AR046076A1 - PROCEDURE FOR OBTAINING A HOMOGENOUS POPULATION OF OLIGODENDROCIT PRECURSOR CELLS AND OBTAINED POPULATION - Google Patents
PROCEDURE FOR OBTAINING A HOMOGENOUS POPULATION OF OLIGODENDROCIT PRECURSOR CELLS AND OBTAINED POPULATIONInfo
- Publication number
- AR046076A1 AR046076A1 ARP040102543A ARP040102543A AR046076A1 AR 046076 A1 AR046076 A1 AR 046076A1 AR P040102543 A ARP040102543 A AR P040102543A AR P040102543 A ARP040102543 A AR P040102543A AR 046076 A1 AR046076 A1 AR 046076A1
- Authority
- AR
- Argentina
- Prior art keywords
- precursor cells
- population
- oligodendrocyte precursor
- obtaining
- procedures
- Prior art date
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A61P39/02—Antidotes
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
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Abstract
Población fenotípicamente homogénea autorenovante de células precursoras de oligodendrocitos con estado de desarrollo sincronizado y procedimientos para obtener una población fenotípicamente homogénea autorenovante de células precursoras de oligodendrocitos. Otros procedimientos incluyen procedimientos para mantener y almacenar una población homogénea de células precursoras de oligodendrocitos durante períodos prolongados sin cambio en las características de las células y procedimientos para diferenciar células precursoras de oligodendrocitos. La población fenotípicamente homogénea autorenovante de células precursoras de oligodendrocitos o población homogénea de oligodendrocitos pueden ser útil para tratar a un paciente que tiene un desorden o condición del sistema nervioso central. Reivindicación 1: Procedimiento para obtener una población homogénea de células precursoras de oligodendrocitos que tienen un estado de desarrollo sincronizado, caracterizado porque comprende cultivar una población heterogénea de células precursoras de oligodendrocitos que tienen un estado de desarrollo no sincronizado, en un medio que comprende una cantidad de factor de crecimiento de fibroblasto (FGF) eficaz para inducir una etapa sincronizada de desarrollo y en donde dicho cultivo se lleva a cabo en ausencia sustancial de factor de crecimiento derivado de plaquetas (FCDP), obteniendo así dicha población homogénea de células precursoras de oligodendrocitos que tienen un estado de desarrollo sincronizado.Phenotypically homogenous self-renewing population of oligodendrocyte precursor cells with synchronized development status and procedures to obtain a phenotypically homogeneous autorenovating population of oligodendrocyte precursor cells. Other procedures include procedures for maintaining and storing a homogeneous population of oligodendrocyte precursor cells for prolonged periods without change in cell characteristics and procedures for differentiating oligodendrocyte precursor cells. The phenotypically homogenous self-renewing population of oligodendrocyte precursor cells or homogeneous population of oligodendrocytes may be useful for treating a patient who has a disorder or condition of the central nervous system. Claim 1: Method for obtaining a homogeneous population of oligodendrocyte precursor cells that have a synchronized development state, characterized in that it comprises culturing a heterogeneous population of oligodendrocyte precursor cells that have a non-synchronized development state, in a medium comprising an amount of fibroblast growth factor (FGF) effective to induce a synchronized stage of development and wherein said culture is carried out in substantial absence of platelet-derived growth factor (FCDP), thereby obtaining said homogeneous population of oligodendrocyte precursor cells They have a synchronized development status.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48793303P | 2003-07-18 | 2003-07-18 |
Publications (1)
Publication Number | Publication Date |
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AR046076A1 true AR046076A1 (en) | 2005-11-23 |
Family
ID=34079394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040102543A AR046076A1 (en) | 2003-07-18 | 2004-07-16 | PROCEDURE FOR OBTAINING A HOMOGENOUS POPULATION OF OLIGODENDROCIT PRECURSOR CELLS AND OBTAINED POPULATION |
Country Status (13)
Country | Link |
---|---|
US (1) | US20060172415A1 (en) |
EP (1) | EP1646711A4 (en) |
JP (1) | JP2007530001A (en) |
KR (1) | KR20060037346A (en) |
CN (1) | CN1833021A (en) |
AR (1) | AR046076A1 (en) |
AU (1) | AU2004257000B2 (en) |
BR (1) | BRPI0412715A (en) |
CA (1) | CA2532216A1 (en) |
MX (1) | MXPA05014161A (en) |
SG (1) | SG144166A1 (en) |
TW (1) | TW200510537A (en) |
WO (1) | WO2005007797A2 (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2597611A1 (en) * | 2005-02-11 | 2006-08-17 | Elan Pharmaceuticals, Inc. | Methods of identifying genes which modulate myelination |
DK1904113T3 (en) * | 2005-06-23 | 2016-03-21 | Tissuegene Inc | NEURO PROTECTIVE EFFECTIVE CONNECTION |
ES2323913B1 (en) * | 2006-03-17 | 2010-05-14 | Universidad De Salamanca (Titular Al 65%) | SONIC HEDGEHOG MITOGENOUS EFFECT (SHH) ON OLIGODENDROCIT PRECURSORS AND ITS USE IN DEMIELINIZING DISEASES. |
JP5703028B2 (en) | 2008-01-30 | 2015-04-15 | アステリアス バイオセラピューティクス インコーポレイテッド | Synthetic surface for culturing stem cell-derived oligodendrocyte progenitor cells |
CA2712891A1 (en) | 2008-01-30 | 2009-08-06 | Corning Incorporated | Synthetic surfaces for culturing stem cell derived cardiomyocytes |
EP2247716B1 (en) * | 2008-01-30 | 2012-04-25 | Geron Corporation | Synthetic surfaces for culturing cells in chemically defined media |
EP2355826A1 (en) * | 2008-11-07 | 2011-08-17 | The Cleveland Clinic Foundation | Compounds and methods of promoting oligodendrocyte precursor differentiation |
US10351823B2 (en) * | 2009-11-12 | 2019-07-16 | Q Therapeutics, Inc. | Methods and compositions for expanding, identifying, characterizing and enhancing potency of mammalian-derived glial restricted progenitor cells |
CN101735983B (en) * | 2009-12-29 | 2011-07-27 | 中国人民解放军第三军医大学 | Method for separating and purifying oligodendrocyte precursor cells |
ES2375860B8 (en) * | 2010-03-31 | 2013-06-10 | Fundación Hospital Nacional De Parapléjicos Para La Investigación Y La Integración (Fuhnpaiin) | METHOD FOR OBTAINING OLIGODENDROCIT PRECURSOR CELLS. |
WO2013021381A1 (en) * | 2011-08-07 | 2013-02-14 | Kadimastem Ltd. | Method of identifying agents that affect maturation, survival and myelination |
KR101409336B1 (en) | 2012-02-15 | 2014-06-27 | 중앙대학교 산학협력단 | Composition for Treating Central Nervous System Disease Comprising Oligodendrocyte Progenitor As Active Ingredient |
WO2013144999A1 (en) * | 2012-03-27 | 2013-10-03 | Okinawa Institute of Science and Technology Graduate University | Neuronal culture medium and method for producing in vivo-like and enhanced synaptogenesis neuron model |
JP6363096B2 (en) * | 2012-12-19 | 2018-07-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Micropillar array for assaying myelin formation |
CN103388007B (en) * | 2013-07-25 | 2016-08-24 | 宗兆文 | A kind of method that mescenchymal stem cell utilizing corium to originate prepares tissue engineering spinal cord |
JP6844953B2 (en) * | 2015-04-22 | 2021-03-17 | 公益財団法人東京都医学総合研究所 | Glial cell system targeting Alzheimer's disease research |
CN105062956B (en) * | 2015-08-21 | 2018-02-09 | 北京市虹天济神经科学研究院 | People's olfactory mucosa Olfactory essheathing cell is separated, passed on, freezing, differentiation technique |
