AR006520A1 - 2-ARYLPIRAZOLISOQUINOLINE AND CINOLINONE DERIVATIVES AND PROCEDURE FOR THE PREPARATION. - Google Patents
2-ARYLPIRAZOLISOQUINOLINE AND CINOLINONE DERIVATIVES AND PROCEDURE FOR THE PREPARATION.Info
- Publication number
- AR006520A1 AR006520A1 ARP970101094A ARP970101094A AR006520A1 AR 006520 A1 AR006520 A1 AR 006520A1 AR P970101094 A ARP970101094 A AR P970101094A AR P970101094 A ARP970101094 A AR P970101094A AR 006520 A1 AR006520 A1 AR 006520A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- phenyl
- bond
- optionally substituted
- alkoxy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de fórmula I en la cual: B,D,E y G cada uno es CH,CA o N siempre que no más de uno de B,D,y G represente CA y no más de uno de B, D, E yG, sea N; X es C=O, C=S, C=NR15, CR3R6 o NR4; Y es N o N+R7 o CR18; Z es OR8 o O; R1 es OH o alquilo C1-6, o con R2 o R5 forma un enlace; R2 es H, alquilo C1-6 (optativamente sustituido por fenilo, COOR9, NR10R11, OR12 o F) ocicloalquilo C3-7, o con R1, R3 o R4 forma un enlace; R3 es H o un enlace con R2; R4 esalquilo C1-6 o un enlace con R1;R5 es un enlace con R1 o R8; R6 es H, alquilo C1-6 (optativamente sustituido, por fenilo) cicloalquilo C3-7, fenilo,halógeno, alcoxi C1-6 alquiltio C1-6, alquilsulfinilo C1-6 ciano o NR13R14; R7 es alquilo C1-6 (optativamente sustituido por fenilo) o cicloalquilo C3-7,cualquiera de los cuales puede estar optativamente sustituido por halógeno, hidroxi, alcoxi C1-6, alquiltio C1-6, alquilsulfinilo C1-6 NR16R17, COOH, COO(alquilo C1-6) o ciano; o R6 y R7 juntos son alquileno C3-5, X e Y formando así un anillo de 5-7 miembros; R8 es H, alquilo C1-6 o un enlace con R5; R9, R10,R11, R12, R15, R16, R17 y R18 independientemente son alquilo C1-8 o H; R13 y R14 son independientemente alquilo C1-6, H o junto con el átomo de nitrógeno alcualestán unidos forman un anillo saturado de 3-7 miembros que contiene optativamente un átomo de oxígeno adicional o un átomo de nitrógenooptativamente sustituido por alquilo C1-6; Ar1 es fenilo, piridilo, piridimilo, 2-benzotiazolilo, 2- o 3- quinolilo o 2-quinoxalinilo, todos optativamentesustituidos por uno o más sustituyentes seleccionados entre halo, nitro, ciano, fenilo, fenilsulfonilo, alquilo C1-6, alcoxi C1-6, alquiltio C1-6alquilsulfonilo C1-6 COOH, COO(ALQUILO C1-6) alquilo C1-6 sustituido por fenilo, o fenilo en el cual cualquier grupo alquilo, alcoxi, alquiltio yA compound of formula I in which: B, D, E, and G are each CH, CA, or N provided that no more than one of B, D, and G represents CA and no more than one of B, D, E and G, let N; X is C = O, C = S, C = NR15, CR3R6 or NR4; Y is N or N + R7 or CR18; Z is OR8 or O; R1 is OH or C1-6 alkyl, or with R2 or R5 forms a bond; R2 is H, C1-6 alkyl (optionally substituted by phenyl, COOR9, NR10R11, OR12 or F) or C3-7 ocycloalkyl, or with R1, R3 or R4 forms a bond; R3 is H or a bond with R2; R4 is C1-6alkyl or a bond with R1; R5 is a bond with R1 or R8; R6 is H, C1-6 alkyl (optionally substituted, by phenyl) C3-7 cycloalkyl, phenyl, halogen, C1-6 alkoxy C1-6 alkylthio, C1-6 alkylsulfinyl cyano or NR13R14; R7 is C1-6 alkyl (optionally substituted by phenyl) or C3-7 cycloalkyl, either of which may be optionally substituted by halogen, hydroxy, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkylsulfinyl NR16R17, COOH, COO (C1-6 alkyl) or cyano; or R6 and R7 together are C3-5 alkylene, X and Y thus forming a 5-7 membered ring; R8 is H, C1-6 alkyl or a bond with R5; R9, R10, R11, R12, R15, R16, R17 and R18 independently are C1-8 alkyl or H; R13 and R14 are independently C1-6 alkyl, H or together with the attached alkaline nitrogen atom form a 3-7 membered saturated ring optionally containing an additional oxygen atom or a nitrogen atom optionally substituted by C1-6 alkyl; Ar1 is phenyl, pyridyl, pyridimyl, 2-benzothiazolyl, 2- or 3-quinolyl or 2-quinoxalinyl, all optionally substituted by one or more substituents selected from halo, nitro, cyano, phenyl, phenylsulfonyl, C1-6 alkyl, C1- alkoxy 6, C1-6 alkylthioC 1-6 alkylsulfonyl COOH, COO (C1-6 ALKYL) C1-6 alkyl substituted by phenyl, or phenyl in which any alkyl, alkoxy, alkylthio and
