ATE464304T1 - Carboxamid-spirolactam-cgrp-rezeptor-antagonist n - Google Patents
Carboxamid-spirolactam-cgrp-rezeptor-antagonist nInfo
- Publication number
- ATE464304T1 ATE464304T1 AT05795301T AT05795301T ATE464304T1 AT E464304 T1 ATE464304 T1 AT E464304T1 AT 05795301 T AT05795301 T AT 05795301T AT 05795301 T AT05795301 T AT 05795301T AT E464304 T1 ATE464304 T1 AT E464304T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- carboxamide
- receptor antagonist
- cgrp receptor
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60943604P | 2004-09-13 | 2004-09-13 | |
| PCT/US2005/032036 WO2006031606A2 (en) | 2004-09-13 | 2005-09-09 | Carboxamide spirolactam cgrp receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE464304T1 true ATE464304T1 (de) | 2010-04-15 |
Family
ID=36060551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05795301T ATE464304T1 (de) | 2004-09-13 | 2005-09-09 | Carboxamid-spirolactam-cgrp-rezeptor-antagonist n |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7390798B2 (de) |
| EP (1) | EP1796678B1 (de) |
| JP (1) | JP5039553B2 (de) |
| CN (1) | CN101448821B (de) |
| AT (1) | ATE464304T1 (de) |
| AU (1) | AU2005285197B2 (de) |
| CA (1) | CA2579840C (de) |
| DE (1) | DE602005020655D1 (de) |
| WO (1) | WO2006031606A2 (de) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE353001T1 (de) | 1999-05-11 | 2007-02-15 | Atrionix Inc | Ballonverankerungsdraht |
| CA2519515A1 (en) * | 2003-03-14 | 2004-10-14 | Merck & Co., Inc. | Benodiazepine spirohydantoin cgrp receptor antagonists |
| ATE537153T1 (de) * | 2004-09-09 | 2011-12-15 | Merck Sharp & Dohme | Arylspirolactamverbindungen als antagonisten des cgrp-rezeptors |
| CA2579850A1 (en) * | 2004-09-13 | 2006-03-23 | Merck & Co., Inc. | Tricyclic anilide spirohydantoin cgrp receptor antagonists |
| CN101018781A (zh) * | 2004-09-13 | 2007-08-15 | 默克公司 | 双环n－酰苯胺螺内酰胺cgrp受体拮抗剂 |
| US7947677B2 (en) | 2005-11-18 | 2011-05-24 | Merck Sharp & Dohme Corp. | Spirolactam tricyclic CGRP receptor antagonists |
| AU2006316644B2 (en) | 2005-11-18 | 2011-11-10 | Merck Sharp & Dohme Corp. | Spirohydantoin tricyclic CGRP receptor antagonists |
| JP2009515971A (ja) | 2005-11-18 | 2009-04-16 | メルク エンド カムパニー インコーポレーテッド | スピロヒダントインアリールｃｇｒｐ受容体アンタゴニスト |
| EP1954135B1 (de) * | 2005-11-18 | 2012-10-10 | Merck Sharp & Dohme Corp. | Spirolactam-aryl cgrp-rezeptor-antagonisten |
| EP2007731B1 (de) * | 2006-04-10 | 2009-07-22 | Merck & Co., Inc. | Herstellungsverfahren für ein zwischenprodukt eines caprolactam-cgrp-antagonisten |
| WO2007130927A2 (en) | 2006-05-02 | 2007-11-15 | Bristol-Myers Squibb Company | Condensed tricyclic compounds as cgrp-receptor antagonists |
| US7470680B2 (en) * | 2006-05-03 | 2008-12-30 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| EP2024358B1 (de) * | 2006-05-09 | 2014-11-05 | Merck Sharp & Dohme Corp. | Substituierte spirocyclische cgrp-rezeptorantagonisten |
| DE602007006961D1 (de) * | 2006-07-21 | 2010-07-15 | Vertex Pharma | Cgrp-rezeptorantagonisten |
| CA2673108A1 (en) * | 2006-12-08 | 2008-06-19 | Merck & Co., Inc. | Constrained spirocyclic compounds as cgrp receptor antagonists |
| US8372859B2 (en) * | 2007-04-11 | 2013-02-12 | Merck, Sharp & Dohme Corp. | CGRP receptor antagonists with tertiary amide, sulfonamide, carbamate and urea end groups |
| WO2008130512A1 (en) * | 2007-04-16 | 2008-10-30 | Merck & Co., Inc. | Bicyclic anilide heterocyclic cgrp receptor antagonists |
| WO2008130524A1 (en) * | 2007-04-16 | 2008-10-30 | Merck & Co., Inc. | Aryl heterocyclic cgrp receptor antagonists |
| AU2008262403B2 (en) * | 2007-06-05 | 2013-11-14 | Merck Sharp & Dohme Llc | Carboxamide heterocyclic CGRP receptor antagonists |
| WO2008153852A1 (en) * | 2007-06-07 | 2008-12-18 | Merck & Co., Inc. | Tricyclic anilide heterocyclic cgrp receptor antagonists |
| WO2009105348A1 (en) * | 2008-02-19 | 2009-08-27 | Merck & Co., Inc. | Imidazobenzazepine cgrp receptor antagonists |
| EP2116618A1 (de) | 2008-05-09 | 2009-11-11 | Agency for Science, Technology And Research | Diagnose und Behandlung des Kawasaki-Syndroms |
| CA2734168A1 (en) | 2008-08-18 | 2010-02-25 | Merck Sharp & Dohme Corp. | 3- and 6-quinolines with n-attached heterocyclic cgrp receptor antagonists |
| TWI522355B (zh) * | 2010-11-12 | 2016-02-21 | 默沙東藥廠 | 六氫吡啶酮甲醯胺氮雜茚滿ｃｇｒｐ受體拮抗劑 |
| US8883807B2 (en) | 2010-11-12 | 2014-11-11 | Merck Sharp & Dohme Corp. | Piperidinone carboxamide indane CGRP receptor antagonists |
| WO2013066360A1 (en) * | 2010-12-22 | 2013-05-10 | Merck Sharp & Dohme Corp. | Fused heterocyclic azaindane carboxamide cgrp receptor antagonists |
| EP2654421B1 (de) * | 2010-12-22 | 2016-10-19 | Merck Sharp & Dohme Corp. | Kondensierte heterocyclische indan-carboxamid-verbindungen als grp-rezeptorantagonisten |
| EP2554539B1 (de) | 2011-08-02 | 2014-12-10 | Universität Potsdam | Verfahren zur Herstellung von gamma-Spirolactamen aus zyklischen ungesättigten Carbonsäuren |
| US10202392B2 (en) | 2012-04-26 | 2019-02-12 | Francis Xavier Tavares | Synthesis of lactams |
| US9296750B2 (en) | 2012-05-09 | 2016-03-29 | Merck Sharp & Dohme Corp. | Spirolactam CGRP receptor antagonists |
| WO2013169563A1 (en) * | 2012-05-09 | 2013-11-14 | Merck Sharp & Dohme Corp. | Pyridine cgrp receptor antagonists |
| US9174989B2 (en) * | 2012-05-09 | 2015-11-03 | Merck Sharp & Dohme Corp. | Process for making CGRP receptor antagonists |
| EP2846800A4 (de) * | 2012-05-09 | 2015-11-11 | Merck Sharp & Dohme | Heterocyclische cgrp-rezeptorantagonisten |
| RU2690006C2 (ru) * | 2013-09-16 | 2019-05-30 | Мерк Шарп И Доум Корп. | Композиции антагонистов рецепторов cgrp |
| AU2015214502B2 (en) | 2014-02-05 | 2019-06-06 | Merck Sharp & Dohme Llc | Tablet formulation for CGRP-active compounds |
| GB201417707D0 (en) | 2014-10-07 | 2014-11-19 | Viral Ltd | Pharmaceutical compounds |
| CA2988601C (en) | 2015-07-02 | 2021-12-07 | F. Hoffmann-La Roche Ag | Bicyclic lactams and methods of use thereof |
| TW201718574A (zh) * | 2015-08-12 | 2017-06-01 | 美國禮來大藥廠 | Ｃｇｒｐ受體拮抗劑 |
| US9815850B2 (en) | 2016-02-05 | 2017-11-14 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| WO2018005865A1 (en) | 2016-07-01 | 2018-01-04 | G1 Therapeutics, Inc. | Synthesis of n-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amines |
| EP3526219B1 (de) | 2016-10-17 | 2021-12-15 | F. Hoffmann-La Roche AG | Bicyclische pyridonlactame und verfahren zur verwendung davon |
