AR019864A1 - PROCESS TO PRODUCE THE ANTIGEN OF TOXOPLASMA SAG1 OR FRAGMENTS OF THE SAME; PROTEIN SAG1 OR FRAGMENTS OF THE SAME EXPRESSED IN SUCH PROCESS; VACCINE COMPOSITIONS THAT INCLUDE SUCH PROTEIN SAG1 OR FRAGMENTS OF THE SAME; USE OF SUCH PROTEIN FOR THE MANUFACTURE OF MEDICINES TO PREVENT - Google Patents
PROCESS TO PRODUCE THE ANTIGEN OF TOXOPLASMA SAG1 OR FRAGMENTS OF THE SAME; PROTEIN SAG1 OR FRAGMENTS OF THE SAME EXPRESSED IN SUCH PROCESS; VACCINE COMPOSITIONS THAT INCLUDE SUCH PROTEIN SAG1 OR FRAGMENTS OF THE SAME; USE OF SUCH PROTEIN FOR THE MANUFACTURE OF MEDICINES TO PREVENTInfo
- Publication number
- AR019864A1 AR019864A1 ARP990102830A ARP990102830A AR019864A1 AR 019864 A1 AR019864 A1 AR 019864A1 AR P990102830 A ARP990102830 A AR P990102830A AR P990102830 A ARP990102830 A AR P990102830A AR 019864 A1 AR019864 A1 AR 019864A1
- Authority
- AR
- Argentina
- Prior art keywords
- sag1
- fragments
- protein
- same
- antigen
- Prior art date
Links
- 101100056797 Canis lupus familiaris SAG gene Proteins 0.000 title abstract 9
- 101100532512 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) SAG1 gene Proteins 0.000 title abstract 9
- 239000012634 fragment Substances 0.000 title abstract 6
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 108010049895 Toxoplasma SAG1 antigen Proteins 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 239000013612 plasmid Substances 0.000 abstract 2
- 241000235058 Komagataella pastoris Species 0.000 abstract 1
- 241000223996 Toxoplasma Species 0.000 abstract 1
- 201000005485 Toxoplasmosis Diseases 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 238000004873 anchoring Methods 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 238000010276 construction Methods 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/45—Toxoplasma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Se trata de un procedimiento para la produccion del antígeno de toxoplasma SAG1 o un fragmento de éste; que comprende: (a)la construccion de un plásmidoque comprende DNA que codifica SAG1 o un fragmento de éste; (b)la transformacion de una célula huesped de P.pastoris con el citado plásmido y el cultivo delhuésped de modo que se exprese el DNA que codifica el SAG1 o un fragmento de éste. También se proporcionan: las proteínas SAG1 truncadas en las que la regionde anclaje está ausente, particularmente SAG1 truncada que comprende los restos aminoácidos 48-307 y composiciones de vacuna que comprenden la SAG1 y un kitpara el diagnostico de toxoplasmosis en sangre, que comprende el antígeno SAG1.It is a process for the production of the SAG1 toxoplasma antigen or a fragment thereof; comprising: (a) the construction of a plasmid comprising DNA encoding SAG1 or a fragment thereof; (b) the transformation of a P. pastoris host cell with said plasmid and the cultivation of the host so that the DNA encoding SAG1 or a fragment thereof is expressed. Also provided are: truncated SAG1 proteins in which the anchoring region is absent, particularly truncated SAG1 comprising amino acid residues 48-307 and vaccine compositions comprising SAG1 and a kit for the diagnosis of blood toxoplasmosis, comprising the antigen SAG1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9812773.1A GB9812773D0 (en) | 1998-06-12 | 1998-06-12 | Vaccine |
| GBGB9908564.9A GB9908564D0 (en) | 1999-04-15 | 1999-04-15 | Novel compounds and process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR019864A1 true AR019864A1 (en) | 2002-03-20 |
Family
ID=26313858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990102830A AR019864A1 (en) | 1998-06-12 | 1999-06-11 | PROCESS TO PRODUCE THE ANTIGEN OF TOXOPLASMA SAG1 OR FRAGMENTS OF THE SAME; PROTEIN SAG1 OR FRAGMENTS OF THE SAME EXPRESSED IN SUCH PROCESS; VACCINE COMPOSITIONS THAT INCLUDE SUCH PROTEIN SAG1 OR FRAGMENTS OF THE SAME; USE OF SUCH PROTEIN FOR THE MANUFACTURE OF MEDICINES TO PREVENT |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1086228A1 (en) |
| AR (1) | AR019864A1 (en) |
| AU (1) | AU4510299A (en) |
| CA (1) | CA2330209A1 (en) |
| CO (1) | CO5070712A1 (en) |
| WO (1) | WO1999066043A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9706957D0 (en) | 1997-04-05 | 1997-05-21 | Smithkline Beecham Plc | Formulation |
| GB9820525D0 (en) | 1998-09-21 | 1998-11-11 | Allergy Therapeutics Ltd | Formulation |
| GB9929434D0 (en) * | 1999-12-13 | 2000-02-09 | Smithkline Beecham Biolog | Novel vaccine composition |
| GB0000891D0 (en) | 2000-01-14 | 2000-03-08 | Allergy Therapeutics Ltd | Formulation |
| AU2002310099A1 (en) * | 2001-05-22 | 2002-12-03 | President And Fellows Of Harvard College | Identification of anti-protozoal agents |
| GB0123580D0 (en) * | 2001-10-01 | 2001-11-21 | Glaxosmithkline Biolog Sa | Vaccine |
| US7094879B2 (en) * | 2002-10-02 | 2006-08-22 | Abbott Laboratories | Genetically engineered P30 antigen, improved antigen cocktail, and uses thereof |
| KR20080003330A (en) | 2005-03-08 | 2008-01-07 | 켄톤 에스.알.엘. | Chimeric recombinant antigens of toxoplasma gondii |
| BRPI0504782A (en) * | 2005-11-01 | 2007-09-18 | Fundacao Oswaldo Cruz | recombinant adenoviruses, recombinant adenovirus construction process, toxoplasmosis vaccine composition, and method of immunization against infections caused by the parasite t. gondii |
| WO2020056229A1 (en) * | 2018-09-14 | 2020-03-19 | Prommune, Inc. | Anti-parasitic immunological compositions |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2722508B1 (en) * | 1994-07-13 | 1996-10-04 | Transgene Sa | TOXOPLASMA GONDII P30 PROTEIN EXPRESSION CASSETTE |
-
1999
- 1999-06-08 AU AU45102/99A patent/AU4510299A/en not_active Abandoned
- 1999-06-08 EP EP99927922A patent/EP1086228A1/en not_active Withdrawn
- 1999-06-08 WO PCT/EP1999/003957 patent/WO1999066043A1/en not_active Application Discontinuation
- 1999-06-08 CA CA002330209A patent/CA2330209A1/en not_active Abandoned
- 1999-06-11 CO CO99036864A patent/CO5070712A1/en unknown
- 1999-06-11 AR ARP990102830A patent/AR019864A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999066043A1 (en) | 1999-12-23 |
| CO5070712A1 (en) | 2001-08-28 |
| AU4510299A (en) | 2000-01-05 |
| EP1086228A1 (en) | 2001-03-28 |
| CA2330209A1 (en) | 1999-12-23 |
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