ATE469149T1 - Verfahren zur herstellung von cabergolin - Google Patents
Verfahren zur herstellung von cabergolinInfo
- Publication number
- ATE469149T1 ATE469149T1 AT05718154T AT05718154T ATE469149T1 AT E469149 T1 ATE469149 T1 AT E469149T1 AT 05718154 T AT05718154 T AT 05718154T AT 05718154 T AT05718154 T AT 05718154T AT E469149 T1 ATE469149 T1 AT E469149T1
- Authority
- AT
- Austria
- Prior art keywords
- cabergoline
- xix
- xviii
- xvii
- xvi
- Prior art date
Links
- KORNTPPJEAJQIU-KJXAQDMKSA-N Cabaser Chemical compound C1=CC([C@H]2C[C@H](CN(CC=C)[C@@H]2C2)C(=O)N(CCCN(C)C)C(=O)NCC)=C3C2=CNC3=C1 KORNTPPJEAJQIU-KJXAQDMKSA-N 0.000 title abstract 3
- 229960004596 cabergoline Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0400517A HUP0400517A3 (en) | 2004-03-04 | 2004-03-04 | Process for producing cabergoline |
| PCT/HU2005/000022 WO2005085243A2 (en) | 2004-03-04 | 2005-03-02 | Process for the preparation of cabergoline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE469149T1 true ATE469149T1 (de) | 2010-06-15 |
Family
ID=89982034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05718154T ATE469149T1 (de) | 2004-03-04 | 2005-03-02 | Verfahren zur herstellung von cabergolin |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7858791B2 (de) |
| EP (1) | EP1720869B1 (de) |
| AT (1) | ATE469149T1 (de) |
| DE (1) | DE602005021461D1 (de) |
| EA (1) | EA010689B1 (de) |
| HU (1) | HUP0400517A3 (de) |
| WO (1) | WO2005085243A2 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060028761A (ko) * | 2003-05-08 | 2006-04-03 | 아이박스 파마슈티컬스 에스.알.오. | 다형의 카베르골린 |
| EP1925616A1 (de) * | 2006-10-26 | 2008-05-28 | LEK Pharmaceuticals D.D. | Verfahren zur Herstellung kristalliner Formen des Cabergolins via stabile Solvate des Cabergolins |
| WO2008104956A2 (en) * | 2007-02-28 | 2008-09-04 | Ranbaxy Laboratories Limited | Process for the preparation of amorphous cabergoline |
| EP2083008A1 (de) * | 2007-12-07 | 2009-07-29 | Axxonis Pharma AG | Ergolin-Derivate als selektive Radikalfänger für Neuronen |
| JP5736040B2 (ja) * | 2010-06-11 | 2015-06-17 | ローズ テクノロジーズ | Ｎ−アリル化合物の調製のための遷移金属触媒プロセスおよびその使用 |
| WO2013191704A1 (en) * | 2012-06-22 | 2013-12-27 | Map Pharmaceuticals, Inc. | Novel cabergoline derivatives |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9205439D0 (en) * | 1992-03-12 | 1992-04-22 | Erba Carlo Spa | Process for the synthesis of ergoline derivatives |
| EP1379526A1 (de) * | 2001-04-16 | 2004-01-14 | Finetech Laboratories Ltd. | Verfahren und zwischenverbindungen zur herstellung von cabergolin und verwandte verbindungen |
| US6696568B2 (en) * | 2001-04-16 | 2004-02-24 | Finetech Ltd. | Process and intermediates for production of cabergoline and related compounds |
-
2004
- 2004-03-04 HU HU0400517A patent/HUP0400517A3/hu unknown
-
2005
- 2005-03-02 DE DE602005021461T patent/DE602005021461D1/de active Active
- 2005-03-02 AT AT05718154T patent/ATE469149T1/de not_active IP Right Cessation
- 2005-03-02 EA EA200601628A patent/EA010689B1/ru not_active IP Right Cessation
- 2005-03-02 US US10/591,202 patent/US7858791B2/en not_active Expired - Fee Related
- 2005-03-02 WO PCT/HU2005/000022 patent/WO2005085243A2/en active Application Filing
- 2005-03-02 EP EP05718154A patent/EP1720869B1/de active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EA010689B1 (ru) | 2008-10-30 |
| EP1720869B1 (de) | 2010-05-26 |
| WO2005085243A3 (en) | 2006-04-06 |
| HUP0400517A2 (hu) | 2005-11-28 |
| HU0400517D0 (en) | 2004-05-28 |
| WO2005085243A2 (en) | 2005-09-15 |
| EP1720869A2 (de) | 2006-11-15 |
| DE602005021461D1 (de) | 2010-07-08 |
| US20070293677A1 (en) | 2007-12-20 |
| US7858791B2 (en) | 2010-12-28 |
| HUP0400517A3 (en) | 2006-05-29 |
| EA200601628A1 (ru) | 2007-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |