ZA9202420B - Grf-analogs ii - Google Patents

Grf-analogs ii

Info

Publication number
ZA9202420B
ZA9202420B ZA922420A ZA9202420A ZA9202420B ZA 9202420 B ZA9202420 B ZA 9202420B ZA 922420 A ZA922420 A ZA 922420A ZA 9202420 A ZA9202420 A ZA 9202420A ZA 9202420 B ZA9202420 B ZA 9202420B
Authority
ZA
South Africa
Prior art keywords
grf
analogs
Prior art date
Application number
ZA922420A
Inventor
Arthur Martin Felix
Martin Felix Arthur
Edgar Philip Heimar
Philip Heimar Edgar
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US68283591A priority Critical
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA9202420B publication Critical patent/ZA9202420B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/60Growth-hormone releasing factors (GH-RF) (Somatoliberin)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
ZA922420A 1991-04-09 1992-04-02 Grf-analogs ii ZA9202420B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US68283591A true 1991-04-09 1991-04-09

Publications (1)

Publication Number Publication Date
ZA9202420B true ZA9202420B (en) 1992-12-30

Family

ID=24741366

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA922420A ZA9202420B (en) 1991-04-09 1992-04-02 Grf-analogs ii

Country Status (10)

Country Link
US (1) US5846936A (en)
EP (2) EP0542937A1 (en)
JP (1) JPH05507939A (en)
AU (1) AU662731B2 (en)
CA (1) CA2084061A1 (en)
IE (1) IE921121A1 (en)
IL (1) IL101452A (en)
NZ (1) NZ242209A (en)
WO (1) WO1992018531A1 (en)
ZA (1) ZA9202420B (en)

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US5512549A (en) * 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
WO1997040071A1 (en) * 1996-04-19 1997-10-30 Novo Nordisk A/S Compounds with growth hormone releasing properties
US5981488A (en) * 1997-03-31 1999-11-09 Eli Lillly And Company Glucagon-like peptide-1 analogs
EP0922446A1 (en) * 1997-12-03 1999-06-16 Applied Research Systems Ars Holding N.V. Solution-phase site-specific preparation of GRF-PEG conjugates
US6696063B1 (en) * 1998-12-30 2004-02-24 Applied Research Systems Ars Holding N.V. Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy
US20040192593A1 (en) 1999-07-26 2004-09-30 Baylor College Of Medicine Protease resistant ti-growth hormone releasing hormone
EP1204321B1 (en) * 1999-07-26 2005-11-09 Baylor College Of Medicine Super-active porcine growth hormone releasing hormone analog
US6486134B2 (en) * 1999-09-17 2002-11-26 Leadergene Limited Gene treatment to enhance feed efficiency and growth rate of livestock
DE20004154U1 (en) 2000-03-08 2001-07-19 Heuser Volkmar Highly insulating window or door
WO2001087322A2 (en) * 2000-05-17 2001-11-22 Bionebraska, Inc. Peptide pharmaceutical formulations
EP1351984A2 (en) 2000-12-13 2003-10-15 Eli Lilly And Company Amidated glucagon-like peptide-1
EA006484B1 (en) 2001-02-02 2005-12-29 Конджачем, Инк. Long lasting growth hormone releasing factor derivatives
AT536100T (en) * 2001-10-26 2011-12-15 Baylor College Medicine Composition for changing bone properties in one sample
WO2003049700A2 (en) 2001-12-11 2003-06-19 Advisys, Inc. Growth hormone releasing hormone suplementation for treating chronically ill subjects
WO2003066825A2 (en) * 2002-02-07 2003-08-14 Baylor College Of Medicine Modified pituitary gland development in offspring from expectant mother animals treated with growth hormone releasing hormone therapy
RU2005111253A (en) * 2002-09-18 2005-11-20 Сантр Оспиталье Де Л` Юниверсите Де Монреаль (Схюм) (Ca) GHRH Analogues
WO2004067719A2 (en) * 2003-01-28 2004-08-12 Advisys, Inc. Growth hormone releasing hormone (ghrh) for use in reducing culling in herd animals
TW200424214A (en) * 2003-04-21 2004-11-16 Advisys Inc Plasmid mediated GHRH supplementation for renal failures
US7361642B2 (en) * 2003-08-04 2008-04-22 Vgx Pharmaceuticals, Inc. Canine specific growth hormone releasing hormone
WO2005065722A2 (en) 2003-12-31 2005-07-21 Advisys, Inc. Reducing arthritis and lameness in subjects by growth hormone releasing hormone (ghrh) supplementation
DE602005027661D1 (en) * 2004-01-20 2011-06-09 VGX Pharmaceuticals LLC Corrosive hormone (ghrh) from muscle cells by specific specific signal peptide
CN101027081A (en) * 2004-07-23 2007-08-29 阿德维希斯公司 Growth hormone releasing hormone enhances the immune response induced by vaccination
WO2008006019A2 (en) * 2006-07-06 2008-01-10 Advisys Inc. Growth hormone releasing hormone treatment to decrease cholesterol levels
BRPI0720306A2 (en) 2006-12-14 2014-02-04 Aileron Therapeutics Inc Bis-sufidril macrocycling systems
ES2558928T3 (en) 2007-01-31 2016-02-09 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
ES2610531T3 (en) 2007-03-28 2017-04-28 President And Fellows Of Harvard College Sewn polypeptides
US20090088380A1 (en) * 2007-07-12 2009-04-02 Pierrette Gaudreau Ghrh analogs and therapeutic uses thereof
JP5799397B2 (en) * 2008-06-12 2015-10-28 イプセン・バイオイノベーション・リミテッドIpsen Bioinnovation Limited Cancer suppression
EP2421548A4 (en) * 2009-04-20 2012-09-26 Theratechnologies Inc Use of (hexenoyl trans-3)hgrf(l-44)nh2 and simvastatin in combination therapy
WO2010121351A1 (en) * 2009-04-20 2010-10-28 Theratechnologies Inc. Use of (hexenoyl trans-3)hgrf(1-44)nh2 and ritonavir in combination therapy
US8980249B2 (en) 2010-06-03 2015-03-17 University Of Miami Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets
JP2013535514A (en) 2010-08-13 2013-09-12 エイルロン セラピューティクス,インコーポレイテッド Peptidomimetic macrocycle
JP6113144B2 (en) 2011-04-21 2017-04-12 セラテクノロジーズ・インコーポレーテッド Growth hormone releasing factor (GRF) analogs and uses thereof
CN108929375A (en) 2011-10-18 2018-12-04 爱勒让治疗公司 Peptidomimetic macrocyclic compound
US9079974B2 (en) * 2011-12-21 2015-07-14 The University Of Miami GH-RH analogs with potent agonistic effects
CN104144695A (en) 2012-02-15 2014-11-12 爱勒让治疗公司 Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
NZ627528A (en) 2012-02-15 2016-05-27 Aileron Therapeutics Inc Peptidomimetic macrocycles
WO2013190520A2 (en) 2012-06-22 2013-12-27 The General Hospital Corporation Gh-releasing agents in the treatment of vascular stenosis and associated conditions
JP6526563B2 (en) 2012-11-01 2019-06-05 エイルロン セラピューティクス,インコーポレイテッド Disubstituted amino acids and methods for their preparation and use
EP2934565B1 (en) 2012-12-21 2019-03-13 University of Miami Ghrh agonists for the treatment of ischemic disorders
WO2014100816A2 (en) 2012-12-21 2014-06-26 University Of Miami Ghrh agonists for islet cell transplantation and function and the treatment of diabetes
SG10201902594QA (en) 2014-09-24 2019-04-29 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
CA2961550A1 (en) * 2014-09-24 2016-03-31 University Of Oregon Proteins increasing pancreatic beta cell number and methods of use
JP2018516844A (en) 2015-03-20 2018-06-28 エルロン・セラピューティクス・インコーポレイテッドAileron Therapeutics,Inc. Peptidomimetic macrocycles and uses thereof
WO2017004548A1 (en) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2017181277A1 (en) 2016-04-19 2017-10-26 Griffon Pharmaceuticals Inc. Pegylated bioactive peptides and uses thereof