| PL3552017T3 (pl) | 2016-12-09 | 2022-08-08 | Denali Therapeutics Inc. | Związki użyteczne jako inhibitory RIPK1 |
| US11072607B2 (en) | 2016-12-16 | 2021-07-27 | Genentech, Inc. | Inhibitors of RIP1 kinase and methods of use thereof |
| EP3366286A1 (de) | 2017-02-22 | 2018-08-29 | Johannes Keller | Verbindungen zur behandlung von sepsis |
| RU2019142591A (ru) | 2017-06-29 | 2021-07-29 | Г1 Терапьютикс, Инк. | Морфологические формы g1t38 и способы их получения |
| EP3781571B1 (de) | 2018-04-20 | 2024-01-17 | F. Hoffmann-La Roche AG | N-[4-oxo-2,3-dihydro-pyrido[3,2-b][1,4]oxazepin-3-yl]-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol-2-carboxamid-derivate und ähnliche verbindungen als rip1 kinase inhibitoren zur behandlung von z.b. reizdarmsyndrom (rds) |
| KR20210049847A (ko) | 2018-08-24 | 2021-05-06 | 쥐원 쎄라퓨틱스, 인크. | 1,4-디아자스피로[5.5]운데칸-3-온의 개선된 합성 |
| WO2022140537A1 (en) | 2020-12-22 | 2022-06-30 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4307108A (en) * | 1979-12-26 | 1981-12-22 | Pfizer Inc. | Method for lowering sorbitol levels using spiro-imides |
| BR0110492A (pt) * | 2000-05-03 | 2003-04-08 | Hoffmann La Roche | Composto, composição farmacêutica que compreende esse composto, processo para a preparação de composição farmacêutica, utilização do composto e processo para a preparação do composto |
| WO2004087648A2 (en) * | 2003-03-12 | 2004-10-14 | Sun Pharmaceutical Industries Limited | Stabilized phenytoin containing composition |
| CA2519515A1 (en) | 2003-03-14 | 2004-10-14 | Merck & Co., Inc. | Benodiazepine spirohydantoin cgrp receptor antagonists |
| ATE535514T1 (de) | 2003-03-14 | 2011-12-15 | Merck Sharp & Dohme | Carboxamid-spirohydantoin-cgrp-rezeptor- antagonisten |
| CN101018781A (zh) * | 2004-09-13 | 2007-08-15 | 默克公司 | 双环n－酰苯胺螺内酰胺cgrp受体拮抗剂 |
-
2005
- 2005-02-09 US US11/660,798 patent/US7390798B2/en active Active
- 2005-09-09 EP EP05795301A patent/EP1796678B1/de active Active
- 2005-09-09 AU AU2005285197A patent/AU2005285197B2/en not_active Ceased
- 2005-09-09 DE DE602005020655T patent/DE602005020655D1/de active Active
- 2005-09-09 WO PCT/US2005/032036 patent/WO2006031606A2/en active Application Filing
- 2005-09-09 AT AT05795301T patent/ATE464304T1/de not_active IP Right Cessation
- 2005-09-09 CN CN2005800305244A patent/CN101448821B/zh active Active
- 2005-09-09 JP JP2007531340A patent/JP5039553B2/ja not_active Expired - Fee Related
- 2005-09-09 CA CA2579840A patent/CA2579840C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006031606A2 (en) | 2006-03-23 |
| CA2579840C (en) | 2012-03-20 |
| JP2008512480A (ja) | 2008-04-24 |
| JP5039553B2 (ja) | 2012-10-03 |
| EP1796678A2 (de) | 2007-06-20 |
| EP1796678A4 (de) | 2009-09-02 |
| CA2579840A1 (en) | 2006-03-23 |
| US7390798B2 (en) | 2008-06-24 |
| DE602005020655D1 (de) | 2010-05-27 |
| EP1796678B1 (de) | 2010-04-14 |
| AU2005285197B2 (en) | 2011-03-10 |
| AU2005285197A1 (en) | 2006-03-23 |
| WO2006031606A3 (en) | 2007-08-09 |
| US20070293470A1 (en) | 2007-12-20 |
| CN101448821B (zh) | 2013-03-27 |
| CN101448821A (zh) | 2009-06-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |