AR006514A1 - A MACROLID, ITS USES, A PROCESS TO PRODUCE IT, A BIOLOGICALLY PURE ISOLATE CAPABLE OF PRODUCING IT, AND A PHARMACEUTICAL COMPOSITION THAT IT INCLUDES - Google Patents
A MACROLID, ITS USES, A PROCESS TO PRODUCE IT, A BIOLOGICALLY PURE ISOLATE CAPABLE OF PRODUCING IT, AND A PHARMACEUTICAL COMPOSITION THAT IT INCLUDESInfo
- Publication number
- AR006514A1 AR006514A1 ARP960103427A AR10342796A AR006514A1 AR 006514 A1 AR006514 A1 AR 006514A1 AR P960103427 A ARP960103427 A AR P960103427A AR 10342796 A AR10342796 A AR 10342796A AR 006514 A1 AR006514 A1 AR 006514A1
- Authority
- AR
- Argentina
- Prior art keywords
- macrolide
- producing
- pharmaceutical composition
- produce
- inclusive
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- General Engineering & Computer Science (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se refiere a un macrólido el cual tiene: i) las posiciones 2 a 6 inclusive, del anillo macrocíclico que se proporcionan por un residuo de ácidopiperidazinilcarboxílico; y/o ii)las posiciones 7 a 9 inclusive, del anillo macrocíclicoque se proporcionan por un residuo alfa-aminoácido aromático;y/o iii) las posiciones 10 a 12 inclusive, del anillo macrocíclico que se proporcionan por un residuo alfa-aminoácido alifático, en forma libreo protegida, o una sal del mismo.Además, s e refiere al uso de dicho macrólido para la preparación de un medicamento para uso como inmunosupresor, al uso dedicho macrólido como un reactivo en un inmunoensayo de desplazamiento para una ciclosporina u otros compuestos que unenciclofilina , a un proceso paraproducir dicho macrólido, a un aislado biológicamente puro de la cepa Streptomyces sp A92-308110 (DSM 9954) o un mutante, recombinante o formamodificada del mismo, el cual es capaz de producir dichomacrólido, y a una composición farmacéutica que comprende a dicho macrólido en asociación con undiluyente o portador farmacéuticamente aceptable.It refers to a macrolide which has: i) positions 2 to 6 inclusive, of the macrocyclic ring that are provided by a piperidazinylcarboxylic acid residue; and / or ii) positions 7 to 9 inclusive, of the macrocyclic ring that are provided by an aromatic alpha-amino acid residue; and / or iii) positions 10 to 12 inclusive, of the macrocyclic ring that are provided by an aliphatic alpha-amino acid residue In addition, it refers to the use of said macrolide for the preparation of a drug for use as an immunosuppressant, to the use of said macrolide as a reagent in a displacement immunoassay for a cyclosporin or other compounds. than unencyclophilin, to a process to produce said macrolide, to a biologically pure isolate of the Streptomyces sp A92-308110 (DSM 9954) strain or a mutant, recombinant or modified form thereof, which is capable of producing dichomacrolide, and to a pharmaceutical composition that It comprises said macrolide in association with a pharmaceutically acceptable diluent or carrier.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9513596.8A GB9513596D0 (en) | 1995-07-04 | 1995-07-04 | Organic compounds |
GBGB9515495.1A GB9515495D0 (en) | 1995-07-28 | 1995-07-28 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR006514A1 true AR006514A1 (en) | 1999-09-08 |
Family
ID=26307320
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP960103427A AR006514A1 (en) | 1995-07-04 | 1996-07-03 | A MACROLID, ITS USES, A PROCESS TO PRODUCE IT, A BIOLOGICALLY PURE ISOLATE CAPABLE OF PRODUCING IT, AND A PHARMACEUTICAL COMPOSITION THAT IT INCLUDES |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0836616A1 (en) |
JP (1) | JPH11509092A (en) |
KR (1) | KR19990028724A (en) |
CN (1) | CN1193979A (en) |
AR (1) | AR006514A1 (en) |
AU (1) | AU708004B2 (en) |
BR (1) | BR9609324A (en) |
CA (1) | CA2224715A1 (en) |
CO (1) | CO4750713A1 (en) |
CZ (1) | CZ424297A3 (en) |
HU (1) | HUP9802320A3 (en) |
IL (1) | IL122844A0 (en) |
NO (1) | NO980016L (en) |
PL (1) | PL324346A1 (en) |
SK (1) | SK498A3 (en) |
TR (1) | TR199800001T1 (en) |
WO (1) | WO1997002285A1 (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6124453A (en) * | 1995-07-04 | 2000-09-26 | Novartis Ag | Macrolides |
GB9811854D0 (en) * | 1998-06-02 | 1998-07-29 | Ciba Geigy Ag | Organic compounds |
US7368423B1 (en) * | 2001-12-05 | 2008-05-06 | The Scripps Research Institute | Composition and method for treating chronic allograft rejection |
EP1768662A2 (en) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
AU2006259348B2 (en) | 2005-06-17 | 2010-07-22 | Novartis Ag | Use of sanglifehrin in HCV |
US8067024B2 (en) | 2006-02-10 | 2011-11-29 | Medtronic Vascular, Inc. | Medical devices to prevent or inhibit restenosis |
CN101289440B (en) * | 2007-06-29 | 2010-08-25 | 中国热带农业科学院热带生物技术研究所 | Polyene macrocyclic compounds, preparation thereof and applications |
WO2010034243A1 (en) | 2008-09-24 | 2010-04-01 | Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences | Novel gene cluster |
WO2011098805A1 (en) | 2010-02-09 | 2011-08-18 | Biotica Technology Limited | Sanglifehrin based compounds |
WO2011098808A1 (en) | 2010-02-09 | 2011-08-18 | Biotica Technology Limited | Sanglifehrin based compounds |
EP2533784B1 (en) | 2010-02-09 | 2015-04-22 | Neurovive Pharmaceutical AB | Sanglifehrin based compounds |
GB201008123D0 (en) | 2010-05-17 | 2010-06-30 | Biotica Tech Ltd | Novel compounds |
UY33775A (en) | 2010-12-10 | 2012-07-31 | Gilead Sciences Inc | MACROCYCLIC INHIBITORS OF VIRUS FLAVIVIRIDAE, PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND AND THEIR USES |
US9271977B2 (en) | 2010-12-20 | 2016-03-01 | Neurovive Pharmaceutical Ab | Sanglifehrin derivatives and methods for their production |
JO3063B1 (en) | 2011-03-29 | 2017-03-15 | Neurovive Pharmaceutical Ab | Novel compound and methods for its production |
GB201118334D0 (en) | 2011-10-24 | 2011-12-07 | Biotica Tech Ltd | Novel dosage form |
NZ724616A (en) | 2012-06-08 | 2018-06-29 | Gilead Sciences Inc | Macrocyclic inhibitors of flaviviridae viruses |
SG11201408047XA (en) | 2012-06-08 | 2015-01-29 | Gilead Sciences Inc | Macrocyclic inhibitors of flaviviridae viruses |
AR091279A1 (en) * | 2012-06-08 | 2015-01-21 | Gilead Sciences Inc | MACROCICLIC INHIBITORS OF VIRUS FLAVIVIRIDAE |
CN110062626A (en) | 2016-11-18 | 2019-07-26 | 纽维制药有限公司 | Purposes of the sanglifehrin Macrocyclic analogs as anticancer compound |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9318144D0 (en) * | 1993-09-01 | 1993-10-20 | Sandoz Ltd | Organic compounds |
WO1995015328A1 (en) * | 1993-11-30 | 1995-06-08 | Abbott Laboratories | Macrocyclic immunomodulators with novel cyclohexyl ring replacements |
-
1996
- 1996-07-03 AR ARP960103427A patent/AR006514A1/en unknown
- 1996-07-04 JP JP9504832A patent/JPH11509092A/en active Pending
- 1996-07-04 BR BR9609324A patent/BR9609324A/en not_active Application Discontinuation
- 1996-07-04 PL PL96324346A patent/PL324346A1/en unknown
- 1996-07-04 AU AU65193/96A patent/AU708004B2/en not_active Ceased
- 1996-07-04 CZ CZ974242A patent/CZ424297A3/en unknown
- 1996-07-04 TR TR1998/00001T patent/TR199800001T1/en unknown
- 1996-07-04 SK SK4-98A patent/SK498A3/en unknown
- 1996-07-04 IL IL12284496A patent/IL122844A0/en unknown
- 1996-07-04 CN CN96196487A patent/CN1193979A/en active Pending
- 1996-07-04 WO PCT/EP1996/002952 patent/WO1997002285A1/en not_active Application Discontinuation
- 1996-07-04 HU HU9802320A patent/HUP9802320A3/en unknown
- 1996-07-04 CO CO96034982A patent/CO4750713A1/en unknown
- 1996-07-04 EP EP96924886A patent/EP0836616A1/en not_active Withdrawn
- 1996-07-04 CA CA002224715A patent/CA2224715A1/en not_active Abandoned
- 1996-07-04 KR KR1019980700022A patent/KR19990028724A/en not_active Application Discontinuation
-
1998
- 1998-01-02 NO NO980016A patent/NO980016L/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX9800217A (en) | 1998-07-31 |
HUP9802320A2 (en) | 1999-02-01 |
EP0836616A1 (en) | 1998-04-22 |
WO1997002285A1 (en) | 1997-01-23 |
HUP9802320A3 (en) | 1999-03-29 |
CA2224715A1 (en) | 1997-01-23 |
IL122844A0 (en) | 1998-08-16 |
SK498A3 (en) | 1998-07-08 |
CZ424297A3 (en) | 1998-04-15 |
JPH11509092A (en) | 1999-08-17 |
TR199800001T1 (en) | 1998-04-21 |
AU6519396A (en) | 1997-02-05 |
CO4750713A1 (en) | 1999-03-31 |
NO980016D0 (en) | 1998-01-02 |
KR19990028724A (en) | 1999-04-15 |
CN1193979A (en) | 1998-09-23 |
NO980016L (en) | 1998-03-02 |
BR9609324A (en) | 1999-05-25 |
PL324346A1 (en) | 1998-05-25 |
AU708004B2 (en) | 1999-07-29 |
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