AU2001232735A1 - Process for solubilizing glucagon-like peptide 1 compounds - Google Patents

Process for solubilizing glucagon-like peptide 1 compounds

Info

Publication number
AU2001232735A1
AU2001232735A1 AU2001232735A AU3273501A AU2001232735A1 AU 2001232735 A1 AU2001232735 A1 AU 2001232735A1 AU 2001232735 A AU2001232735 A AU 2001232735A AU 3273501 A AU3273501 A AU 3273501A AU 2001232735 A1 AU2001232735 A1 AU 2001232735A1
Authority
AU
Australia
Prior art keywords
glp
solution
compound
compounds
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001232735A
Inventor
Walter Francis Junior Prouty
Joseph Vincent Junior Rinella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of AU2001232735A1 publication Critical patent/AU2001232735A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Disclosed is a method of preparing a GLP-1 compound that is soluble in aqueous solution at pH 7.4 from a GLP-1 compound that is substantially insoluble in aqueous solution at pH 7.4. The insoluble GLP-1 compound is dissolved in aqueous base or in aqueous acid to form a GLP-1 solution. The GLP-1 solution is then neutralized to a pH at which substantially no amino acid racemization of the GLP-1 compounds occurs, after which the soluble GLP-1 compound is isolated from the neutralized solution.
AU2001232735A 2000-01-27 2001-01-16 Process for solubilizing glucagon-like peptide 1 compounds Abandoned AU2001232735A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17843800P 2000-01-27 2000-01-27
US60178438 2000-01-27
US22405800P 2000-08-09 2000-08-09
US60224058 2000-08-09
PCT/US2001/000010 WO2001055213A2 (en) 2000-01-27 2001-01-16 Process for solubilizing glucagon-like peptide 1 (glp-1) compounds

Publications (1)

Publication Number Publication Date
AU2001232735A1 true AU2001232735A1 (en) 2001-08-07

Family

ID=26874307

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001232735A Abandoned AU2001232735A1 (en) 2000-01-27 2001-01-16 Process for solubilizing glucagon-like peptide 1 compounds

Country Status (17)

Country Link
US (4) US7598222B2 (en)
EP (1) EP1257577B1 (en)
JP (1) JP2003523366A (en)
KR (1) KR20020073184A (en)
AT (1) ATE264870T1 (en)
AU (1) AU2001232735A1 (en)
BR (1) BR0107837A (en)
CA (1) CA2396920A1 (en)
DE (1) DE60102899T2 (en)
DK (1) DK1257577T3 (en)
ES (1) ES2218381T3 (en)
HU (1) HUP0204281A3 (en)
IL (2) IL150913A0 (en)
MX (1) MXPA02007231A (en)
PT (1) PT1257577E (en)
TR (1) TR200401142T4 (en)
WO (1) WO2001055213A2 (en)

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US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
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Also Published As

Publication number Publication date
US7598222B2 (en) 2009-10-06
US8455433B2 (en) 2013-06-04
WO2001055213A3 (en) 2002-02-28
DK1257577T3 (en) 2004-08-02
US20130072658A1 (en) 2013-03-21
WO2001055213A2 (en) 2001-08-02
US8222205B2 (en) 2012-07-17
CA2396920A1 (en) 2001-08-02
JP2003523366A (en) 2003-08-05
DE60102899D1 (en) 2004-05-27
IL150913A0 (en) 2003-02-12
EP1257577A2 (en) 2002-11-20
US20030060412A1 (en) 2003-03-27
US20120101034A9 (en) 2012-04-26
MXPA02007231A (en) 2002-12-09
HUP0204281A3 (en) 2007-03-28
DE60102899T2 (en) 2005-03-31
ES2218381T3 (en) 2004-11-16
US20110053838A1 (en) 2011-03-03
US8268780B2 (en) 2012-09-18
BR0107837A (en) 2003-01-14
US20120208980A1 (en) 2012-08-16
EP1257577B1 (en) 2004-04-21
IL189371A0 (en) 2008-06-05
PT1257577E (en) 2004-08-31
HUP0204281A2 (en) 2003-04-28
TR200401142T4 (en) 2004-07-21
ATE264870T1 (en) 2004-05-15
KR20020073184A (en) 2002-09-19

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