ATE449097T1 - Pyridoä2,3-düpyrimidin-2,4-diamin-verbindungen als ptpib-hemmer - Google Patents

Pyridoä2,3-düpyrimidin-2,4-diamin-verbindungen als ptpib-hemmer

Info

Publication number
ATE449097T1
ATE449097T1 AT06777692T AT06777692T ATE449097T1 AT E449097 T1 ATE449097 T1 AT E449097T1 AT 06777692 T AT06777692 T AT 06777692T AT 06777692 T AT06777692 T AT 06777692T AT E449097 T1 ATE449097 T1 AT E449097T1
Authority
AT
Austria
Prior art keywords
pyridoä2
düpyrimidine
diamine compounds
compounds
ptpib inhibitors
Prior art date
Application number
AT06777692T
Other languages
English (en)
Inventor
Steven Berthel
Adrian Cheung
Kyungjin Kim
Shiming Li
Kshitij Thakkar
Weiya Yun
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE449097T1 publication Critical patent/ATE449097T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT06777692T 2005-07-21 2006-07-11 Pyridoä2,3-düpyrimidin-2,4-diamin-verbindungen als ptpib-hemmer ATE449097T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70146705P 2005-07-21 2005-07-21
PCT/EP2006/064091 WO2007009911A1 (en) 2005-07-21 2006-07-11 PYRIDO [2 , 3-D] PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS

Publications (1)

Publication Number Publication Date
ATE449097T1 true ATE449097T1 (de) 2009-12-15

Family

ID=37027932

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06777692T ATE449097T1 (de) 2005-07-21 2006-07-11 Pyridoä2,3-düpyrimidin-2,4-diamin-verbindungen als ptpib-hemmer

Country Status (14)

Country Link
US (3) US20070021445A1 (de)
EP (1) EP1910359B1 (de)
JP (1) JP4880684B2 (de)
KR (1) KR100962723B1 (de)
CN (1) CN101243081A (de)
AT (1) ATE449097T1 (de)
AU (1) AU2006271809B2 (de)
BR (1) BRPI0613604A2 (de)
CA (1) CA2614443C (de)
DE (1) DE602006010564D1 (de)
ES (1) ES2336603T3 (de)
IL (1) IL188475A0 (de)
MX (1) MX2008000885A (de)
WO (1) WO2007009911A1 (de)

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US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
DE10352499A1 (de) * 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
DE102004022672A1 (de) * 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituierte Azachinazoline
US8515516B2 (en) 2004-07-13 2013-08-20 Dexcom, Inc. Transcutaneous analyte sensor
US20060270922A1 (en) 2004-07-13 2006-11-30 Brauker James H Analyte sensor
US9149266B2 (en) * 2005-05-20 2015-10-06 Neotract, Inc. Deforming anchor device
DE102005027517A1 (de) 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
CA2666193A1 (en) 2006-08-08 2008-02-14 Sanofi-Aventis Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, process for preparing them, medicaments comprising these compounds, and their use
US20100063032A1 (en) * 2007-03-28 2010-03-11 Debenham John S Substituted pyrido[2,3-d]pyrimidine derivatives as cannabinoid-1 receptor modulators
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AR072707A1 (es) 2008-07-09 2010-09-15 Sanofi Aventis Compuestos heterociclicos, procesos para su preparacion, medicamentos que comprenden estos compuestos y el uso de los mismos
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
DK2470552T3 (en) 2009-08-26 2014-02-17 Sanofi Sa NOVEL, CRYSTALLINE, heteroaromatic FLUORGLYCOSIDHYDRATER, MEDICINES COVERING THESE COMPOUNDS AND THEIR USE
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120053A1 (de) 2011-03-08 2012-09-13 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (de) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridin-4-carbonsäureamidderivate als kinaseinhibitoren
JP6899323B2 (ja) 2014-10-14 2021-07-07 ラ ホーヤ インスティテュート オブ アレルギー アンド イミュノロジー 低分子量タンパク質チロシンホスファターゼの阻害剤、及びその使用
CN104803931A (zh) * 2015-03-03 2015-07-29 佛山市赛维斯医药科技有限公司 一类含四氮唑结构的ptp1b抑制剂、制备方法及其用途
CN104803932A (zh) * 2015-03-03 2015-07-29 佛山市赛维斯医药科技有限公司 一类含四氮唑结构的ptp1b抑制剂及其用途
CN104744386A (zh) * 2015-03-03 2015-07-01 佛山市赛维斯医药科技有限公司 一种含四氮唑结构的ptp1b抑制剂及其用途
CN104803933A (zh) * 2015-03-03 2015-07-29 佛山市赛维斯医药科技有限公司 一种含四氮唑结构的ptp1b抑制剂、其制备方法及用途
CN104744387A (zh) * 2015-03-03 2015-07-01 佛山市赛维斯医药科技有限公司 一类含四氮唑和卤苯结构的ptp1b抑制剂、制备方法及其用途
CN104744388A (zh) * 2015-03-03 2015-07-01 佛山市赛维斯医药科技有限公司 含四氮唑结构的ptp1b抑制剂、制备方法及其用途
CN104744385A (zh) * 2015-03-03 2015-07-01 佛山市赛维斯医药科技有限公司 一种含四氮唑结构的ptp1b抑制剂化合物及其用途
WO2018157843A1 (zh) * 2017-03-02 2018-09-07 中国科学院上海药物研究所 2-(取代苯杂基)芳香甲酸类fto抑制剂，其制备方法及其应用
US11066420B2 (en) 2017-05-01 2021-07-20 Sanford Burnham Prebys Medical Discovery Institute Inhibitors of low molecular weight protein tyrosine phosphatase (LMPTP) and uses thereof
CN109053771B (zh) * 2018-08-22 2020-02-28 珠海优润医药科技有限公司 一种托法替布的有关物质及其制备方法和应用
MX2023007084A (es) * 2020-12-15 2023-08-30 Mirati Therapeutics Inc Inhibidores de pan-kras de azaquinazolina.

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ATE252100T1 (de) * 1995-02-27 2003-11-15 Hoffmann La Roche Dioxopyrrolo-pyrrolderivate
CA2286909A1 (en) * 1997-04-16 1998-10-22 Abbott Laboratories 5,7-disubstituted 4-aminopyrido¬2,3-d|pyrimidine compounds and their use as adenosine kinase inhibitors
AP2002002586A0 (en) * 2000-01-25 2002-09-30 Warner Lambert Co Pyrido[2,3-d] pyrimidine-2,7-diamine kinase inhibitors.
CN100376571C (zh) * 2001-02-12 2008-03-26 霍夫曼-拉罗奇有限公司 6-取代的吡啶并嘧啶类化合物
HUP0700040A2 (en) * 2001-06-28 2007-05-29 Essential Therapeutics Fused pyrimidines as d-alanyl-d-alanine ligase inhibitors, and process for producing them
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AU2003251869A1 (en) * 2002-07-15 2004-02-02 Merck & Co., Inc. Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes
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Also Published As

Publication number Publication date
EP1910359B1 (de) 2009-11-18
KR20080018957A (ko) 2008-02-28
US20090062276A1 (en) 2009-03-05
CN101243081A (zh) 2008-08-13
WO2007009911A1 (en) 2007-01-25
US20070021445A1 (en) 2007-01-25
JP2009501758A (ja) 2009-01-22
DE602006010564D1 (de) 2009-12-31
US20100280021A1 (en) 2010-11-04
MX2008000885A (es) 2008-03-18
BRPI0613604A2 (pt) 2011-01-18
ES2336603T3 (es) 2010-04-14
KR100962723B1 (ko) 2010-06-09
JP4880684B2 (ja) 2012-02-22
IL188475A0 (en) 2008-04-13
EP1910359A1 (de) 2008-04-16
AU2006271809A1 (en) 2007-01-25
CA2614443A1 (en) 2007-01-25
AU2006271809B2 (en) 2010-03-18
CA2614443C (en) 2011-03-22

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