ZA969179B - 4-Phenyl-4-oxo-2-butenoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity - Google Patents

4-Phenyl-4-oxo-2-butenoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity

Info

Publication number
ZA969179B
ZA969179B ZA969179A ZA969179A ZA969179B ZA 969179 B ZA969179 B ZA 969179B ZA 969179 A ZA969179 A ZA 969179A ZA 969179 A ZA969179 A ZA 969179A ZA 969179 B ZA969179 B ZA 969179B
Authority
ZA
South Africa
Prior art keywords
kynurenine
oxo
phenyl
acid derivatives
inhibiting activity
Prior art date
Application number
ZA969179A
Other languages
English (en)
Inventor
Antonio Giordani
Paolo Pevarello
Carmela Speciale
Mario Varasi
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of ZA969179B publication Critical patent/ZA969179B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA969179A 1995-11-03 1996-10-31 4-Phenyl-4-oxo-2-butenoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity ZA969179B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9522617.1A GB9522617D0 (en) 1995-11-03 1995-11-03 4-Phenyl-4-oxo-butenoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity

Publications (1)

Publication Number Publication Date
ZA969179B true ZA969179B (en) 1997-05-29

Family

ID=10783386

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA969179A ZA969179B (en) 1995-11-03 1996-10-31 4-Phenyl-4-oxo-2-butenoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity

Country Status (7)

Country Link
US (1) US6048896A (fr)
EP (1) EP0858442A1 (fr)
JP (1) JP2000511872A (fr)
AU (1) AU7295096A (fr)
GB (1) GB9522617D0 (fr)
WO (1) WO1997017316A1 (fr)
ZA (1) ZA969179B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9716101D0 (en) * 1997-07-30 1997-10-01 Pharmacia & Upjohn Spa Fused heterocyclic compounds
GB9725055D0 (en) * 1997-11-26 1998-01-28 Pharmacia & Upjohn Spa 1,3,4-thiadiazoles compounds
US6380249B1 (en) 1998-06-03 2002-04-30 Merck & Co., Inc. HIV integrase inhibitors
US6306891B1 (en) 1998-06-03 2001-10-23 Merck & Co., Inc. HIV integrase inhibitors
EP1082121A4 (fr) * 1998-06-03 2003-02-05 Merck & Co Inc Inhibiteurs de vih integrase
US6262055B1 (en) 1998-06-03 2001-07-17 Merck & Co., Inc. HIV integrase inhibitors
DE69925918T2 (de) 1998-07-27 2006-05-11 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Diketosäure-derivate als hemmstoffe von polymerasen
GB9816358D0 (en) 1998-07-27 1998-09-23 Angeletti P Ist Richerche Bio Enzyme inhibitors
AU3738600A (en) * 1999-03-12 2000-09-28 Johns Hopkins University, The Modulation of protein expression using carbocyclic aryl alkenoic acid derivatives
US7557144B1 (en) 2000-03-11 2009-07-07 The Johns Hopkins University Modulation of protein expression using carbocyclic aryl alkenoic acid derivatives
US6852876B1 (en) 2001-06-08 2005-02-08 University Of Central Florida Treatment of colon cancer
US6686496B1 (en) 2001-06-08 2004-02-03 University Of Central Florida Treatment of myeloma
US6602907B1 (en) 2001-06-08 2003-08-05 University Of Central Florida Treatment of breast cancer
CN102151262A (zh) * 2001-06-12 2011-08-17 维尔斯达医疗公司 用于治疗代谢失调的化合物
WO2003097568A1 (fr) * 2002-05-15 2003-11-27 Sankio Chemical Co., Ltd. Procede de fabrication de derive d'ester 4-phenyl-4-oxo-2-butenoique
CN103159618B (zh) * 2011-12-09 2016-05-11 天津市国际生物医药联合研究院有限公司 4-羰基-2-丁烯酸类化合物及其用途
US9822058B2 (en) 2012-04-05 2017-11-21 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
JP2016536350A (ja) 2013-09-26 2016-11-24 シーエイチディーアイ ファウンデーション，インコーポレーテッド キヌレニン−３−モノオキシゲナーゼ阻害薬、医薬組成物、及びこれらの使用方法
WO2015047978A1 (fr) 2013-09-26 2015-04-02 Chdi Foundation, Inc. Inhibiteurs de kynurénine-3-monooxygénase, compositions pharmaceutiques et procédés d'utilisation de ceux-ci
CN110487931A (zh) * 2019-08-21 2019-11-22 浙江华海药业股份有限公司 一种(e)-4-苯基-4-氧代-2-丁烯酸乙酯的分析方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6717403A (fr) * 1966-12-30 1968-07-01
US4008323A (en) * 1974-03-25 1977-02-15 Pierre Fabre S.A. Method of reducing cholesterol using certain aromatic keto acids
FR2481118A1 (fr) * 1980-04-24 1981-10-30 Roussel Uclaf Application a titre de medicaments de derives substitues de l'acide phenyl-4-oxo-2-butenoique
US5519055A (en) * 1993-08-06 1996-05-21 University Of Maryland At Baltimore Substituted kynurenines and process for their preparation

Also Published As

Publication number Publication date
US6048896A (en) 2000-04-11
AU7295096A (en) 1997-05-29
WO1997017316A1 (fr) 1997-05-15
JP2000511872A (ja) 2000-09-12
EP0858442A1 (fr) 1998-08-19
GB9522617D0 (en) 1996-01-03

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