ZA9903938B - Ziprasidone formulations. - Google Patents

Ziprasidone formulations.


Publication number
ZA9903938B ZA9903938A ZA9903938A ZA9903938B ZA 9903938 B ZA9903938 B ZA 9903938B ZA 9903938 A ZA9903938 A ZA 9903938A ZA 9903938 A ZA9903938 A ZA 9903938A ZA 9903938 B ZA9903938 B ZA 9903938B
South Africa
Prior art keywords
ziprasidone formulations
Prior art date
Application number
Frank Robert Busch
Angela Carol Gatlin Hausberger
Bijan Rasadi
Daniel Ray Arenson
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US8922998P priority Critical
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of ZA9903938B publication Critical patent/ZA9903938B/en
First worldwide family litigation filed litigation Critical "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.



    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1688Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
ZA9903938A 1998-06-15 1999-06-14 Ziprasidone formulations. ZA9903938B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US8922998P true 1998-06-15 1998-06-15

Publications (1)

Publication Number Publication Date
ZA9903938B true ZA9903938B (en) 2000-12-14



Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9903938A ZA9903938B (en) 1998-06-15 1999-06-14 Ziprasidone formulations.

Country Status (42)

Country Link
US (1) US6150366A (en)
EP (1) EP0965343B1 (en)
JP (2) JP3441676B2 (en)
KR (1) KR100338915B1 (en)
CN (1) CN1307994C (en)
AP (1) AP1216A (en)
AR (1) AR015553A1 (en)
AT (1) AT240732T (en)
AU (1) AU753820B2 (en)
BG (1) BG64691B1 (en)
BR (1) BR9902268A (en)
CA (1) CA2274338C (en)
CO (1) CO5070579A1 (en)
CZ (1) CZ297954B6 (en)
DE (1) DE69908021T2 (en)
DK (1) DK0965343T3 (en)
EA (1) EA002223B1 (en)
ES (1) ES2197581T3 (en)
GT (1) GT199900080A (en)
HK (1) HK1024184A1 (en)
HN (1) HN1999000089A (en)
HR (1) HRP990193B1 (en)
HU (1) HU226487B1 (en)
ID (1) ID23546A (en)
IL (1) IL130424A (en)
IS (1) IS2182B (en)
MA (1) MA26647A1 (en)
MY (1) MY121397A (en)
NO (1) NO316713B1 (en)
NZ (1) NZ336271A (en)
OA (1) OA11064A (en)
PA (1) PA8475601A1 (en)
PE (1) PE06322000A1 (en)
PL (2) PL195209B1 (en)
PT (1) PT965343E (en)
RS (1) RS49611B (en)
SG (1) SG77243A1 (en)
SK (1) SK286245B6 (en)
TR (1) TR199901379A2 (en)
TW (1) TW590774B (en)
UY (1) UY25649A1 (en)
ZA (1) ZA9903938B (en)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007027273A1 (en) * 2005-06-20 2007-03-08 Elan Pharma International Limited Nanoparticulate and controlled release compositions comprising aryl-heterocyclic compounds
US20080113025A1 (en) * 1998-11-02 2008-05-15 Elan Pharma International Limited Compositions comprising nanoparticulate naproxen and controlled release hydrocodone
US7175855B1 (en) 1999-05-27 2007-02-13 Pfizer Inc. Ziprasidone suspension
CA2371550C (en) * 1999-05-27 2007-01-02 Pfizer Products Inc. Ziprasidone suspension
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
AU764453B2 (en) 1999-10-29 2003-08-21 Euro-Celtique S.A. Controlled release hydrocodone formulations
KR100960200B1 (en) 2000-10-30 2010-05-27 유로-셀티크 소시에떼 아노뉨 Controlled release hydrocodone formulations
US20040048876A1 (en) * 2002-02-20 2004-03-11 Pfizer Inc. Ziprasidone composition and synthetic controls
UY27668A1 (en) * 2002-02-20 2003-10-31 Pfizer Prod Inc Ziprasidone composition and synthetic controls
EP1505967B1 (en) * 2002-05-17 2016-07-13 Duke University Method for treating obesity
AU2003300814A1 (en) * 2002-12-04 2004-06-23 Dr. Reddy's Laboratories Inc. Polymorphic forms of ziprasidone and its hydrochloride
WO2004050655A1 (en) * 2002-12-04 2004-06-17 Dr. Reddy's Laboratories Limited Polymorphic forms of ziprasidone and its hydrochloride
AU2003245027A1 (en) * 2003-04-11 2004-11-01 Hetero Drugs Limited Novel crystalline forms of ziprasidone hydrochloride
AU2004233846B2 (en) * 2003-04-29 2010-07-01 Nalpropion Pharmaceuticals, Inc. Compositions for affecting weight loss
KR100880279B1 (en) * 2003-06-03 2009-01-28 테바 파마슈티컬 인더스트리즈 리미티드 CRISTALLINE ZIPRASIDONE HCl AND PROCESSES FOR PREPARATION THEREOF
US20050049295A1 (en) * 2003-06-12 2005-03-03 Dr. Reddy's Laboratories Limited Process for the preparation of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1piperazinyl) ethyl)-6-chloro-1, 3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride) and its intermediate
US20070190129A1 (en) * 2003-09-02 2007-08-16 Pfizer Inc. Sustained release dosage forms of ziprasidone
US7667037B2 (en) * 2003-10-24 2010-02-23 Teva Pharmaceutical Industries Ltd. Processes for preparation of ziprasidone
AU2003285600A1 (en) * 2003-11-28 2005-06-24 Siddiqui Mohammed Jaweed Mukarram Process for the preparing ziprasidone monohydrochloride hydrate
CA2550485A1 (en) * 2003-12-18 2005-07-07 Teva Pharmaceutical Industries Ltd. Polymorphic form b2 of ziprasidone base
EP1703898A2 (en) * 2003-12-31 2006-09-27 Alpharma, Inc. Ziprasidone formulations
CA2553207A1 (en) * 2004-01-13 2005-08-04 Kishore M. Gadde Compositions of an anticonvulsant and an antipsychotic drug for affecting weight loss
US7713959B2 (en) * 2004-01-13 2010-05-11 Duke University Compositions of an anticonvulsant and mirtazapine to prevent weight gain
DE602005018171D1 (en) * 2004-02-27 2010-01-21 Ranbaxy Lab Ltd A process for preparing ziprasidone
MXPA06012685A (en) * 2004-05-03 2007-01-16 Univ Duke Compositions for affecting weight loss.
WO2005107719A2 (en) * 2004-05-06 2005-11-17 Sandoz Ag Pharmaceutical composition comprising hydrophobic drug having improved solubility
CA2467538C (en) * 2004-05-14 2010-08-24 Apotex Pharmachem Inc. New amorphous ziprasidone hydrochloride (5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride) and processes to produce the same
WO2005123086A2 (en) * 2004-06-11 2005-12-29 Dr. Reddy's Laboratories Ltd. Ziprasidone dosage form
CA2471219A1 (en) * 2004-06-14 2005-12-14 Apotex Pharmachem Inc. Improved preparation of an anhydrate form of 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride)
US9044503B2 (en) * 2004-08-27 2015-06-02 University Of Kentucky Research Foundation Amyloid peptide inactivating enzyme to treat alzheimer's disease peripherally
MX2007002378A (en) * 2004-08-31 2007-04-23 Pfizer Prod Inc Pharmaceutical dosage forms comprising a low-solubility drug and a polymer.
ES2526092T3 (en) * 2004-11-16 2015-01-05 Alkermes Pharma Ireland Limited Injectable formulations of olanzapine nanoparticles
US20080268034A1 (en) * 2005-01-07 2008-10-30 Girish Karanth Solid Oral Dosage Forms of Ziprasidone Containing Colloidal Silicone Dioxide
US7749529B2 (en) * 2005-02-08 2010-07-06 Ash Access Technology, Inc. Catheter lock solution comprising citrate and a paraben
EP1863806A1 (en) * 2005-02-11 2007-12-12 Teva Pharmaceutical Industries Ltd Amorphous ziprasidone mesylate
ITMI20050346A1 (en) 2005-03-07 2006-09-08 Dipharma Spa solid ziprasidone hydrochloride Form
CA2500667C (en) * 2005-03-11 2013-01-15 Apotex Pharmachem Inc. Preparation of acid addition salts of ziprasidone and intermediates thereof by solid phase-gas phase reactions
EP1858892A1 (en) * 2005-03-14 2007-11-28 Teva Pharmaceutical Industries Ltd Anhydrous ziprasidone mesylate and a process for its preparation
EP1858891A2 (en) * 2005-03-14 2007-11-28 Teva Pharmaceutical Industries Ltd. Crystalline forms of ziprasidone mesylate
BRPI0609299A2 (en) * 2005-04-13 2010-03-23 Pfizer Prod Inc depàsito injectable formulations and methods for providing sustained nanoparticle compositions liberaÇço
US20080305161A1 (en) * 2005-04-13 2008-12-11 Pfizer Inc Injectable depot formulations and methods for providing sustained release of nanoparticle compositions
CA2605447A1 (en) * 2005-04-22 2006-11-02 Wyeth Therapeutic combinations for the treatment or prevention of psychotic disorders
CN102048734B (en) 2005-05-26 2013-11-20 大日本住友制药株式会社 Pharmaceutical composition
CN101242813A (en) * 2005-06-20 2008-08-13 依兰药物国际有限公司 Nanoparticulate and controlled release compositions comprising aryl-heterocyclic compounds
AU2006323048B2 (en) 2005-11-22 2013-07-04 Nalpropion Pharmaceuticals, Inc. Compositions and methods for increasing insulin sensitivity
TWI425944B (en) * 2005-11-28 2014-02-11 Orexigen Therapeutics Inc Sustained-release formulation of zonisamide
PL379569A1 (en) * 2006-04-28 2007-10-29 Pliva Kraków Zakłady Farmaceutyczne Spółka Akcyjna Production method of pharmaceutical composition containing active substance ziprasidone or its pharmaceutically admitted salt, increasing solubility and bio-availability of this drug, pharmaceutical composition and application of hydrophilic auxiliary subs
US8916195B2 (en) 2006-06-05 2014-12-23 Orexigen Therapeutics, Inc. Sustained release formulation of naltrexone
EP1889844A3 (en) * 2006-08-02 2008-03-05 Krka Polymorphic forms of ziprasidone sulphates
EP1892243A1 (en) * 2006-08-02 2008-02-27 KRKA, tovarna zdravil, d.d., Novo mesto Polymorphic forms of ziprasidone sulphate salts
DK2089005T3 (en) 2006-11-09 2010-07-19 Orexigen Therapeutics Inc Layered pharmaceutical formulations comprising a rapidly dissolving intermediate layer
KR20160072276A (en) 2006-11-09 2016-06-22 오렉시젠 세러퓨틱스 인크. Unit dosage packages
CA2683276A1 (en) * 2007-05-18 2008-11-27 Scidose Llc Ziprasidone formulations
EP2197446A4 (en) * 2007-08-31 2012-01-25 Reddys Lab Ltd Dr Preparation of ziprasidone hydrochloride monohydrate
WO2009116085A2 (en) * 2008-03-11 2009-09-24 Alkem Laboratories Ltd. An improved process for the preparation of ziprasidone
DE102008045854A1 (en) 2008-09-05 2010-03-11 Tiefenbacher Pharmachemikalien Alfred E. Tiefenbacher Gmbh & Co. Kg Particles of ziprasidone and a disintegrant containing pharmaceutical composition
AU2010266040B2 (en) * 2009-06-25 2015-01-15 Alkermes Pharma Ireland Limited Prodrugs of NH-acidic compounds
EP2340834A1 (en) 2009-12-30 2011-07-06 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Enhanced Solubility of Ziprasidone
KR101841442B1 (en) 2010-01-11 2018-03-23 오렉시젠 세러퓨틱스 인크. Methods of providing weight loss therapy in patients with major depression
SI2538925T1 (en) 2010-02-25 2016-04-29 Bristol-Myers Squibb Company Apixaban formulations
WO2011148253A2 (en) 2010-05-25 2011-12-01 Aurobindo Pharma Limited Solid dosage forms of antipsychotics
SI23610A (en) 2011-01-13 2012-07-31 Diagen@d@o@o New addition salts of ziprasidone, process for their preparation and their use in therapy
MX2014014822A (en) 2012-06-06 2015-05-11 Orexigen Therapeutics Inc Methods of treating overweight and obesity.
JP6440625B2 (en) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー The methods and compositions for treating schizophrenia

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264446A (en) * 1980-09-09 1993-11-23 Bayer Aktiengesellschaft Solid medicament formulations containing nifedipine, and processes for their preparation
MX173362B (en) * 1987-03-02 1994-02-23 Pfizer Piperazinyl heterocyclic compounds and process for their preparation
US4831031A (en) * 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
US4883795A (en) * 1988-01-22 1989-11-28 Pfizer Inc. Piperazinyl-heterocyclic compounds
DE4141268A1 (en) * 1991-12-14 1993-06-17 Merck Patent Gmbh pharmaceutical preparation
US5206366A (en) * 1992-08-26 1993-04-27 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds
US5338846A (en) * 1992-08-26 1994-08-16 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds with a piperazine salt
US5312925A (en) * 1992-09-01 1994-05-17 Pfizer Inc. Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride
US5359068A (en) * 1993-06-28 1994-10-25 Pfizer Inc. Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one
DE69726206T2 (en) * 1996-02-13 2004-04-15 Pfizer Inc. Prodrugs of 5- (2- (4- (1,2-benzisothiazol-3-yl) -1-piperazinyl) ethyl) -6-chloro-1,3-dihydro-2H-indol-2-one
DK0901786T3 (en) * 1997-08-11 2007-10-08 Pfizer Prod Inc Solid pharmaceutical dispersions possess increased bioavailability

