ZA9803930B - Excitatory amino acid receptor modulators. - Google Patents

Excitatory amino acid receptor modulators.

Info

Publication number
ZA9803930B
ZA9803930B ZA9803930A ZA9803930A ZA9803930B ZA 9803930 B ZA9803930 B ZA 9803930B ZA 9803930 A ZA9803930 A ZA 9803930A ZA 9803930 A ZA9803930 A ZA 9803930A ZA 9803930 B ZA9803930 B ZA 9803930B
Authority
ZA
South Africa
Prior art keywords
amino acid
receptor modulators
acid receptor
excitatory amino
excitatory
Prior art date
Application number
ZA9803930A
Inventor
Steven March Massey
James Allen Monn
Matthew John Valli
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US4701197P priority Critical
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA9803930B publication Critical patent/ZA9803930B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/52Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/64Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00Compounds containing azido groups
    • C07C247/14Compounds containing azido groups with azido groups bound to carbon atoms of rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32Oximes
    • C07C251/34Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/44Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/26Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/07Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/383Cycloaliphatic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/18All rings being cycloaliphatic the ring system containing six carbon atoms
ZA9803930A 1997-05-14 1998-05-08 Excitatory amino acid receptor modulators. ZA9803930B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US4701197P true 1997-05-14 1997-05-14

Publications (1)

Publication Number Publication Date
ZA9803930B true ZA9803930B (en) 1999-11-08

Family

ID=21946570

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9803930A ZA9803930B (en) 1997-05-14 1998-05-08 Excitatory amino acid receptor modulators.

Country Status (29)

Country Link
US (3) US5958960A (en)
EP (1) EP0878463B1 (en)
JP (1) JP4191263B2 (en)
KR (1) KR20010012489A (en)
CN (1) CN1125807C (en)
AR (1) AR015664A1 (en)
AT (1) AT198190T (en)
AU (1) AU729632B2 (en)
BR (1) BR9808787A (en)
CA (1) CA2289472C (en)
CO (1) CO4950558A1 (en)
DE (1) DE69800430T2 (en)
DK (1) DK0878463T3 (en)
EA (1) EA199901029A1 (en)
ES (1) ES2152738T3 (en)
GR (1) GR3035156T3 (en)
HU (1) HU0001404A3 (en)
ID (1) ID23183A (en)
IL (1) IL132894D0 (en)
NO (1) NO995480L (en)
NZ (1) NZ500954A (en)
PE (1) PE73599A1 (en)
PL (1) PL336793A1 (en)
PT (1) PT878463E (en)
SV (1) SV1998000056A (en)
TR (1) TR199902777T2 (en)
TW (1) TW505623B (en)
WO (1) WO1998051655A1 (en)
ZA (1) ZA9803930B (en)

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CN1247527C (en) 1998-08-31 2006-03-29 大正制药株式会社 6-fluorobicyclo [3.1.0] hexame derivatives
PE12362000A1 (en) * 1998-11-13 2000-11-10 Lilly Co Eli Receptor Modulators excitatory amino acid
JP4399932B2 (en) * 1998-12-18 2010-01-20 大正製薬株式会社 Method for preparing intermediate and fluorinated amino compound using the same
KR100567288B1 (en) * 1998-12-18 2006-04-04 다이쇼 세이야꾸 가부시끼가이샤 Intermediates and Process for Producing Fluorine-Containing Amino Acid Compound by Using The Same
JP4505926B2 (en) * 1999-03-25 2010-07-21 大正製薬株式会社 New carboxylic acid derivatives and a method for manufacturing the same
US6479674B1 (en) 1999-03-25 2002-11-12 Taisho Pharmaceutical Co., Ltd. Carboxylic acid derivatives and process for producing same
US6528499B1 (en) * 2000-04-27 2003-03-04 Georgetown University Ligands for metabotropic glutamate receptors and inhibitors of NAALADase
DE60020962T2 (en) 1999-04-28 2006-05-24 Georgetown University Ligands for metabotropic glutamate receptors
US6417366B2 (en) * 1999-06-24 2002-07-09 Abbott Laboratories Preparation of quinoline-substituted carbonate and carbamate derivatives
JP4783967B2 (en) * 1999-07-21 2011-09-28 大正製薬株式会社 Pharmaceuticals containing fluorine-containing amino acid derivatives as active ingredients
AU1572301A (en) * 1999-12-08 2001-06-18 Eli Lilly And Company Cyclopentyl sulfonamide derivatives
US6639107B1 (en) 1999-12-08 2003-10-28 Eli Lilly And Company Cyclopentyl sulfonamide derivatives
CN1267407C (en) * 2001-01-11 2006-08-02 伊莱利利公司 Prodrugs of excitatory amino acids
EP1351925A1 (en) * 2001-01-11 2003-10-15 Eli Lilly And Company Prodrugs of excitatory amino acids
WO2002068380A1 (en) * 2001-02-22 2002-09-06 Eli Lilly And Company Synthetic excitatory amino acids
US20040116489A1 (en) * 2002-02-12 2004-06-17 Massey Steven Marc Synthetic excitatory amino acids
SI1459765T1 (en) * 2001-12-27 2009-02-28 Taisho Pharma Co Ltd 6-fluorobicyclo 3.1.0 hexane derivatives
US20050192273A1 (en) * 2002-04-03 2005-09-01 Johnson Bryan G. Therapy for psychoses combining an atypical antipsychotic and an mglu2/3 receptor agonist
JP4342437B2 (en) * 2002-06-11 2009-10-14 イーライ リリー アンド カンパニー Prodrugs of excitatory amino acid
CN100482680C (en) * 2002-06-11 2009-04-29 伊莱利利公司 Prodrugs of excitatory amino acids
CN100582087C (en) 2003-06-26 2010-01-20 大正制药株式会社 2-aminobicyclo 3.1.0 hexane-2,6-dicarboxylic ester derivative
CA2530706C (en) 2003-06-26 2012-11-27 Taisho Pharmaceutical Co., Ltd. 2-amino-bicyclo[3.1.0] hexane-2,6-dicarboxylic ester derivative
JP4984529B2 (en) 2003-06-26 2012-07-25 大正製薬株式会社 2-Aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid derivative
AU2004289652B8 (en) * 2003-11-07 2011-01-20 Taisho Pharmaceutical Co., Ltd. Processes for preparing bicyclo [3.1.0] hexane derivatives, and intermediates thereto
CA2659215C (en) 2005-07-27 2018-07-10 Dov Pharmaceutical, Inc. Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP1928437A2 (en) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
WO2007134136A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20080045725A1 (en) 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
MX2008014320A (en) 2006-05-09 2009-03-25 Braincells Inc 5 ht receptor mediated neurogenesis.
KR20090064418A (en) 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20080269348A1 (en) * 2006-11-07 2008-10-30 Phil Skolnick Novel Arylbicyclo[3.1.0]Hexylamines And Methods And Compositions For Their Preparation And Use
US8138377B2 (en) * 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
DK2097111T3 (en) 2006-11-08 2015-08-24 Molecular Insight Pharm Inc Heterodimers of glutamic acid
CN101686952A (en) * 2007-03-12 2010-03-31 Vm生物医药公司 Novel agents of calcium ion channel modulators
WO2008153937A2 (en) * 2007-06-06 2008-12-18 Dov Pharmaceutical, Inc. Novel 1- heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
US8562945B2 (en) 2008-01-09 2013-10-22 Molecular Insight Pharmaceuticals, Inc. Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
WO2009142184A1 (en) * 2008-05-21 2009-11-26 大正製薬株式会社 Method of producing bicyclo[3.1.0]hexane derivative using enzyme
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2010111080A2 (en) 2009-03-27 2010-09-30 Eli Lilly And Company Optimized treatment of schizophrenia
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TWI520935B (en) * 2010-11-18 2016-02-11 Lilly Co Eli As the mGluR2 / 3 antagonist of the 4- substituted phenyl sulfonic acyl methyl -3--- bicyclo [3.1.0] hexane compound
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HUE030171T2 (en) * 2011-06-17 2017-05-29 Lilly Co Eli Bicyclo(3.1.0)hexane-2,6-dicarboxylic acid derivatives as mglu2 receptor agonist
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ZA9803930B (en) * 1997-05-14 1999-11-08 Lilly Co Eli Excitatory amino acid receptor modulators.

Also Published As

Publication number Publication date
JP4191263B2 (en) 2008-12-03
KR20010012489A (en) 2001-02-15
CN1255117A (en) 2000-05-31
AT198190T (en) 2001-01-15
DK878463T3 (en)
GR3035156T3 (en) 2001-04-30
EP0878463B1 (en) 2000-12-20
JP2001525825A (en) 2001-12-11
US6268507B1 (en) 2001-07-31
CA2289472C (en) 2007-04-24
US6160009A (en) 2000-12-12
CN1125807C (en) 2003-10-29
DE69800430T2 (en) 2001-06-13
NO995480L (en) 1999-11-09
DK0878463T3 (en) 2001-02-19
TW505623B (en) 2002-10-11
CO4950558A1 (en) 2000-09-01
AR015664A1 (en) 2001-05-16
PL336793A1 (en) 2000-07-17
DE69800430D1 (en) 2001-01-25
ES2152738T3 (en) 2001-02-01
PE73599A1 (en) 1999-08-14
EA199901029A1 (en) 2000-06-26
BR9808787A (en) 2000-07-11
AU7386998A (en) 1998-12-08
SV1998000056A (en) 1999-01-18
TR199902777T2 (en) 2000-07-21
ID23183A (en) 2000-03-23
AU729632B2 (en) 2001-02-08
WO1998051655A1 (en) 1998-11-19
HU0001404A2 (en) 2000-08-28
NZ500954A (en) 2001-06-29
EP0878463A1 (en) 1998-11-18
NO995480D0 (en) 1999-11-09
IL132894D0 (en) 2001-03-19
US5958960A (en) 1999-09-28
PT878463E (en) 2001-04-30
HU0001404A3 (en) 2000-09-28
CA2289472A1 (en) 1998-11-19

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