AR002459A1 - TRASCINIC BENZACEPINE VASOPRESIN ANTAGONISTS, A PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM, A METHOD FOR TREATING DISEASES AND A PROCEDURE FOR THEIR PREPARATION. - Google Patents
TRASCINIC BENZACEPINE VASOPRESIN ANTAGONISTS, A PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM, A METHOD FOR TREATING DISEASES AND A PROCEDURE FOR THEIR PREPARATION.Info
- Publication number
- AR002459A1 AR002459A1 ARP960101027A AR10102796A AR002459A1 AR 002459 A1 AR002459 A1 AR 002459A1 AR P960101027 A ARP960101027 A AR P960101027A AR 10102796 A AR10102796 A AR 10102796A AR 002459 A1 AR002459 A1 AR 002459A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutical composition
- antagonists
- trascinic
- benzacepine
- vasopresin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/38—[b, e]- or [b, f]-condensed with six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D267/20—[b, f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Antagonistas de vasopresina de benzacepina tricíclicos que tienen la fórmula general (I), definidos en la memoria descriptiva que exhiben actividadantagonista en receptores V1 y/o V2 y exhiben actividad antagonista de vasopresina inv ivo, métodos para usar dichos compuestos para tratarenfermedades caracterizadas por un exceso de reabsorción renal de agua, procedimientos para preparar dichos compuestos y una composición farmacéuticaque los contiene.Tricyclic benzazepine vasopressin antagonists having the general formula (I), defined in the specification that exhibit antagonistic activity at V1 and / or V2 receptors and exhibit inv ivo vasopressin antagonist activity, methods for using such compounds to treat diseases characterized by excess of renal water reabsorption, processes for preparing said compounds and a pharmaceutical composition containing them.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37316995A | 1995-01-17 | 1995-01-17 | |
US08/548,805 US5849735A (en) | 1995-01-17 | 1995-12-22 | Tricyclic benzazepine vasopressin antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
AR002459A1 true AR002459A1 (en) | 1998-03-25 |
Family
ID=27006077
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP960101027A AR002459A1 (en) | 1995-01-17 | 1996-01-15 | TRASCINIC BENZACEPINE VASOPRESIN ANTAGONISTS, A PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM, A METHOD FOR TREATING DISEASES AND A PROCEDURE FOR THEIR PREPARATION. |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0804420A1 (en) |
JP (1) | JPH10512865A (en) |
CN (1) | CN1190391A (en) |
AR (1) | AR002459A1 (en) |
AU (1) | AU4904296A (en) |
BR (1) | BR9606977A (en) |
CA (1) | CA2210688A1 (en) |
CZ (1) | CZ224597A3 (en) |
EA (1) | EA000752B1 (en) |
HU (1) | HUP9801219A3 (en) |
IL (1) | IL116777A (en) |
NZ (1) | NZ302881A (en) |
TW (1) | TW449584B (en) |
WO (1) | WO1996022282A1 (en) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5693635A (en) * | 1993-07-29 | 1997-12-02 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
AU3296497A (en) * | 1996-06-13 | 1998-01-07 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
WO1999006403A1 (en) * | 1997-07-30 | 1999-02-11 | American Home Products Corporation | Tricyclic vasopressin agonists |
US6194407B1 (en) | 1997-07-30 | 2001-02-27 | American Home Products Corporation | Tricyclic pyrido vasopressin agonists |
AR018818A1 (en) * | 1998-04-03 | 2001-12-12 | Yamano Masaki | A PHARMACEUTICAL COMPOSITION FOR THE THERAPY OF AN EDEMA. |
US7138393B2 (en) | 1998-07-24 | 2006-11-21 | Wyeth | Biologically active vasopressin agonist metabolites |
US6090803A (en) * | 1998-07-24 | 2000-07-18 | American Home Products Corporation | Tricyclic vasopressin agonists |
US6297234B1 (en) | 1999-02-04 | 2001-10-02 | American Home Products Corporation | Arylthiophene vasopressin agonists |
WO2001017971A1 (en) * | 1999-09-06 | 2001-03-15 | Takeda Chemical Industries, Ltd. | Process for the preparation of 2,3-dihydroazepine derivatives |
US7326700B2 (en) | 2001-04-12 | 2008-02-05 | Wyeth | Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists |
US7022699B2 (en) | 2001-04-12 | 2006-04-04 | Wyeth | Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators |
WO2002083145A1 (en) | 2001-04-12 | 2002-10-24 | Wyeth | N-biphenylcarbonyl- and n-phenylpyridylcarbonyl substituted bi- and tricyclic azepines and diazepines as vasopressing agonists |
