AR095421A1 - Moduladores de p2x7 - Google Patents

Moduladores de p2x7

Info

Publication number
AR095421A1
AR095421A1 ARP140100965A ARP140100965A AR095421A1 AR 095421 A1 AR095421 A1 AR 095421A1 AR P140100965 A ARP140100965 A AR P140100965A AR P140100965 A ARP140100965 A AR P140100965A AR 095421 A1 AR095421 A1 AR 095421A1
Authority
AR
Argentina
Prior art keywords
pyridinyl
phenyl
pyrazizyl
thiophenyl
pyrazinyl
Prior art date
Application number
ARP140100965A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR095421A1 publication Critical patent/AR095421A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Abstract

Reivindicación 1: Un compuesto de la fórmula (1) o un enantiómero o diastereómero de este; o una sal farmacéuticamente aceptable de estos; en donde n es un entero de 0 - 1; X es CH₂ cuando n es 0, o X es CH₂ u oxígeno cuando n es 1; R¹ es fenilo o piridinilo, en donde el fenilo o piridinilo se sustituye, opcionalmente, con 1 a 4 sustituyentes seleccionados independientemente de halógeno y alquilo; y R² es fenilo, piridinilo, pirazinilo, piradizinilo, pirimidinilo, pirrolilo, pirazolilo, tiazolilo o tiofenilo, en donde el fenilo, piridinilo, pirazinilo, piradizinilo, pirimidinilo, pirrolilo, pirazolilo, tiazolilo o tiofenilo se sustituye, opcionalmente, con 1 a 2 sustituyentes seleccionados independientemente del grupo que consiste en halógeno, alquilo, hidroxi y alcoxi.
ARP140100965A 2013-03-14 2014-03-13 Moduladores de p2x7 AR095421A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361785558P 2013-03-14 2013-03-14

Publications (1)

Publication Number Publication Date
AR095421A1 true AR095421A1 (es) 2015-10-14

Family

ID=50631041

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP140100965A AR095421A1 (es) 2013-03-14 2014-03-13 Moduladores de p2x7

Country Status (10)

Country Link
US (3) US9540388B2 (es)
EP (2) EP2970287B1 (es)
JP (1) JP6294954B2 (es)
AR (1) AR095421A1 (es)
ES (2) ES2652648T3 (es)
HK (2) HK1218649A1 (es)
JO (1) JO3509B1 (es)
TW (1) TWI627174B (es)
UY (1) UY35447A (es)
WO (1) WO2014152621A1 (es)

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JP6736660B2 (ja) * 2015-09-04 2020-08-05 ヤンセン ファーマシューティカ エヌ．ベー． 疼痛のための治療化合物及びその合成
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Also Published As

Publication number Publication date
TW201522339A (zh) 2015-06-16
TWI627174B (zh) 2018-06-21
WO2014152621A1 (en) 2014-09-25
ES2652648T3 (es) 2018-02-05
US10053462B2 (en) 2018-08-21
JO3509B1 (ar) 2020-07-05
HK1218649A1 (zh) 2017-03-03
EP3309161B1 (en) 2019-12-18
US9540388B2 (en) 2017-01-10
US20170088550A1 (en) 2017-03-30
US9102686B2 (en) 2015-08-11
EP2970287B1 (en) 2017-11-01
UY35447A (es) 2014-09-30
EP3309161A1 (en) 2018-04-18
ES2776654T3 (es) 2020-07-31
HK1254111A1 (zh) 2019-07-12
US20160039836A1 (en) 2016-02-11
EP2970287A1 (en) 2016-01-20
JP2016513702A (ja) 2016-05-16
US20140275056A1 (en) 2014-09-18
JP6294954B2 (ja) 2018-03-14

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