AU2001236589A1 - Methods and apparatus for high-throughput detection and characterization of alternatively spliced genes - Google Patents

Methods and apparatus for high-throughput detection and characterization of alternatively spliced genes

Info

Publication number
AU2001236589A1
AU2001236589A1 AU2001236589A AU3658901A AU2001236589A1 AU 2001236589 A1 AU2001236589 A1 AU 2001236589A1 AU 2001236589 A AU2001236589 A AU 2001236589A AU 3658901 A AU3658901 A AU 3658901A AU 2001236589 A1 AU2001236589 A1 AU 2001236589A1
Authority
AU
Australia
Prior art keywords
characterization
methods
alternatively spliced
throughput detection
spliced genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001236589A
Inventor
David Kagen Hanzel
Sharron Gaynor Penn
David Russell Rank
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aeomica Inc
Original Assignee
Aeomica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0024263A external-priority patent/GB2360284B/en
Application filed by Aeomica Inc filed Critical Aeomica Inc
Publication of AU2001236589A1 publication Critical patent/AU2001236589A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1089—Design, preparation, screening or analysis of libraries using computer algorithms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B45/00—ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
AU2001236589A 2000-02-04 2001-01-29 Methods and apparatus for high-throughput detection and characterization of alternatively spliced genes Abandoned AU2001236589A1 (en)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US18031200P 2000-02-04 2000-02-04
US60/180,312 2000-02-04
US20745600P 2000-05-26 2000-05-26
US60/207,456 2000-05-26
US60840800A 2000-06-30 2000-06-30
US09/608,408 2000-06-30
US63236600A 2000-08-03 2000-08-03
US09/632,366 2000-08-03
US23468700P 2000-09-21 2000-09-21
US60/234,687 2000-09-21
US23635900P 2000-09-27 2000-09-27
US60/236,359 2000-09-27
GB0024263A GB2360284B (en) 2000-02-04 2000-10-04 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart
GB0024263.6 2000-10-04
PCT/US2001/003003 WO2001057252A2 (en) 2000-02-04 2001-01-29 Methods and apparatus for high-throughput detection and characterization of alternatively spliced genes

Publications (1)

Publication Number Publication Date
AU2001236589A1 true AU2001236589A1 (en) 2001-08-14

Family

ID=27562579

Family Applications (12)

Application Number Title Priority Date Filing Date
AU2001233114A Abandoned AU2001233114A1 (en) 2000-02-04 2001-01-29 Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
AU3087801A Pending AU3087801A (en) 2000-02-04 2001-01-29 Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human breast and hbl 100 cells
AU2001236589A Abandoned AU2001236589A1 (en) 2000-02-04 2001-01-29 Methods and apparatus for high-throughput detection and characterization of alternatively spliced genes
AU2001232758A Abandoned AU2001232758A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human lung
AU2001230883A Abandoned AU2001230883A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human hela cells or other human cervical epithelial cells
AU2001232757A Abandoned AU2001232757A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human adult liver
AU2001230881A Abandoned AU2001230881A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart
AU2001232760A Abandoned AU2001232760A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human fetal liver
AU2001230879A Abandoned AU2001230879A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human breast and bt 474 cells
AU2001230880A Abandoned AU2001230880A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human placenta
AU2001232759A Abandoned AU2001232759A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human brain
AU2001230882A Abandoned AU2001230882A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human bone marrow

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AU2001233114A Abandoned AU2001233114A1 (en) 2000-02-04 2001-01-29 Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
AU3087801A Pending AU3087801A (en) 2000-02-04 2001-01-29 Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human breast and hbl 100 cells

Family Applications After (9)

Application Number Title Priority Date Filing Date
AU2001232758A Abandoned AU2001232758A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human lung
AU2001230883A Abandoned AU2001230883A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human hela cells or other human cervical epithelial cells
AU2001232757A Abandoned AU2001232757A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human adult liver
AU2001230881A Abandoned AU2001230881A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart
AU2001232760A Abandoned AU2001232760A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human fetal liver
AU2001230879A Abandoned AU2001230879A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human breast and bt 474 cells
AU2001230880A Abandoned AU2001230880A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human placenta
AU2001232759A Abandoned AU2001232759A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human brain
AU2001230882A Abandoned AU2001230882A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human bone marrow

Country Status (5)

Country Link
US (1) US20020081590A1 (en)
EP (11) EP1290217A2 (en)
AU (12) AU2001233114A1 (en)
GB (11) GB2373500B (en)
WO (12) WO2001057251A2 (en)

