AR063028A1 - Derivados heterociclicos de piridin-2-carboxamida activadores de glucoquinasas, utiles para el tratamiento de diabetes y obesidad y composiciones farmaceuticas que los contienen. - Google Patents

Derivados heterociclicos de piridin-2-carboxamida activadores de glucoquinasas, utiles para el tratamiento de diabetes y obesidad y composiciones farmaceuticas que los contienen.

Info

Publication number
AR063028A1
AR063028A1 ARP070104280A ARP070104280A AR063028A1 AR 063028 A1 AR063028 A1 AR 063028A1 AR P070104280 A ARP070104280 A AR P070104280A AR P070104280 A ARP070104280 A AR P070104280A AR 063028 A1 AR063028 A1 AR 063028A1
Authority
AR
Argentina
Prior art keywords
lower alkyl
alkyl group
aliphatic ring
piridin
carboxamide
Prior art date
Application number
ARP070104280A
Other languages
English (en)
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Publication of AR063028A1 publication Critical patent/AR063028A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Reivindicacion 1: Un compuesto representado por la formula (1): o una sal farmacéuticamente aceptable del mismo en la que: R1 y R2 son independientemente cada uno un grupo alquilo inferior; X1 representa una formula (II-I) en la que R11 y R12 son independientemente cada uno un átomo de hidrogeno o un grupo alquilo inferior; R11 y R12 y un átomo de nitrogeno forman conjuntamente un anillo alifático con nitrogeno de 4 a 7 miembros; uno cualquiera de los átomos de carbono de (CH2)m y R11 o R12 forman conjuntamente un anillo alifático con nitrogeno de 4 a 7 miembros; estando sustituido dicho anillo alifático de 4 a 7 miembros con un grupo oxo; estando anadido un átomo de oxígeno a dicho átomo de nitrogeno al que se unen tanto R11 como R12; estando sustituido dicho uno cualquiera de los átomos de carbono de (CH2)m con un grupo alquilo inferior; m representa un entero de 1 a 3; o una formula (II-2): en la que R21 y R22 representan independientemente cada uno un átomo de hidrogeno o un grupo alquilo inferior; o R21, R22 y un átomo de nitrogeno pueden formar conjuntamente un anillo alifático de 4 a 7 miembros; estando sustituido dicho anillo alifático de 4 a 7 miembros con un grupo oxo; estando sustituido uno cualquiera de los átomos de carbono de (CH2)q con un grupo alquilo inferior; q es un enero de 0 o 1.
ARP070104280A 2006-10-06 2007-09-27 Derivados heterociclicos de piridin-2-carboxamida activadores de glucoquinasas, utiles para el tratamiento de diabetes y obesidad y composiciones farmaceuticas que los contienen. AR063028A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2006275824 2006-10-06

Publications (1)

Publication Number Publication Date
AR063028A1 true AR063028A1 (es) 2008-12-23

Family

ID=39282963

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070104280A AR063028A1 (es) 2006-10-06 2007-09-27 Derivados heterociclicos de piridin-2-carboxamida activadores de glucoquinasas, utiles para el tratamiento de diabetes y obesidad y composiciones farmaceuticas que los contienen.

Country Status (22)

Country Link
US (1) US8338460B2 (es)
EP (1) EP2077266B1 (es)
JP (1) JP5292100B2 (es)
KR (1) KR20090060426A (es)
CN (1) CN101522673A (es)
AR (1) AR063028A1 (es)
AU (1) AU2007307560B2 (es)
BR (1) BRPI0716590A2 (es)
CA (1) CA2667068C (es)
CL (1) CL2007002890A1 (es)
CO (1) CO6180507A2 (es)
CR (1) CR10673A (es)
GT (1) GT200900065A (es)
IL (1) IL197714A0 (es)
MA (1) MA30813B1 (es)
MX (1) MX2009003073A (es)
NO (1) NO20091793L (es)
PE (1) PE20081195A1 (es)
RU (1) RU2009117209A (es)
SV (1) SV2009003196A (es)
TW (1) TW200831504A (es)
WO (1) WO2008044777A1 (es)

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NZ540791A (en) * 2003-02-13 2009-09-25 Banyu Pharma Co Ltd Novel 2-pyridinecarboxamide derivatives
AR063028A1 (es) 2006-10-06 2008-12-23 Banyu Pharma Co Ltd Derivados heterociclicos de piridin-2-carboxamida activadores de glucoquinasas, utiles para el tratamiento de diabetes y obesidad y composiciones farmaceuticas que los contienen.
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AU2008321959B2 (en) 2007-11-12 2014-02-13 Msd K.K. Heteroaryloxy quinazoline derivative
AU2009280579A1 (en) 2008-08-15 2010-02-18 Banyu Pharmaceutical Co.,Ltd. Acetyl pyrrolidinyl indole derivative
CA2734981A1 (en) * 2008-08-29 2010-03-04 Banyu Pharmaceutical Co., Ltd. Oxotetrahydrofuran-2-yl-benzimidazole derivative
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2931718B1 (en) * 2012-12-17 2019-01-16 Merck Sharp & Dohme Corp. Novel 2-pyridinecarboxamide derivatives, compositions containing such compounds, and methods of treatment
CN113045546A (zh) * 2021-03-25 2021-06-29 浙江天宇药业股份有限公司 一种吡咯替尼杂质、其制备方法及用途

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Also Published As

Publication number Publication date
RU2009117209A (ru) 2010-11-20
TW200831504A (en) 2008-08-01
CA2667068A1 (en) 2008-04-17
AU2007307560B2 (en) 2012-10-04
NO20091793L (no) 2009-05-05
CR10673A (es) 2009-09-03
MX2009003073A (es) 2009-04-02
US8338460B2 (en) 2012-12-25
CO6180507A2 (es) 2010-07-19
AU2007307560A1 (en) 2008-04-17
CL2007002890A1 (es) 2008-01-18
BRPI0716590A2 (pt) 2012-12-25
JPWO2008044777A1 (ja) 2010-02-18
EP2077266B1 (en) 2012-07-25
KR20090060426A (ko) 2009-06-12
JP5292100B2 (ja) 2013-09-18
WO2008044777A1 (en) 2008-04-17
EP2077266A1 (en) 2009-07-08
CN101522673A (zh) 2009-09-02
SV2009003196A (es) 2009-07-28
PE20081195A1 (es) 2008-09-04
GT200900065A (es) 2010-04-28
IL197714A0 (en) 2009-12-24
MA30813B1 (fr) 2009-10-01
EP2077266A4 (en) 2010-07-07
CA2667068C (en) 2012-03-27
US20080090799A1 (en) 2008-04-17

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