AR083022A1 - DERIVATIVES OF (S) -N, N-DIMETIL-3- (NAFTALEN-1-ILOXI) -1-FENILPROPAN-1-AMINA, PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES AND METHODS OF MANUFACTURING THE SAME - Google Patents

DERIVATIVES OF (S) -N, N-DIMETIL-3- (NAFTALEN-1-ILOXI) -1-FENILPROPAN-1-AMINA, PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES AND METHODS OF MANUFACTURING THE SAME

Info

Publication number
AR083022A1
AR083022A1 ARP110103394A ARP110103394A AR083022A1 AR 083022 A1 AR083022 A1 AR 083022A1 AR P110103394 A ARP110103394 A AR P110103394A AR P110103394 A ARP110103394 A AR P110103394A AR 083022 A1 AR083022 A1 AR 083022A1
Authority
AR
Argentina
Prior art keywords
derivatives
pharmaceutical compositions
dapoxetine
methods
compounds
Prior art date
Application number
ARP110103394A
Other languages
Spanish (es)
Inventor
Jung Oh
Jung A Hoon-Lee
Keun Ryu
Tae Kon Ho-Kim
bong Lee
Seok Hyun Yong-Hong
Soo Min Lee
Minseok Park
Hyuk Min Kim
Jae-Sun Kim
Original Assignee
Sk Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sk Chemicals Co Ltd filed Critical Sk Chemicals Co Ltd
Publication of AR083022A1 publication Critical patent/AR083022A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se revelan derivados de dapoxetina y sus sales farmacéuticamente aceptables. Los compuestos son solubles en agua, estables y fáciles de procesar en preparaciones. Además, los compuestos muestran una tasa de disolución y un sabor mejorados. Asimismo, los compuestos muestran una pequeña diferencia en la tasa de disolución dependiendo del pH. Se revelan además composiciones farmacéuticas que incluyen los compuestos. Las composiciones farmacéuticas son útiles para el tratamiento, manejo o prevención de la eyaculación precoz. También se revelan métodos para preparar los derivados de dapoxetina.Reivindicación 1: Una prodroga de dapoxetina en la cual un progrupo Rp está unido al grupo de amina terciaria de la dapoxetina, caracterizado por la fórmula (1).Dapoxetine derivatives and their pharmaceutically acceptable salts are disclosed. The compounds are water soluble, stable and easy to process in preparations. In addition, the compounds show an improved dissolution rate and taste. Also, the compounds show a small difference in the dissolution rate depending on the pH. Pharmaceutical compositions that include the compounds are further disclosed. Pharmaceutical compositions are useful for the treatment, management or prevention of premature ejaculation. Methods for preparing dapoxetine derivatives are also disclosed. Claim 1: A dapoxetine prodrug in which an Rp progroup is linked to the tertiary amine group of dapoxetine, characterized by the formula (1).

ARP110103394A 2010-09-17 2011-09-16 DERIVATIVES OF (S) -N, N-DIMETIL-3- (NAFTALEN-1-ILOXI) -1-FENILPROPAN-1-AMINA, PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES AND METHODS OF MANUFACTURING THE SAME AR083022A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20100091416 2010-09-17
KR1020110082839A KR20120068678A (en) 2010-09-17 2011-08-19 (s)-n,n-dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine derivatives, pharmaceutical compositions containing them, and manufacturing methods thereof

Publications (1)

Publication Number Publication Date
AR083022A1 true AR083022A1 (en) 2013-01-23

Family

ID=46687281

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110103394A AR083022A1 (en) 2010-09-17 2011-09-16 DERIVATIVES OF (S) -N, N-DIMETIL-3- (NAFTALEN-1-ILOXI) -1-FENILPROPAN-1-AMINA, PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES AND METHODS OF MANUFACTURING THE SAME

Country Status (2)

Country Link
KR (1) KR20120068678A (en)
AR (1) AR083022A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014042416A1 (en) * 2012-09-13 2014-03-20 주식회사 씨티씨바이오 Oral composition containing dapoxetin-free base
CN115105481A (en) * 2022-07-20 2022-09-27 江西制药有限责任公司 Dapoxetine hydrochloride tablet and preparation method thereof

Also Published As

Publication number Publication date
KR20120068678A (en) 2012-06-27

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