AR039768A1 - ONCOLITICAL VIRUSES AS AGENTS FOR THE DETERMINATION OF THE NEOPLASM PHENOTYPE - Google Patents
ONCOLITICAL VIRUSES AS AGENTS FOR THE DETERMINATION OF THE NEOPLASM PHENOTYPEInfo
- Publication number
- AR039768A1 AR039768A1 ARP030102317A ARP030102317A AR039768A1 AR 039768 A1 AR039768 A1 AR 039768A1 AR P030102317 A ARP030102317 A AR P030102317A AR P030102317 A ARP030102317 A AR P030102317A AR 039768 A1 AR039768 A1 AR 039768A1
- Authority
- AR
- Argentina
- Prior art keywords
- tumors
- phenotype
- viruses
- oncolitical
- neoplasm
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/14—Reoviridae, e.g. rotavirus, bluetongue virus, Colorado tick fever virus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Hospice & Palliative Care (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Método de diagnóstico de neoplasmas que presentan un fenotipo particular que comprende el uso de virus oncolíticos que se replican selectivamente en neoplasmas de un fenotipo particular. Por ejemplo, los reovirus no se replican en células normales. Sin embargo, los reovirus se replican selectivamente en células con una vía del ras activada, lo cual conduce a la muerte de estas células. Por ello, una célula que se vuelve neoplásica debido, al menoas en parte, a actividades elevadas de la vía del ras puede ser diagnosticada por su susceptibilidad a la replicación del reovirus. Se puede aplicar además, con el uso de otros virus oncolíticos, en el diagnóstico y/o tratamiento de otros tumores, tal como tumores sensibles a interferón, tumores deficientes en p53 y tumores deficientes en RB. También se proveen conjuntos de elementos (Kits) de utilidad en el diagnóstico o tratamiento según la invención.Method of diagnosing neoplasms that have a particular phenotype that includes the use of oncolytic viruses that selectively replicate in neoplasms of a particular phenotype. For example, reoviruses do not replicate in normal cells. However, reoviruses selectively replicate in cells with an activated ras pathway, which leads to the death of these cells. Therefore, a cell that becomes neoplastic due, in part, to elevated activities of the flush pathway can be diagnosed by its susceptibility to reovirus replication. It can also be applied, with the use of other oncolytic viruses, in the diagnosis and / or treatment of other tumors, such as interferon-sensitive tumors, p53-deficient tumors and RB-deficient tumors. Sets of elements (Kits) useful in the diagnosis or treatment according to the invention are also provided.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39203102P | 2002-06-28 | 2002-06-28 | |
| US44318803P | 2003-01-29 | 2003-01-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR039768A1 true AR039768A1 (en) | 2005-03-09 |
Family
ID=30003222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030102317A AR039768A1 (en) | 2002-06-28 | 2003-06-26 | ONCOLITICAL VIRUSES AS AGENTS FOR THE DETERMINATION OF THE NEOPLASM PHENOTYPE |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US7306902B2 (en) |
| EP (2) | EP1520175B1 (en) |
| JP (1) | JP2005531306A (en) |
| CN (1) | CN1666105B (en) |
| AR (1) | AR039768A1 (en) |
| AT (2) | ATE377754T1 (en) |
| AU (2) | AU2003245760B2 (en) |
| BR (1) | BR0311983A (en) |
| CA (1) | CA2487824C (en) |
| DE (1) | DE60317331T2 (en) |
| DK (2) | DK1890151T3 (en) |
| ES (2) | ES2385845T3 (en) |
| HK (2) | HK1069877A1 (en) |
| IL (2) | IL165498A0 (en) |
| MX (1) | MXPA04012414A (en) |
| NZ (1) | NZ537116A (en) |
| PT (1) | PT1890151E (en) |
| SI (1) | SI1890151T1 (en) |
| TW (3) | TWI402345B (en) |
| WO (1) | WO2004003562A2 (en) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ425699A0 (en) | 1999-11-25 | 1999-12-23 | University Of Newcastle Research Associates Limited, The | A method of treating a malignancy in a subject and a pharmaceutical composition for use in same |
| US8491884B2 (en) * | 2000-05-03 | 2013-07-23 | Oncolytics Biotech Inc. | Virus clearance of neoplastic cells from mixed cellular compositions |
| US7306902B2 (en) * | 2002-06-28 | 2007-12-11 | Oncolyties Biotech Inc. | Oncolytic viruses as phenotyping agents for neoplasms |
| US20040115170A1 (en) * | 2001-11-30 | 2004-06-17 | Brown Earl Garnet | Oncolytic virus |
| EP1523333A4 (en) | 2002-07-24 | 2007-01-24 | Univ Arizona | Use of vaccinia virus deleted for the e3l gene as a vaccine vector |
| AU2002953436A0 (en) | 2002-12-18 | 2003-01-09 | The University Of Newcastle Research Associates Limited | A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis |
| EP1648233A4 (en) * | 2003-07-08 | 2006-08-23 | Univ Arizona | Mutants of vaccinia virus as oncolytic agents |
| WO2005111200A1 (en) * | 2004-05-17 | 2005-11-24 | Universite De Montreal | Novel strains of reoviruses and methods of uses thereof |
| US10668119B2 (en) | 2005-08-01 | 2020-06-02 | Virocure, Inc. | Attenuated reovirus |
| EP1917351A4 (en) | 2005-08-01 | 2009-12-16 | Univ Technologies Int | Attenuated reovirus |
| CA2634591A1 (en) * | 2005-12-22 | 2007-07-05 | Memorial Sloan-Kettering Cancer Center | Method for detection of cancer cells using virus |
| US20070190032A1 (en) * | 2006-02-13 | 2007-08-16 | Oncolytics Biotech Inc. | Use of Local Immune Suppression to Enhance Oncolytic Viral Therapy |
| US10369171B2 (en) | 2007-03-13 | 2019-08-06 | Virocure, Inc. | Attenuated reoviruses for selection of cell populations |
| US9241998B2 (en) * | 2007-05-21 | 2016-01-26 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of cancer using oncolytic RSV activity |
| WO2009143468A1 (en) * | 2008-05-22 | 2009-11-26 | Uti Limited Partnership | Tumor suppressor-based susceptibility of hyperproliferative cells to oncolytic viral therapy |
| MX339014B (en) * | 2008-05-27 | 2016-05-09 | Oncolytics Biotech Inc | Modulating interstitial pressure and oncolytic viral delivery and distribution. |
| US8470312B2 (en) * | 2008-05-27 | 2013-06-25 | Oncolytics Biotech, Inc. | Abrogating proinflammatory cytokine production during oncolytic reovirus therapy |
| US8481297B2 (en) * | 2009-01-08 | 2013-07-09 | Yale University | Compositions and methods of use of an oncolytic vesicular stomatitis virus |
| ES2385251B1 (en) | 2009-05-06 | 2013-05-06 | Fundació Privada Institut D'investigació Biomèdica De Bellvitge | ONCOLYTIC ADENOVIRUSES FOR THE TREATMENT OF CANCER. |
| WO2012106281A2 (en) | 2011-01-31 | 2012-08-09 | The General Hospital Corporation | Multimodal trail molecules and uses in cellular therapies |
| WO2013052915A2 (en) | 2011-10-05 | 2013-04-11 | Genelux Corporation | Method for detecting replication or colonization of a biological therapeutic |
| WO2013138522A2 (en) | 2012-03-16 | 2013-09-19 | Genelux Corporation | Methods for assessing effectiveness and monitoring oncolytic virus treatment |
| WO2013158265A1 (en) | 2012-04-20 | 2013-10-24 | Genelux Corporation | Imaging methods for oncolytic virus therapy |
| EP2877572B1 (en) | 2012-07-24 | 2018-11-28 | The General Hospital Corporation | Oncolytic virus therapy for resistant tumors |
| US9605074B2 (en) | 2012-08-30 | 2017-03-28 | The General Hospital Corporation | Multifunctional nanobodies for treating cancer |
| WO2014055960A1 (en) | 2012-10-05 | 2014-04-10 | Genelux Corporation | Energy absorbing-based diagnostic and therapeutic methods employing nucleic acid molecules encoding chromophore-producing enzymes |
| US20160303174A1 (en) * | 2013-12-11 | 2016-10-20 | The General Hospital Corporation | Stem cell delivered oncolytic herpes simplex virus and methods for treating brain tumors |
| US10238700B2 (en) | 2014-01-02 | 2019-03-26 | Genelux Corporation | Oncolytic virus adjunct therapy with agents that increase virus infectivity |
| EA201700181A1 (en) | 2014-10-14 | 2017-09-29 | Галозим, Инк. | COMPOSITIONS OF ADENOSINDEMINASE-2 (ADA-2), THEIR OPTIONS AND METHODS OF USE |
| CA2977660A1 (en) | 2015-02-25 | 2016-09-15 | Memorial Sloan-Kettering Cancer Center | Use of inactivated nonreplicating modified vaccinia virus ankara (mva) as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors |
| KR20180006916A (en) | 2015-04-17 | 2018-01-19 | 메모리얼 슬로안-케터링 캔서 센터 | Use of MVA or MVA delta E3L as an immunotherapeutic agent for solid tumors |
| MX2018010231A (en) | 2016-02-25 | 2019-06-06 | Memorial Sloan Kettering Cancer Center | Recombinant mva or mvadele3l expressing human flt3l and use thereof as immuno-therapeutic agents against solid tumors. |
| CA3015650A1 (en) | 2016-02-25 | 2017-08-31 | Memorial Sloan Kettering Cancer Center | Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human flt3l or gm-csf for cancer immunotherapy |
| CN109715657A (en) | 2016-04-15 | 2019-05-03 | 高山免疫科学股份有限公司 | CD80 variant immune modulator and application thereof |
| KR20230051602A (en) | 2016-04-15 | 2023-04-18 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Icos ligand variant immunomodulatory proteins and uses thereof |
| WO2017205674A1 (en) | 2016-05-25 | 2017-11-30 | Arizona Board Of Regents On Behalf Of Arizona State University | Oncolytic vaccinia virus mutants and using same for cancer treatment |
| US11471488B2 (en) | 2016-07-28 | 2022-10-18 | Alpine Immune Sciences, Inc. | CD155 variant immunomodulatory proteins and uses thereof |
| WO2018022945A1 (en) | 2016-07-28 | 2018-02-01 | Alpine Immune Sciences, Inc. | Cd112 variant immunomodulatory proteins and uses thereof |
| CA3032120A1 (en) | 2016-07-28 | 2018-02-01 | Alpine Immune Sciences, Inc. | Cd155 variant immunomodulatory proteins and uses thereof |
| EP3518947B1 (en) * | 2016-09-27 | 2023-07-05 | Sator Therapeutics LLC | Optimized oncolytic viruses and uses thereof |
| CN110352245A (en) | 2016-10-20 | 2019-10-18 | 高山免疫科学股份有限公司 | Variant immune modulator and engineering cell therapy can be secreted |
| JP2020507349A (en) | 2017-02-09 | 2020-03-12 | インダプタ セラピューティクス インコーポレイテッド | Engineered natural killer (NK) cells and compositions and methods thereof |
| CN110809581A (en) | 2017-03-16 | 2020-02-18 | 高山免疫科学股份有限公司 | PD-L2 variant immunomodulatory proteins and uses thereof |
| JP2020509776A (en) | 2017-03-16 | 2020-04-02 | アルパイン イミューン サイエンシズ インコーポレイテッド | PD-L1 variant immunomodulatory proteins and uses thereof |
| WO2018170026A2 (en) | 2017-03-16 | 2018-09-20 | Alpine Immune Sciences, Inc. | Cd80 variant immunomodulatory proteins and uses thereof |
| CN111107872A (en) | 2017-05-12 | 2020-05-05 | 纪念斯隆-凯特林癌症中心 | Vaccinia virus mutants useful for cancer immunotherapy |
| TW201925223A (en) | 2017-10-18 | 2019-07-01 | 美商艾爾潘免疫科學有限公司 | Variant ICOS ligand immunomodulatory proteins and related compositions and methods |
| ES2966045T3 (en) | 2018-06-04 | 2024-04-18 | Calidi Biotherapeutics Inc | Cell-based vehicles for the enhancement of viral therapy |
| US11505782B2 (en) | 2018-06-04 | 2022-11-22 | Calidi Biotherapeutics, Inc. | Cell-based vehicles for potentiation of viral therapy |
| US20210363219A1 (en) | 2018-06-15 | 2021-11-25 | Alpine Immune Sciences, Inc. | Pd-1 variant immunomodulatory proteins and uses thereof |
| WO2020047161A2 (en) | 2018-08-28 | 2020-03-05 | Actym Therapeutics, Inc. | Engineered immunostimulatory bacterial strains and uses thereof |
