AR060352A1 - SALTS OF 8- [(1- (3,5-BIS- (TRIFLUOROMETIL) PHENYL) -ETOXI) -METIL] -8-PHENYL-1,7 -DIAZA- ESPIRO [4.5] DECAN -2-ONA AND PREPARATION PROCESS FROM THE SAME - Google Patents

SALTS OF 8- [(1- (3,5-BIS- (TRIFLUOROMETIL) PHENYL) -ETOXI) -METIL] -8-PHENYL-1,7 -DIAZA- ESPIRO [4.5] DECAN -2-ONA AND PREPARATION PROCESS FROM THE SAME

Info

Publication number
AR060352A1
AR060352A1 ARP070101435A ARP070101435A AR060352A1 AR 060352 A1 AR060352 A1 AR 060352A1 AR P070101435 A ARP070101435 A AR P070101435A AR P070101435 A ARP070101435 A AR P070101435A AR 060352 A1 AR060352 A1 AR 060352A1
Authority
AR
Argentina
Prior art keywords
phenyl
decan
diaza
bis
espiro
Prior art date
Application number
ARP070101435A
Other languages
Spanish (es)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AR060352A1 publication Critical patent/AR060352A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Una forma de la sal cristalina de esilato de (5S,8S)-8-[{(1R)-1-(3,5-Bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-espiro[4.5]decan-2-ona de formula 1; la cual se caracteriza por el siguiente patron de difraccion de rayos X sobre muestras de polvo expresado en términos del ángulo de difraccion (en 2 Q, espaciado ôdö de retícula (en angstroms) e intensidades de pico relativo (Rl): Ángulo de difraccion (2Q Rl Espacio de retícula (L +- 0.04) 11.4 Medias 7.73 12.8 Medias 6.90 20.0 Medias 4.44 21.2 Medias 18A form of the crystalline salt of (5S, 8S) -8 - [{(1R) -1- (3,5-Bis- (trifluoromethyl) phenyl) -ethoxy} -methyl] -8-phenyl-1, 7-diaza-spiro [4.5] decan-2-one of formula 1; which is characterized by the following pattern of diffraction of X-rays on samples of dust expressed in terms of the angle of diffraction (in 2 Q, spacing ôdö of reticulum (in angstroms) and intensities of relative peak (Rl): Angle of diffraction ( 2Q Rl Grid space (L + - 0.04) 11.4 Averages 7.73 12.8 Averages 6.90 20.0 Averages 4.44 21.2 Averages 18

ARP070101435A 2006-04-05 2007-04-04 SALTS OF 8- [(1- (3,5-BIS- (TRIFLUOROMETIL) PHENYL) -ETOXI) -METIL] -8-PHENYL-1,7 -DIAZA- ESPIRO [4.5] DECAN -2-ONA AND PREPARATION PROCESS FROM THE SAME AR060352A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78951306P 2006-04-05 2006-04-05

Publications (1)

Publication Number Publication Date
AR060352A1 true AR060352A1 (en) 2008-06-11

Family

ID=38470135

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070101435A AR060352A1 (en) 2006-04-05 2007-04-04 SALTS OF 8- [(1- (3,5-BIS- (TRIFLUOROMETIL) PHENYL) -ETOXI) -METIL] -8-PHENYL-1,7 -DIAZA- ESPIRO [4.5] DECAN -2-ONA AND PREPARATION PROCESS FROM THE SAME

Country Status (5)

Country Link
AR (1) AR060352A1 (en)
CL (1) CL2007000947A1 (en)
PE (1) PE20080353A1 (en)
TW (1) TW200806666A (en)
WO (1) WO2007114922A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2584838T3 (en) 2006-04-05 2016-09-29 Opko Health, Inc Salt of 8 - [{1- (3,5-bis- (trifluoromethyl) phenyl) -ethoxy} -methyl] -8-phenyl-1,7-diaza-spiro [4.5] decan-2-one and process of preparation of it
AR066191A1 (en) 2007-03-22 2009-08-05 Schering Corp PROCESS AND INTERMEDIARIES FOR THE SYNTHESIS OF COMPOUNDS 8- [(1- (3,5- BIS- (TRIFLUOROMETIL) PHENYL) - ETOXI) - METAL] - 8 PHENYL - 1,7- DIAZA - ESPIRO (4, 5) DECAN - 2 ONA
JP5736313B2 (en) 2008-09-05 2015-06-17 オプコ ヘルス， インコーポレイテッド 8-[{1- (3,5-bis- (trifluoromethyl) phenyl) -ethoxy} -methyl] -8-phenyl-1,7-diaza-spiro [4.5] decan-2-one Processes and intermediates for synthesis
CN105017251B (en) * 2015-06-30 2018-06-29 齐鲁制药有限公司 A kind of Preparation Method And Their Intermediate of nk 1 receptor antagonist

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20030762A1 (en) * 2001-12-18 2003-09-05 Schering Corp HETEROCYCLIC COMPOUNDS AS NK1 ANTAGONISTS
JP2007515425A (en) * 2003-12-22 2007-06-14 シェーリング　コーポレイション Pharmaceutical composition

Also Published As

Publication number Publication date
WO2007114922A3 (en) 2008-01-17
WO2007114922A2 (en) 2007-10-11
PE20080353A1 (en) 2008-04-25
TW200806666A (en) 2008-02-01
CL2007000947A1 (en) 2008-01-25

Similar Documents

Publication Publication Date Title
AR060353A1 (en) HYDROCLORIDE SALTS OF 8 - [(1- (3,5 -BIS- (TRIFLUOROMETIL) PHENYL) -ETOXI) -METIL] -8-FENIL-1,7 -DIAZA- SPIRO [4.5] DECAN -2-ONA. PHARMACEUTICAL COMPOSITIONS
USD652626S1 (en) Brush head for electric toothbrush
AR060352A1 (en) SALTS OF 8- [(1- (3,5-BIS- (TRIFLUOROMETIL) PHENYL) -ETOXI) -METIL] -8-PHENYL-1,7 -DIAZA- ESPIRO [4.5] DECAN -2-ONA AND PREPARATION PROCESS FROM THE SAME
USD658883S1 (en) Toothbrush handle
AR121612A2 (en) GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
USD790862S1 (en) Toothbrush
USD621160S1 (en) Toothbrush handle
MX2009010210A (en) Tablet formulations containing 8-[{1-(3,5-bis-(trifluoromethyl)ph enyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one salts and tablets made therefrom.
SI1924585T1 (en) NOVEL CRYSTALLINE FORM OF A PYRIDAZINO ?á4 , 5-B?å INDOLE DERIVATIVE
EA201000250A1 (en) NEW SALT BASEDOXYPHENE
NO20083267L (en) Azaindole inhibitors of aurora kinases
USD632085S1 (en) Toilet brush
USD671116S1 (en) Media gateway, server and storage device
MX2014000452A (en) Azabenzimidazole derivative having ampk-activating activity.
EA201290397A1 (en) 1,3,4-OXADIAZOL-2-CARBOXAMIDE COMPOUND
USD586060S1 (en) Paint brush holder
EA200702039A1 (en) 7-NATIONAL CONSUMPTIONAL CONSULTANCY HOUSEHOLD MEMBERSHIP
USD614241S1 (en) Tag holder without sell by track
IL217557A (en) 1-oxa-4,9-diazaspiro[5.5]undec-4-yl(1,3-thiazole-4-yl)methanone derivatives and salts thereof
USD584512S1 (en) Combination toothbrush/toothpaste dispenser
DOP2011000154A (en) 3-AMINOCICLOPENTANCARBOXAMIDAS
USD625106S1 (en) Toothbrush
WO2009063991A1 (en) Pyridooxazepine derivative and use thereof
USD640289S1 (en) Disc of rotary mower
ITTO20050284A1 (en) LOCKING GROUP FOR A SECURITY DOOR.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal