ATE213245T1 - Triazolo(4,5-d)pyrimidinyl-derivate und ihre verwendung als medikamente - Google Patents

Triazolo(4,5-d)pyrimidinyl-derivate und ihre verwendung als medikamente

Info

Publication number
ATE213245T1
ATE213245T1 AT97951356T AT97951356T ATE213245T1 AT E213245 T1 ATE213245 T1 AT E213245T1 AT 97951356 T AT97951356 T AT 97951356T AT 97951356 T AT97951356 T AT 97951356T AT E213245 T1 ATE213245 T1 AT E213245T1
Authority
AT
Austria
Prior art keywords
triazolo
medications
pyrimidinyl derivatives
derivatives
pyrimidinyl
Prior art date
Application number
AT97951356T
Other languages
English (en)
Inventor
Roger Bonnert
Anthony Ingall
Brian Springthorpe
Paul Willis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9604788A external-priority patent/SE9604788D0/xx
Priority claimed from SE9604787A external-priority patent/SE9604787D0/xx
Application filed filed Critical
Application granted granted Critical
Publication of ATE213245T1 publication Critical patent/ATE213245T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT97951356T 1996-12-20 1997-12-12 Triazolo(4,5-d)pyrimidinyl-derivate und ihre verwendung als medikamente ATE213245T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9604788A SE9604788D0 (sv) 1996-12-20 1996-12-20 New compounds
SE9604787A SE9604787D0 (sv) 1996-12-20 1996-12-20 New compounds
PCT/SE1997/002091 WO1998028300A1 (en) 1996-12-20 1997-12-12 Triazolo[4,5-d]pyrimidinyl derivatives and their use as medicaments

Publications (1)

Publication Number Publication Date
ATE213245T1 true ATE213245T1 (de) 2002-02-15

Family

ID=26662831

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97951356T ATE213245T1 (de) 1996-12-20 1997-12-12 Triazolo(4,5-d)pyrimidinyl-derivate und ihre verwendung als medikamente

Country Status (7)

Country Link
US (1) US6297232B1 (de)
EP (1) EP0946561B1 (de)
JP (1) JP4125790B2 (de)
AT (1) ATE213245T1 (de)
AU (1) AU5501598A (de)
DE (1) DE69710490T2 (de)
WO (1) WO1998028300A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR017014A1 (es) * 1997-07-22 2001-08-22 Astrazeneca Ab Compuestos de triazolo [4,5-d]pirimidina, composiciones farmaceuticas, uso de los mismos para preparar medicamentos y procesos para la preparacionde dichos compuestos
SE9702773D0 (sv) * 1997-07-22 1997-07-22 Astra Pharma Prod Novel compounds
SE9702772D0 (sv) * 1997-07-22 1997-07-22 Astra Pharma Prod Novel compounds
DE69905451T2 (de) * 1998-02-17 2003-11-20 Astrazeneca Uk Ltd Neue triazolo(4,5d) pyrimidinverbindungen
SE9802574D0 (sv) * 1998-07-17 1998-07-17 Astra Pharma Prod Novel compounds
TWI229674B (en) * 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
SE9903290D0 (sv) * 1999-09-15 1999-09-15 Astra Pharma Prod Novel compounds
SE9904128D0 (sv) * 1999-11-15 1999-11-15 Astra Pharma Prod Novel compounds
SE9904129D0 (sv) * 1999-11-15 1999-11-15 Astra Pharma Prod Novel compounds
GB0013488D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Chemical compound
GB0013407D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Forms of a chemical compound
US7018985B1 (en) 2000-08-21 2006-03-28 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US6897201B2 (en) 2000-08-21 2005-05-24 Inspire Pharmaceuticals, Inc. Compositions and methods for the treatment of glaucoma or ocular hypertension
US7452870B2 (en) 2000-08-21 2008-11-18 Inspire Pharmaceuticals, Inc. Drug-eluting stents coated with P2Y12 receptor antagonist compound
US7115585B2 (en) 2000-08-21 2006-10-03 Inspire Pharmaceuticals, Inc. Compositions for treating epithelial and retinal tissue diseases
US7132408B2 (en) 2000-08-21 2006-11-07 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US7435724B2 (en) 2002-02-27 2008-10-14 Inspire Pharmaceutical, Inc. Degradation-resistant mononucleoside phosphate compounds
GB0219746D0 (en) * 2002-08-23 2002-10-02 Inst Of Ex Botany Ascr Azapurine derivatives
US7504497B2 (en) * 2003-10-21 2009-03-17 Inspire Pharmaceuticals, Inc. Orally bioavailable compounds and methods for inhibiting platelet aggregation
US7749981B2 (en) * 2003-10-21 2010-07-06 Inspire Pharmaceuticals, Inc. Drug-eluting stents coated with non-nucleotide P2Y12 receptor antagonist compound
US7335648B2 (en) * 2003-10-21 2008-02-26 Inspire Pharmaceuticals, Inc. Non-nucleotide composition and method for inhibiting platelet aggregation
US7368438B2 (en) 2003-10-21 2008-05-06 Inspire Pharmaceuticals, Inc. Non-nucleotide compositions and method for inhibiting platelet aggregation
GB2418425B (en) * 2004-08-11 2008-09-03 Univ Cambridge Tech Anti-inflammatory agents
US7932376B2 (en) 2005-05-05 2011-04-26 Inspire Pharmaceuticals, Inc. Pyrimidine-based non-nucleotide composition and method for inhibiting platelet aggregation
WO2006134384A1 (en) 2005-06-15 2006-12-21 Cambridge Enterprise Limited Anti-inflammatory agents
US7566722B2 (en) 2006-10-31 2009-07-28 Janssen Pharmaceutica, N.V. Triazolopyrimidine derivatives as ADP P2Y12 receptor antagonists
WO2008054796A2 (en) * 2006-10-31 2008-05-08 Janssen Pharmaceutica, N.V. Triazolopyrimidine derivatives as adp p2y12 receptor antagonists
US20110144049A1 (en) * 2009-10-21 2011-06-16 Serebruany Victor L Treating Cardiac Arrhythmias, Heart Failure, Peripheral Artery Disease and Stroke with Cyclopentyl-Triazolo-Pyrimidine or Derivative Thereof
CN105061431B (zh) * 2015-07-28 2017-03-29 山东百诺医药股份有限公司 6‑n‑（2‑（甲硫基）乙基）‑2‑（（3,3,3‑三氟丙基）硫代）‑9h‑嘌呤及其制备方法和应用
CN110803996B (zh) * 2019-11-13 2022-01-11 台州市创源工业技术有限公司 一种羟基苄胺的合成方法
CN111116592A (zh) * 2019-11-27 2020-05-08 杭州沧海帆医药科技有限公司 嘧啶并三氮唑类化合物及其医药用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4742064A (en) 1985-09-10 1988-05-03 Regents Of The University Of Minnesota Antiviral carbocyclic analogs of xylofuranosylpurines
GB8826205D0 (en) * 1988-11-09 1988-12-14 Wellcome Found Heterocyclic compounds
EP0840740B1 (de) * 1995-07-11 2002-05-02 AstraZeneca AB Inhibitoren der plättchenaggregation

Also Published As

Publication number Publication date
EP0946561A1 (de) 1999-10-06
DE69710490T2 (de) 2002-10-24
US6297232B1 (en) 2001-10-02
WO1998028300A1 (en) 1998-07-02
AU5501598A (en) 1998-07-17
DE69710490D1 (de) 2002-03-21
JP4125790B2 (ja) 2008-07-30
JP2001507023A (ja) 2001-05-29
EP0946561B1 (de) 2002-02-13

Similar Documents

Publication Publication Date Title
ATE213245T1 (de) Triazolo(4,5-d)pyrimidinyl-derivate und ihre verwendung als medikamente
TR199800012T1 (xx) Piroloprimidinler ve preparasyon i�in tatbikler.
ATE160342T1 (de) 9h-indeno(1,2-b>pyrazin-3(4h)-one und 9h- indeno(1,2-b>pyrazine-2,3(1h,4h)-dione und ihre herstellung und verwendung
AU9693998A (en) Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
TR200000197T2 (tr) Yeni bileşimler
IL119461A0 (en) Pyrrolopyrimidines
DE60037578D1 (de) Verwendung von triacetyluridin zur behandlung von mitochondrialen erkrankungen
DE69325904T2 (de) MERCAPTOACETYLAMIDE VON PYRIDAZO[1,2-a][1,2]-DIAZEPIN -DERIVATEN ALS EUKEPHALINASE UND ACE-INHIBITOREN
BG102789A (en) Parimido[5,4-d]pyrimidines, medicamentous forms containing them, their application and method for their preparation
DE59808992D1 (de) 3-substituierte 3,4-dihydro-thieno 2,3-d]pyrimidin-derivate, ihre herstellung und verwendung
ES2150233T3 (es) Pirrolo(2,3-c)carbazol-6-onas condensadas que potencian la actividad de interferon gamma.
DE69833297D1 (de) Substituierte Pyridylmethylpiperazin- und piperidinderivate, deren Herstellung und deren Verwendung in der Behandlung von Erkrankungen des Zentralnervensystems (ZNS)
ATE252587T1 (de) 3-substituierte pyrido 4',3':4,5) thieno 2,3- d)pyrimidin-derivate, ihre herstellung und verwendung
DE69633503D1 (de) 1,2,4- triazolo (4,3-b) pyridazinderivate und ihre verwendung
TR200000371T2 (tr) 3-İkame edilen 3,4,5,7,- tetrahidro-pirrolo [3',4':4,5] tieno[2,3-D] pirimidin türevleri, üretimi ve 5HT-antagonistleri olarak kullanımları.
DE59708511D1 (de) Verwendung von 7-(1-aminomethyl-2-oxa-7-aza-bicyclo 3.3.0]oct-7-yl)-chinoloncarbonsäure- und -naphthyridoncarbonsäure-derivaten zur therapie von helicobacter-pylori-infektionen und den damit assoziierten gastroduodenalen erkrankungen
ATE116320T1 (de) 5,11-dihydro-6h-pyrido(2,3-b)(1,4)benzodiazepin 6-one und -thione und deren verwendung bei der vorbeugung und und behandlung von aids.
TR199701605A2 (xx) S�lfonamid-substit�e edilmi� bile�ikler
DE69517767D1 (de) IMIDAZOLYLALKYLDERIVATE VON IMIDAZO[1,5-a]INDOL-3-ON UND IHRE VERWENDUNG ALS ARZNEIMITTEL
DE50106048D1 (de) Substituierte 3,4-dihydro-pyrimido [1,2-a]pyrimidine und 3,4-dihydropyrazino [1,2-a]pyrimidine
DE68919780T2 (de) Bicyclische sauerstoffhaltige Derivate und ihre Verwendung als parfümierende Bestandteile.
DK0833638T3 (da) Anvendelse af imidazo[1,5-a]quinoloner som neuroprotektive midler
GR1001385B (el) Παράγωγα ιμιδαζο 1,2-α (πυρρολο,?ειενο η φουρανο) 3,2-d αζεπίνης συν?έσεις και μέ?οδοι χρήσεως.
CA2241852A1 (en) Fused pyrrolo(2,3-c)carbazole-6-ones which potentiate activity of gamma interferon
ATE98244T1 (de) Kondensierte pyrimidine, ihre herstellung und verwendung.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties