AR245221A1 - A method for the production of clavulanic acid by fermenting s. clavuligerus. - Google Patents
A method for the production of clavulanic acid by fermenting s. clavuligerus.Info
- Publication number
- AR245221A1 AR245221A1 AR85302065A AR30206585A AR245221A1 AR 245221 A1 AR245221 A1 AR 245221A1 AR 85302065 A AR85302065 A AR 85302065A AR 30206585 A AR30206585 A AR 30206585A AR 245221 A1 AR245221 A1 AR 245221A1
- Authority
- AR
- Argentina
- Prior art keywords
- clavuligerus
- fermenting
- production
- clavulanic acid
- clavulanic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES537160A ES8602804A1 (en) | 1984-10-27 | 1984-10-27 | Prodn. of clavulanic acid in higher yields and purity |
ES537157A ES537157A0 (en) | 1984-10-27 | 1984-10-27 | PROCEDURE FOR THE IMPROVEMENT OF THE FERMENTATION OF CLAVULANIC ACID AND ITS SALTS |
ES537159A ES8602000A1 (en) | 1984-10-27 | 1984-10-27 | Clavulanic acid prepn. |
ES537158A ES8601999A1 (en) | 1984-10-27 | 1984-10-27 | Clavulanic acid extraction |
Publications (1)
Publication Number | Publication Date |
---|---|
AR245221A1 true AR245221A1 (en) | 1993-12-30 |
Family
ID=27444000
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR85302065A AR245221A1 (en) | 1984-10-27 | 1985-10-25 | A method for the production of clavulanic acid by fermenting s. clavuligerus. |
Country Status (12)
Country | Link |
---|---|
EP (2) | EP0312813A3 (en) |
JP (1) | JPH0646949B2 (en) |
CN (1) | CN1010415B (en) |
AR (1) | AR245221A1 (en) |
AU (1) | AU600655B2 (en) |
CA (1) | CA1307223C (en) |
DE (1) | DE3583281D1 (en) |
HK (1) | HK26696A (en) |
IE (1) | IE58365B1 (en) |
IN (1) | IN162768B (en) |
MX (1) | MX7417E (en) |
NZ (1) | NZ213963A (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2010143A6 (en) * | 1989-03-01 | 1989-10-16 | Pharma Mar S A Pharmar | A new process for obtainment of Z(2R,5R)-3-(2-hydroxyethyliden)-7-oxo-4-oxa-1-azabicyclo(3,2,0)-heptane-2-carboxylic acid and pharmaceutically acceptable salts and esters thereof, from fermentation broths of Streptomyces sp. |
AT400033B (en) | 1992-03-10 | 1995-09-25 | Biochemie Gmbh | NEW METHOD FOR ISOLATING AND PURIFYING CLAVULANIC ACID AND FOR PRODUCING PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF |
SI9300296B (en) * | 1992-06-11 | 1998-06-30 | Smithkline Beecham P.L.C. | Process and intermediates for the preparation of clavulanic acid |
GB2282810B (en) * | 1992-06-11 | 1997-02-26 | Smithkline Beecham Plc | Preparation or purification of clavulanic acid |
AT475U1 (en) * | 1992-06-11 | 1995-11-27 | Smithkline Beecham Plc | METHOD FOR THE PRODUCTION OF CLAVULANIC ACID |
AT1447U1 (en) * | 1992-06-11 | 1997-05-26 | Smithkline Beecham Plc | NEW CLAVULANIC ACID SALTS |
AT1446U1 (en) * | 1992-10-31 | 1997-05-26 | Smithkline Beecham Plc | METHOD FOR PRODUCING AND / OR PURIFYING CLAVULANIC ACID |
GB9315393D0 (en) * | 1993-07-24 | 1993-09-08 | Smithkline Beecham Plc | Novel product |
WO1995011295A1 (en) * | 1993-10-22 | 1995-04-27 | Gist-Brocades N.V. | An improved process to recover an aqueous fermentation broth |
SI9400107A (en) | 1994-03-02 | 1995-10-31 | Lek Tovarna Farmacevtskih | New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804. |
AP9701116A0 (en) * | 1995-02-25 | 1997-10-31 | Spurcourt Ltd | Clavulanic acid salts |
SI9500074A (en) * | 1995-03-10 | 1996-10-31 | Lek Tovarna Farmacevtskih | Process for preparation of alkani salts of clavulanic acid. |
SI9500134B (en) * | 1995-04-20 | 2004-04-30 | Lek, | Preparation procedure of pure alkali salts of clavulanic acid |
GB9515809D0 (en) * | 1995-08-02 | 1995-10-04 | Smithkline Beecham Plc | Process |
