AR071891A1 - Anticuerpos humanos anti-flt3 (receptor tirosina cinasa 3 tipo fms humano) - Google Patents
Anticuerpos humanos anti-flt3 (receptor tirosina cinasa 3 tipo fms humano)Info
- Publication number
- AR071891A1 AR071891A1 ARP090101855A ARP090101855A AR071891A1 AR 071891 A1 AR071891 A1 AR 071891A1 AR P090101855 A ARP090101855 A AR P090101855A AR P090101855 A ARP090101855 A AR P090101855A AR 071891 A1 AR071891 A1 AR 071891A1
- Authority
- AR
- Argentina
- Prior art keywords
- seq
- sequence
- antibody
- thirosine
- kinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Adem s proporciona metodos para tratar leucemia al administrar una cantidad efectiva de un anticuerpo ya sea solo o en combinacion con un agente anti-c ncer o tratamiento que incluye metotrexato. Reivindicacion 1: Un anticuerpo que enlaza espec¡ficamente el FLT3 humano (SEQ ID Ns 43), caracterizado porque comprende un CDRH1 que tiene la secuencia SYYMH (SEQ ID Ns 2), un CDRH2 que tiene la secuencia IINPSGGSTSYAQKFQG (SEQ ID Ns 3), un CDRH3 que tiene la secuencia GVGAHDAFDI (SEQ ID Ns 4) o VVAAAVADY (SEQ ID Ns 5), un CDRL1 que tiene la secuencia RSSQSLLHSNGNNYLD (SEQ ID Ns 6) o RSSQSLLHSNGYNYLD (SEQ ID Ns 7), un CDRL2 que tiene la secuencia LGSNRAS (SEQ ID Ns 8), y un CDRL3 que tiene la secuencia MQGTHPAIS (SEQ ID Ns 9) o MQSLQTPFT (SEQ ID Ns 11). Reivindicacion 8: Un cido polinucleico aislado, caracterizado porque comprende una secuencia de nucleotidos que codifica el anticuerpo o fragmento de conformidad con cualesquiera de las reivindicaciones 1-7. Reivindicacion 12: Una composicion farmaceutica, caracterizada porque comprende un anticuerpo o fragmento de conformidad con las reivindicaciones 1-7 o 11 junto con un portador, diluyente o excipiente farmaceuticamente aceptable.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13039508P | 2008-05-30 | 2008-05-30 | |
US13039408P | 2008-05-30 | 2008-05-30 | |
US13053908P | 2008-05-30 | 2008-05-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR071891A1 true AR071891A1 (es) | 2010-07-21 |
Family
ID=41092183
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090101855A AR071891A1 (es) | 2008-05-30 | 2009-05-22 | Anticuerpos humanos anti-flt3 (receptor tirosina cinasa 3 tipo fms humano) |
Country Status (18)
Country | Link |
---|---|
US (3) | US20090297529A1 (es) |
EP (1) | EP2300500A1 (es) |
JP (1) | JP2011521647A (es) |
KR (1) | KR20110004455A (es) |
CN (1) | CN102046659A (es) |
AR (1) | AR071891A1 (es) |
AU (1) | AU2009260517B2 (es) |
BR (1) | BRPI0912173A2 (es) |
CA (1) | CA2726522A1 (es) |
CL (1) | CL2009001277A1 (es) |
EA (1) | EA201071421A1 (es) |
IL (1) | IL209142A0 (es) |
MX (1) | MX2010013144A (es) |
NZ (1) | NZ588791A (es) |
PE (1) | PE20091963A1 (es) |
TW (1) | TWI374032B (es) |
WO (1) | WO2009155015A1 (es) |
ZA (1) | ZA201008024B (es) |
Families Citing this family (59)
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AR071891A1 (es) * | 2008-05-30 | 2010-07-21 | Imclone Llc | Anticuerpos humanos anti-flt3 (receptor tirosina cinasa 3 tipo fms humano) |
HUE045270T2 (hu) | 2010-01-05 | 2019-12-30 | Inst Nat Sante Rech Med | FLT3 receptor anatgonisták fájdalom rendellenességek kezelésére |
