AR047460A1 - PROCESS FOR THE MANUFACTURE OF 2-METHYL-4- (4-METHYL-1-PIPERAZINYL) ACETATE -10H-TIENO [2,3-B] [1,5] BENZODIAZEPIN (OLANZAPINE ACETATE) - Google Patents

PROCESS FOR THE MANUFACTURE OF 2-METHYL-4- (4-METHYL-1-PIPERAZINYL) ACETATE -10H-TIENO [2,3-B] [1,5] BENZODIAZEPIN (OLANZAPINE ACETATE)

Info

Publication number
AR047460A1
AR047460A1 ARP050100259A ARP050100259A AR047460A1 AR 047460 A1 AR047460 A1 AR 047460A1 AR P050100259 A ARP050100259 A AR P050100259A AR P050100259 A ARP050100259 A AR P050100259A AR 047460 A1 AR047460 A1 AR 047460A1
Authority
AR
Argentina
Prior art keywords
acetate
methyl
olanzapine
tieno
benzodiazepin
Prior art date
Application number
ARP050100259A
Other languages
Spanish (es)
Inventor
Rolf Keltjens
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Bv filed Critical Synthon Bv
Publication of AR047460A1 publication Critical patent/AR047460A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Reivindicacion 1: Una sal e olanzapina caracterizado porque es un acetato de olanzapina. Reivindicacion 3: Un proceso para preparar el compuesto de acuerdo con la reivindicacion 1 o 2 en forma solida, caracterizado porque comprende poner en contacto una fuente de olanzapina con ácido acético en un solvente, y precipitar el acetato de olanzapina de dicho solvente.Claim 1: An olanzapine salt characterized in that it is an olanzapine acetate. Claim 3: A process for preparing the compound according to claim 1 or 2 in solid form, characterized in that it comprises contacting a source of olanzapine with acetic acid in a solvent, and precipitating olanzapine acetate from said solvent.

ARP050100259A 2004-01-27 2005-01-26 PROCESS FOR THE MANUFACTURE OF 2-METHYL-4- (4-METHYL-1-PIPERAZINYL) ACETATE -10H-TIENO [2,3-B] [1,5] BENZODIAZEPIN (OLANZAPINE ACETATE) AR047460A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53912004P 2004-01-27 2004-01-27
US56222504P 2004-04-15 2004-04-15
US56960704P 2004-05-11 2004-05-11

Publications (1)

Publication Number Publication Date
AR047460A1 true AR047460A1 (en) 2006-01-18

Family

ID=34812083

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP050100260A AR047461A1 (en) 2004-01-27 2005-01-26 TRAINING, PURIFICATION AND USE OF N-FORMILOLANZAPINE
ARP050100259A AR047460A1 (en) 2004-01-27 2005-01-26 PROCESS FOR THE MANUFACTURE OF 2-METHYL-4- (4-METHYL-1-PIPERAZINYL) ACETATE -10H-TIENO [2,3-B] [1,5] BENZODIAZEPIN (OLANZAPINE ACETATE)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP050100260A AR047461A1 (en) 2004-01-27 2005-01-26 TRAINING, PURIFICATION AND USE OF N-FORMILOLANZAPINE

Country Status (3)

Country Link
EP (2) EP1720885A1 (en)
AR (2) AR047461A1 (en)
WO (2) WO2005070939A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI21850A (en) * 2004-07-28 2006-02-28 Krka, Tovarna Zdravil, D.D., Novo Mesto Salts of olanzapin and their transformation into free base of olanzapin
PL377084A1 (en) * 2005-09-15 2007-03-19 Koźluk Tomasz Nobilus Ent New olanzapine compounds and method for their manufacture
WO2007096895A1 (en) * 2006-02-27 2007-08-30 Lee Pharma Limited Preparation of anhydrous olanzapine of form-1
JP6085900B2 (en) * 2012-04-02 2017-03-01 大日本印刷株式会社 Olanzapine production method

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU629879A3 (en) * 1974-11-26 1978-10-25 Лилли Индастриз Лимитед, (Фирма) Method of obtaining thieno(1,5)-benzodiazepines or salts thereof
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
US5631250A (en) * 1995-03-24 1997-05-20 Eli Lilly And Company Process and solvate of 2-methyl-thieno-benzodiazepine
AU9583498A (en) * 1997-09-30 1999-04-23 Eli Lilly And Company Method for treating sexual dysfunction
CA2395774C (en) * 1999-12-28 2009-09-15 Cipla Limited New polymorphic forms of olanzapine
CZ2003566A3 (en) * 2000-08-31 2004-01-14 Dr. Reddy's Laboratories Ltd. Process for preparing olanzapin hydrates and their conversion to olanzapin crystal forms
CA2471341C (en) * 2001-12-24 2012-01-24 Sun Pharmaceutical Industries Limited Crystalline form i of 2-methyl-4-(4-methyl-1-piperazinyl) 10h thieno [2,3-b][1,5]benzodiazepine
PL196814B1 (en) * 2002-05-17 2008-02-29 Inst Farmaceutyczny Method of obtaining polymorphous form of i olansapine
US7297789B2 (en) * 2002-05-31 2007-11-20 Sandoz, Inc. Process of preparation of olanzapine form I
PL199016B1 (en) * 2002-06-20 2008-08-29 Adamed Sp Z Oo Method of manufacture of alanzapine, new derivative of n-demethyl olanzapine and method of manufacture of new derivative of n-demethyl olanzapine
SI21270A (en) * 2002-07-15 2004-02-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Crystal forms of olanzapine and procedures for their preparation

Also Published As

Publication number Publication date
AR047461A1 (en) 2006-01-18
WO2005070939A1 (en) 2005-08-04
EP1720885A1 (en) 2006-11-15
WO2005070937A1 (en) 2005-08-04
EP1711503A1 (en) 2006-10-18

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