AR006550A1 - METHOD OF PREPARATION OF PHOSPHODIESTERASE IV INHIBITORS - Google Patents
METHOD OF PREPARATION OF PHOSPHODIESTERASE IV INHIBITORSInfo
- Publication number
- AR006550A1 AR006550A1 ARP970101372A ARP970101372A AR006550A1 AR 006550 A1 AR006550 A1 AR 006550A1 AR P970101372 A ARP970101372 A AR P970101372A AR P970101372 A ARP970101372 A AR P970101372A AR 006550 A1 AR006550 A1 AR 006550A1
- Authority
- AR
- Argentina
- Prior art keywords
- phosphodiesterase
- inhibitors
- preparation
- phenyl
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
- C07D213/34—Sulfur atoms to which a second hetero atom is attached
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Abstract
Un procedimiento para la preparación de inhibidores de fosfodiessterasa IV de fórmula estructural I en donde R1 es alquil, alquenil fenil o fenilsustituido, que comprende la adición de P1 a un intermediario 2, mediante el tratamiento de 2 con (r1)3M seguido por remoción reductiva del grupo sulfinilo.A process for the preparation of phosphodiesterase IV inhibitors of structural formula I where R1 is alkyl, alkenyl phenyl or phenyl substituted, comprising the addition of P1 to an intermediate 2, by treating 2 with (r1) 3M followed by reductive removal of the sulfinyl group.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1568796P | 1996-04-17 | 1996-04-17 | |
GBGB9612083.7A GB9612083D0 (en) | 1996-06-10 | 1996-06-10 | Method of preparing phosphodiesterase IV inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
AR006550A1 true AR006550A1 (en) | 1999-09-08 |
Family
ID=26309476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970101372A AR006550A1 (en) | 1996-04-17 | 1997-04-07 | METHOD OF PREPARATION OF PHOSPHODIESTERASE IV INHIBITORS |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0898564A1 (en) |
CN (1) | CN1216532A (en) |
AR (1) | AR006550A1 (en) |
AU (1) | AU2459297A (en) |
BR (1) | BR9708684A (en) |
CZ (1) | CZ333298A3 (en) |
EA (1) | EA000877B1 (en) |
SK (1) | SK143198A3 (en) |
TW (1) | TW426669B (en) |
WO (1) | WO1997038976A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2265826A1 (en) * | 1996-09-17 | 1998-03-26 | Merck & Co., Inc. | Method of preparing phosphodiesterase iv inhibitors |
TW508353B (en) * | 1996-09-17 | 2002-11-01 | Merck & Co Inc | Method of preparing phosphodiesterase IV inhibitors |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW263495B (en) * | 1992-12-23 | 1995-11-21 | Celltech Ltd | |
GB9326173D0 (en) * | 1993-12-22 | 1994-02-23 | Celltech Ltd | Chemical compounds and process |
-
1997
- 1997-04-07 AR ARP970101372A patent/AR006550A1/en unknown
- 1997-04-14 SK SK1431-98A patent/SK143198A3/en unknown
- 1997-04-14 WO PCT/US1997/006131 patent/WO1997038976A1/en not_active Application Discontinuation
- 1997-04-14 CZ CZ983332A patent/CZ333298A3/en unknown
- 1997-04-14 EP EP97920379A patent/EP0898564A1/en not_active Withdrawn
- 1997-04-14 EA EA199800931A patent/EA000877B1/en not_active IP Right Cessation
- 1997-04-14 CN CN97193932A patent/CN1216532A/en active Pending
- 1997-04-14 AU AU24592/97A patent/AU2459297A/en not_active Abandoned
- 1997-04-14 BR BR9708684A patent/BR9708684A/en unknown
- 1997-04-15 TW TW086104869A patent/TW426669B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1997038976A1 (en) | 1997-10-23 |
CN1216532A (en) | 1999-05-12 |
EA199800931A1 (en) | 1999-04-29 |
BR9708684A (en) | 1999-08-03 |
CZ333298A3 (en) | 1999-03-17 |
EP0898564A1 (en) | 1999-03-03 |
SK143198A3 (en) | 1999-06-11 |
AU2459297A (en) | 1997-11-07 |
TW426669B (en) | 2001-03-21 |
EA000877B1 (en) | 2000-06-26 |
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