US7202239B2 (en) | 2001-04-12 | 2007-04-10 | Wyeth | Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists |
US6900200B2 (en) | 2001-04-12 | 2005-05-31 | Wyeth | Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists |
US7064120B2 (en) | 2001-04-12 | 2006-06-20 | Wyeth | Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists |
US7109193B2 (en) | 2001-04-12 | 2006-09-19 | Wyeth | Tricyclic diazepines tocolytic oxytocin receptor antagonists |
US6977254B2 (en) | 2001-04-12 | 2005-12-20 | Wyeth | Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists |
ATE375346T1 (en) | 2001-04-12 | 2007-10-15 | Wyeth Corp | CYCLOHEXYLPHENYL VASOPRESSIN AGONISTS |
SE0102299D0 (en) * | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
SE0102764D0 (en) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
PE20080145A1 (en) | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | TETRAHYDRO-PYRIMIDOAZEPINE AS MODULATORS OF TRPV1 |
EP2229364B1 (en) * | 2007-12-05 | 2015-02-25 | Janssen Pharmaceutica, N.V. | Dibenzoazepine and dibenzooxazepine trpa1 agonists |
PE20091102A1 (en) | 2007-12-17 | 2009-07-25 | Janssen Pharmaceutica Nv | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 |
AR076221A1 (en) | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | DERIVED FROM PIRAZOL [4,5-E] PYRIMIDINE AND ITS USE TO TREAT DIABETES AND OBESITY |
JP6557674B2 (en) * | 2014-03-12 | 2019-08-07 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | A new class of mu-opioid receptor agonists |
TWI698430B (en) * | 2015-02-13 | 2020-07-11 | 南北兄弟藥業投資有限公司 | Tricyclic compounds and uses thereof in medicine |
CA3046809A1 (en) * | 2016-12-12 | 2018-06-21 | The University Of Sydney | Non-peptide oxytocin receptor agonists |
EP3651752A1 (en) | 2017-07-11 | 2020-05-20 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
CN115916754A (en) | 2020-05-05 | 2023-04-04 | 纽威伦特公司 | Heteroaromatic macrocyclic ether chemotherapeutic agents |
CA3179702A1 (en) | 2020-05-05 | 2021-11-11 | Nuvalent, Inc. | Heteroaromatic macrocyclic ether chemotherapeutic agents |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5258510A (en) * | 1989-10-20 | 1993-11-02 | Otsuka Pharma Co Ltd | Benzoheterocyclic compounds |
DE69026708T2 (en) * | 1989-10-20 | 1997-04-03 | Otsuka Pharma Co Ltd | BENZOHETEROCYCLIC COMPOUNDS |
GB9307527D0 (en) * | 1993-04-13 | 1993-06-02 | Fujisawa Pharmaceutical Co | New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
DE69434032T2 (en) * | 1993-07-21 | 2005-09-22 | Yamanouchi Pharmaceutical Co., Ltd. | Intermediate for the preparation of condensed benzazepine derivatives |
US5516774A (en) * | 1993-07-29 | 1996-05-14 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
US5512563A (en) * | 1993-07-29 | 1996-04-30 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
-
1996
- 1996-01-15 AR ARP960101027A patent/AR002459A1/en unknown
- 1996-01-16 JP JP8522448A patent/JPH10512865A/en not_active Ceased
- 1996-01-16 HU HU9801219A patent/HUP9801219A3/en unknown
- 1996-01-16 EA EA199700116A patent/EA000752B1/en not_active IP Right Cessation
- 1996-01-16 CZ CZ972245A patent/CZ224597A3/en unknown
- 1996-01-16 EP EP96905227A patent/EP0804420A1/en not_active Withdrawn
- 1996-01-16 AU AU49042/96A patent/AU4904296A/en not_active Abandoned
- 1996-01-16 CA CA002210688A patent/CA2210688A1/en not_active Abandoned
- 1996-01-16 WO PCT/US1996/001051 patent/WO1996022282A1/en not_active Application Discontinuation
- 1996-01-16 NZ NZ302881A patent/NZ302881A/en unknown
- 1996-01-16 TW TW085100462A patent/TW449584B/en not_active IP Right Cessation
- 1996-01-16 IL IL11677796A patent/IL116777A/en not_active IP Right Cessation
- 1996-01-16 BR BR9606977A patent/BR9606977A/en not_active Application Discontinuation
- 1996-01-16 CN CN96192568A patent/CN1190391A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AU4904296A (en) | 1996-08-07 |
CZ224597A3 (en) | 1997-12-17 |
JPH10512865A (en) | 1998-12-08 |
EA000752B1 (en) | 2000-04-24 |
EA199700116A1 (en) | 1997-12-30 |
WO1996022282A1 (en) | 1996-07-25 |
NZ302881A (en) | 1999-03-29 |
EP0804420A1 (en) | 1997-11-05 |
IL116777A (en) | 2000-11-21 |
CA2210688A1 (en) | 1996-07-25 |
TW449584B (en) | 2001-08-11 |
HUP9801219A2 (en) | 1998-10-28 |
IL116777A0 (en) | 1996-05-14 |
HUP9801219A3 (en) | 2000-07-28 |
CN1190391A (en) | 1998-08-12 |
BR9606977A (en) | 1997-11-04 |
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