| CA3116192A1 (en) | 2018-11-06 | 2020-05-14 | Calidi Biotherapeutics, Inc. | Enhanced systems for cell-mediated oncolytic viral therapy |
| EP3884041A2 (en) | 2018-11-21 | 2021-09-29 | Indapta Therapeutics, Inc. | Methods for expansion of natural killer (nk) cell subset and related compositions and methods |
| WO2020113141A2 (en) | 2018-11-30 | 2020-06-04 | Alpine Immune Sciences, Inc. | Cd86 variant immunomodulatory proteins and uses thereof |
| JP2022524951A (en) | 2019-02-27 | 2022-05-11 | アクティム・セラピューティクス・インコーポレイテッド | Tumors, tumor-resident immune cells and immunostimulatory bacteria engineered to colonize the tumor microenvironment |
| CA3180658A1 (en) | 2020-04-22 | 2021-10-28 | Indapta Therapeutics, Inc. | Natural killer (nk) cell compositions and methods for generating same |
| WO2022147481A1 (en) | 2020-12-30 | 2022-07-07 | Ansun Biopharma Inc. | Combination therapy of an oncolytic virus delivering a foreign antigen and an engineered immune cell expressing a chimeric receptor targeting the foreign antigen |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) * | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| US5670330A (en) * | 1992-09-29 | 1997-09-23 | Mcgill University | Anti-tumor agent assay using PKR |
| ATE178490T1 (en) | 1993-02-16 | 1999-04-15 | Onyx Pharmaceuticals | CYTOPATHIC VIRUSES FOR THE THERAPY AND PROPHYLAXIS OF NEOPLASIA |
| US5846945A (en) | 1993-02-16 | 1998-12-08 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
| DE69435118D1 (en) | 1993-04-30 | 2008-08-28 | Wellstat Biologics Corp | Purified compositions of Newcastle disease virus |
| WO1995016464A1 (en) | 1993-12-14 | 1995-06-22 | Johns Hopkins University School Of Medicine | Controlled release of pharmaceutically active substances for immunotherapy |
| WO1995032300A1 (en) | 1994-05-23 | 1995-11-30 | University Of Medicine & Dentistry Of New Jersey | Selective biological destruction of tumor cells |
| US5585096A (en) | 1994-06-23 | 1996-12-17 | Georgetown University | Replication-competent herpes simplex virus mediates destruction of neoplastic cells |
| US5840502A (en) | 1994-08-31 | 1998-11-24 | Activated Cell Therapy, Inc. | Methods for enriching specific cell-types by density gradient centrifugation |
| US6777177B1 (en) * | 1997-10-10 | 2004-08-17 | Vanderbilt University | Mammalian genes involved in viral infection and tumor suppression |
| US6110461A (en) | 1997-08-13 | 2000-08-29 | Oncolytics Biotech Inc. | Reovirus for the treatment of neoplasia |
| CA2508238C (en) | 1997-08-13 | 2008-01-15 | Oncolytics Biotech Inc. | Reovirus for the treatment of neoplasia |
| US6136307A (en) * | 1997-08-13 | 2000-10-24 | Oncolytics Biotech Inc. | Reovirus for the treatment of cellular proliferative disorders |
| CA2305269C (en) | 1997-10-09 | 2012-07-03 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
| US7780962B2 (en) * | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
| US6475481B2 (en) | 1997-11-18 | 2002-11-05 | Canji Inc | Purging of stem cell products |
| EP1061806A4 (en) | 1998-03-12 | 2001-09-12 | Univ Pennsylvania | Producer cells for replication selective viruses in the treatment of malignancy |
| CA2342203C (en) | 1998-08-31 | 2011-03-01 | Julian L. Ambrus | Method for removal of hiv and other viruses from blood |
| EP1390046A4 (en) | 1999-04-15 | 2005-04-20 | Wellstat Biologics Corp | Treatment of neoplasms with viruses |
| DE19934788B4 (en) * | 1999-07-27 | 2004-05-27 | T-Mobile Deutschland Gmbh | Process for automatically adapting data to the capabilities of a user software |
| CA2386920C (en) | 1999-09-17 | 2012-01-24 | Pro-Virus, Inc. | Oncolytic virus |
| CA2388807C (en) | 1999-11-12 | 2013-08-06 | Matthew C. Coffey | Viruses for the treatment of cellular proliferative disorders |