US20130156764A1 (en) * | 2010-03-12 | 2013-06-20 | The Johns Hopkins University | Neutralization of flt3 ligand as a leukemia therapy |
ES2806146T3 (es) * | 2011-09-22 | 2021-02-16 | Amgen Inc | Proteínas de unión al antígeno CD27L |
US20150064203A1 (en) | 2012-03-08 | 2015-03-05 | Japan Science And Technology Agency | Anticancer agent |
EP3593812A3 (en) | 2014-03-15 | 2020-05-27 | Novartis AG | Treatment of cancer using chimeric antigen receptor |
JP2017528433A (ja) | 2014-07-21 | 2017-09-28 | ノバルティス アーゲー | 低い免疫増強用量のmTOR阻害剤とCARの組み合わせ |
WO2016126608A1 (en) | 2015-02-02 | 2016-08-11 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
CN107614010A (zh) * | 2015-03-09 | 2018-01-19 | 艾更斯司股份有限公司 | 结合至flt3蛋白的抗体药物偶联物(adc) |
EP3286211A1 (en) | 2015-04-23 | 2018-02-28 | Novartis AG | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
US11667691B2 (en) | 2015-08-07 | 2023-06-06 | Novartis Ag | Treatment of cancer using chimeric CD3 receptor proteins |
EP3569244A1 (en) * | 2015-09-23 | 2019-11-20 | CytoImmune Therapeutics, LLC | Flt3 directed car cells for immunotherapy |
EP3380620A1 (en) | 2015-11-23 | 2018-10-03 | Novartis AG | Optimized lentiviral transfer vectors and uses thereof |
ES2944597T3 (es) | 2015-12-30 | 2023-06-22 | Novartis Ag | Terapias con células efectoras inmunitarias de eficacia mejorada |
US11549099B2 (en) | 2016-03-23 | 2023-01-10 | Novartis Ag | Cell secreted minibodies and uses thereof |
US11299546B2 (en) * | 2016-05-27 | 2022-04-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | FLT3-specific chimeric antigen receptors and methods using same |
US10111966B2 (en) | 2016-06-17 | 2018-10-30 | Magenta Therapeutics, Inc. | Methods for the depletion of CD117+ cells |
WO2018111340A1 (en) | 2016-12-16 | 2018-06-21 | Novartis Ag | Methods for determining potency and proliferative function of chimeric antigen receptor (car)-t cells |
US11236171B2 (en) | 2016-12-21 | 2022-02-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies specific for FLT3 and uses thereof |
IL268058B2 (en) | 2017-01-20 | 2023-09-01 | Magenta Therapeutics Inc | Compositions and methods for depleting cd137 plus cells |
US11535662B2 (en) | 2017-01-26 | 2022-12-27 | Novartis Ag | CD28 compositions and methods for chimeric antigen receptor therapy |
US20190375815A1 (en) | 2017-01-31 | 2019-12-12 | Novartis Ag | Treatment of cancer using chimeric t cell receptor proteins having multiple specificities |
EP3589647A1 (en) | 2017-02-28 | 2020-01-08 | Novartis AG | Shp inhibitor compositions and uses for chimeric antigen receptor therapy |
US20200171022A1 (en) | 2017-05-17 | 2020-06-04 | Inserm (Institut National De La Santé Et Da La Recherche Médicale) | Flt3 inhibitors for improving pain treatments by opioids |
SG10202108528QA (en) * | 2017-06-02 | 2021-09-29 | Pfizer | Chimeric antigen receptors targeting flt3 |
PE20191846A1 (es) * | 2017-06-02 | 2019-12-31 | Pfizer | Anticuerpos especificos para flt3 y sus usos |
WO2018229715A1 (en) | 2017-06-16 | 2018-12-20 | Novartis Ag | Compositions comprising anti-cd32b antibodies and methods of use thereof |
MA49769A (fr) * | 2017-07-31 | 2021-04-21 | Dragonfly Therapeutics Inc | Protéines se liant à nkg2d, cd16 et flt3 |