Families Citing this family (191)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8212000B2 (en) 1970-02-11 2012-07-03 Immatics Biotechnologies Gmbh Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules
US8258260B2 (en) 1970-02-11 2012-09-04 Immatics Biotechnologies Gmbh Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules
US8211999B2 (en) 1970-02-11 2012-07-03 Immatics Biotechnologies Gmbh Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules
US6943236B2 (en) 1997-02-25 2005-09-13 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
WO2002018435A1 (en) * 2000-08-28 2002-03-07 Human Genome Sciences, Inc. 18 human secreted proteins
US6960570B2 (en) 1998-03-18 2005-11-01 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US7579160B2 (en) 1998-03-18 2009-08-25 Corixa Corporation Methods for the detection of cervical cancer
US7258860B2 (en) 1998-03-18 2007-08-21 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US6696247B2 (en) 1998-03-18 2004-02-24 Corixa Corporation Compounds and methods for therapy and diagnosis of lung cancer
US6329503B1 (en) 1998-06-01 2001-12-11 Agensys, Inc. Serpentine transmembrane antigens expressed in human cancers and uses thereof
US6833438B1 (en) 1999-06-01 2004-12-21 Agensys, Inc. Serpentine transmembrane antigens expressed in human cancers and uses thereof
US20030149531A1 (en) 2000-12-06 2003-08-07 Hubert Rene S. Serpentine transmembrane antigens expressed in human cancers and uses thereof
JP4315301B2 (en) * 1998-10-30 2009-08-19 独立行政法人科学技術振興機構 Human H37 protein and cDNA encoding this protein
US6962980B2 (en) 1999-09-24 2005-11-08 Corixa Corporation Compositions and methods for the therapy and diagnosis of ovarian cancer
US7888477B2 (en) 1998-12-17 2011-02-15 Corixa Corporation Ovarian cancer-associated antibodies and kits
US6699664B1 (en) 1998-12-17 2004-03-02 Corixa Corporation Compositions and methods for the therapy and diagnosis of ovarian cancer
US6468546B1 (en) 1998-12-17 2002-10-22 Corixa Corporation Compositions and methods for therapy and diagnosis of ovarian cancer
US6858710B2 (en) 1998-12-17 2005-02-22 Corixa Corporation Compositions and methods for the therapy and diagnosis of ovarian cancer
US6844325B2 (en) 1998-12-28 2005-01-18 Corixa Corporation Compositions for the treatment and diagnosis of breast cancer and methods for their use
US7598226B2 (en) 1998-12-28 2009-10-06 Corixa Corporation Compositions and methods for the therapy and diagnosis of breast cancer
US6969518B2 (en) 1998-12-28 2005-11-29 Corixa Corporation Compositions and methods for the therapy and diagnosis of breast cancer
US7244827B2 (en) 2000-04-12 2007-07-17 Agensys, Inc. Nucleic acid and corresponding protein entitled 24P4C12 useful in treatment and detection of cancer
US6943235B1 (en) 1999-04-12 2005-09-13 Agensys, Inc. Transmembrane protein expressed in prostate cancer
US20060073150A1 (en) 2001-09-06 2006-04-06 Mary Faris Nucleic acid and corresponding protein entitled STEAP-1 useful in treatment and detection of cancer
CA2392510A1 (en) 1999-11-30 2001-06-07 Corixa Corporation Compositions and methods for therapy and diagnosis of breast cancer
US20020048777A1 (en) 1999-12-06 2002-04-25 Shujath Ali Method of diagnosing monitoring, staging, imaging and treating prostate cancer
CA2399644A1 (en) * 2000-02-03 2001-08-09 Hyseq, Inc. Methods and materials relating to neurotrimin-like polypeptides and polynucleotides
US7811574B2 (en) 2000-02-23 2010-10-12 Glaxosmithkline Biologicals S.A. Tumour-specific animal proteins
CA2400842C (en) 2000-02-23 2013-01-15 Smithkline Beecham Biologicals S.A. Novel compounds
JP2004500825A (en) 2000-03-03 2004-01-15 トゥラリック　インコーポレイテッド KCNB: a novel potassium channel protein
US20030144476A1 (en) * 2000-03-06 2003-07-31 Pankaj Agarwal Novel compounds
CA2404555A1 (en) * 2000-03-31 2001-10-11 Hyseq, Inc. Novel nucleic acids and polypeptides
US6774209B1 (en) 2000-04-03 2004-08-10 Dyax Corp. Binding peptides for carcinoembryonic antigen (CEA)
KR100378949B1 (en) * 2000-05-13 2003-04-08 주식회사 리젠 바이오텍 Peptides and derivatives thereof showing cell attachment, spreading and detachment activity
WO2001092524A2 (en) * 2000-05-26 2001-12-06 Aeomica, Inc. Myosin-like gene expressed in human heart and muscle
GB2380197A (en) * 2000-05-26 2003-04-02 Aeomica Inc Myosin-like gene expressed in human heart and muscle
US6582935B2 (en) * 2000-05-30 2003-06-24 Applera Corporation Isolated nucleic acid molecules encoding human aspartate aminotransferase protein and uses thereof
WO2001092305A2 (en) * 2000-05-31 2001-12-06 Zymogenetics, Inc. Mammalian transforming growth factor beta-10
DE60109922D1 (en) 2000-05-31 2005-05-12 Genzyme Corp THERAPEUTIC COMPOUNDS AGAINST EGG CANCER
WO2001094412A2 (en) * 2000-06-05 2001-12-13 Millennium Pharmaceuticals, Inc. 56201, a novel human sodium ion channel family member and uses thereof
ATE452909T1 (en) * 2000-06-05 2010-01-15 Brigham & Womens Hospital FOR A HOMOLOGUE OF THE HUMAN GENE RESPONSIBLE FOR MULTIPLE RESISTANCE, P-GLYCOPROTEINS ON CHROMOSOME 7P15-21 AND USES THEREOF
WO2001094416A2 (en) * 2000-06-07 2001-12-13 Curagen Corporation Human proteins and nucleic acids encoding same
US20020019028A1 (en) * 2000-06-13 2002-02-14 Kabir Chaturvedi Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
CA2309371A1 (en) 2000-06-16 2001-12-16 Christopher J. Ong Gene sequence tag method
WO2002006454A2 (en) * 2000-07-17 2002-01-24 Bayer Aktiengesellschaft Regulation of human carboxylesterase-like enzyme
WO2002010449A2 (en) * 2000-07-28 2002-02-07 Compugen Inc. Oligonucleotide library for detecting rna transcripts and splice variants that populate a transcriptome
AU2001283062A1 (en) 2000-08-02 2002-02-13 The Johns Hopkins University Endothelial cell expression patterns
DE60120420T2 (en) * 2000-08-18 2007-05-16 Merck Patent Gmbh MFQ-111, A HUMAN GTPASE SIMILAR PROTEIN
US6713257B2 (en) 2000-08-25 2004-03-30 Rosetta Inpharmatics Llc Gene discovery using microarrays
US7807447B1 (en) * 2000-08-25 2010-10-05 Merck Sharp & Dohme Corp. Compositions and methods for exon profiling
US6391606B1 (en) * 2000-09-14 2002-05-21 Pe Corporation Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof
GB0022670D0 (en) 2000-09-15 2000-11-01 Astrazeneca Ab Molecules
US20050100896A1 (en) * 2000-09-23 2005-05-12 Miller Jeffery L. Identification of the dombrock blood group glycoprotein as a polymorphic member of the adp-ribosyltransferase gene family
WO2002029049A2 (en) * 2000-10-05 2002-04-11 Bayer Aktiengesellschaft Regulation of human sodium-dependent monoamine transporter
US6584419B1 (en) * 2000-10-12 2003-06-24 Agilent Technologies, Inc. System and method for enabling an operator to analyze a database of acquired signal pulse characteristics
WO2002036625A2 (en) 2000-11-03 2002-05-10 The Regents Of The University Of California Prokineticin polypeptides, related compositions and methods
EP1355937A2 (en) * 2000-11-17 2003-10-29 ZymoGenetics, Inc. Mammalian alpha-helical protein-53
EP1415005B1 (en) 2000-12-07 2012-11-21 Novartis Vaccines and Diagnostics, Inc. Endogenous retroviruses up-regulated in prostate cancer
US20040067553A1 (en) * 2000-12-28 2004-04-08 Masanori Miwa Novel g protein-coupled receptor protein and dna thereof
EP1373526A4 (en) * 2001-03-08 2006-01-25 Curagen Corp Therapeutic polypeptides, nucleic acids encoding same, and methodes of use
WO2002077257A1 (en) * 2001-03-21 2002-10-03 Hyseq, Inc. Novel nucleic acids and polypeptides
SE0103754L (en) * 2001-04-05 2002-10-06 Forskarpatent I Syd Ab Peptides from apolipoprotein B, use thereof immunization, method of diagnosis or therapeutic treatment of ischemic cardiovascular diseases, and pharmaceutical composition and vaccine containing such peptide
US20030105003A1 (en) 2001-04-05 2003-06-05 Jan Nilsson Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein
IL158293A0 (en) 2001-04-10 2004-05-12 Agensys Inc Nucleic acid and corresponding protein entitled 158p3d2 and pharmaceutical compositions containing the same
US7811575B2 (en) 2001-04-10 2010-10-12 Agensys, Inc. Nucleic acids and corresponding proteins entitled 158P3D2 useful in treatment and detection of cancer
WO2002083860A2 (en) 2001-04-10 2002-10-24 Agensys, Inc. Nucleic acid and corresponding protein entitled 151p3d4 useful in treatment and detection of cancer
US20030191073A1 (en) 2001-11-07 2003-10-09 Challita-Eid Pia M. Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer
CA2443123A1 (en) 2001-04-10 2002-10-24 Agensys, Inc. Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
US20030235821A1 (en) * 2001-06-04 2003-12-25 Zerhusen Bryan D. Novel Human proteins, polynucleotides encoding them and methods of using the same
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7833779B2 (en) * 2001-07-25 2010-11-16 Jivan Biologies Inc. Methods and systems for polynucleotide detection
US7340349B2 (en) * 2001-07-25 2008-03-04 Jonathan Bingham Method and system for identifying splice variants of a gene
JP2005507244A (en) * 2001-08-10 2005-03-17 ノバルティス アクチエンゲゼルシャフト Peptides that bind to atherosclerotic lesions
US7494646B2 (en) 2001-09-06 2009-02-24 Agensys, Inc. Antibodies and molecules derived therefrom that bind to STEAP-1 proteins
US20050222070A1 (en) 2002-05-29 2005-10-06 Develogen Aktiengesellschaft Fuer Entwicklungsbiologische Forschung Pancreas-specific proteins
GB0122789D0 (en) * 2001-09-21 2001-11-14 Babraham Inst Differential gene expression in schizophrenia
EP1295951A1 (en) * 2001-09-24 2003-03-26 The University of British Columbia Cell library method
KR20040081418A (en) 2001-09-28 2004-09-21 에스페리온 테라피유틱스 인코포레이티드 Prevention and treatment of restenosis by local administration of drug
US7521053B2 (en) 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
JP4200100B2 (en) 2001-11-07 2008-12-24 アジェンシス，インコーポレイテッド Nucleic acids and corresponding proteins referred to as 161P2F10B useful in cancer treatment and detection
IS7221A (en) * 2001-11-15 2004-04-15 Memory Pharmaceuticals Corporation Cyclic adenosine monophosphate phosphodiesterase 4D7 isoforms and methods for their use
WO2003046564A2 (en) * 2001-11-23 2003-06-05 Syn.X Pharma, Inc. Protein biopolymer markers predictive of alzheimers disease
JP4282483B2 (en) 2001-11-28 2009-06-24 ザ ジェネラル ホスピタル コーポレーション Blood-based assay for dysferlinopathy
AU2002359567A1 (en) * 2001-11-28 2003-06-10 Incyte Genomics, Inc. Molecules for disease detection and treatment
AU2002232563A1 (en) * 2001-12-05 2003-06-23 Genzyme Corporation Compounds for therapy and diagnosis and methods for using same
WO2003050258A2 (en) * 2001-12-07 2003-06-19 Chiron Corporation Endogenous retrovirus polypeptides linked to oncogenic transformation
KR20030062789A (en) * 2002-01-19 2003-07-28 포휴먼텍(주) Biomolecule transduction peptide sim2-btm and biotechnological products including it
WO2003072710A2 (en) * 2002-02-21 2003-09-04 Eastern Virginia Medical School Protein biomarkers that distinguish prostate cancer from non-malignant cells
DE10211088A1 (en) * 2002-03-13 2003-09-25 Ugur Sahin Gene products differentially expressed in tumors and their use
US20030194704A1 (en) * 2002-04-03 2003-10-16 Penn Sharron Gaynor Human genome-derived single exon nucleic acid probes useful for gene expression analysis two
IL164376A0 (en) 2002-04-03 2005-12-18 Applied Research Systems Ox4or binding agents, their preparation and pharmaceutical compositions containing them
EP1507553A2 (en) * 2002-05-29 2005-02-23 DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung Pancreas-specific proteins
ATE545651T1 (en) 2002-06-13 2012-03-15 Novartis Vaccines & Diagnostic VECTORS FOR EXPRESSING HML-2 POLYPEPTIDES
EP1573034A4 (en) 2002-06-20 2006-06-14 Bristol Myers Squibb Co Identification and modulation of a g-protein coupled receptor (gpcr), rai3, associated with chronic obstructive pulmonary disease (copd) and nf-kb and e-selectin regulation
US20090110702A1 (en) 2002-07-12 2009-04-30 The Johns Hopkins University Mesothelin Vaccines and Model Systems and Control of Tumors
US9200036B2 (en) 2002-07-12 2015-12-01 The Johns Hopkins University Mesothelin vaccines and model systems
AU2003259109A1 (en) 2002-07-12 2004-02-02 The Johns Hopkins University Mesothelin vaccines and model systems
AU2003254081A1 (en) 2002-07-24 2004-02-09 New York University Truncated rgr in t cell malignancy
WO2004016733A2 (en) 2002-08-16 2004-02-26 Agensys, Inc. Nucleic acid and corresponding protein entitled 251p5g2 useful in treatment and detection of cancer
EP1567552A2 (en) * 2002-12-04 2005-08-31 Applied Research Systems ARS Holding N.V. Novel ifngamma-like polypeptides
CA2508847A1 (en) * 2002-12-06 2004-06-24 Singapore General Hospital Pte Ltd. Central nervous system damage
GB0303006D0 (en) * 2003-02-10 2003-03-12 Genomica Sau A method to detect polymeric nucleic acids
US20050017981A1 (en) * 2003-03-17 2005-01-27 Jonathan Bingham Methods of representing gene product sequences and expression
US20040234963A1 (en) * 2003-05-19 2004-11-25 Sampas Nicholas M. Method and system for analysis of variable splicing of mRNAs by array hybridization
DE10332854A1 (en) * 2003-07-18 2005-02-17 Universitätsklinikum der Charité der Humboldt-Universität zu Berlin Use of the newly identified human gene 7a5 / prognostin for tumor diagnostics and tumor therapy
MXPA06001326A (en) * 2003-08-07 2006-05-04 Hoffmann La Roche Ra antigenic peptides.
US7341850B2 (en) * 2003-08-18 2008-03-11 Wyeth Human LXRα variants
EP1522857A1 (en) 2003-10-09 2005-04-13 Universiteit Maastricht Method for identifying a subject at risk of developing heart failure by determining the level of galectin-3 or thrombospondin-2
JP4019147B2 (en) 2003-10-31 2007-12-12 独立行政法人農業生物資源研究所 Seed-specific promoter and its use
DE602004021847D1 (en) 2003-11-27 2009-08-13 Develogen Ag METHOD FOR THE PREVENTION AND TREATMENT OF DIABETES WITH NEURTURINE
US7173119B2 (en) * 2004-03-25 2007-02-06 Medical College Of Georgia Research Institute SUMO4 gene and methods of use for type 1 diabetes
US8926958B2 (en) 2004-04-06 2015-01-06 Cedars-Sinai Medical Center Prevention and treatment of vascular disease with recombinant adeno-associated virus vectors encoding apolipoprotein A-I and apolipoprotein A-I milano
EP1742966B1 (en) 2004-04-22 2013-11-27 Agensys, Inc. Antibodies and molecules derived therefrom that bind to steap-1 proteins
JP4649575B2 (en) * 2004-05-19 2011-03-09 財団法人ヒューマンサイエンス振興財団 Diagnosis of novel mucin genes and mucosal-related diseases
WO2006045750A2 (en) * 2004-10-20 2006-05-04 Friedrich-Alexander- Universität Erlangen- Nürnberg T-cell stimulatory peptides from the melanoma-associated chondroitin sulfate proteoglycan and their use
