ATE246678T1 - Zyclische amidino mittel als stickstoffoxid- synthase inhibitoren - Google Patents

Zyclische amidino mittel als stickstoffoxid- synthase inhibitoren

Info

Publication number
ATE246678T1
ATE246678T1 AT96910833T AT96910833T ATE246678T1 AT E246678 T1 ATE246678 T1 AT E246678T1 AT 96910833 T AT96910833 T AT 96910833T AT 96910833 T AT96910833 T AT 96910833T AT E246678 T1 ATE246678 T1 AT E246678T1
Authority
AT
Austria
Prior art keywords
oxide synthase
agents
synthase inhibitors
nitrogen oxide
cyclic amidino
Prior art date
Application number
AT96910833T
Other languages
English (en)
Inventor
Donald W Hansen Jr
E Ann Hallinan
Timothy J Hagen
Steven W Kramer
Suzanne Metz
Karen B Peterson
Dale P Spangler
Mihaly V Toth
Kam F Fok
Arija A Bergmanis
R Keith Webber
Mahima Trivedi
Foe S Tjoeng
Barnett S Pitzele
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of ATE246678T1 publication Critical patent/ATE246678T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
AT96910833T 1995-04-20 1996-04-19 Zyclische amidino mittel als stickstoffoxid- synthase inhibitoren ATE246678T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42583195A 1995-04-20 1995-04-20
PCT/US1996/005315 WO1996033175A1 (en) 1995-04-20 1996-04-19 Cyclic amidino agents useful as nitric oxide synthase inhibitors

Publications (1)

Publication Number Publication Date
ATE246678T1 true ATE246678T1 (de) 2003-08-15

Family

ID=23688212

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96910833T ATE246678T1 (de) 1995-04-20 1996-04-19 Zyclische amidino mittel als stickstoffoxid- synthase inhibitoren

Country Status (15)

Country Link
US (3) US6011028A (de)
EP (1) EP0821674B1 (de)
JP (1) JPH11504319A (de)
KR (1) KR100442561B1 (de)
CN (2) CN1105706C (de)
AT (1) ATE246678T1 (de)
AU (1) AU712315B2 (de)
BR (1) BR9608012A (de)
CA (1) CA2216882A1 (de)
DE (1) DE69629364T2 (de)
ES (1) ES2206571T3 (de)
HK (1) HK1039324A1 (de)
NZ (1) NZ305799A (de)
TW (1) TW401401B (de)
WO (1) WO1996033175A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2136661C1 (ru) * 1993-10-21 1999-09-10 Джи Ди Сирл энд Ко. Амидинопроизводные, их применение и фармацевтическая композиция
WO1996033175A1 (en) * 1995-04-20 1996-10-24 G.D. Searle & Co. Cyclic amidino agents useful as nitric oxide synthase inhibitors
US6620848B2 (en) * 1997-01-13 2003-09-16 Smithkline Beecham Corporation Nitric oxide synthase inhibitors
CN1295561A (zh) 1998-06-03 2001-05-16 Gpinil控股公司 N－杂环羧酸或羧酸等排物的n－结合氨磺酰
US6552052B2 (en) 1998-06-10 2003-04-22 Monsanto/G.D. Searle Pyrrolo[2,1-c][1,2,4] thiadiazoles and Pyrollo[2,1-c][1,12,4]oxadiazoles useful as nitric oxide synthase inhibitors
US6489323B1 (en) 1998-06-10 2002-12-03 G.D. Searle & Co. Heterobicyclic and tricyclic nitric oxide synthase inhibitors
US7141552B2 (en) * 2000-01-10 2006-11-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases
AU2001247745B2 (en) 2000-03-24 2006-08-31 Pharmacia Corporation Amidino compounds useful as nitric oxide synthase inhibitors
US6545170B2 (en) 2000-04-13 2003-04-08 Pharmacia Corporation 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
AR030416A1 (es) 2000-04-13 2003-08-20 Pharmacia Corp COMPUESTO DERIVADO HALOGENADO DEL ACIDO 2-AMINO-3,4 HEPTENOICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE Y SU USO EN LA FABRICACION DE UN MEDICAMENTO uTIL COMO INHIBIDOR DE LA OXIDO NITRICO SINTETASA
US6787668B2 (en) 2000-04-13 2004-09-07 Pharmacia Corporation 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
AR034120A1 (es) 2000-04-13 2004-02-04 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico
AR032318A1 (es) 2000-04-13 2003-11-05 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa
US6956131B2 (en) 2000-04-13 2005-10-18 Pharmacia Corporation 2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors
US6451821B1 (en) * 2000-06-09 2002-09-17 Aventis Pharma S.A. Use of 2-aminothiazoline derivatives as inhibitors of inducible no-synthase
AU2001281083A1 (en) 2000-08-01 2002-02-13 Pharmacia Corporation Hexahydro-7-1h-azepin-2-yl-haxanoic acid derivatives as inhibitors of inducible nitric oxide synthase
US7012098B2 (en) 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
US20030232370A1 (en) * 2002-04-22 2003-12-18 Trifiro Mark A. Glucose sensor and uses thereof
AU2002313690A1 (en) * 2002-07-19 2004-02-09 Targacept, Inc. Five-membered heteroaromatic olefinic azacyclic compounds, pharmaceutical compositions containing them and their use as inhibitors of ncotinic cholinergic receptors
DE10315569A1 (de) 2003-04-05 2004-10-14 Merck Patent Gmbh Substituierte Pyrazolverbindungen
DE10315573A1 (de) * 2003-04-05 2004-10-14 Merck Patent Gmbh Substituierte Pyrazole
DE10315572A1 (de) * 2003-04-05 2004-10-14 Merck Patent Gmbh Substituierte Pyrazole
DE10315571A1 (de) 2003-04-05 2004-10-14 Merck Patent Gmbh Pyrazolverbindungen
US20080260861A1 (en) * 2004-04-07 2008-10-23 The General Hospital Corporation Modulating Lymphatic Function
ES2328626T3 (es) * 2005-03-31 2009-11-16 Nycomed Gmbh Derivados de imidazopiridina utiles como inhibidores de inos.
WO2008031788A1 (en) * 2006-09-12 2008-03-20 Nycomed Gmbh Aminoazepine derivatives as highly efficient inhibitors of the inducible nitric oxide synthase
CN108084173B (zh) * 2017-12-26 2020-04-07 商丘师范学院 一种含异噁唑结构的吡唑类化合物及其制备方法、应用
CN114835623B (zh) * 2022-06-08 2023-07-04 河北桑迪亚医药技术有限责任公司 一种番杏科生物碱(±)Mesembrine的合成新方法

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2049582A (en) * 1931-11-04 1936-08-04 Rohm & Haas Amidines
US3109848A (en) * 1961-03-30 1963-11-05 Rohm & Haas Substituted iminopyrrolines and iminopyrrolidines
US3132151A (en) * 1961-05-15 1964-05-05 Rohm & Haas Specific substituted iminopyrrolidines
US3121093A (en) * 1962-08-31 1964-02-11 Rohm & Haas Substituted iminopyrrolidines
DE1670859A1 (de) * 1967-04-24 1971-03-11 Bayer Ag Verfahren zur Herstellung von 2-Phenyl-imino-1-azacycloalkanen
US3501487A (en) * 1967-06-29 1970-03-17 Mcneilab Inc Certain hetero-aryl lower alkylene derivatives of 1 - lower alkyl - 2-imino-pyrrolidines
GB1180876A (en) * 1968-08-15 1970-02-11 Akad Wissenschaften Ddr Process for the Preparation of 1-Substituted 3-Imino-Pyrazolidines
US3725435A (en) * 1970-11-05 1973-04-03 Mc Neil Labor Inc 2-imino-pyrrolidines
US3694432A (en) * 1971-03-01 1972-09-26 Searle & Co 2-benzyloxyimino cyclic amines
ZA722407B (en) * 1971-05-13 1973-01-31 Richardson Merrell Inc Substituted cycloalkyl lactamimides
FR2186236B1 (de) * 1972-05-03 1975-08-01 Logeais Labor Jacques
US3816457A (en) * 1973-01-05 1974-06-11 Richardson Merrell Inc Lactamimide derivatives
US4153235A (en) * 1973-08-09 1979-05-08 Richardson-Merrell Inc. Substituted cycloalkyl lactamimides
US4046909A (en) * 1974-08-22 1977-09-06 Mcneil Laboratories, Incorporated Pyrrolidylidene, piperidylidene and hexahydroazepinylidene ureas as CNS depressants
US4061746A (en) * 1976-04-23 1977-12-06 Richardson-Merrell Inc. Lactamimide inhibitors of gastrointestinal hypersecretion
FR2431494A1 (fr) * 1978-07-17 1980-02-15 Logeais Labor Jacques Nouveaux derives du benzofuranne, leur procede de preparation et leur application en therapeutique
US4533739A (en) * 1982-10-12 1985-08-06 G. D. Searle & Co. 2-[(Aminophenyl and amidophenyl)amino]-1-azacycloalkanes having antidiarrheal activity
FR2540109B1 (fr) * 1983-01-28 1985-08-30 Logeais Labor Jacques Imino-2 pyrrolidines, leur procede de preparation et leurs applications en therapeutique
US4525476A (en) * 1983-05-26 1985-06-25 Warner-Lambert Company N-[1-oxo-3-(5-oxo-2-pyrrolidinyl)propyl]-alpha-aminoacids and derivatives as cognition activators
US4523020A (en) * 1983-11-10 1985-06-11 G. D. Searle & Co. Substituted 2-(3-aminophenoxymethyl)imidazolines
US4579951A (en) * 1984-03-19 1986-04-01 G. D. Searle & Co. Substituted (azacycloalk-2-yl)iminophenols and esters thereof
US4880827A (en) * 1986-03-18 1989-11-14 Sumitomo Pharmaceuticals Company, Ltd. Pyrrolidine derivatives having inhibitory action for proline specific endopepidase
DE3631414A1 (de) * 1986-09-16 1988-03-24 Basf Ag Verfahren zur herstellung von (alpha)-pyrrolidonen, deren verwendung und neue (alpha)-pyrrolidone
US5015633A (en) * 1987-04-27 1991-05-14 E. R. Squibb & Sons, Inc. Method for inhibiting loss of cognitive functions employing an ace inhibitor
US5196439A (en) * 1987-11-27 1993-03-23 Eisai Co., Ltd. Piperidine compounds useful to treat cerebrovascular diseases
ZA898440B (en) * 1988-11-10 1990-07-25 Merrell Dow Pharma Lactamimides in the treatment of drug-resistant protozoal infections
US5028627A (en) * 1989-09-13 1991-07-02 Cornell Research Foundation, Inc. Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor
US5216025A (en) * 1989-09-13 1993-06-01 Board Of Regents, The University Of Texas System Nitric oxide synthesis inhibitors for potentiating the action of pressor agents in certain hypotensive patients
US5059712A (en) * 1989-09-13 1991-10-22 Cornell Research Foundation, Inc. Isolating aminoarginine and use to block nitric oxide formation in body
