ZA9607766B - Arylalkyl-diazinone - Google Patents

Arylalkyl-diazinone

Info

Publication number
ZA9607766B
ZA9607766B ZA9607766A ZA9607766A ZA9607766B ZA 9607766 B ZA9607766 B ZA 9607766B ZA 9607766 A ZA9607766 A ZA 9607766A ZA 9607766 A ZA9607766 A ZA 9607766A ZA 9607766 B ZA9607766 B ZA 9607766B
Authority
ZA
South Africa
Prior art keywords
diazinone
arylalkyl
Prior art date
Application number
ZA9607766A
Inventor
Rochus Jonas
Michael Wolf
Norbert Beier
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE1995133975 priority Critical patent/DE19533975A1/en
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA9607766B publication Critical patent/ZA9607766B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
ZA9607766A 1995-09-14 1996-09-13 Arylalkyl-diazinone ZA9607766B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE1995133975 DE19533975A1 (en) 1995-09-14 1995-09-14 Arylalkyl diazinone

Publications (1)

Publication Number Publication Date
ZA9607766B true ZA9607766B (en) 1997-03-26

Family

ID=7772083

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9607766A ZA9607766B (en) 1995-09-14 1996-09-13 Arylalkyl-diazinone

Country Status (23)

Country Link
US (1) US5859008A (en)
EP (1) EP0763534B1 (en)
JP (1) JP4149532B2 (en)
KR (1) KR100435301B1 (en)
CN (1) CN1110495C (en)
AT (1) AT233258T (en)
AU (1) AU716113B2 (en)
BR (1) BR9603736A (en)
CA (1) CA2185397C (en)
CZ (1) CZ286567B6 (en)
DE (2) DE19533975A1 (en)
DK (1) DK0763534T3 (en)
ES (1) ES2192213T3 (en)
HU (1) HU9602511A3 (en)
MX (1) MX9604020A (en)
NO (1) NO309679B1 (en)
PL (1) PL185961B1 (en)
PT (1) PT763534E (en)
RU (1) RU2167159C2 (en)
SI (1) SI0763534T1 (en)
SK (1) SK281474B6 (en)
TW (1) TW363063B (en)
ZA (1) ZA9607766B (en)

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DE19502699A1 (en) * 1995-01-28 1996-08-01 Merck Patent Gmbh Arylalkyl thiadiazinones
PT1042319E (en) * 1997-12-15 2004-06-30 Altana Pharma Ag Di-hydro-benzofuranes
PT1070056E (en) * 1998-03-14 2004-11-30 Altana Pharma Ag Pde iii / iv inhibitors based on ftalazinone
ES2260043T3 (en) 1999-08-21 2006-11-01 Altana Pharma Ag Synergic combination of roflumilast and salmeterol.
CN1146562C (en) 1999-10-25 2004-04-21 奥坦纳医药公司 Thtraphydrothiopy 2,3-diazanaphthylaone derivatives as PDE4 inhibitors
CA2388121A1 (en) 1999-10-25 2001-05-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinone derivatives as pde 4 inhibitors
US6933296B2 (en) * 2000-06-05 2005-08-23 Altana Pharma B.V. Compounds effective as β2-adrenoreceptor agonists as well as PDE4-inhibitors
DE10064997A1 (en) * 2000-12-23 2002-06-27 Merck Patent Gmbh New 1-benzoyl-3-phenyl-tetrahydropyridazine derivatives, useful for treating e.g. allergy, are selective inhibitors of phosphodiesterase IV, and new intermediates
CA2437932A1 (en) * 2001-02-12 2002-09-19 Merck Patent Gesellschaft Mit Beschraenkter Haftung Use of type 4 phosphodiesterase inhibitors in myocardial diseases
BR0207278A (en) 2001-02-15 2004-02-10 Altana Pharma Ag Phthalazinone-piperidine derivatives as pde4 inhibitors
EP1385848A2 (en) 2001-04-25 2004-02-04 ALTANA Pharma AG Phtalazinones derivatives useful as pde4/7 inhibitors
MXPA03009806A (en) 2001-04-25 2004-01-29 Altana Pharma Ag Process for producing purified piperidine derivative.
BR0211209A (en) 2001-07-18 2004-07-13 Merck Patent Gmbh 4- (Benzylidenoamino) -3- (methylsulfanyl) -4h-1,2,4-triazin-5-one derivatives having an antagonistic action of tnf and pde iv inhibition for the treatment of heart disease and allergies
DE10150517A1 (en) * 2001-10-12 2003-04-17 Merck Patent Gmbh Medicaments containing pyridazinone, thiadiazinone or oxadiazinone derivatives, used e.g. for treatment of osteoporosis, tumors, atherosclerosis, rheumatoid arthritis or multiple sclerosis
EP1463509A1 (en) * 2001-10-31 2004-10-06 MERCK PATENT GmbH Type 4 phosphodiesterase inhibitors and uses thereof
ES2195785B1 (en) * 2002-05-16 2005-03-16 Almirall Prodesfarma, S.A. New derivatives of piridazin-3 (2h) -ona.
DE10227269A1 (en) * 2002-06-19 2004-01-08 Merck Patent Gmbh thiazole
RS51445B (en) 2002-08-10 2011-04-30 Nycomed Gmbh. Pyrrolidinedione substituted piperidine-phtalazones as pde4 inhibitors
CA2494650A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Pyridazinone-derivatives as pde4 inhibitors
ES2211344B1 (en) * 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. New derivatives of piridazin-3 (2h) -ona.
JP2006522151A (en) 2003-04-01 2006-09-28 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ Phosphodiesterase inhibitors in infertility
WO2005075437A1 (en) * 2004-02-04 2005-08-18 Altana Pharma Ag Pyridazinone derivatives and their use as pde4 inhibitors
ES2304692T3 (en) 2004-02-04 2008-10-16 Nycomed Gmbh Derivatives of 2- (piperidin-4-il) -4,5-dihidro-2h-piridazin-3-ona as pde4 inhibitors.
ES2251866B1 (en) * 2004-06-18 2007-06-16 Laboratorios Almirall S.A. New derivatives of piridazin-3 (2h) -ona.
ES2251867B1 (en) * 2004-06-21 2007-06-16 Laboratorios Almirall S.A. New derivatives of piridazin-3 (2h) -ona.
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
WO2007134136A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
JP2009513672A (en) 2005-10-31 2009-04-02 ブレインセルス,インコーポレイティド GABA receptor-mediated regulation of neurogenesis
DE102005055354A1 (en) * 2005-11-21 2007-10-31 Merck Patent Gmbh Substituted 5-phenyl-3,6-dihydro-2-oxo-6H- [1,3,4] thiadiazines
DE102005055355A1 (en) * 2005-11-21 2007-10-31 Merck Patent Gmbh thiadiazine derivatives 3,6-dihydro-2-oxo-6H- [1,3,4]
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2026813A2 (en) 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
CA2662491A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
ES2320954B1 (en) * 2007-03-02 2010-03-16 Laboratorio Almirall S.A. New preparation procedure for 3-methyl-4-phenylisoxazolo (3,4-d) iridazin-7 (6h) -ona.
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE788476A (en) * 1971-09-08 1973-03-06 Sandoz Sa New derivatives of pyridazinone, their preparation and their use as medicines
DE3505609A1 (en) * 1985-02-19 1986-08-21 Merck Patent Gmbh Benzimidazolyl pyridazinones
AU614965B2 (en) * 1987-06-06 1991-09-19 Merck Patent Gesellschaft Mit Beschrankter Haftung Thiadiazinones
DE3734083A1 (en) * 1987-10-08 1989-04-20 Heumann Pharma Gmbh & Co Benzimidazoles, process for their production and these compounds containing drug
GB8816944D0 (en) * 1988-07-15 1988-08-17 Sobio Lab Compounds
US5247076A (en) * 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
DE4134893A1 (en) * 1991-10-23 1993-04-29 Merck Patent Gmbh thiadiazinones
DE4310699A1 (en) * 1993-04-01 1994-10-06 Merck Patent Gmbh thiadiazinones
DE4330915C1 (en) * 1993-09-11 1994-09-08 Steinel Bernhard Werkzeugmasch Pallet changer for machine tools
DE19500558A1 (en) * 1995-01-11 1996-07-18 Merck Patent Gmbh 3-alkoxycarbonyl-thiadiazinones
DE19502699A1 (en) * 1995-01-28 1996-08-01 Merck Patent Gmbh Arylalkyl thiadiazinones
DE19514568A1 (en) * 1995-04-20 1996-10-24 Merck Patent Gmbh Arylalkyl pyridazinones

Also Published As

Publication number Publication date
CN1110495C (en) 2003-06-04
CZ263096A3 (en) 1998-03-18
SK110096A3 (en) 1997-08-06
JP4149532B2 (en) 2008-09-10
NO963852D0 (en) 1996-09-13
DK0763534T3 (en) 2003-06-10
CZ286567B6 (en) 2000-05-17
AU716113B2 (en) 2000-02-17
EP0763534A1 (en) 1997-03-19
AT233258T (en) 2003-03-15
SI0763534T1 (en) 2003-10-31
PL316070A1 (en) 1997-03-17
PL185961B1 (en) 2003-09-30
CA2185397C (en) 2010-01-05
JPH09124611A (en) 1997-05-13
KR970015578A (en) 1997-04-28
HU9602511A3 (en) 1998-04-28
HU9602511D0 (en) 1996-11-28
MX9604020A (en) 1997-03-29
DE19533975A1 (en) 1997-03-20
DE59610164D1 (en) 2003-04-03
AU6551796A (en) 1997-03-20
CN1157287A (en) 1997-08-20
RU2167159C2 (en) 2001-05-20
BR9603736A (en) 1998-05-26
TW363063B (en) 1999-07-01
SK281474B6 (en) 2001-04-09
NO309679B1 (en) 2001-03-12
PT763534E (en) 2003-07-31
KR100435301B1 (en) 2004-09-07
HU9602511A2 (en) 1997-03-28
EP0763534B1 (en) 2003-02-26
ES2192213T3 (en) 2003-10-01
NO963852L (en) 1997-03-17
DK763534T3 (en)
US5859008A (en) 1999-01-12
CA2185397A1 (en) 1997-03-15

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