CN105695409B (en) * | 2016-03-22 | 2019-09-27 | 中国人民解放军第二军医大学 | A kind of naked mole oligodendrocyte precursor cells cultural method |
WO2017173064A1 (en) | 2016-03-30 | 2017-10-05 | Asterias Biotherapeutics, Inc. | Oligodendrocyte progenitor cell compositions |
US20190262405A1 (en) * | 2016-09-14 | 2019-08-29 | Asterias Biotherapeutics, Inc. | Pluripotent stem cell-derived oligodendrocyte progenitor cells for the treatment of spinal cord injury |
CN109722418B (en) * | 2017-10-29 | 2023-01-03 | 复旦大学 | Method for obtaining and purifying oligodendrocyte precursor cells of newborn mice |
CN108624560B (en) * | 2018-06-01 | 2022-04-08 | 南京艾尔普再生医学科技有限公司 | Differentiation culture medium and preparation method of oligodendrocyte precursor cells |
CN113481161A (en) * | 2021-07-30 | 2021-10-08 | 四川省医学科学院·四川省人民医院 | Culture medium, and induction culture method and application of oligodendrocyte progenitor cells |
CN115340982A (en) * | 2022-08-23 | 2022-11-15 | 徐州医科大学 | Method for separating and purifying oligodendrocyte precursor cells in cortical region of newborn mouse |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5753506A (en) * | 1996-05-23 | 1998-05-19 | Cns Stem Cell Technology, Inc. | Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals |
US6361996B1 (en) * | 1997-05-07 | 2002-03-26 | University Of Utah Research Foundation | Neuroepithelial stem cells and glial-restricted intermediate precursors |
US6235527B1 (en) * | 1997-11-29 | 2001-05-22 | University Of Utah Research Foundation | Lineage restricted glial precursors from the central nervous system |
US6576464B2 (en) * | 2000-11-27 | 2003-06-10 | Geron Corporation | Methods for providing differentiated stem cells |
US20040029269A1 (en) * | 2002-05-07 | 2004-02-12 | Goldman Steven A | Promoter-based isolation, purification, expansion, and transplantation of neuronal progenitor cells, oligodendrocyte progenitor cells, or neural stem cells from a population of embryonic stem cells |
US7285415B2 (en) * | 2002-07-11 | 2007-10-23 | The Regents Of The University Of California | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
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2004
- 2004-07-16 AR ARP040102543A patent/AR046076A1/en unknown
- 2004-07-19 EP EP04744291A patent/EP1646711A4/en not_active Withdrawn
- 2004-07-19 TW TW093121529A patent/TW200510537A/en unknown
- 2004-07-19 US US10/564,819 patent/US20060172415A1/en not_active Abandoned
- 2004-07-19 BR BRPI0412715-3A patent/BRPI0412715A/en not_active IP Right Cessation
- 2004-07-19 AU AU2004257000A patent/AU2004257000B2/en not_active Expired - Fee Related
- 2004-07-19 WO PCT/IB2004/002670 patent/WO2005007797A2/en active Application Filing
- 2004-07-19 CA CA002532216A patent/CA2532216A1/en not_active Abandoned
- 2004-07-19 KR KR1020067000833A patent/KR20060037346A/en not_active Application Discontinuation
- 2004-07-19 SG SG200804940-5A patent/SG144166A1/en unknown
- 2004-07-19 CN CNA2004800193757A patent/CN1833021A/en active Pending
- 2004-07-19 MX MXPA05014161A patent/MXPA05014161A/en active IP Right Grant
- 2004-07-19 JP JP2006520045A patent/JP2007530001A/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP1646711A2 (en) | 2006-04-19 |
MXPA05014161A (en) | 2006-05-25 |
JP2007530001A (en) | 2007-11-01 |
CA2532216A1 (en) | 2005-01-27 |
WO2005007797A3 (en) | 2006-05-11 |
EP1646711A4 (en) | 2008-03-19 |
WO2005007797A2 (en) | 2005-01-27 |
BRPI0412715A (en) | 2006-09-26 |
US20060172415A1 (en) | 2006-08-03 |
SG144166A1 (en) | 2008-07-29 |
KR20060037346A (en) | 2006-05-03 |
AU2004257000B2 (en) | 2011-07-21 |
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