ATE118770T1 - Thiazolidinone und oxazolidenonederivate, ihre herstellung und ihre anwendung als vasodilatatoren. - Google Patents

Thiazolidinone und oxazolidenonederivate, ihre herstellung und ihre anwendung als vasodilatatoren.

Info

Publication number
ATE118770T1
ATE118770T1 AT92302674T AT92302674T ATE118770T1 AT E118770 T1 ATE118770 T1 AT E118770T1 AT 92302674 T AT92302674 T AT 92302674T AT 92302674 T AT92302674 T AT 92302674T AT E118770 T1 ATE118770 T1 AT E118770T1
Authority
AT
Austria
Prior art keywords
vasodilaters
oxazolidenone
thiazolidinones
derivatives
production
Prior art date
Application number
AT92302674T
Other languages
English (en)
Inventor
Sadao C O Sankyo Comp Ishihara
Fujio C O Sankyo Company Saito
Takao C O Sankyo Comp Yoshioka
Hiroyuki C O Sankyo Comp Koike
Sigeki C O Sankyo Compa Miyake
Hiroshi C O Sankyo Comp Mizuno
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Application granted granted Critical
Publication of ATE118770T1 publication Critical patent/ATE118770T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Indole Compounds (AREA)
AT92302674T 1991-03-27 1992-03-27 Thiazolidinone und oxazolidenonederivate, ihre herstellung und ihre anwendung als vasodilatatoren. ATE118770T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP6308891 1991-03-27
JP10275191 1991-05-08
JP33030491 1991-12-13

Publications (1)

Publication Number Publication Date
ATE118770T1 true ATE118770T1 (de) 1995-03-15

Family

ID=27298042

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92302674T ATE118770T1 (de) 1991-03-27 1992-03-27 Thiazolidinone und oxazolidenonederivate, ihre herstellung und ihre anwendung als vasodilatatoren.

Country Status (23)

Country Link
US (2) US5298516A (de)
EP (1) EP0506434B1 (de)
JP (1) JPH0780859B2 (de)
KR (1) KR0152097B1 (de)
CN (2) CN1031824C (de)
AT (1) ATE118770T1 (de)
AU (1) AU647599B2 (de)
CA (1) CA2064108C (de)
CZ (1) CZ282529B6 (de)
DE (1) DE69201451T2 (de)
DK (1) DK0506434T3 (de)
ES (1) ES2072095T3 (de)
FI (1) FI106260B (de)
HK (1) HK123595A (de)
HU (2) HU217969B (de)
IE (1) IE67383B1 (de)
IL (1) IL101395A (de)
IS (1) IS1746B (de)
NO (1) NO304311B1 (de)
NZ (1) NZ242154A (de)
PH (1) PH30493A (de)
RU (1) RU2055073C1 (de)
TW (1) TW226015B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3454531B2 (ja) * 1991-11-07 2003-10-06 三共株式会社 ニトロキシアルキルアミド誘導体
EP0689435A1 (de) * 1993-03-15 1996-01-03 Byk Nederland Bv Verwendung von substituierten alkylnitraten zur behandlung des krankhaft erhöhten augeninnendruckes
DE4429461A1 (de) * 1994-08-19 1996-02-22 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
HUT77131A (hu) * 1994-12-15 1998-03-02 Sankyo Co., Ltd. Tiazolidinonszármazékok, eljárás előállításukra és ezeket tartalmazó gyógyászati készítmények
US5925658A (en) * 1995-03-02 1999-07-20 Sankyo Company, Limited Optically active thiazolidinone derivative
WO1996026931A1 (fr) * 1995-03-02 1996-09-06 Sankyo Company, Limited Derives de thiazolidinone optiquement actifs
AU6016496A (en) * 1995-06-14 1997-01-15 Sankyo Company Limited Antianginal drug comprising nitroxy derivative as active ingredient
BE1010768A3 (nl) * 1996-11-26 1999-01-05 Dsm Nv Een werkwijze voor de bereiding van alpha-aminozuuramiden, alpha-aminozuren en derivaten ervan.
IL120531A (en) 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them
WO2002069967A1 (fr) * 2001-03-01 2002-09-12 Sankyo Company, Limited Compositions a absorption percutanee
JP2014524936A (ja) * 2011-07-28 2014-09-25 プロメンテイス・フアーマシユーテイカルズ・インコーポレイテツド システインプロドラッグ
US10239847B1 (en) 2016-03-03 2019-03-26 Cellactin Method for 2-oxothiazolidine-4-carboxylic acid for cellular glutathione

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200640A (en) * 1976-04-02 1980-04-29 Chugai Seiyaku Kabushiki Kaisha Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use
GB8717068D0 (en) * 1987-07-20 1987-08-26 Fujisawa Pharmaceutical Co Nitric ester derivative
WO1990012791A1 (en) * 1989-04-21 1990-11-01 E.I. Du Pont De Nemours And Company Fungicidal oxazolidinones

Also Published As

Publication number Publication date
RU2055073C1 (ru) 1996-02-27
NZ242154A (en) 1993-09-27
CN1096265C (zh) 2002-12-18
IE67383B1 (en) 1996-03-20
KR920018036A (ko) 1992-10-21
IL101395A0 (en) 1992-11-15
EP0506434A1 (de) 1992-09-30
HUT68242A (en) 1995-06-28
HU217969B (hu) 2000-05-28
PH30493A (en) 1997-05-28
TW226015B (de) 1994-07-01
HU211969A9 (en) 1996-01-29
KR0152097B1 (ko) 1998-10-15
FI921340A (fi) 1992-09-28
US5298516A (en) 1994-03-29
CN1113435A (zh) 1995-12-20
CZ282529B6 (cs) 1997-08-13
IS1746B (is) 2000-07-11
IE920966A1 (en) 1992-10-07
HU9201033D0 (en) 1992-06-29
US5356918A (en) 1994-10-18
FI106260B (fi) 2000-12-29
EP0506434B1 (de) 1995-02-22
CN1031824C (zh) 1996-05-22
CA2064108A1 (en) 1992-09-28
HK123595A (en) 1995-08-04
ES2072095T3 (es) 1995-07-01
JPH0780859B2 (ja) 1995-08-30
IL101395A (en) 1996-10-16
CZ91692A3 (en) 1993-01-13
NO921159L (no) 1992-09-28
AU1312292A (en) 1992-10-01
CN1066067A (zh) 1992-11-11
FI921340A0 (fi) 1992-03-26
NO921159D0 (no) 1992-03-25
CA2064108C (en) 2000-09-26
DE69201451T2 (de) 1995-10-12
NO304311B1 (no) 1998-11-30
IS3828A (is) 1992-09-28
DK0506434T3 (da) 1995-07-24
AU647599B2 (en) 1994-03-24
DE69201451D1 (de) 1995-03-30
JPH05213910A (ja) 1993-08-24

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee