ZA9202420B - Grf-analogs ii - Google Patents

Grf-analogs ii

Info

Publication number
ZA9202420B
ZA9202420B ZA922420A ZA9202420A ZA9202420B ZA 9202420 B ZA9202420 B ZA 9202420B ZA 922420 A ZA922420 A ZA 922420A ZA 9202420 A ZA9202420 A ZA 9202420A ZA 9202420 B ZA9202420 B ZA 9202420B
Authority
ZA
South Africa
Prior art keywords
grf
analogs ii
analogs
ii
Prior art date
Application number
ZA922420A
Inventor
Arthur Martin Felix
Martin Felix Arthur
Edgar Philip Heimar
Philip Heimar Edgar
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US68283591A priority Critical
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA9202420B publication Critical patent/ZA9202420B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/60Growth-hormone releasing factors (GH-RF) (Somatoliberin)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
ZA922420A 1991-04-09 1992-04-02 Grf-analogs ii ZA9202420B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US68283591A true 1991-04-09 1991-04-09

Publications (1)

Publication Number Publication Date
ZA9202420B true ZA9202420B (en) 1992-12-30

Family

ID=24741366

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA922420A ZA9202420B (en) 1991-04-09 1992-04-02 Grf-analogs ii

Country Status (10)

Country Link
US (1) US5846936A (en)
EP (2) EP0525838A3 (en)
JP (1) JPH05507939A (en)
AU (1) AU662731B2 (en)
CA (1) CA2084061A1 (en)
IE (1) IE921121A1 (en)
IL (1) IL101452A (en)
NZ (1) NZ242209A (en)
WO (1) WO1992018531A1 (en)
ZA (1) ZA9202420B (en)