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9605803.7A GB9605803D0 (en) | 1996-03-20 | 1996-03-20 | Pharmaceutically-active compound |
| GBGB9610474.0A GB9610474D0 (en) | 1996-05-18 | 1996-05-18 | Pharmaceutically active compounds |
| GBGB9610894.9A GB9610894D0 (en) | 1996-05-24 | 1996-05-24 | Pharmaceutically useful compounds |
| GBGB9700862.7A GB9700862D0 (en) | 1997-01-16 | 1997-01-16 | Pharmaceutically useful compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR006520A1 true AR006520A1 (en) | 1999-09-08 |
Family
ID=27451427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970101094A AR006520A1 (en) | 1996-03-20 | 1997-03-19 | 2-ARYLPIRAZOLISOQUINOLINE AND CINOLINONE DERIVATIVES AND PROCEDURE FOR THE PREPARATION. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0888347A1 (en) |
| JP (1) | JP2000506884A (en) |
| KR (1) | KR20000064716A (en) |
| CN (1) | CN1218472A (en) |
| AR (1) | AR006520A1 (en) |
| AU (1) | AU712141B2 (en) |
| BR (1) | BR9708103A (en) |
| CA (1) | CA2247814A1 (en) |
| CZ (1) | CZ297798A3 (en) |
| EE (1) | EE9800298A (en) |
| ID (1) | ID16283A (en) |
| IL (1) | IL126271A0 (en) |
| IS (1) | IS4848A (en) |
| NO (1) | NO984290L (en) |
| NZ (1) | NZ331614A (en) |
| PL (1) | PL328921A1 (en) |
| SK (1) | SK118798A3 (en) |
| TR (1) | TR199801861T2 (en) |
| WO (1) | WO1997034893A1 (en) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10110749A1 (en) * | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituted aminodicarboxylic acid derivatives |
| JP2003002863A (en) * | 2001-06-25 | 2003-01-08 | Nippon Soda Co Ltd | Method for producing benzoic acids, and new compound |
| US6642249B2 (en) | 2001-07-04 | 2003-11-04 | Active Biotech Ab | Immunomodulating compounds |
| SE0102404D0 (en) * | 2001-07-04 | 2001-07-04 | Active Biotech Ab | Novel immunomodulating compounds |
| DE10229762A1 (en) * | 2002-07-03 | 2004-01-22 | Aventis Pharma Deutschland Gmbh | Pyrazoloisoquinoline derivatives for the inhibition of NFkappaB-inducing kinase |
| EP1562944B1 (en) * | 2002-11-22 | 2007-02-14 | Active Biotech AB | Pyrazoloquinolines with immunomodulating activity |
| ATE425164T1 (en) | 2002-12-16 | 2009-03-15 | Active Biotech Ab | TETRACYCLIC IMMUNOMODULATING COMPOUNDS |
| EP2284172A1 (en) * | 2003-03-14 | 2011-02-16 | MediGene Ltd. | Immunomodulating heterocyclic compounds |
| GB0325644D0 (en) | 2003-11-04 | 2003-12-10 | Avidex Ltd | Immuno ihibitory pyrazolone compounds |
| AU2004298486A1 (en) | 2003-12-12 | 2005-06-30 | Wyeth | Quinolines useful in treating cardiovascular disease |
| FR2870239B1 (en) * | 2004-05-11 | 2006-06-16 | Sanofi Synthelabo | DERIVATIVES OF 2H- OR 3H-BENZO [E] INDAZOL-1-YLE CARBAMATE, THEIR PREPARATION AND THEIR THERAPEUTIC USE. |
| GB0411770D0 (en) * | 2004-05-26 | 2004-06-30 | Avidex Ltd | Immuno inhibitory heterocyclic compouds |
| DK1776366T3 (en) | 2004-08-09 | 2009-02-16 | Medigene Ltd | Immunomodulatory oxopyrazolocinnolines as CD80 inhibitors |
| PT2089367E (en) | 2006-10-31 | 2012-02-01 | Pfizer Prod Inc | Pyrazoline compounds as mineralocorticoid receptor antagonists |
