ZA9810219B - Benzothiazole protein tyrosine kinase inhibitors. - Google Patents
Benzothiazole protein tyrosine kinase inhibitors.Info
- Publication number
- ZA9810219B ZA9810219B ZA9810219A ZA9810219A ZA9810219B ZA 9810219 B ZA9810219 B ZA 9810219B ZA 9810219 A ZA9810219 A ZA 9810219A ZA 9810219 A ZA9810219 A ZA 9810219A ZA 9810219 B ZA9810219 B ZA 9810219B
- Authority
- ZA
- South Africa
- Prior art keywords
- benzothiazole
- tyrosine kinase
- kinase inhibitors
- protein tyrosine
- protein
- Prior art date
Links
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title 2
- 239000005483 tyrosine kinase inhibitor Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6504297P | 1997-11-10 | 1997-11-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA9810219B true ZA9810219B (en) | 2000-06-22 |
Family
ID=22059964
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA9810219A ZA9810219B (en) | 1997-11-10 | 1998-11-09 | Benzothiazole protein tyrosine kinase inhibitors. |
Country Status (25)
Country | Link |
---|---|
US (1) | US6825355B2 (ko) |
EP (1) | EP1037632B1 (ko) |
JP (1) | JP2001522800A (ko) |
KR (1) | KR20010031912A (ko) |
CN (1) | CN1290165A (ko) |
AR (1) | AR017588A1 (ko) |
AT (1) | ATE315394T1 (ko) |
AU (1) | AU744281B2 (ko) |
BR (1) | BR9814956A (ko) |
CA (1) | CA2309319A1 (ko) |
DE (1) | DE69833224T2 (ko) |
ES (1) | ES2256969T3 (ko) |
HU (1) | HUP0102101A3 (ko) |
ID (1) | ID24289A (ko) |
IL (1) | IL135176A0 (ko) |
NO (1) | NO20002121L (ko) |
NZ (1) | NZ503491A (ko) |
PE (1) | PE129799A1 (ko) |
PL (1) | PL340727A1 (ko) |
RU (1) | RU2212407C2 (ko) |
TR (1) | TR200001312T2 (ko) |
TW (1) | TW510898B (ko) |
UY (1) | UY25242A1 (ko) |
WO (1) | WO1999024035A1 (ko) |
ZA (1) | ZA9810219B (ko) |
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US20030130209A1 (en) * | 1999-12-22 | 2003-07-10 | Cheresh David A. | Method of treatment of myocardial infarction |
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EP2298311B1 (en) | 1999-01-13 | 2012-05-09 | Bayer HealthCare LLC | w-Carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
AU779089B2 (en) * | 1999-04-15 | 2005-01-06 | Bristol-Myers Squibb Holdings Ireland Unlimited Company | Cyclic protein tyrosine kinase inhibitors |
EP1222187B1 (en) * | 1999-10-06 | 2004-09-22 | Boehringer Ingelheim Pharmaceuticals Inc. | Heterocyclic compounds useful as inhibitors of tyrosine kinases |
US6506769B2 (en) | 1999-10-06 | 2003-01-14 | Boehringer Ingelheim Pharmaceuticals, Inc. | Heterocyclic compounds useful as inhibitors of tyrosine kinases |
DE19951360A1 (de) * | 1999-10-26 | 2001-05-03 | Aventis Pharma Gmbh | Substituierte Indole |
US7101869B2 (en) | 1999-11-30 | 2006-09-05 | Pfizer Inc. | 2,4-diaminopyrimidine compounds useful as immunosuppressants |
KR20020084116A (ko) | 2000-02-07 | 2002-11-04 | 애보트 게엠베하 운트 콤파니 카게 | 2-벤조티아졸릴 우레아 유도체 및 이의 단백질 키나제억제제로서의 용도 |
GB0003254D0 (en) * | 2000-02-11 | 2000-04-05 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
ATE385794T1 (de) | 2000-06-21 | 2008-03-15 | Hoffmann La Roche | Benzothiazolderivate zur behandlung von alzheimer und parkinson |
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AU2002232439A1 (en) * | 2000-11-29 | 2002-06-11 | Glaxo Group Limited | Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors |
ES2200617B1 (es) | 2001-01-19 | 2005-05-01 | Almirall Prodesfarma, S.A. | Derivados de urea como antagonistas de integrinas alfa 4. |
HN2002000156A (es) | 2001-07-06 | 2003-11-27 | Inc Agouron Pharmaceuticals | Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas y metodos para su utilización. |
MXPA04004301A (es) | 2001-11-09 | 2004-08-11 | Boehringer Ingelheim Pharma | Bencimidazoles sustituidos utiles como inhibidores de la proteina cinasa. |
US6734179B2 (en) | 2001-12-12 | 2004-05-11 | Hoffmann-La Roche Inc. | Benzothiazoles |
WO2003068228A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Aryl ureas with angiogenesis inhibiting activity |
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KR20180014832A (ko) | 2015-06-22 | 2018-02-09 | 액테리온 파마슈티칼 리미티드 | Nadph 옥시다제 4 억제제 |
KR102089122B1 (ko) | 2016-08-25 | 2020-03-13 | 주식회사 엘지화학 | 디아민 화합물 및 이를 이용하여 제조된 플렉시블 소자용 기판 |
CN107021937B (zh) * | 2017-03-27 | 2019-06-21 | 沈阳药科大学 | 苯并噻唑甲酰胺类化合物及其应用 |
WO2018202155A1 (zh) * | 2017-05-04 | 2018-11-08 | 上海长森药业有限公司 | 双并环类核衣壳抑制剂和其作为药物用于治疗乙型肝炎的用途 |
US20210147405A1 (en) * | 2017-06-14 | 2021-05-20 | European Molecular Biology Laboratory | Bicyclic heteroaromatic urea or carbamate compounds for use in therapy |
JP2020536116A (ja) * | 2017-10-02 | 2020-12-10 | ファースト・バイオセラピューティクス・インコーポレイテッド1St Biotherapeutics,Inc. | ベンゾオチアゾール化合物及び神経変性障害を治療するためにそれを使用する方法 |
MX2020008905A (es) | 2018-06-12 | 2020-12-03 | Vtv Therapeutics Llc | Usos terapeuticos de activadores de glucoquinasa en combinacion con insulina o analogos de insulinas. |
CN115594671B (zh) * | 2021-07-08 | 2024-03-15 | 沈阳药科大学 | 苯并噻唑类衍生物及其制备方法和用途 |
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US3966706A (en) * | 1971-01-27 | 1976-06-29 | Ciba-Geigy Ag | 2,6-Dihydroxy-3-cyano-4-methylpyridine containing azo dyes which contain a functional amino group |
JPS50140442A (ko) * | 1974-04-16 | 1975-11-11 | ||
JPS5632549A (en) * | 1979-08-27 | 1981-04-02 | Toyo Ink Mfg Co Ltd | Pigment composition |
JPS62194251A (ja) * | 1986-02-20 | 1987-08-26 | Konishiroku Photo Ind Co Ltd | 保存安定性が改良されたハロゲン化銀写真感光材料 |
IL90337A0 (en) | 1988-05-24 | 1989-12-15 | Pfizer | Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents |
US4970318A (en) * | 1988-05-24 | 1990-11-13 | Pfizer Inc. | Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents |
JPH0667923B2 (ja) * | 1989-05-11 | 1994-08-31 | 東洋紡績株式会社 | 新規なベンゾチアゾール誘導体 |
JP2869561B2 (ja) | 1989-05-22 | 1999-03-10 | 大塚製薬株式会社 | 血小板粘着抑制剤 |
US5296486A (en) | 1991-09-24 | 1994-03-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Leukotriene biosynthesis inhibitors |
EP0638564B1 (en) * | 1993-02-19 | 1999-09-01 | Asahi Kasei Kogyo Kabushiki Kaisha | Benzothiazolesulfonamide derivative, process for producing the same, and use thereof |
US5496816A (en) | 1994-03-14 | 1996-03-05 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
HRP960159A2 (en) | 1995-04-21 | 1997-08-31 | Bayer Ag | Benzocyclopentane oxazolidinones containing heteroatoms |
TW513418B (en) | 1996-07-31 | 2002-12-11 | Otsuka Pharma Co Ltd | Thiazole derivatives, their production and use |
WO1998024805A1 (en) | 1996-12-06 | 1998-06-11 | Vertex Pharmaceuticals Incorporated | INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME |
US6022884A (en) | 1997-11-07 | 2000-02-08 | Amgen Inc. | Substituted pyridine compounds and methods of use |
ATE401312T1 (de) | 1997-12-15 | 2008-08-15 | Astellas Pharma Inc | Pyrimidin-5-carboxamid-derivate |
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1998
- 1998-11-02 EP EP98957468A patent/EP1037632B1/en not_active Expired - Lifetime
- 1998-11-02 KR KR1020007005014A patent/KR20010031912A/ko not_active Application Discontinuation
- 1998-11-02 ES ES98957468T patent/ES2256969T3/es not_active Expired - Lifetime
- 1998-11-02 NZ NZ503491A patent/NZ503491A/xx unknown
- 1998-11-02 IL IL13517698A patent/IL135176A0/xx unknown
- 1998-11-02 CN CN98811003A patent/CN1290165A/zh active Pending
- 1998-11-02 AT AT98957468T patent/ATE315394T1/de not_active IP Right Cessation
- 1998-11-02 AU AU13719/99A patent/AU744281B2/en not_active Ceased
- 1998-11-02 ID IDW20000858A patent/ID24289A/id unknown
- 1998-11-02 JP JP2000520127A patent/JP2001522800A/ja active Pending
- 1998-11-02 HU HU0102101A patent/HUP0102101A3/hu unknown
- 1998-11-02 TR TR2000/01312T patent/TR200001312T2/xx unknown
- 1998-11-02 BR BR9814956-3A patent/BR9814956A/pt not_active IP Right Cessation
- 1998-11-02 WO PCT/US1998/023204 patent/WO1999024035A1/en not_active Application Discontinuation
- 1998-11-02 PL PL98340727A patent/PL340727A1/xx not_active Application Discontinuation
- 1998-11-02 DE DE69833224T patent/DE69833224T2/de not_active Expired - Lifetime
- 1998-11-02 CA CA002309319A patent/CA2309319A1/en not_active Abandoned
- 1998-11-02 RU RU2000114635/04A patent/RU2212407C2/ru not_active IP Right Cessation
- 1998-11-05 TW TW087118450A patent/TW510898B/zh not_active IP Right Cessation
- 1998-11-09 ZA ZA9810219A patent/ZA9810219B/xx unknown
- 1998-11-10 AR ARP980105676A patent/AR017588A1/es not_active Application Discontinuation
- 1998-11-10 UY UY25242A patent/UY25242A1/es not_active Application Discontinuation
- 1998-11-10 PE PE1998001078A patent/PE129799A1/es not_active Application Discontinuation
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2000
- 2000-04-26 NO NO20002121A patent/NO20002121L/no not_active Application Discontinuation
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2001
- 2001-10-26 US US10/032,609 patent/US6825355B2/en not_active Expired - Lifetime
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TW510898B (en) | 2002-11-21 |
NO20002121D0 (no) | 2000-04-26 |
RU2212407C2 (ru) | 2003-09-20 |
JP2001522800A (ja) | 2001-11-20 |
DE69833224T2 (de) | 2006-09-28 |
DE69833224D1 (en) | 2006-04-06 |
CA2309319A1 (en) | 1999-05-20 |
PL340727A1 (en) | 2001-02-26 |
EP1037632A4 (en) | 2002-08-21 |
HUP0102101A2 (hu) | 2001-11-28 |
AU744281B2 (en) | 2002-02-21 |
CN1290165A (zh) | 2001-04-04 |
KR20010031912A (ko) | 2001-04-16 |
NO20002121L (no) | 2000-05-09 |
PE129799A1 (es) | 2000-03-08 |
US6825355B2 (en) | 2004-11-30 |
EP1037632A1 (en) | 2000-09-27 |
AU1371999A (en) | 1999-05-31 |
WO1999024035A1 (en) | 1999-05-20 |
ID24289A (id) | 2000-07-13 |
IL135176A0 (en) | 2001-05-20 |
ATE315394T1 (de) | 2006-02-15 |
US20020123484A1 (en) | 2002-09-05 |
UY25242A1 (es) | 2001-08-27 |
EP1037632B1 (en) | 2006-01-11 |
AR017588A1 (es) | 2001-09-12 |
BR9814956A (pt) | 2000-10-03 |
HUP0102101A3 (en) | 2002-11-28 |
NZ503491A (en) | 2002-08-28 |
ES2256969T3 (es) | 2006-07-16 |
TR200001312T2 (tr) | 2000-09-21 |
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