US20090028889A1 (en) * 2005-01-31 2009-01-29 Vaxinnate Corporation Novel Polypeptide Ligands For Toll-Like Receptor 2 (TLR2)
EP2444099A1 (en) 2005-03-31 2012-04-25 Agensys, Inc. Antibodies and related molecules that bind to 161P2F10B proteins
US8350009B2 (en) 2005-03-31 2013-01-08 Agensys, Inc. Antibodies and related molecules that bind to 161P2F10B proteins
EP1891234B1 (en) * 2005-06-01 2014-12-10 Evotec International GmbH Use of slc39a12 proteins as target in diagnosis and drug screening in alzheimer's disease
GB0515180D0 (en) * 2005-07-22 2005-08-31 Ares Trading Sa Protein
JP4890806B2 (en) * 2005-07-27 2012-03-07 富士通株式会社 Prediction program and prediction device
EP1924595A2 (en) * 2005-08-12 2008-05-28 Cartela R & D AB Novel peptides and uses thereof
US20070048764A1 (en) * 2005-08-23 2007-03-01 Jonathan Bingham Indicator polynucleotide controls
EP1806358B1 (en) 2005-09-05 2010-03-17 Immatics Biotechnologies GmbH Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules
US7962291B2 (en) 2005-09-30 2011-06-14 Affymetrix, Inc. Methods and computer software for detecting splice variants
FR2892730A1 (en) * 2005-10-28 2007-05-04 Biomerieux Sa Detecting the presence/risk of cancer development in a mammal, comprises detecting the presence/absence or (relative) quantity e.g. of nucleic acids and/or polypeptides coded by the nucleic acids, which indicates the presence/risk
WO2007097469A1 (en) * 2006-02-24 2007-08-30 Oncotherapy Science, Inc. A dominant negative peptide of imp-3, polynucleotide encoding the same, pharmaceutical composition containing the same, and methods for treating or preventing cancer
US8541169B2 (en) 2006-10-10 2013-09-24 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Prostate cancer-specific alternations in ERG gene expression and detection and treatment methods based on those alterations
SI2502938T1 (en) 2006-10-27 2015-05-29 Genentech, Inc. Antibodies and immunoconjugates and uses therefor
WO2008104803A2 (en) 2007-02-26 2008-09-04 Oxford Genome Sciences (Uk) Limited Proteins
US8999634B2 (en) * 2007-04-27 2015-04-07 Quest Diagnostics Investments Incorporated Nucleic acid detection combining amplification with fragmentation
US8569449B2 (en) * 2007-05-08 2013-10-29 University Of Louisville Research Foundation, Inc. Synthetic peptides and peptide mimetics
CN101809030A (en) * 2007-08-09 2010-08-18 诺瓦提斯公司 Thiopeptide precursor protein, gene encoding it and uses thereof
PT2190469E (en) * 2007-09-04 2015-06-25 Compugen Ltd Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
GB2453589A (en) 2007-10-12 2009-04-15 King S College London Protease inhibition
JP2011508598A (en) 2008-01-04 2011-03-17 サントル ナショナル ドゥ ラ ルシェルシュ シアンティフィク In vitro molecular diagnosis of breast cancer
JO2913B1 (en) 2008-02-20 2015-09-15 امجين إنك, Antibodies directed to angiopoietin-1 and angiopoietin-2 and uses thereof
JP5960946B2 (en) * 2008-10-27 2016-08-02 北海道公立大学法人 札幌医科大学 Cancer stem cell molecular marker
CA2758687A1 (en) 2008-11-14 2010-05-20 Gen-Probe Incorporated Compositions, kits and methods for detection of campylobacter nucleic acid
KR20120014054A (en) 2009-05-27 2012-02-15 글락소스미스클라인 바이오로지칼즈 에스.에이. Casb7439 constructs
EA201270316A1 (en) 2009-08-25 2012-09-28 БиДжи МЕДИСИН, ИНК. GALEKTIN-3 AND HEART RESINCHRONIZING THERAPY
US8075895B2 (en) * 2009-09-22 2011-12-13 Janssen Pharmaceutica N.V. Identification of antigenic peptides from multiple myeloma cells
US8609092B2 (en) 2010-02-08 2013-12-17 Agensys, Inc. Antibody drug conjugates (ADC) that bind to 161P2F10B proteins
US20140038834A1 (en) * 2010-07-07 2014-02-06 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg Novel biomarkers for detecting neuronal loss
RU2013126626A (en) 2010-11-12 2014-12-20 Седарс-Синаи Медикал Сентер IMMUNOMODULATING METHODS AND SYSTEMS FOR TREATMENT AND / OR PREVENTION OF HYPERTENSIONS
CN103501806A (en) 2010-11-12 2014-01-08 赛达斯西奈医疗中心 Immunomodulatory methods and systems for treatment and/or prevention of aneurysms
JP6126009B2 (en) * 2010-11-17 2017-05-10 アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． Regulation of α-synuclein expression
WO2012098281A2 (en) 2011-01-19 2012-07-26 Universidad Miguel Hernández De Elche Trp-receptor-modulating peptides and uses thereof
US8494967B2 (en) * 2011-03-11 2013-07-23 Bytemark, Inc. Method and system for distributing electronic tickets with visual display
US20120252026A1 (en) * 2011-04-01 2012-10-04 Harris Reuben S Cancer biomarker, diagnostic methods, and assay reagents
US20150139937A1 (en) * 2012-05-18 2015-05-21 Board Of Regents Of The University Of Nebraska Methods and Compositions For Inhibiting Diseases of the Central Nervous System
GB201214746D0 (en) * 2012-08-17 2012-10-03 Cancer Rec Tech Ltd Biomolecular complexes
WO2014087005A1 (en) * 2012-12-07 2014-06-12 Centre National De La Recherche Scientifique Antibody against the protein trio and its method of production