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US5512549A (en) * 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
EP0910579A1 (en) * 1996-04-19 1999-04-28 Novo Nordisk A/S Compounds with growth hormone releasing properties
US5981488A (en) * 1997-03-31 1999-11-09 Eli Lillly And Company Glucagon-like peptide-1 analogs
EP0922446A1 (en) * 1997-12-03 1999-06-16 Applied Research Systems Ars Holding N.V. Solution-phase site-specific preparation of GRF-PEG conjugates
US6696063B1 (en) * 1998-12-30 2004-02-24 Applied Research Systems Ars Holding N.V. Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy
US20040192593A1 (en) 1999-07-26 2004-09-30 Baylor College Of Medicine Protease resistant ti-growth hormone releasing hormone
KR20020047096A (en) * 1999-07-26 2002-06-21 크로커 사무엘 에스 Super-active porcine growth hormone releasing hormone analog
US6486134B2 (en) * 1999-09-17 2002-11-26 Leadergene Limited Gene treatment to enhance feed efficiency and growth rate of livestock
WO2001087322A2 (en) * 2000-05-17 2001-11-22 Bionebraska, Inc. Peptide pharmaceutical formulations
WO2002048192A2 (en) 2000-12-13 2002-06-20 Eli Lilly And Company Amidated glucagon-like peptide-1
CN101696240A (en) * 2001-02-02 2010-04-21 康久化学生物技术公司; Long lasting growth hormone releasing factor derivatives
MXPA04003944A (en) 2001-10-26 2004-07-08 Baylor College Medicine A composition and method to alter lean body mass and bone properties in a subject.
BR0214869A (en) 2001-12-11 2005-03-08 Advisys Inc Plasmid-mediated supplementation for treatment of chronically ill patients
MXPA04007638A (en) * 2002-02-07 2004-12-06 Baylor College Medicine Modified pituitary gland development in offspring from expectant mother animals treated with growth hormone releasing hormone therapy.
MXPA05002991A (en) * 2002-09-18 2005-10-05 Univ Montreal Ct Hospitalier Chum Ghrh analogues.
WO2004067719A2 (en) * 2003-01-28 2004-08-12 Advisys, Inc. Growth hormone releasing hormone (ghrh) for use in reducing culling in herd animals
TW200424214A (en) * 2003-04-21 2004-11-16 Advisys Inc Plasmid mediated GHRH supplementation for renal failures
CA2575926C (en) * 2003-08-04 2014-02-25 Advisys, Inc. Canine specific growth hormone releasing hormone
EP1711187B1 (en) 2003-12-31 2010-05-12 VGX Pharmaceuticals, LLC Reducing arthritis and lameness in subjects by growth hormone releasing hormone (ghrh) supplementation
EP1713828B1 (en) * 2004-01-20 2011-04-27 VGX Pharmaceuticals, LLC Enhanced secretion/retention of growth hormone releasing hormone (ghrh) from muscle cells by species-specific signal peptide
US20060025368A1 (en) * 2004-07-23 2006-02-02 Advisys, Inc. Growth hormone releasing hormone enhances vaccination response
WO2008006019A2 (en) * 2006-07-06 2008-01-10 Advisys Inc. Growth hormone releasing hormone treatment to decrease cholesterol levels
US7960506B2 (en) 2006-12-14 2011-06-14 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
EP2952522A1 (en) 2007-01-31 2015-12-09 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
EP3159352A1 (en) 2007-03-28 2017-04-26 President and Fellows of Harvard College Stitched polypeptides
WO2009009727A2 (en) * 2007-07-12 2009-01-15 Akela Pharma Srl Ghrh analogs and therapeutic uses thereof
BRPI0915142A2 (en) * 2008-06-12 2016-02-16 Syntaxin Ltd polypeptides, nucleic acid and uses thereof
US20100267635A1 (en) * 2009-04-20 2010-10-21 Theratechonolgies Inc. Use of protease inhibitors and grf molecules in combination therapy
US20100267636A1 (en) * 2009-04-20 2010-10-21 Theratechnologies Inc. Use of cytochrome p450-metabolized drugs and grf molecules in combination therapy
US8980249B2 (en) 2010-06-03 2015-03-17 University Of Miami Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets
RU2016111360A (en) 2010-08-13 2018-11-27 Эйлерон Терапьютикс, Инк. peptidomimetic macrocycles
CN103547591A (en) 2011-04-21 2014-01-29 瑟瑞技术公司 Growth hormone releasing factor (GRF) analogs and uses thereof
MX358886B (en) 2011-10-18 2018-08-31 Aileron Therapeutics Inc Peptidomimetic macrocyles.
US9079974B2 (en) 2011-12-21 2015-07-14 The University Of Miami GH-RH analogs with potent agonistic effects
JP6450192B2 (en) 2012-02-15 2019-01-09 エイルロン セラピューティクス,インコーポレイテッド Triazole-bridged and thioether-bridged peptidomimetic macrocycles
JP6450191B2 (en) 2012-02-15 2019-01-09 エイルロン セラピューティクス,インコーポレイテッド Peptide mimetic macrocycle
WO2013190520A2 (en) 2012-06-22 2013-12-27 The General Hospital Corporation Gh-releasing agents in the treatment of vascular stenosis and associated conditions
KR20150082307A (en) 2012-11-01 2015-07-15 에일러론 테라퓨틱스 인코포레이티드 Disubstituted amino acids and methods of preparation and use thereof
EP2935317B1 (en) 2012-12-21 2019-03-27 University of Miami Ghrh agonists for islet cell transplantation and function and the treatment of diabetes
WO2014100809A2 (en) 2012-12-21 2014-06-26 University Of Miami Ghrh agonists for the treatment of ischemic disorders
MX2017011834A (en) 2015-03-20 2018-04-11 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof.
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CA3021231A1 (en) 2016-04-19 2017-10-26 Griffon Pharmaceuticals Inc. Pegylated bioactive peptides and uses thereof

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US4618598A (en) * 1982-04-12 1986-10-21 Duke University Method of regulating hormone function or release
US4517181A (en) * 1982-09-15 1985-05-14 The Salk Institute For Biological Studies Mammalian PGRF
US4728726A (en) * 1982-10-04 1988-03-01 The Salk Institute For Biological Studies GRF analogs IIIb
US4703035A (en) * 1982-10-04 1987-10-27 The Salk Institute For Biological Studies Human pancreatic GRF amidated fragments
US4563352A (en) * 1982-10-04 1986-01-07 The Salk Institute For Biological Studies Human pancreatic GRF
IL70530A (en) * 1983-01-13 1986-09-30 Salk Inst For Biological Studi Synthetic peptides having growth hormone releasing factor activity and compositions containing them
US4529595A (en) * 1983-01-13 1985-07-16 The Salk Institute For Biological Studies GRF Analogs
US4528190A (en) * 1983-10-25 1985-07-09 The Salk Institute For Biological Studies GRF Analogs IV
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US4628043A (en) * 1983-04-26 1986-12-09 The Salk Institute For Biological Studies Hypothalamic GRF agonists
US4595676A (en) * 1983-04-26 1986-06-17 The Salk Institute For Biological Studies Rat hypothalamic GRF
US4610976A (en) * 1983-08-29 1986-09-09 The Salk Institute For Biological Studies Porcine GRF
US4626523A (en) * 1983-09-13 1986-12-02 The Salk Institute For Biological Studies GRF analogs II
US4617149A (en) * 1983-09-21 1986-10-14 Eli Lilly And Company Growth hormone release factor analogs
US4585756A (en) * 1983-10-12 1986-04-29 The Salk Institute For Biological Studies Bovine GRF
US4562175A (en) * 1984-02-03 1985-12-31 Ding Chang Synthetic peptides
US4605643A (en) * 1984-03-02 1986-08-12 The Salk Institute For Biological Studies Ovine GRF
US4649039A (en) * 1984-07-03 1987-03-10 E. I. Du Pont De Nemours And Company Radiolabeling of methionine-containing proteins and peptides
US4622312A (en) * 1984-09-24 1986-11-11 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
US4734399A (en) * 1985-08-06 1988-03-29 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
US4649131A (en) * 1984-09-24 1987-03-10 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
US4689318A (en) * 1985-08-29 1987-08-25 The Salk Institute For Biological Studies GRF analogs
US4783524A (en) * 1985-09-17 1988-11-08 Monsanto Company Growth factors
US4784987A (en) * 1987-01-13 1988-11-15 The Salk Institute For Biological Studies GRF analogs VI
US4914189A (en) * 1987-02-05 1990-04-03 The Adminstrators Of The Tulane Educational Fund Synthetic GHRH analogs
US5002931A (en) * 1987-05-22 1991-03-26 The Salk Institute For Biological Studies GRF analogs VII
NZ227770A (en) * 1988-01-29 1991-08-27 Upjohn Co Growth hormone releasing factor (grf) peptide containing a cysteic acid residue in position 3 or 25
US5043322A (en) * 1988-07-22 1991-08-27 The Salk Institute For Biological Studies Cyclic GRF analogs
US5084442A (en) * 1988-09-06 1992-01-28 Hoffmann-La Roche Inc. Cyclic growth hormone releasing factor analogs and method for the manufacture thereof
AU4955490A (en) * 1989-01-27 1990-08-24 Upjohn Company, The Stabilized, potent grf analogs
ES2063360T3 (en) * 1989-06-16 1995-01-01 Upjohn Co potent GRF analogs stabilized.

Also Published As

Publication number Publication date
IL101452A (en) 1996-11-14
AU1448592A (en) 1992-11-17
EP0525838A3 (en) 1993-02-10
WO1992018531A1 (en) 1992-10-29
EP0542937A1 (en) 1993-05-26
NZ242209A (en) 1994-04-27
EP0525838A2 (en) 1993-02-03
CA2084061A1 (en) 1992-10-10
AU662731B2 (en) 1995-09-14
JPH05507939A (en) 1993-11-11
US5846936A (en) 1998-12-08
IE921121A1 (en) 1992-10-21
IL101452D0 (en) 1992-12-30

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