SI9500265A1 (en) | 1995-08-28 | 1997-02-28 | Lek Tovarna Farmacevtskih | Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration |
AT403375B (en) * | 1995-11-15 | 1998-01-26 | Biochemie Gmbh | METHOD FOR FILLING ALKALINE SALTS OF CLAVULANIC ACID |
ES2101658B1 (en) * | 1995-11-23 | 1998-03-01 | Antibioticos Sa | NEW PROCEDURE FOR THE PRODUCTION OF CLAVULANIC ACID AND ITS SALTS. |
SI9600120A (en) * | 1996-04-12 | 1997-12-31 | Lek Tovarna Farmacevtskih | New and improved fermentative procedure for the production of clavulanic acid and its salts |
ATE327340T1 (en) * | 1997-02-20 | 2006-06-15 | Dsm Ip Assets Bv | FERMENTATIVE PRODUCTION OF RECYCLABLE MATERIALS ON AN INDUSTRIAL SCALE BY USING CHEMICALLY DEFINED MEDIA |
AR015825A1 (en) * | 1997-05-28 | 2001-05-30 | Gist Brocades Bv | FERMENTATIVE PRODUCTION OF CLAVULANIC ACID UNDER CONTROLLED PHOSPHATE CONDITIONS |
JP4644893B2 (en) * | 2000-01-12 | 2011-03-09 | ヤマハ株式会社 | Performance equipment |
CN1222528C (en) | 2000-05-13 | 2005-10-12 | 史密斯克莱·比奇曼公司 | Process for purification of salt of clavulanic acid |
GB0022841D0 (en) | 2000-09-18 | 2000-11-01 | Smithkline Beecham Plc | Process |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1508977A (en) * | 1974-04-20 | 1978-04-26 | Beecham Group Ltd | Beta-lactam antibiotic from streptomyces clavuligerus |
GB1543563A (en) * | 1975-02-07 | 1979-04-04 | Glaxo Lab Ltd | Beta-lactam antibiotic in purified form |
CH592445A5 (en) * | 1975-06-17 | 1977-10-31 | Sulzer Ag | |
GB1561395A (en) * | 1976-02-26 | 1980-02-20 | Beecham Group Ltd | -lactam antibiotic |
EP0002564B1 (en) * | 1977-11-12 | 1984-06-20 | Beecham Group Plc | Derivatives of 7-oxo-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylic acid, their preparation, pharmaceutical compositions containing them and intermediates |
CA1115699A (en) * | 1978-05-20 | 1982-01-05 | Alan D. Curzons | Lithium pseudomonate and its preparation |
JPS55136282A (en) * | 1979-04-06 | 1980-10-23 | Shionogi & Co Ltd | Novel antibiotic pa-31088-4 |
JPS5714832A (en) * | 1980-07-01 | 1982-01-26 | Minolta Camera Co Ltd | Camera provided with data imprinting device |
-
1985
- 1985-10-25 MX MX8544U patent/MX7417E/en unknown
- 1985-10-25 AU AU49090/85A patent/AU600655B2/en not_active Expired
- 1985-10-25 AR AR85302065A patent/AR245221A1/en active
- 1985-10-25 NZ NZ213963A patent/NZ213963A/en unknown
- 1985-10-26 CN CN85108444A patent/CN1010415B/en not_active Expired
- 1985-10-28 JP JP60242586A patent/JPH0646949B2/en not_active Expired - Lifetime
- 1985-10-28 EP EP88115979A patent/EP0312813A3/en not_active Withdrawn
- 1985-10-28 DE DE8585307783T patent/DE3583281D1/en not_active Expired - Lifetime
- 1985-10-28 EP EP85307783A patent/EP0182522B1/en not_active Expired - Lifetime
- 1985-10-28 IN IN855/MAS/85A patent/IN162768B/en unknown
- 1985-10-28 CA CA000494016A patent/CA1307223C/en not_active Expired - Lifetime
- 1985-11-01 IE IE269985A patent/IE58365B1/en not_active IP Right Cessation
-
1996
- 1996-02-08 HK HK26696A patent/HK26696A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NZ213963A (en) | 1989-01-06 |
EP0312813A3 (en) | 1989-12-13 |
CN85108444A (en) | 1986-08-06 |
JPH0646949B2 (en) | 1994-06-22 |
EP0182522B1 (en) | 1991-06-19 |
IE58365B1 (en) | 1993-09-08 |
AU4909085A (en) | 1986-05-01 |
IN162768B (en) | 1988-07-09 |
CN1010415B (en) | 1990-11-14 |
JPS61119195A (en) | 1986-06-06 |
IE852699L (en) | 1986-04-27 |
CA1307223C (en) | 1992-09-08 |
AU600655B2 (en) | 1990-08-23 |
DE3583281D1 (en) | 1991-07-25 |
EP0182522A1 (en) | 1986-05-28 |
EP0312813A2 (en) | 1989-04-26 |
MX7417E (en) | 1988-10-14 |
HK26696A (en) | 1996-02-16 |
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