US9384239B2 (en) * 2012-12-17 2016-07-05 Microsoft Technology Licensing, Llc Parallel local sequence alignment
JP6391676B2 (en) * 2013-05-23 2018-09-19 アジュ ユニバーシティー インダストリー−アカデミック コーオペレイション ファウンデーションＡｊｏｕ Ｕｎｉｖｅｒｓｉｔｙ Ｉｎｄｕｓｔｒｙ−Ａｃａｄｅｍｉｃ Ｃｏｏｐｅｒａｔｉｏｎ Ｆｏｕｎｄａｔｉｏｎ Tumor penetrating peptide specific for neuropilin and fusion protein fused with this peptide
WO2015020960A1 (en) * 2013-08-09 2015-02-12 Novartis Ag Novel lncrna polynucleotides
WO2015050259A1 (en) * 2013-10-03 2015-04-09 大日本住友製薬株式会社 Tumor antigen peptide
JP6657075B2 (en) 2013-10-11 2020-03-04 オックスフォード バイオセラピューティックス リミテッドＯｘｆｏｒｄ Ｂｉｏｔｈｅｒａｐｅｕｔｉｃｓ Ｌｔｄ Composite antibodies to LY75 for cancer treatment
GB201319446D0 (en) * 2013-11-04 2013-12-18 Immatics Biotechnologies Gmbh Personalized immunotherapy against several neuronal and brain tumors
ES2639855T3 (en) * 2013-12-23 2017-10-30 Exchange Imaging Technologies Gmbh Nanoparticle conjugated to CD44 binding peptides
WO2015114633A1 (en) * 2014-01-30 2015-08-06 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Ltd. Actin binding peptides and compositions comprising same for inhibiting angiogenes is and treating medical conditions associated with same
WO2015124702A1 (en) * 2014-02-21 2015-08-27 Ventana Medical Systems, Inc. Single-stranded oligonucleotide probes for chromosome or gene copy enumeration
US10550163B2 (en) * 2014-04-03 2020-02-04 The Regents Of The University Of California Peptide fragments of netrin-1 and compositions and methods thereof
EP3259283B1 (en) * 2015-02-17 2021-06-09 Santonico, Elena Hybrid protein for the identification of neddylated substrates
IL298914A (en) 2015-03-27 2023-02-01 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against various tumors
GB201505305D0 (en) 2015-03-27 2015-05-13 Immatics Biotechnologies Gmbh Novel Peptides and combination of peptides for use in immunotherapy against various tumors
GB201507719D0 (en) * 2015-05-06 2015-06-17 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers
GB201513921D0 (en) * 2015-08-05 2015-09-23 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against prostate cancer and other cancers
MA55153A (en) 2016-02-19 2021-09-29 Immatics Biotechnologies Gmbh NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST NON-HODGKIN'S LYMPHOMA AND OTHER CANCERS
GB201602918D0 (en) * 2016-02-19 2016-04-06 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against NHL and other cancers
US10961305B2 (en) 2016-12-21 2021-03-30 Mereo Biopharma 3 Limited Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta
JP7174492B2 (en) * 2017-01-04 2022-11-17 ウォルグ ファーマシューティカルズ （ハンジョウ） カンパニー，リミテッド S-arrestin peptides and their therapeutic use
DK3565579T3 (en) 2017-01-05 2023-09-04 Kahr Medical Ltd PD1-41BBL FUSION PROTEIN AND METHODS OF USING THEREOF
WO2018127918A1 (en) 2017-01-05 2018-07-12 Kahr Medical Ltd. A sirp alpha-cd70 fusion protein and methods of use thereof
WO2018127919A1 (en) 2017-01-05 2018-07-12 Kahr Medical Ltd. A SIRP1 alpha-41BBL FUSION PROTEIN AND METHODS OF USE THEREOF
WO2018127916A1 (en) 2017-01-05 2018-07-12 Kahr Medical Ltd. A pd1-cd70 fusion protein and methods of use thereof
BR112019014042A2 (en) * 2017-01-17 2020-02-04 Illumina Inc determination of oncogenic splice variant
JP7320796B2 (en) 2017-01-30 2023-08-04 国立研究開発法人国立循環器病研究センター Use of peptide that specifically binds to vascular endothelial cells, and peptide
JP7017726B2 (en) 2017-01-30 2022-02-09 国立研究開発法人国立循環器病研究センター Use of peptides that specifically bind to vascular endothelial cells, and peptides
EP3382032A1 (en) * 2017-03-30 2018-10-03 Euroimmun Medizinische Labordiagnostika AG Assay for the diagnosis of dermatophytosis
RU2019134462A (en) 2017-04-03 2021-05-05 Ф. Хоффманн-Ля Рош Аг ANTIBODIES BINDING WITH STEAP-1
TWI809004B (en) 2017-11-09 2023-07-21 美商Ionis製藥公司 Compounds and methods for reducing snca expression
MX2020007433A (en) 2018-01-12 2020-09-14 Bristol Myers Squibb Co Antisense oligonucleotides targeting alpha-synuclein and uses thereof.
MX2021000263A (en) 2018-07-11 2021-05-12 Kahr Medical Ltd SIRPalpha-4-1BBL VARIANT FUSION PROTEIN AND METHODS OF USE THEREOF.
CN109371143B (en) * 2018-12-16 2021-05-07 华中农业大学 SNP molecular marker associated with pig growth traits
WO2020146902A2 (en) * 2019-01-11 2020-07-16 Minerva Biotechnologies Corporation Anti-variable muc1* antibodies and uses thereof
CN111370057B (en) * 2019-07-31 2021-03-30 深圳思勤医疗科技有限公司 Method for determining chromosome structure variation signal intensity and insert length distribution characteristics of sample and application
CN110897989B (en) * 2019-12-24 2021-11-26 广州蜜妆生物科技有限公司 Sensitive skin repair emulsion
WO2022214635A1 (en) * 2021-04-08 2022-10-13 Stichting Vu Nucleic acid molecules for compensation of stxbp1 haploinsufficiency and their use in the treatment of stxbp1-related disorders
WO2023192883A2 (en) * 2022-03-31 2023-10-05 Emory University Rolling sensor systems for detecting analytes and diagnostic methods related thereto

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB230477A (en) * 1924-03-06 1926-01-21 P. Gossen & Company Kommanditgesellschaft
US5166315A (en) * 1989-12-20 1992-11-24 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
US5235033A (en) * 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
EP0639582B1 (en) * 1985-03-15 1998-09-16 Antivirals Inc. Polynucleotide assay reagent and method
US5217866A (en) * 1985-03-15 1993-06-08 Anti-Gene Development Group Polynucleotide assay reagent and method
CA1320161C (en) * 1987-12-16 1993-07-13 Hugues Blaudin De The Steroid/thyroid hormone receptor-related gene, which is inappropriately expressed in human heptocellular carcinoma, and which is a retinoic acid receptor
US6040138A (en) * 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US6433142B1 (en) * 1989-08-08 2002-08-13 Genetics Institute, Llc Megakaryocyte stimulating factors
JPH03147799A (en) * 1989-11-02 1991-06-24 Hoechst Japan Ltd Novel oligonucleotide probe
US5184444A (en) * 1991-08-09 1993-02-09 Aec-Able Engineering Co., Inc. Survivable deployable/retractable mast
SE9201929D0 (en) * 1992-06-23 1992-06-23 Pharmacia Lkb Biotech METHOD AND SYSTEM FOR MOLECULAR-BIOLOGICAL DIAGNOSTICS
US5879898A (en) * 1992-11-20 1999-03-09 Isis Innovation Limited Antibodies specific for peptide corresponding to CD44 exon 6, and use of these antibodies for diagnosis of tumors
US5955272A (en) * 1993-02-26 1999-09-21 University Of Massachusetts Detection of individual gene transcription and splicing
US5714320A (en) * 1993-04-15 1998-02-03 University Of Rochester Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
GB2285445A (en) * 1993-12-06 1995-07-12 Pna Diagnostics As Protecting nucleic acids and methods of analysis
US5854033A (en) * 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
JP2002515738A (en) * 1996-01-23 2002-05-28 アフィメトリックス，インコーポレイティド Nucleic acid analysis
WO1998001148A1 (en) * 1996-07-09 1998-01-15 President And Fellows Of Harvard College Use of papillomavirus e2 protein in treating papillomavirus-infected cells and compositions containing the protein
AU6721696A (en) * 1996-07-15 1998-03-06 Human Genome Sciences, Inc. Cd44-like protein
US5866080A (en) * 1996-08-12 1999-02-02 Corning Incorporated Rectangular-channel catalytic converters
WO1998018966A1 (en) * 1996-10-31 1998-05-07 Jennifer Lescallett Primers for amplification of brca1
WO1998025125A2 (en) * 1996-12-03 1998-06-11 Swift Michael R Predisposition to breast cancer by mutations at the ataxia-telangiectasia genetic locus
JP2001508303A (en) * 1997-01-13 2001-06-26 デイヴィッド・エイチ・マック Expression monitoring for gene function identification
US6492109B1 (en) * 1997-09-23 2002-12-10 Gene Logic, Inc. Susceptibility mutation 6495delGC of BRCA2
WO1999015704A1 (en) * 1997-09-23 1999-04-01 Oncormed, Inc. Genetic panel assay for susceptibility mutations in breast and ovarian cancer
WO1999023254A1 (en) * 1997-10-31 1999-05-14 Affymetrix, Inc. Expression profiles in adult and fetal organs
AU1045199A (en) * 1997-11-05 1999-05-24 Isis Innovation Limited Cancer gene
JPH11169172A (en) * 1997-12-08 1999-06-29 Hitachi Ltd Estimation of protein-encoding region on dna base sequence and recording medium
AU1929599A (en) * 1997-12-30 1999-07-19 Chiron Corporation Bone marrow secreted proteins and polynucleotides
WO1999039004A1 (en) * 1998-02-02 1999-08-05 Affymetrix, Inc. Iterative resequencing
US6004755A (en) * 1998-04-07 1999-12-21 Incyte Pharmaceuticals, Inc. Quantitative microarray hybridizaton assays
CA2330731A1 (en) * 1998-06-24 1999-12-29 Smithkline Beecham Corporation Method for detecting, analyzing, and mapping rna transcripts
AU5495600A (en) * 1999-06-17 2001-01-09 Fred Hutchinson Cancer Research Center Oligonucleotide arrays for high resolution hla typing

Also Published As

Publication number Publication date
EP1325150A2 (en) 2003-07-09
EP1290217A2 (en) 2003-03-12
GB2385053B (en) 2004-12-22
AU2001232758A1 (en) 2001-11-20
WO2001057274A2 (en) 2001-08-09
EP1309724A2 (en) 2003-05-14
GB0123361D0 (en) 2001-11-21
GB2375111A (en) 2002-11-06
GB0217188D0 (en) 2002-09-04
WO2001057275A3 (en) 2003-04-17
AU3087801A (en) 2001-08-14
WO2001057271A3 (en) 2003-02-20
WO2001057274A3 (en) 2003-05-08
WO2001057251A2 (en) 2001-08-09
WO2001057277A2 (en) 2001-08-09
GB0217805D0 (en) 2002-09-11
WO2001057273A8 (en) 2002-02-28
WO2001057272A2 (en) 2001-08-09
GB0217811D0 (en) 2002-09-11
GB2376018B (en) 2005-07-13
GB2378754B (en) 2004-12-01
WO2001086003A2 (en) 2001-11-15
EP1309725A2 (en) 2003-05-14
EP1292705A2 (en) 2003-03-19
EP1292704A2 (en) 2003-03-19
WO2001057252A3 (en) 2003-08-07
WO2001057251A9 (en) 2002-10-31
EP1290216A2 (en) 2003-03-12
WO2001057251A3 (en) 2003-01-03
EP1309723A2 (en) 2003-05-14
GB2375539B (en) 2004-12-08
WO2001057273A2 (en) 2001-08-09
EP1341930A2 (en) 2003-09-10
WO2001086003A8 (en) 2002-05-16
GB0217861D0 (en) 2002-09-11
WO2001057275A2 (en) 2001-08-09
WO2001057270A3 (en) 2003-02-13
GB0217714D0 (en) 2002-09-11
GB2382814B (en) 2004-12-15
WO2001057272A3 (en) 2003-01-03
GB0218673D0 (en) 2002-09-18
AU2001233114A1 (en) 2001-08-14
GB2374929A (en) 2002-10-30
GB0217835D0 (en) 2002-09-11
GB2385053A (en) 2003-08-13
WO2001057271A8 (en) 2001-12-06
GB2373500B (en) 2004-12-15
AU2001230880A1 (en) 2001-08-14
WO2001057276A3 (en) 2003-01-09
AU2001230882A1 (en) 2001-08-14
GB2378754A (en) 2003-02-19
WO2001057276A2 (en) 2001-08-09
WO2001057271A2 (en) 2001-08-09
WO2001057277A3 (en) 2003-02-13
US20020081590A1 (en) 2002-06-27
GB2376018A (en) 2002-12-04
GB2373500A (en) 2002-09-25
GB2375111B (en) 2004-12-01
WO2001086003A3 (en) 2003-05-22
WO2001057252A2 (en) 2001-08-09
GB2375539A (en) 2002-11-20
WO2001057278A3 (en) 2003-01-09
GB2382814A (en) 2003-06-11
WO2001057276A9 (en) 2004-03-04
AU2001230881A1 (en) 2001-08-14
AU2001232757A1 (en) 2001-08-14
WO2001057275A9 (en) 2002-10-17
GB2376237A (en) 2002-12-11
AU2001232759A1 (en) 2001-08-14
GB2374872A (en) 2002-10-30
WO2001057274A8 (en) 2001-12-20
WO2001057270A2 (en) 2001-08-09
GB2383043A (en) 2003-06-18
WO2001057278A2 (en) 2001-08-09
GB0217112D0 (en) 2002-09-04
GB2383043B (en) 2005-07-27
AU2001230879A1 (en) 2001-08-14
WO2001057273A3 (en) 2003-06-26
AU2001230883A1 (en) 2001-08-14
GB0216928D0 (en) 2002-08-28
EP1325149A2 (en) 2003-07-09
GB0217049D0 (en) 2002-08-28
AU2001232760A1 (en) 2001-08-14
EP1332224A2 (en) 2003-08-06

Similar Documents

Publication Publication Date Title
AU2001236589A1 (en) Methods and apparatus for high-throughput detection and characterization of alternatively spliced genes
AU2003239963A1 (en) Method and apparatus for detecting substances of interest
AU2002310031A1 (en) Method and apparatus for detecting illicit substances
AU2002219847A1 (en) Optical method and apparatus for inspecting large area planar objects
AU4226900A (en) Apparatus for fast preparation and analysis of nucleic acids
AU2733700A (en) Method and apparatus for measurement of microtome performance
AU2001261548A1 (en) Method and apparatus for detection of acid reflux
AU2001259566A1 (en) Method and apparatus for end-point detection
EP1425548A4 (en) Microcantilever apparatus and methods for detection of enzymes
AU2001282704A1 (en) Method and apparatus for well testing
AU2001236586A1 (en) Method and apparatus for determining chemical properties
AU2001266886A1 (en) Method and apparatus for the detection of surface characteristics
AU2001261048A1 (en) Method and apparatus for the detection of hydrogenous materials
AU9517901A (en) Tyre testing method and apparatus
AU2001284638A1 (en) Apparatus and methods for detecting explosives and other substances
AU2003224996A1 (en) Method and apparatus for detection of bioaerosols
AU2001274303A1 (en) Apparatus for and method of optical detection and analysis of an object
AU2001292639A1 (en) Method and apparatus for measuring physical properties of matter
AU2001271893A1 (en) Method and apparatus for synthesis of arrays of dna probes
AU4677301A (en) Apparatus for and method of testing applications
AU2002329175A1 (en) Method and apparatus for ignition detection
AU6632600A (en) Apparatus and method of detecting fluid
AU5439200A (en) Apparatus and method for measuring polarization dependent loss
GB0608619D0 (en) Apparatus and methods for fluorescent detection of nucleic acids
AU2001297960A1 (en) Detection method and apparatus