AU2001228862A1 - Remedies or preventives for liver diseases containing diaminotrifluoromethylpyridine derivatives - Google Patents

Remedies or preventives for liver diseases containing diaminotrifluoromethylpyridine derivatives

Info

Publication number
AU2001228862A1
AU2001228862A1 AU2001228862A AU2886201A AU2001228862A1 AU 2001228862 A1 AU2001228862 A1 AU 2001228862A1 AU 2001228862 A AU2001228862 A AU 2001228862A AU 2886201 A AU2886201 A AU 2886201A AU 2001228862 A1 AU2001228862 A1 AU 2001228862A1
Authority
AU
Australia
Prior art keywords
group
alkyl
liver diseases
preventives
remedies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001228862A
Inventor
Kimie Sakai
Shuichi Yotsuya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ishihara Sangyo Kaisha Ltd
Original Assignee
Ishihara Sangyo Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ishihara Sangyo Kaisha Ltd filed Critical Ishihara Sangyo Kaisha Ltd
Publication of AU2001228862A1 publication Critical patent/AU2001228862A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

A therapeutic or preventive agent for liver diseases, containing as an active ingredient a diaminotrifluoromethylpyridine derivative represented by the formula (I) or its salt: <CHEM> wherein X is a -CW<1>R<1> group, a -COCOR<2> group, a -CW<1>NHCOR<2> group, a -C(=W<1>)W<2>R<3> group or a -CW<1>N(R<4>)R<5> group; Y is an alkyl group, a -CW<3>R<6> group, a -COCOR<7> group, a -NHCOR<7> group, a -C(=W<3>)W<4>R<8> group, a -(NH)mSO2R<9> group, a -(NH)mSO2OR<10> group or a -(NH)mSO2N(R<11>)R<12> group; each of R<1>, R<6> and R<9> is a chain hydrocarbon group, a monocyclic hydrocarbon group, a polycyclic hydrocarbon group, a monocyclic heterocycle group or a polycyclic heterocycle group; each of R<2> and R<7> is an alkyl group, an alkoxy group, a phenyl group or a phenoxy group; each of R<3>, R<8> and R<10> is an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a phenyl group or a benzyl group; each of R<4>, R<5>, R<11> and R<12> is an alkyl group; each of W<1>, W<2>, W<3> and W<4> is an oxygen atom or a sulfur atom; . and m is 0 or 1, is provided.
AU2001228862A 2000-02-01 2001-01-30 Remedies or preventives for liver diseases containing diaminotrifluoromethylpyridine derivatives Abandoned AU2001228862A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000024350 2000-02-01
JP2000-24350 2000-02-01
PCT/JP2001/000615 WO2001056569A1 (en) 2000-02-01 2001-01-30 Remedies or preventives for liver diseases containing diaminotrifluoromethylpyridine derivatives

Publications (1)

Publication Number Publication Date
AU2001228862A1 true AU2001228862A1 (en) 2001-08-14

Family

ID=18550354

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001228862A Abandoned AU2001228862A1 (en) 2000-02-01 2001-01-30 Remedies or preventives for liver diseases containing diaminotrifluoromethylpyridine derivatives

Country Status (7)

Country Link
US (1) US6664279B2 (en)
EP (1) EP1252891B1 (en)
AT (1) ATE305783T1 (en)
AU (1) AU2001228862A1 (en)
DE (1) DE60113808T2 (en)
TW (1) TWI257864B (en)
WO (1) WO2001056569A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101246568B1 (en) * 2006-06-09 2013-03-25 삼성전자주식회사 Method and device of displaying a landscape picture in a mobile display device, and mobile liquid crystal display device having the same
JP5584518B2 (en) 2009-05-28 2014-09-03 石原産業株式会社 Anti-shock agent containing diaminotrifluoromethylpyridine derivative
KR20200083500A (en) 2017-11-02 2020-07-08 이시하라 산교 가부시끼가이샤 Sustained release pharmaceutical composition
MX2020008992A (en) 2018-03-01 2020-09-28 Ishihara Sangyo Kaisha Pharmaceutical composition with excellent storage stability.
TW202110800A (en) 2019-05-15 2021-03-16 日商石原產業股份有限公司 Anhydrous crystal of monosodium n-(2-ethylsulfonylamino-5-trifluoromethyl-3-pyridyl)cyclohexane carboxamide
KR20230084205A (en) 2020-09-29 2023-06-12 이시하라 산교 가부시끼가이샤 Liquid pharmaceutical composition showing excellent preservation effect