| CN102372710A (en) * | 2010-08-18 | 2012-03-14 | 山东轩竹医药科技有限公司 | Fused cyclic compound being taken as mineral corticoid recept antagonist |
| WO2012108511A1 (en) | 2011-02-09 | 2012-08-16 | 日産化学工業株式会社 | Pyrazole derivative and pest control agent |
| WO2020049017A1 (en) | 2018-09-07 | 2020-03-12 | Merck Patent Gmbh | 5-morpholin-4-yl-pyrazolo[4,3-b]pyridine derivatives |
| WO2021257857A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Naphthyridinone compounds as jak2 v617f inhibitors |
| US11753413B2 (en) | 2020-06-19 | 2023-09-12 | Incyte Corporation | Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors |
| WO2022006456A1 (en) | 2020-07-02 | 2022-01-06 | Incyte Corporation | Tricyclic pyridone compounds as jak2 v617f inhibitors |
| AU2021300429A1 (en) | 2020-07-02 | 2023-02-16 | Incyte Corporation | Tricyclic urea compounds as JAK2 V617F inhibitors |
| US11661422B2 (en) | 2020-08-27 | 2023-05-30 | Incyte Corporation | Tricyclic urea compounds as JAK2 V617F inhibitors |
| US11919908B2 (en) | 2020-12-21 | 2024-03-05 | Incyte Corporation | Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors |
| TW202302589A (en) | 2021-02-25 | 2023-01-16 | 美商英塞特公司 | Spirocyclic lactams as jak2 v617f inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4524146A (en) * | 1982-12-08 | 1985-06-18 | Ciba-Geigy Corporation | Certain -2-heterocycle substituted pyrazoloquinolines |
| JPS61112075A (en) * | 1984-11-05 | 1986-05-30 | Shionogi & Co Ltd | Thienylpyrazoloquinoline derivative |
| SE8903564D0 (en) * | 1989-10-26 | 1989-10-26 | Pharmacia Ab | NEW USE CONDENSED QUINOLINE COMPOUND |
| JPH05194515A (en) * | 1991-07-31 | 1993-08-03 | Kyowa Hakko Kogyo Co Ltd | Condensed naphthyridine derivative |
-
1997
- 1997-03-19 AR ARP970101094A patent/AR006520A1/en unknown
- 1997-03-19 ID IDP970892A patent/ID16283A/en unknown
- 1997-03-20 WO PCT/SE1997/000471 patent/WO1997034893A1/en not_active Application Discontinuation
- 1997-03-20 PL PL97328921A patent/PL328921A1/en unknown
- 1997-03-20 CA CA002247814A patent/CA2247814A1/en not_active Abandoned
- 1997-03-20 TR TR1998/01861T patent/TR199801861T2/en unknown
- 1997-03-20 EP EP97914729A patent/EP0888347A1/en not_active Withdrawn
- 1997-03-20 EE EE9800298A patent/EE9800298A/en unknown
- 1997-03-20 IL IL12627197A patent/IL126271A0/en unknown
- 1997-03-20 SK SK1187-98A patent/SK118798A3/en unknown
- 1997-03-20 CZ CZ982977A patent/CZ297798A3/en unknown
- 1997-03-20 CN CN97194665A patent/CN1218472A/en active Pending
- 1997-03-20 BR BR9708103A patent/BR9708103A/en unknown
- 1997-03-20 KR KR1019980707441A patent/KR20000064716A/en not_active Application Discontinuation
- 1997-03-20 NZ NZ331614A patent/NZ331614A/en unknown
- 1997-03-20 AU AU21867/97A patent/AU712141B2/en not_active Ceased
- 1997-03-20 JP JP9533412A patent/JP2000506884A/en active Pending
-
1998
- 1998-09-16 IS IS4848A patent/IS4848A/en unknown
- 1998-09-16 NO NO984290A patent/NO984290L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EE9800298A (en) | 1999-02-15 |
| NZ331614A (en) | 2000-07-28 |
| AU712141B2 (en) | 1999-10-28 |
| WO1997034893A1 (en) | 1997-09-25 |
| SK118798A3 (en) | 1999-03-12 |
| CA2247814A1 (en) | 1997-09-25 |
| EP0888347A1 (en) | 1999-01-07 |
| JP2000506884A (en) | 2000-06-06 |
| KR20000064716A (en) | 2000-11-06 |
| IS4848A (en) | 1998-09-16 |
| AU2186797A (en) | 1997-10-10 |
| NO984290L (en) | 1998-10-27 |
| IL126271A0 (en) | 1999-05-09 |
| NO984290D0 (en) | 1998-09-16 |
| BR9708103A (en) | 1999-07-27 |
| TR199801861T2 (en) | 1998-12-21 |
| CN1218472A (en) | 1999-06-02 |
| CZ297798A3 (en) | 1999-03-17 |
| ID16283A (en) | 1997-09-18 |
| PL328921A1 (en) | 1999-03-01 |
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