AR113929A1 - Compuestos heterocíclicos - Google Patents

Compuestos heterocíclicos

Info

Publication number
AR113929A1
AR113929A1 ARP180103635A ARP180103635A AR113929A1 AR 113929 A1 AR113929 A1 AR 113929A1 AR P180103635 A ARP180103635 A AR P180103635A AR P180103635 A ARP180103635 A AR P180103635A AR 113929 A1 AR113929 A1 AR 113929A1
Authority
AR
Argentina
Prior art keywords
group
heterocyclyl
heteroaryl
cycloalkyl
aryl
Prior art date
Application number
ARP180103635A
Other languages
English (en)
Inventor
Satoshi Tsuchiya
Hans Richter
Bernd Kuhn
Buelent Kocer
Benoit Hornsperger
Uwe Grether
Joerg Benz
Charles Bell
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR113929A1 publication Critical patent/AR113929A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Reivindicación 1: Un compuesto de fórmula (1) donde: A se selecciona del grupo que consiste en arilo, heteroarilo, cicloalquilo y heterociclilo, en donde cada uno de dichos arilo, heteroarilo, cicloalquilo y heterociclilo esta independientemente sustituido con R⁴ y R⁵; L se selecciona del grupo que consiste en heterociclilo, -O-, -C(O)-, -S(O)₂-, -CHR⁶-, -CH₂CH₂-, -(CH₂)ₚ-C(O)-NR⁷- y -(CH₂)-NR⁸-C(O)-; X es N o C-R⁹; cada uno de m, n, p y q es independientemente un número entero seleccionado del grupo que consiste en 0 y 1; y cada uno de R¹, R², R³, R⁴, R⁵, R⁶, R⁷, R⁸ y R⁹ se selecciona independientemente del grupo que consiste en hidrógeno, hidroxi, halógeno, ciano, alquilo, haloalquilo, cicloalquilo, alcoxi, haloalcoxi, arilo y heteroarilo; o una sal farmacéuticamente aceptable del mismo.
ARP180103635A 2017-12-15 2018-12-13 Compuestos heterocíclicos AR113929A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17207830 2017-12-15

Publications (1)

Publication Number Publication Date
AR113929A1 true AR113929A1 (es) 2020-07-01

Family

ID=60673737

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180103635A AR113929A1 (es) 2017-12-15 2018-12-13 Compuestos heterocíclicos

Country Status (7)

Country Link
US (2) US20200308158A1 (es)
EP (1) EP3724186A1 (es)
JP (1) JP7403453B2 (es)
CN (1) CN111295383A (es)
AR (1) AR113929A1 (es)
TW (1) TW201930300A (es)
WO (1) WO2019115660A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR114136A1 (es) 2017-10-10 2020-07-29 Hoffmann La Roche Compuestos heterocíclicos
JP7269948B2 (ja) 2017-11-28 2023-05-09 エフ． ホフマン－ラ ロシュ アーゲー 新規複素環式化合物
JP7269943B2 (ja) 2018-01-08 2023-05-09 エフ． ホフマン－ラ ロシュ アーゲー Ｍａｇｌ阻害剤としてのオクタヒドロピリド［１，２－アルファ］ピラジン
MX2021001433A (es) 2018-08-13 2021-04-12 Hoffmann La Roche Nuevos compuestos heterociclicos como inhibidores de la monoacilglicerol lipasa.
US20230090255A1 (en) * 2019-09-05 2023-03-23 Lunan Pharmaceutical Group Corporation Magl inhibitor, preparation method therefor and use thereof
US20210094971A1 (en) * 2019-09-09 2021-04-01 Hoffmann-La Roche Inc. Heterocyclic compounds
CN114269755A (zh) * 2019-09-12 2022-04-01 豪夫迈·罗氏有限公司 作为magl抑制剂的4,4a,5,7,8,8a-六吡啶并[4,3-b][1,4]噁嗪-3-酮化合物
CN114650994A (zh) * 2019-09-12 2022-06-21 豪夫迈·罗氏有限公司 放射性标记的化合物
CN114401969A (zh) * 2019-09-23 2022-04-26 豪夫迈·罗氏有限公司 杂环化合物
US20210094972A1 (en) * 2019-09-24 2021-04-01 Hoffmann-La Roche Inc. Heterocyclic compounds
CR20230115A (es) 2020-09-03 2023-04-11 Hoffmann La Roche Compuestos heterocíclicos
CN112341396B (zh) * 2020-11-04 2022-07-26 四川大学华西医院 一种新型单酰基甘油酯酶抑制剂及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010111626A2 (en) * 2009-03-27 2010-09-30 Takeda Pharmaceutical Company Limited Poly (adp-ribose) polymerase (parp) inhibitors
RU2011147201A (ru) * 2009-04-22 2013-05-27 Янссен Фармацевтика Нв Регероматические и ароматические пиперазинил ацетидинил амиды как моноцилглицероловые ингибиторы липазы
FR2960875B1 (fr) * 2010-06-04 2012-12-28 Sanofi Aventis Derives de carbamates d'hexafluoroisopropyle, leur preparation et leur application en therapeutique
WO2016158956A1 (ja) * 2015-03-30 2016-10-06 武田薬品工業株式会社 複素環化合物
JP6832342B2 (ja) * 2016-03-31 2021-02-24 武田薬品工業株式会社 複素環化合物
JP7269948B2 (ja) * 2017-11-28 2023-05-09 エフ． ホフマン－ラ ロシュ アーゲー 新規複素環式化合物

Also Published As

Publication number Publication date
TW201930300A (zh) 2019-08-01
WO2019115660A1 (en) 2019-06-20
EP3724186A1 (en) 2020-10-21
CN111295383A (zh) 2020-06-16
US20230183224A1 (en) 2023-06-15
JP7403453B2 (ja) 2023-12-22
US20200308158A1 (en) 2020-10-01
JP2021506760A (ja) 2021-02-22

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