ATE305978T1 - METHOD FOR PURIFYING S-ADENOSYL-L-METHIONINE AND FOR PRODUCING PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF - Google Patents
METHOD FOR PURIFYING S-ADENOSYL-L-METHIONINE AND FOR PRODUCING PHARMACEUTICALLY ACCEPTABLE SALTS THEREOFInfo
- Publication number
- ATE305978T1 ATE305978T1 AT00120521T AT00120521T ATE305978T1 AT E305978 T1 ATE305978 T1 AT E305978T1 AT 00120521 T AT00120521 T AT 00120521T AT 00120521 T AT00120521 T AT 00120521T AT E305978 T1 ATE305978 T1 AT E305978T1
- Authority
- AT
- Austria
- Prior art keywords
- adenosyl
- methionine
- pharmaceutically acceptable
- acceptable salts
- purifying
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
- C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The invention relates to a process for the purification of S-adenosyl-L-methionine (SAMe) and for the preparation of the pharmaceutically acceptable salts thereof starting from yeasts enriched with SAMe and allows to obtain the desired products with high yield and purity.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999MI002070A IT1315236B1 (en) | 1999-10-05 | 1999-10-05 | PROCESS FOR THE PURIFICATION OF S-ADENOSYL-METHIONINE AND FOR THE PREPARATION OF ITS PHARMACEUTICALLY ACCEPTABLE SALTS. |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE305978T1 true ATE305978T1 (en) | 2005-10-15 |
Family
ID=11383720
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00120521T ATE305978T1 (en) | 1999-10-05 | 2000-09-20 | METHOD FOR PURIFYING S-ADENOSYL-L-METHIONINE AND FOR PRODUCING PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1091001B1 (en) |
AT (1) | ATE305978T1 (en) |
CA (1) | CA2322231C (en) |
DE (1) | DE60022960T2 (en) |
DK (1) | DK1091001T3 (en) |
ES (1) | ES2249221T3 (en) |
IT (1) | IT1315236B1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005009751A1 (en) | 2005-03-03 | 2006-09-07 | Consortium für elektrochemische Industrie GmbH | Process for the fermentative production of S-adenosyl-methionine |
WO2007083631A1 (en) | 2006-01-17 | 2007-07-26 | Mitsubishi Gas Chemical Company, Inc. | Method of stabilizing s-adenosyl-l-methionine and stabilized composition |
EP2017331B1 (en) | 2006-05-16 | 2015-04-01 | Mitsubishi Gas Chemical Company, Inc. | Method of producing s-adenosyl-l-methionine-containing dry yeast having excellent storage stability |
WO2008090905A1 (en) | 2007-01-25 | 2008-07-31 | Mitsubishi Gas Chemical Company, Inc. | Method for production of dry yeast containing s-adenosyl-l-methionine and having excellent storage stability, product produced by the method, and molded composition of the dry yeast |
CN102321136B (en) * | 2011-09-19 | 2014-10-22 | 北京化工大学 | Preparation method for S-adenosine-L-methionine disulfate tosylate |
CN104211744A (en) * | 2013-05-30 | 2014-12-17 | 北京东方瑞德生物技术有限公司 | Preparation method of S-adenosyl methionline p-toluenesulfonate sulfate |
CN109456377A (en) * | 2018-12-17 | 2019-03-12 | 山东金城生物药业有限公司 | A kind of preparation method of adenosylmethionine |
CN110396120B (en) * | 2019-02-13 | 2020-05-12 | 山东惠仕莱生物科技有限公司 | Method for extracting and separating S-adenosylmethionine from S-adenosylmethionine fermentation liquor |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1803978C2 (en) * | 1968-10-18 | 1985-05-02 | Boehringer Mannheim Gmbh, 6800 Mannheim | Process for the production of S-adenosyl-l-methionine and S-adenosyl-l-ethionine |
US3962034A (en) * | 1973-02-01 | 1976-06-08 | Ajinomoto Co., Inc. | Method for producing s-adenosylmethionine or methylthioadenosine by yeast |
US4028183A (en) * | 1973-06-27 | 1977-06-07 | Bioresearch Limited | Process of preparing double salts of S-adenosyl-L-methionine |
GB2116172B (en) * | 1982-02-25 | 1986-07-09 | Nippon Zeon Co | Microbial cells containing s-adenosyl methionine in high concentrations and process for production of s adenosyl methionine |
IT1169773B (en) * | 1983-08-24 | 1987-06-03 | Bioresearch Spa | PROCESS FOR THE PRODUCTION OF STABLE SALTS OF SULPHO-ADENOSYL-L-METHIONINE |
-
1999
- 1999-10-05 IT IT1999MI002070A patent/IT1315236B1/en active
-
2000
- 2000-09-20 ES ES00120521T patent/ES2249221T3/en not_active Expired - Lifetime
- 2000-09-20 AT AT00120521T patent/ATE305978T1/en active
- 2000-09-20 DE DE60022960T patent/DE60022960T2/en not_active Expired - Lifetime
- 2000-09-20 EP EP00120521A patent/EP1091001B1/en not_active Expired - Lifetime
- 2000-09-20 DK DK00120521T patent/DK1091001T3/en active
- 2000-10-04 CA CA002322231A patent/CA2322231C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE60022960D1 (en) | 2006-02-16 |
ITMI992070A0 (en) | 1999-10-05 |
CA2322231A1 (en) | 2001-04-05 |
EP1091001B1 (en) | 2005-10-05 |
IT1315236B1 (en) | 2003-02-03 |
DE60022960T2 (en) | 2006-06-29 |
ITMI992070A1 (en) | 2001-04-05 |
EP1091001A1 (en) | 2001-04-11 |
CA2322231C (en) | 2009-03-17 |
ES2249221T3 (en) | 2006-04-01 |
DK1091001T3 (en) | 2005-11-14 |
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Legal Events
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