd | Circuit diagram input device |
GB9816837D0 (en) * | 1998-08-04 | 1998-09-30 | Zeneca Ltd | Amide derivatives |
ZA928276B (en) | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
US5612360A (en) | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
JPH08504769A (en) | 1992-12-15 | 1996-05-21 | コルバス・インターナショナル、インコーポレイテッド | Novel inhibitor of factor Xa |
US5610335A (en) | 1993-05-26 | 1997-03-11 | Cornell Research Foundation | Microelectromechanical lateral accelerometer |
TW300888B (en) | 1994-12-02 | 1997-03-21 | Yamanouchi Pharma Co Ltd | |
CA2214685C (en) | 1995-03-10 | 2008-05-20 | Berlex Laboratories, Inc. | Benzamidine derivatives their preparation and their use as anti-coagulants |
EP0742208A1 (en) | 1995-05-05 | 1996-11-13 | Grelan Pharmaceutical Co., Ltd. | 2-Ureido-benzamide derivatives |
US5849759A (en) | 1995-12-08 | 1998-12-15 | Berlex Laboratories, Inc. | Naphthyl-substituted benzimidazole derivatives as anti-coagulants |
US5994375A (en) | 1996-02-12 | 1999-11-30 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants |
JP2000516234A (en) | 1996-08-16 | 2000-12-05 | デュポン ファーマシューティカルズ カンパニー | Amidinophenyl-pyrrolidines, amidinophenyl-pyrrolines, and amidinophenyl-isoxazolidines and derivatives thereof |
JP2002511836A (en) | 1996-09-09 | 2002-04-16 | スミスクライン・ビーチャム・コーポレイション | Compounds and methods |
CZ225699A3 (en) | 1996-12-23 | 2000-09-13 | Du Pont Pharmaceuticals Company | Nitrogenous heteroaromatic compounds functioning as inhibitors of Xa factor |
ATE236890T1 (en) * | 1996-12-23 | 2003-04-15 | Bristol Myers Squibb Pharma Co | OXYGEN OR SULFUR CONTAINING 5-MEMBED HETEROAROMATIC DERIVATIVES AS FACTOR XA INHIBITORS |
CA2293824A1 (en) | 1997-06-19 | 1998-12-23 | Mimi Lifen Quan | (amidino)6-membered aromatics as factor xa inhibitors |
CA2295153A1 (en) | 1997-06-26 | 1999-01-07 | Gerald Floyd Smith | Antithrombotic agents |
IL133623A0 (en) | 1997-06-26 | 2001-04-30 | Lilly Co Eli | Antithrombotic agents |
AU8270698A (en) * | 1997-06-26 | 1999-01-19 | Eli Lilly And Company | Antithrombotic agents |
IL133621A0 (en) | 1997-06-26 | 2001-04-30 | Lilly Co Eli | Antithrombotic agents |
CA2295620A1 (en) | 1997-08-11 | 1999-02-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | 5,6-heteroaryl-dipyrido¬2,3-b:3',2'-f|azepines and their use in the prevention or treatment of hiv infection |
KR20010023364A (en) | 1997-08-27 | 2001-03-26 | 간자와 무츠와 | 3-amidinoaniline derivatives, activated blood coagulation factor x inhibitors, and intermediates for producing both |
US6140351A (en) | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
RU2226529C2 (en) | 1997-12-19 | 2004-04-10 | Шеринг Акциенгезельшафт | Derivatives of ortho-antranilamide as anti-coagulating agents, pharmaceutical composition and method for treatment |
EP0937711A1 (en) | 1998-02-18 | 1999-08-25 | Roche Diagnostics GmbH | Thiobenzamides, process for their preparation and medicaments containing them |
JPH11302177A (en) | 1998-04-27 | 1999-11-02 | Otsuka Pharmaceut Factory Inc | Medicine for treating nephritis |
EA200100639A1 (en) | 1998-12-09 | 2002-06-27 | Американ Хоум Продактс Корпорейшн | TIOMOCHEVIN DERIVATIVES CONTAINING HETEROCYCLIC CARBOXAMIDE AND PROTECTIVE PHENYLETHYLENAMINE GROUP, AS HERPES VIRUS INHIBITORS |
JP2002531545A (en) | 1998-12-09 | 2002-09-24 | ワイス | Herpesvirus thiourea inhibitors |
PT1137645E (en) | 1998-12-09 | 2004-09-30 | Wyeth Corp | HERPES VIRUS INHIBITORS BASED ON ALPHA-METHYLBENZYLATE THIOUREIA CONTAINING A PHENYLENE IODINE GROUP |
SK7682001A3 (en) | 1998-12-09 | 2002-07-02 | Wyeth Corp | Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group |
WO2000034237A2 (en) | 1998-12-09 | 2000-06-15 | American Home Products Corporation | Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses |
WO2000034269A1 (en) | 1998-12-09 | 2000-06-15 | American Home Products Corporation | Thiourea inhibitors of herpes viruses |
JP2002531557A (en) | 1998-12-09 | 2002-09-24 | ワイス | Herpesvirus thiourea inhibitors |
EP1140903B1 (en) | 1998-12-23 | 2004-08-04 | Eli Lilly And Company | Aromatic amides |
US6632815B2 (en) | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
KR20020047175A (en) | 1999-09-17 | 2002-06-21 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | Inhibitors of Factor Xa |
US6720317B1 (en) | 1999-09-17 | 2004-04-13 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
ATE311366T1 (en) | 2000-02-29 | 2005-12-15 | Millennium Pharm Inc | BENZAMIDE AND SIMILAR FACTOR XA INHIBITORS |
AU776053B2 (en) | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
US6373515B1 (en) * | 2000-08-09 | 2002-04-16 | Hewlett-Packard Company | Variable resolution transition placement device |
US7312235B2 (en) | 2001-03-30 | 2007-12-25 | Millennium Pharmaceuticals, Inc. | Benzamide inhibitors of factor Xa |
ATE287397T1 (en) * | 2001-07-31 | 2005-02-15 | Univ Wayne State | CHINOLINE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS |
EP1678161B1 (en) * | 2003-10-09 | 2009-12-30 | Millennium Pharmaceuticals, Inc. | Thioether-substituted benzamides as inhibitors of factor xa |
AU2005257999B2 (en) * | 2004-06-18 | 2011-12-08 | Millennium Pharmaceuticals, Inc. | Factor Xa inhibitors |
US7696352B2 (en) * | 2004-06-18 | 2010-04-13 | Millennium Pharmaceuticals, Inc. | Factor Xa inhibitors |
NZ567992A (en) * | 2005-11-08 | 2011-05-27 | Millennium Pharm Inc | Pharmaceutical salts and polymorphs of N-(5-chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxy-benzamide, a factor Xa inhibitor |
WO2007112367A2 (en) * | 2006-03-27 | 2007-10-04 | Portola Pharmaceuticals, Inc. | Potassium channel modulators and platelet procoagulant activity |
EP2016072B1 (en) * | 2006-05-05 | 2014-07-16 | Millennium Pharmaceuticals, Inc. | Factor xa inhibitors |
CN105193799A (en) * | 2006-12-08 | 2015-12-30 | 米伦纽姆医药公司 | Unit dose formulations and methods of treating thrombosis with an oral factor Xa inhibitor |
EP2114930A2 (en) * | 2007-01-05 | 2009-11-11 | Millennium Pharmaceuticals, Inc. | Factor xa inhibitors |
WO2008127682A2 (en) * | 2007-04-13 | 2008-10-23 | Millennium Pharmaceuticals, Inc. | Combination anticoagulant therapy with a compound that acts as a factor xa inhibitor |
PT2146705E (en) * | 2007-05-02 | 2014-05-23 | Portola Pharm Inc | Combination therapy with a compound acting as a platelet adp receptor inhibitor |
-
2001
- 2001-02-28 AT AT01918257T patent/ATE311366T1/en active
- 2001-02-28 DK DK01918257T patent/DK1259485T3/en active
- 2001-02-28 WO PCT/US2001/006255 patent/WO2001064643A2/en active IP Right Grant
- 2001-02-28 EP EP01918257A patent/EP1259485B1/en not_active Expired - Lifetime
- 2001-02-28 WO PCT/US2001/006247 patent/WO2001064642A2/en active Search and Examination
- 2001-02-28 DE DE60115394T patent/DE60115394T2/en not_active Expired - Lifetime
- 2001-02-28 ES ES01918257T patent/ES2254385T3/en not_active Expired - Lifetime
- 2001-02-28 AU AU2001250783A patent/AU2001250783A1/en not_active Abandoned
- 2001-02-28 CA CA2401778A patent/CA2401778C/en not_active Expired - Lifetime
- 2001-02-28 US US09/794,225 patent/US6376515B2/en not_active Expired - Lifetime
- 2001-02-28 AU AU2001245353A patent/AU2001245353A1/en not_active Abandoned
-
2002
- 2002-04-22 US US10/126,976 patent/US20030162690A1/en not_active Abandoned
-
2003
- 2003-05-27 HK HK03103788A patent/HK1051539A1/en not_active IP Right Cessation
- 2003-10-15 US US10/687,334 patent/US6835739B2/en not_active Expired - Lifetime
-
2004
- 2004-09-15 US US10/942,733 patent/US7314874B2/en not_active Expired - Fee Related
-
2006
- 2006-05-26 US US11/442,060 patent/US7342013B2/en not_active Expired - Lifetime
- 2006-07-17 US US11/488,455 patent/US7727982B2/en not_active Expired - Fee Related
-
2007
- 2007-10-25 US US11/924,480 patent/US7727981B2/en not_active Expired - Fee Related
-
2010
- 2010-04-07 US US12/756,037 patent/US8063036B2/en not_active Expired - Fee Related
-
2011
- 2011-09-28 US US13/247,937 patent/US8518977B2/en not_active Expired - Fee Related
-
2012
- 2012-09-12 US US13/612,597 patent/US8691847B2/en not_active Expired - Fee Related
-
2014
- 2014-02-07 US US14/175,087 patent/US9108922B2/en not_active Expired - Fee Related
-
2015
- 2015-06-17 US US14/742,465 patent/US9629831B2/en not_active Expired - Fee Related
-
2017
- 2017-03-22 US US15/466,530 patent/US10179124B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2001245353A1 (en) | Benzamides and related inhibitors of factor xa | |
WO2001056989A3 (en) | Inhibitors of factor xa | |
WO2002026712A3 (en) | Quaternary amines and related inhibitors of factor xa | |
WO2000071493A3 (en) | INHIBITORS OF FACTOR Xa | |
NZ511927A (en) | Phenylglycine derivatives | |
BG106586A (en) | Pyrazolopyramidines as therapeutic agents | |
BR0014078A (en) | Xa factor inhibitors | |
WO2000071516A3 (en) | INHIBITORS OF FACTOR Xa | |
BG106013A (en) | New compounds and compositions as protease inhibitors | |
BRPI0014076B8 (en) | benzamides and related factor xa inhibitors | |
MXPA03006483A (en) | Phenyl derivatives. | |
WO2001072708A3 (en) | OXINDOLE INHIBITORS OF FACTOR Xa | |
WO2001057021A3 (en) | 2-[1H]-QUINOLONE AND 2-[1H]-QUINOXALONE INHIBITORS OF FACTOR Xa | |
MXPA03008215A (en) | INHIBITORS OF INTEGRIN agr;v. | |
WO2002026720A3 (en) | PIPERAZINE BASED INHIBITORS OF FACTOR Xa | |
ATE368643T1 (en) | FACTOR XA BENZAMIDINE INHIBITORS | |
GEP20053505B (en) | Diphenyl Ether Compounds Useful in Therapy | |
MX9709910A (en) | Inhibitors of factor xa. | |
AU2001290480A1 (en) | Cyclized benzamide neurokinin antagonists for use in therapy | |
WO2002006280A3 (en) | INHIBITORS OF FACTOR Xa | |
WO2002026718A3 (en) | Bicyclic pyrimidin-4-one based inhibitors of factor xa | |
ATE211482T1 (en) | SELECTIVE INHIBITORS OF FACTOR X CONTAINING AN AZEPINE STRUCTURE | |
WO2002026731A3 (en) | Quaternary amidino based inhibitors of factor xa | |
AU2002211493A1 (en) | Indole derivatives as pde5-inhibitors | |
AU4944899A (en) | New pharmaceutically active compounds |