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US4618598A (en) * 1982-04-12 1986-10-21 Duke University Method of regulating hormone function or release
US4517181A (en) * 1982-09-15 1985-05-14 The Salk Institute For Biological Studies Mammalian PGRF
US4563352A (en) * 1982-10-04 1986-01-07 The Salk Institute For Biological Studies Human pancreatic GRF
US4728726A (en) * 1982-10-04 1988-03-01 The Salk Institute For Biological Studies GRF analogs IIIb
US4703035A (en) * 1982-10-04 1987-10-27 The Salk Institute For Biological Studies Human pancreatic GRF amidated fragments
IL70530A (en) * 1983-01-13 1986-09-30 Salk Inst For Biological Studi Synthetic peptides having growth hormone releasing factor activity and compositions containing them
US4518586A (en) * 1983-01-13 1985-05-21 The Salk Institute For Biological Studies GRF Analogs III
US4529595A (en) * 1983-01-13 1985-07-16 The Salk Institute For Biological Studies GRF Analogs
US4528190A (en) * 1983-10-25 1985-07-09 The Salk Institute For Biological Studies GRF Analogs IV
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NZ207378A (en) * 1983-03-07 1989-05-29 Hoffmann La Roche Leu 27 - and nle 27 -grf (human growth hormone releasing factor), preparation and pharmaceutical composition
US4595676A (en) * 1983-04-26 1986-06-17 The Salk Institute For Biological Studies Rat hypothalamic GRF
US4628043A (en) * 1983-04-26 1986-12-09 The Salk Institute For Biological Studies Hypothalamic GRF agonists
US4610976A (en) * 1983-08-29 1986-09-09 The Salk Institute For Biological Studies Porcine GRF
US4626523A (en) * 1983-09-13 1986-12-02 The Salk Institute For Biological Studies GRF analogs II
US4617149A (en) * 1983-09-21 1986-10-14 Eli Lilly And Company Growth hormone release factor analogs
US4585756A (en) * 1983-10-12 1986-04-29 The Salk Institute For Biological Studies Bovine GRF
US4562175A (en) * 1984-02-03 1985-12-31 Ding Chang Synthetic peptides
US4605643A (en) * 1984-03-02 1986-08-12 The Salk Institute For Biological Studies Ovine GRF
US4649039A (en) * 1984-07-03 1987-03-10 E. I. Du Pont De Nemours And Company Radiolabeling of methionine-containing proteins and peptides
US4649131A (en) * 1984-09-24 1987-03-10 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
US4734399A (en) * 1985-08-06 1988-03-29 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
US4622312A (en) * 1984-09-24 1986-11-11 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
US4689318A (en) * 1985-08-29 1987-08-25 The Salk Institute For Biological Studies GRF analogs
US4783524A (en) * 1985-09-17 1988-11-08 Monsanto Company Growth factors
US4784987A (en) * 1987-01-13 1988-11-15 The Salk Institute For Biological Studies GRF analogs VI
US4914189A (en) * 1987-02-05 1990-04-03 The Adminstrators Of The Tulane Educational Fund Synthetic GHRH analogs
US5002931A (en) * 1987-05-22 1991-03-26 The Salk Institute For Biological Studies GRF analogs VII
AU617426B2 (en) * 1988-01-29 1991-11-28 Upjohn Company, The Growth hormone releasing factor analogs
US5043322A (en) * 1988-07-22 1991-08-27 The Salk Institute For Biological Studies Cyclic GRF analogs
US5084442A (en) * 1988-09-06 1992-01-28 Hoffmann-La Roche Inc. Cyclic growth hormone releasing factor analogs and method for the manufacture thereof
AU4955490A (en) * 1989-01-27 1990-08-24 Upjohn Company, The Stabilized, potent grf analogs
AT113965T (en) * 1989-06-16 1994-11-15 Upjohn Co Stabilized, strong grf analog.

Also Published As

Publication number Publication date
JPH05507939A (en) 1993-11-11
NZ242209A (en) 1994-04-27
AU1448592A (en) 1992-11-17
IE921121A1 (en) 1992-10-21
CA2084061A1 (en) 1992-10-10
IL101452A (en) 1996-11-14
AU662731B2 (en) 1995-09-14
IL101452D0 (en) 1992-12-30
EP0542937A1 (en) 1993-05-26
EP0525838A3 (en) 1993-02-10
WO1992018531A1 (en) 1992-10-29
EP0525838A2 (en) 1993-02-03
US5846936A (en) 1998-12-08

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