EP3700933A1 (en) | 2017-10-25 | 2020-09-02 | Novartis AG | Antibodies targeting cd32b and methods of use thereof |
KR20200069358A (ko) | 2017-10-25 | 2020-06-16 | 노파르티스 아게 | 키메라 항원 수용체 발현 세포의 제조 방법 |
US20210179709A1 (en) | 2017-10-31 | 2021-06-17 | Novartis Ag | Anti-car compositions and methods |
US20210047405A1 (en) | 2018-04-27 | 2021-02-18 | Novartis Ag | Car t cell therapies with enhanced efficacy |
WO2019213282A1 (en) | 2018-05-01 | 2019-11-07 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
EP3801769A1 (en) | 2018-05-25 | 2021-04-14 | Novartis AG | Combination therapy with chimeric antigen receptor (car) therapies |
EP3802825A1 (en) | 2018-06-08 | 2021-04-14 | Intellia Therapeutics, Inc. | Compositions and methods for immunooncology |
AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
JOP20210151A1 (ar) * | 2018-12-18 | 2023-01-30 | Boehringer Ingelheim Io Canada Inc | أجسام مضادة ناهضة لـ flt3 واستخداماتها |
AU2019402189B2 (en) | 2018-12-20 | 2023-04-13 | Novartis Ag | Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
BR112021015783A2 (pt) | 2019-02-15 | 2021-10-05 | Novartis Ag | Derivados de 3-(1-oxo-5-(piperidin-4-il)isoindolin-2-il)piperidina-2,6-diona e usos dos mesmos |
BR112021015672A2 (pt) | 2019-02-15 | 2021-10-05 | Novartis Ag | Derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona substituída e usos dos mesmos |
US20220160771A1 (en) * | 2019-04-10 | 2022-05-26 | Iulia Diaconu | Flt3-specific chimeric antigen receptors and methods of using the same |
SG11202111130SA (en) * | 2019-04-30 | 2021-11-29 | Senti Biosciences Inc | Chimeric receptors and methods of use thereof |
TW202112812A (zh) * | 2019-05-24 | 2021-04-01 | 香港商安立璽榮生醫(香港)有限公司 | Csf1r抗體、il10融合蛋白及其用途 |
US20240132598A1 (en) * | 2019-10-15 | 2024-04-25 | Dragonfly Therapeutics, Inc. | Antibodies targeting flt3 and use thereof |
KR20220116257A (ko) | 2019-12-20 | 2022-08-22 | 노파르티스 아게 | 골수섬유증 및 골수이형성 증후군을 치료하기 위한, 데시타빈 또는 항 pd-1 항체 스파르탈리주맙을 포함하거나 또는 포함하지 않는, 항 tim-3 항체 mbg453 및 항 tgf-베타 항체 nis793의 조합물 |
EP4136114A1 (en) * | 2020-04-14 | 2023-02-22 | Les Laboratoires Servier | Anti-flt3 antibodies and compositions |
IL297236A (en) | 2020-04-17 | 2022-12-01 | Hope City | Cells modified with a flt3-specific chimeric antigen receptor for the treatment of flt3-positive cancers |
US20230174614A1 (en) | 2020-04-30 | 2023-06-08 | Terry J FRY | Multispecific anti-flt3 chimeric antigen receptors |
CA3185455A1 (en) | 2020-06-11 | 2021-12-16 | Novartis Ag | Zbtb32 inhibitors and uses thereof |
CN115916199A (zh) | 2020-06-23 | 2023-04-04 | 诺华股份有限公司 | 包含3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物的给药方案 |
CN111808821B (zh) * | 2020-06-24 | 2022-06-14 | 南方医科大学珠江医院 | Flt3-nkg2d双靶点car-t的构建与制备 |
JP2023536164A (ja) | 2020-08-03 | 2023-08-23 | ノバルティス アーゲー | ヘテロアリール置換3-(1-オキソイソインドリン-2-イル)ピペリジン-2,6-ジオン誘導体及びその使用 |
WO2022104061A1 (en) | 2020-11-13 | 2022-05-19 | Novartis Ag | Combination therapies with chimeric antigen receptor (car)-expressing cells |
TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途 |
TW202309294A (zh) | 2021-04-27 | 2023-03-01 | 瑞士商諾華公司 | 病毒載體生產系統 |