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2777678B2 (en) 1990-06-11 1998-07-23 敏一 中村 Recombinant human hepatocyte growth factor and method for producing the same
ZA915023B (en) 1990-07-10 1992-05-27 Ishihara Sangyo Kaisha Diaminotrifluoromethylpyridine derivatives,process for their production and phospholipase a2 inhibitor containing them
EP0465913B1 (en) * 1990-07-10 1997-09-10 Ishihara Sangyo Kaisha, Ltd. Diaminotrifluoromethylpyrimidine derivatives, process for their production and phospholipase A2 inhibitor containing them
JPH06239856A (en) 1993-02-15 1994-08-30 Shin Nippon Yakuhin Kk 1,3-benzoxathiol-2-thione derivative
JP3186365B2 (en) 1993-09-02 2001-07-11 日本油脂株式会社 Liver disease drug
ZA981430B (en) 1997-02-28 1998-08-24 Ishihara Sangyo Kaisha Anticancer composition
JPH10298076A (en) 1997-02-28 1998-11-10 Ishihara Sangyo Kaisha Ltd Anticancer medicine
JPH11228563A (en) 1998-02-19 1999-08-24 Dainippon Pharmaceut Co Ltd 3-hydroxy-2,3-dihydrobenzofuran (or benzothiophene) derivative and liver disease treating agent

Also Published As

Publication number Publication date
DE60113808D1 (en) 2006-02-16
ATE305783T1 (en) 2005-10-15
US20030018054A1 (en) 2003-01-23
EP1252891A4 (en) 2003-05-14
EP1252891B1 (en) 2005-10-05
DE60113808T2 (en) 2006-05-18
WO2001056569A1 (en) 2001-08-09
EP1252891A1 (en) 2002-10-30
TWI257864B (en) 2006-07-11
US6664279B2 (en) 2003-12-16

Similar Documents

Publication Publication Date Title
AU5781898A (en) CETP activity inhibitor
DK0976748T3 (en) Pyrrolidine derivatives with phospholipase A2 inhibitory activity
HU9600278D0 (en) Remedy for nervous diseases
PT937722E (en) BENZIMIDAZOLE DERIVATIVES AS CICLOOXIGENASE-2 INHIBITORS
AU7517400A (en) N-substituted 4-aminopteridines, synthesis and use thereof as pharmaceutical agent
EP1252890A4 (en) Remedies or preventives for digestive diseases containing diaminotrifluoromethylpyridine derivatives
EP0974348A4 (en) Visceral fat lowering agent
DE69623497T2 (en) 1-methylcarbapenem DERIVATIVES
AU2001228862A1 (en) Remedies or preventives for liver diseases containing diaminotrifluoromethylpyridine derivatives
EP1152004A4 (en) Phosphonic acid derivatives having carboxypeptidase b inhibitory activity
DE69828197D1 (en) AMID DERIVATIVES FOR THE TREATMENT OF NEURODEEGENERATIVE DISORDERS OF THE NETWORK
PT1209166E (en) NEW DERIVATIVES OF A-500359
EP1103560A4 (en) Novel thiazolidine derivatives
EP0712838A4 (en) Acylphenylglycine derivative and preventive and remedy for diseases caused by increased collagenase activity containing said compound as active ingredient
HK1042654A1 (en) Neuropathy improvers containing nitrogenous compounds as the active ingredient
TR28240A (en) Insecticide, nematocide and acaricide containing amidothiophosphate derivative and active inhibitor.