ATE483689T1 - PYRAZOLE DERIVATIVES AS MODULATORS OF PROTEIN KINASE - Google Patents
PYRAZOLE DERIVATIVES AS MODULATORS OF PROTEIN KINASEInfo
- Publication number
- ATE483689T1 ATE483689T1 AT04806258T AT04806258T ATE483689T1 AT E483689 T1 ATE483689 T1 AT E483689T1 AT 04806258 T AT04806258 T AT 04806258T AT 04806258 T AT04806258 T AT 04806258T AT E483689 T1 ATE483689 T1 AT E483689T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- carbon atoms
- compounds
- protein kinase
- atoms
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invention provides compounds of the formula: (I) having protein kinase B inhibiting activity: wherein A is a saturated hydrocarbon linker group containing from 1 to 7 carbon atoms, the linker group having a maximum chain length of 5 atoms extending between Rand NRRand a maximum chain length of 4 atoms extending between E and NRR, wherein one of the carbon atoms in the linker group may optionally be replaced by an oxygen or nitrogen atom; and wherein the carbon atoms of the inker group A may optionally bear one or more substituents selected from oxo, fluorine and hydroxy, provided that the hydroxy group when present is not located at a carbon atom a with respect to the NRRgroup and provided that the oxo group when present is located at a carbon atom a with respect to the NRRgroup; E is a monocyclic or bicyclic carbocyclic or heterocyclic group; Ris an aryl or heteroaryl group; and R, R, Rand Rare as defined in the claims. Also provided are pharmaceutical compositions containing the compounds, methods for preparing the compounds and their use as anticancer agents.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53219903P | 2003-12-23 | 2003-12-23 | |
| GB0329617A GB0329617D0 (en) | 2003-12-23 | 2003-12-23 | Pharmaceutical compounds |
| US57784304P | 2004-06-08 | 2004-06-08 | |
| PCT/GB2004/005464 WO2005061463A1 (en) | 2003-12-23 | 2004-12-23 | Pyrazole derivatives as protein kinase modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE483689T1 true ATE483689T1 (en) | 2010-10-15 |
Family
ID=30776233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04806258T ATE483689T1 (en) | 2003-12-23 | 2004-12-23 | PYRAZOLE DERIVATIVES AS MODULATORS OF PROTEIN KINASE |
Country Status (11)
| Country | Link |
|---|---|
| CN (1) | CN1922148B (en) |
| AT (1) | ATE483689T1 (en) |
| DE (1) | DE602004029501D1 (en) |
| DK (1) | DK1706385T3 (en) |
| GB (1) | GB0329617D0 (en) |
| ME (1) | ME01934B (en) |
| PT (1) | PT1706385E (en) |
| RS (1) | RS51546B (en) |
| SI (1) | SI1706385T1 (en) |
| UA (1) | UA90461C2 (en) |
| ZA (1) | ZA200605127B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0704932D0 (en) * | 2007-03-14 | 2007-04-25 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| CN108339121A (en) * | 2017-01-25 | 2018-07-31 | 苏州大学 | Purposes of the protein kinase A inhibitor in preparing treatment platelet counts and increasing relevant disease drug |
| CN111056990B (en) * | 2019-12-16 | 2022-06-17 | 爱斯特（成都）生物制药股份有限公司 | Preparation method for synthesizing 1-tert-butyloxycarbonyl-4- (4-carboxyphenyl) piperidine |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9804734D0 (en) * | 1998-03-05 | 1998-04-29 | Pfizer Ltd | Compounds |
| CN1193026C (en) * | 1999-07-30 | 2005-03-16 | 艾博特股份有限两合公司 | Z-pyrazoline-5-ones |
-
2003
- 2003-12-23 GB GB0329617A patent/GB0329617D0/en not_active Ceased
-
2004
- 2004-12-23 DE DE602004029501T patent/DE602004029501D1/en active Active
- 2004-12-23 RS RSP-2010/0532A patent/RS51546B/en unknown
- 2004-12-23 ME MEP-2010-532A patent/ME01934B/en unknown
- 2004-12-23 DK DK04806258.2T patent/DK1706385T3/en active
- 2004-12-23 SI SI200431571T patent/SI1706385T1/en unknown
- 2004-12-23 PT PT04806258T patent/PT1706385E/en unknown
- 2004-12-23 AT AT04806258T patent/ATE483689T1/en active
- 2004-12-23 CN CN2004800420375A patent/CN1922148B/en not_active Expired - Fee Related
- 2004-12-23 UA UAA200608166A patent/UA90461C2/en unknown
-
2006
- 2006-06-21 ZA ZA200605127A patent/ZA200605127B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SI1706385T1 (en) | 2011-01-31 |
| DK1706385T3 (en) | 2011-01-10 |
| CN1922148A (en) | 2007-02-28 |
| ZA200605127B (en) | 2010-07-28 |
| ME01934B (en) | 2011-06-30 |
| CN1922148B (en) | 2012-03-21 |
| PT1706385E (en) | 2010-12-22 |
| GB0329617D0 (en) | 2004-01-28 |
| DE602004029501D1 (en) | 2010-11-18 |
| RS51546B (en) | 2011-06-30 |
| UA90461C2 (en) | 2010-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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