CA3229526A1 (en) * | 2021-08-16 | 2023-02-23 | Hemogenyx Pharmaceuticals Llc | Anti-flt3 antibodies, cars, car t cells and methods of use |
WO2023105087A1 (en) * | 2021-12-10 | 2023-06-15 | Tubulis Gmbh | Novel flt3 antibodies and antibody-drug-conjugates based thereon, therapeutic methods and uses thereof in combination with tyrosine kinase inhibitors |
WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
WO2024089639A1 (en) | 2022-10-26 | 2024-05-02 | Novartis Ag | Lentiviral formulations |
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US5185438A (en) | 1991-04-02 | 1993-02-09 | The Trustees Of Princeton University | Nucleic acids encoding hencatoporetic stem cell receptor flk-2 |
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2009
- 2009-05-22 AR ARP090101855A patent/AR071891A1/es not_active Application Discontinuation
- 2009-05-25 CL CL2009001277A patent/CL2009001277A1/es unknown
- 2009-05-25 PE PE2009000733A patent/PE20091963A1/es not_active Application Discontinuation
- 2009-05-28 EA EA201071421A patent/EA201071421A1/ru unknown
- 2009-05-28 NZ NZ588791A patent/NZ588791A/en not_active IP Right Cessation
- 2009-05-28 JP JP2011511791A patent/JP2011521647A/ja not_active Withdrawn
- 2009-05-28 MX MX2010013144A patent/MX2010013144A/es active IP Right Grant
- 2009-05-28 US US12/473,295 patent/US20090297529A1/en not_active Abandoned
- 2009-05-28 WO PCT/US2009/045365 patent/WO2009155015A1/en active Application Filing
- 2009-05-28 CN CN2009801189357A patent/CN102046659A/zh active Pending
- 2009-05-28 BR BRPI0912173A patent/BRPI0912173A2/pt not_active IP Right Cessation
- 2009-05-28 AU AU2009260517A patent/AU2009260517B2/en not_active Expired - Fee Related
- 2009-05-28 CA CA2726522A patent/CA2726522A1/en not_active Abandoned
- 2009-05-28 KR KR1020107026790A patent/KR20110004455A/ko not_active Application Discontinuation
- 2009-05-28 US US12/994,956 patent/US20110091470A1/en not_active Abandoned
- 2009-05-28 EP EP09767327A patent/EP2300500A1/en not_active Ceased
- 2009-06-01 TW TW098118092A patent/TWI374032B/zh not_active IP Right Cessation
-
2010
- 2010-09-27 US US12/890,793 patent/US8071099B2/en not_active Expired - Fee Related
- 2010-11-04 IL IL209142A patent/IL209142A0/en unknown
- 2010-11-09 ZA ZA2010/08024A patent/ZA201008024B/en unknown
Also Published As
Publication number | Publication date |
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KR20110004455A (ko) | 2011-01-13 |
US20110091470A1 (en) | 2011-04-21 |
TWI374032B (en) | 2012-10-11 |
BRPI0912173A2 (pt) | 2016-07-26 |
CN102046659A (zh) | 2011-05-04 |
CA2726522A1 (en) | 2009-12-23 |
US8071099B2 (en) | 2011-12-06 |
ZA201008024B (en) | 2012-04-25 |
CL2009001277A1 (es) | 2010-10-08 |
JP2011521647A (ja) | 2011-07-28 |
US20110008355A1 (en) | 2011-01-13 |
NZ588791A (en) | 2012-05-25 |
TW201010722A (en) | 2010-03-16 |
EP2300500A1 (en) | 2011-03-30 |
US20090297529A1 (en) | 2009-12-03 |
EA201071421A1 (ru) | 2011-08-30 |
IL209142A0 (en) | 2011-01-31 |
AU2009260517B2 (en) | 2012-12-06 |
AU2009260517A1 (en) | 2009-12-23 |
PE20091963A1 (es) | 2010-01-15 |
WO2009155015A1 (en) | 2009-12-23 |
MX2010013144A (es) | 2010-12-21 |
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