Also Published As

Publication number Publication date
JP2002003492A (en) 2002-01-09
BG64691B1 (en) 2005-12-30
YU27199A (en) 2002-12-10
HU226487B1 (en) 2009-03-02
AP9901579A0 (en) 1999-06-30
EP0965343A3 (en) 2000-02-23
BR9902268A (en) 2000-05-02
NZ336271A (en) 2000-10-27
SG77243A1 (en) 2000-12-19
NO992892D0 (en) 1999-06-14
KR20000006143A (en) 2000-01-25
IL130424A (en) 2003-10-31
CZ297954B6 (en) 2007-05-09
CO5070579A1 (en) 2001-08-28
SK286245B6 (en) 2008-06-06
RS49611B (en) 2007-06-04
PE06322000A1 (en) 2000-07-26
SK76999A3 (en) 2000-12-11
PL195606B1 (en) 2007-10-31
PL195209B1 (en) 2007-08-31
TW590774B (en) 2004-06-11
IS2182B (en) 2006-12-15
HN1999000089A (en) 1999-11-03
UY25649A1 (en) 2000-02-23
DK0965343T3 (en) 2003-08-04
JP4187423B2 (en) 2008-11-26
AT240732T (en) 2003-06-15
EA199900467A3 (en) 2000-04-24
EP0965343A2 (en) 1999-12-22
CN1307994C (en) 2007-04-04
HU9901960A2 (en) 2000-08-28
HRP990193B1 (en) 2003-08-31
CN1242987A (en) 2000-02-02
BG103489A (en) 2000-07-31
CA2274338A1 (en) 1999-12-15
AP1216A (en) 2003-10-19
NO316713B1 (en) 2004-04-13
MY121397A (en) 2006-01-28
HU9901960D0 (en) 1999-08-30
JP3441676B2 (en) 2003-09-02
ES2197581T3 (en) 2004-01-01
TR199901379A2 (en) 2000-01-21
GT199900080A (en) 2000-11-29
US6150366A (en) 2000-11-21
CZ212799A3 (en) 2000-09-13
AU753820B2 (en) 2002-10-31
KR100338915B1 (en) 2002-05-30
EA002223B1 (en) 2002-02-28
AR015553A1 (en) 2001-05-02
HU9901960A3 (en) 2000-09-28
OA11064A (en) 2002-03-13
EA199900467A2 (en) 1999-12-29
CA2274338C (en) 2003-04-15
PA8475601A1 (en) 2000-09-29
HK1024184A1 (en) 2007-09-07
DK965343T3 (en)
PT965343E (en) 2003-08-29
JP2000007566A (en) 2000-01-11
HRP990193A2 (en) 2000-02-29
NO992892L (en) 1999-12-16
AU3398399A (en) 1999-12-23
DE69908021T2 (en) 2003-11-27
DE69908021D1 (en) 2003-06-26
IL130424D0 (en) 2000-06-01
IS5079A (en) 1999-12-16
EP0965343B1 (en) 2003-05-21
ID23546A (en) 2000-05-04
MA26647A1 (en) 2004-12-20
PL333737A1 (en) 1999-12-20

Similar Documents

Publication Publication Date Title
DE69941083D1 (en) 12,13-cyclopropan-epothilonderivate
EG24814A (en) Novel compounds.
HK1057106A1 (en) Zeroclick.
HK1047599A1 (en) Hydrophobic material.
ZA200202161B (en) Chair.
ZA200102092B (en) Inhaler.
ZA200004963B (en) Sustained release preparations.
ZA200202289B (en) Antiviral compositions.
ZA200303062B (en) 4-amino-quinazolines.
HK1042420A1 (en) Mouthpiece.
ZA9803054B (en) Fungicidal trifluoromethylalkylamino-triazolopyrimidines.
ZA9803055B (en) Fungicidal trifluorophenyl-triazolopyrimidines.
ZA9807489B (en) Fungicidal 2-methoxybenzophenones.
HK1039920A1 (en) Castor.
ZA9901544B (en) Dental abrasive.
GB9806143D0 (en) Undergarment
ZA200200543B (en) Substituted oxoazaheterocyclyl compounds.
AU4003999A (en) Healthbar formulations
ZA200101371B (en) Antiperspirant compositions.
ZA200100285B (en) Rapidly disintegrable solid preparation.
ZA200109841B (en) 5-cyano-2-aminopyrimidine derivatives.
ZA200000894B (en) 4-Phenyl-pyridine derivatives.
HK1048237A1 (en) Ergonomic bookpack.
ZA200110130B (en) DNA vaccine-PCV.
HK1042413A1 (en) An undergarment.