| AUPQ425699A0 (en) | 1999-11-25 | 1999-12-23 | University Of Newcastle Research Associates Limited, The | A method of treating a malignancy in a subject and a pharmaceutical composition for use in same |
| AR028040A1 (en) | 2000-05-03 | 2003-04-23 | Oncolytics Biotech Inc | REMOVAL OF NEOPLASTIC CELL VIRUSES FROM MIXED CELL COMPOSITIONS |
| US7306902B2 (en) * | 2002-06-28 | 2007-12-11 | Oncolyties Biotech Inc. | Oncolytic viruses as phenotyping agents for neoplasms |
| AR028039A1 (en) | 2000-05-03 | 2003-04-23 | Oncolytics Biotech Inc | REMOVAL OF REOVIRUS FROM NEOPLASTIC CELLS INTERMEDIATE BY RAS FROM MIXED CELL COMPOSITIONS |
| CN1250711C (en) * | 2000-06-26 | 2006-04-12 | 威尔斯达特生物制剂公司 | Purging of cells using viruses |
| WO2002004596A2 (en) | 2000-07-07 | 2002-01-17 | President And Fellows Of Harvard College | Diagnosing and treating cancer cells using mutant viruses |
| DE60142485D1 (en) | 2000-11-09 | 2010-08-12 | Oncolytics Biotech Inc | Method for the evaluation of cellular proliferative diseases |
| US20030138405A1 (en) * | 2001-04-17 | 2003-07-24 | Juan Fueyo | Conditionally replicative adenovirus to target the Rb and Rb-related pathways |
-
2003
- 2003-06-24 US US10/602,024 patent/US7306902B2/en not_active Expired - Lifetime
- 2003-06-25 CN CN03815353.XA patent/CN1666105B/en not_active Expired - Lifetime
- 2003-06-25 DE DE60317331T patent/DE60317331T2/en not_active Expired - Lifetime
- 2003-06-25 PT PT07021569T patent/PT1890151E/en unknown
- 2003-06-25 AU AU2003245760A patent/AU2003245760B2/en not_active Expired
- 2003-06-25 EP EP03737795A patent/EP1520175B1/en not_active Expired - Lifetime
- 2003-06-25 MX MXPA04012414A patent/MXPA04012414A/en active IP Right Grant
- 2003-06-25 AT AT03737795T patent/ATE377754T1/en not_active IP Right Cessation
- 2003-06-25 ES ES07021569T patent/ES2385845T3/en not_active Expired - Lifetime
- 2003-06-25 AT AT07021569T patent/ATE555388T1/en active
- 2003-06-25 SI SI200332164T patent/SI1890151T1/en unknown
- 2003-06-25 EP EP07021569A patent/EP1890151B1/en not_active Expired - Lifetime
- 2003-06-25 DK DK07021569.4T patent/DK1890151T3/en active
- 2003-06-25 DK DK03737795T patent/DK1520175T3/en active
- 2003-06-25 JP JP2004516379A patent/JP2005531306A/en active Pending
- 2003-06-25 BR BR0311983-1A patent/BR0311983A/en not_active IP Right Cessation
- 2003-06-25 NZ NZ537116A patent/NZ537116A/en unknown
- 2003-06-25 CA CA2487824A patent/CA2487824C/en not_active Expired - Lifetime
- 2003-06-25 ES ES03737795T patent/ES2292981T3/en not_active Expired - Lifetime
- 2003-06-25 WO PCT/CA2003/000951 patent/WO2004003562A2/en active Application Filing
- 2003-06-26 TW TW098118162A patent/TWI402345B/en not_active IP Right Cessation
- 2003-06-26 TW TW092117377A patent/TWI327167B/en not_active IP Right Cessation
- 2003-06-26 AR ARP030102317A patent/AR039768A1/en unknown
- 2003-06-26 TW TW098135545A patent/TWI334444B/en not_active IP Right Cessation
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2004
- 2004-12-01 IL IL16549804A patent/IL165498A0/en active IP Right Grant
-
2005
- 2005-04-18 HK HK05103306A patent/HK1069877A1/en not_active IP Right Cessation
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2007
- 2007-05-30 US US11/807,771 patent/US20080014577A1/en not_active Abandoned
-
2008
- 2008-06-26 HK HK08107121.9A patent/HK1112509A1/en not_active IP Right Cessation
- 2008-08-28 AU AU2008207579A patent/AU2008207579B2/en not_active Expired
-
2010
- 2010-01-05 US US12/652,289 patent/US8222036B2/en not_active Expired - Lifetime
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2012
- 2012-06-04 IL IL220139A patent/IL220139A/en active IP Right Grant
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