GB8929076D0 (en) * 1989-12-22 1990-02-28 Scras Treatment of shock by blocking agents of edrf effect or formation
CA2036770C (en) * 1990-02-26 2003-09-09 Jeffrey P. Whitten Inhibitors of nitric oxide biosynthesis
IT1247697B (it) * 1990-06-21 1994-12-30 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche comprendenti 3-ammino-e-caprolattami per il potenziamento dei processi di apprendimento e della memoria.
US5273875A (en) * 1991-03-22 1993-12-28 Cornell Research Foundation, Inc. N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body
US5132453A (en) * 1991-03-22 1992-07-21 Cornell Research Foundation, Inc. N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body
US5246971A (en) * 1991-12-16 1993-09-21 Washington University Method of inhibiting nitric oxide formation
GB9127376D0 (en) * 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
US5296466A (en) * 1992-02-19 1994-03-22 Board Of Regents, The University Of Texas System Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein
US5266594A (en) * 1992-05-12 1993-11-30 Dawson Valina L Inhibitors of nitric oxide synthase and use thereof to prevent glutamate neurotoxicity
US5281627A (en) * 1992-05-28 1994-01-25 Cornell Research Foundation, Inc. Substituted arginines and substituted homoarginines and use thereof
US5362747A (en) * 1992-11-25 1994-11-08 Abbott Laboratories 2-nitroaryl and 2-cyanoaryl compounds as regulators of nitric oxide synthase
IL107771A0 (en) * 1992-11-27 1994-02-27 Wellcome Found Pharmaceutical compositions containing isothiourea derivatives certain such novel compounds and their preparation
WO1994014780A1 (en) * 1992-12-18 1994-07-07 The Wellcome Foundation Limited Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors
WO1994016729A1 (en) * 1993-01-28 1994-08-04 Neorx Corporation Targeted nitric oxide pathway or nitric oxide synthase modulation
US5807885A (en) * 1993-08-12 1998-09-15 Astra Aktiebolag Amidine derivatives with nitric oxide synthetase activities
US5654343A (en) * 1993-10-13 1997-08-05 Otsuka Pharmaceutical Co., Ltd. Method of treating a nitric oxide-associated disease with phenanthrene derivatives
RU2136661C1 (ru) * 1993-10-21 1999-09-10 Джи Ди Сирл энд Ко. Амидинопроизводные, их применение и фармацевтическая композиция
DE4418097A1 (de) * 1994-05-24 1995-11-30 Cassella Ag Verwendung von Tetrahydropteridin-Derivaten als Hemmstoffe der NO-Synthase
DE4418096A1 (de) * 1994-05-24 1995-11-30 Cassella Ag Verwendung von Pteridin-Derivaten als Hemmstoffe der NO-Synthase
US5621004A (en) * 1994-06-03 1997-04-15 Robert W. Dunn Method for treating emesis
US5629322A (en) * 1994-11-15 1997-05-13 Merck & Co., Inc. Cyclic amidine analogs as inhibitors of nitric oxide synthase
AU4149696A (en) * 1994-11-15 1996-06-06 Merck & Co., Inc. Substituted heterocycles as inhibitors of nitric oxide synthase
CA2163399A1 (en) * 1994-11-24 1996-05-25 Katsuhiro Kawano Triazine derivative, chymase activity inhibitor and nitric oxide production inhibitor
DE4442116A1 (de) * 1994-11-25 1996-05-30 Cassella Ag 2-Amino-1,3-thiazine als Hemmstoffe der Stickstoffmonoxid-Synthase
WO1996018616A1 (en) * 1994-12-12 1996-06-20 Merck & Co., Inc. Substituted 2-aminopyridines as inhibitors of nitric oxide synthase
JPH08333258A (ja) * 1994-12-14 1996-12-17 Japan Tobacco Inc チアジン又はチアゼピン誘導体及びそれら化合物を含有してなる一酸化窒素合成酵素阻害剤
WO1996033175A1 (en) * 1995-04-20 1996-10-24 G.D. Searle & Co. Cyclic amidino agents useful as nitric oxide synthase inhibitors
AU700078B2 (en) * 1995-11-01 1998-12-17 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases

Also Published As

Publication number Publication date
DE69629364T2 (de) 2004-06-09
WO1996033175A1 (en) 1996-10-24
BR9608012A (pt) 1999-01-05
DE69629364D1 (de) 2003-09-11
EP0821674A1 (de) 1998-02-04
AU712315B2 (en) 1999-11-04
AU5391696A (en) 1996-11-07
CN1305993A (zh) 2001-08-01
CN1105706C (zh) 2003-04-16
US5883251A (en) 1999-03-16
HK1039324A1 (zh) 2002-04-19
ES2206571T3 (es) 2004-05-16
NZ305799A (en) 1999-01-28
JPH11504319A (ja) 1999-04-20
CN1189823A (zh) 1998-08-05
EP0821674B1 (de) 2003-08-06
US6011028A (en) 2000-01-04
KR19990007887A (ko) 1999-01-25
US6043261A (en) 2000-03-28
KR100442561B1 (ko) 2004-10-14
CA2216882A1 (en) 1996-10-24
TW401401B (en) 2000-08-11

Similar Documents

Publication Publication Date Title
ATE246678T1 (de) Zyclische amidino mittel als stickstoffoxid- synthase inhibitoren
ATE222100T1 (de) Amidino-derivate nützlich als no synthase-hemmer
ATE196628T1 (de) Hydroxyamidinderivate verwendbar als stickoxidsynthese inhibitoren
DE59900369D1 (de) Stickoxidemissionsmindernde Abgasreinigungsanlage
TR200102029T2 (tr) 1-Heterosiklil ikameli diarilaminler.
DK0724570T3 (da) Amidinoderivater som NO syntase inhibitorer
BR0008176A (pt) Derivados anti-convulsivantes úteis no tratamento de cefaléias em cacho
DE60010761D1 (de) Initiator/amidine komplexe, solche komplexe enthaltende systeme, und damit hergestellte polymerisierte zusammensetzungen
MY138239A (en) Nitrogen containing heterobicycles as factor xa inhibitors
ATE297898T1 (de) 4-carboxamino-2-subsitutierte-1,2,3,4- tetrahydrochinoline als cetp inhibitoren
ATE216997T1 (de) Zyklische gmp-spezifische phosphodiesteraseinhibitoren
DE69924302D1 (de) Organoboran-amin-komplex-initiatorsysteme und damit hergestellte polymerisierbarezusammensetzungen
DE69917790D1 (de) 4-amino substituierte -2-subsituierte-1,2,3,4-tetrahydrochinoline als cetp inhibitoren
DK0960107T3 (da) 6-Thiosubstituerede paclitaxeler
MY135233A (en) N-aryl-2-oxazolidinone-5-carboxamides and their derivatives and their use as antibacterials
MY138285A (en) Fab i inhibitors
DE60132618D1 (de) 4,6-diphenylpyridinderivate als entzündungshemmende mittel
ES2191830T3 (es) Inhibidores de trombina.
NL1013625A1 (nl) Laterale hoogspanning halfgeleiderinrichting.
BR9608133A (pt) Inibidores da sintase de óxido nítrico derivados de amidinas cíclas
ATE254917T1 (de) Mittel gegen parasitäre protozoen
ES2186807T3 (es) Inhibidores de trombina.
EE9900474A (et) Amidiini derivaadid lämmastikoksiidi süntaasi inhibiitoritena
BR9914722A (pt) Derivados de anticonvulsivo úteis no tratamento de dependência, vìcio e abuso do álcool
BR0316544A (pt) Compostos calcilìticos

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties