US5240928A
(en)
*
|
1989-07-03 |
1993-08-31 |
Merck & Co., Inc. |
Substituted quinazolinones as angiotensin II antagonists
|
US5449682A
(en)
*
|
1990-02-13 |
1995-09-12 |
Merck & Co., Inc. |
Angiotensin II antagonists incorporating a substituted benzyl element
|
CA2037630C
(en)
*
|
1990-03-07 |
2001-07-03 |
Akira Morimoto |
Nitrogen-containing heterocylic compounds, their production and use
|
FR2681067B1
(fr)
*
|
1991-09-10 |
1993-12-17 |
Elf Sanofi |
Derives heterocycliques n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
|
US5270317A
(en)
*
|
1990-03-20 |
1993-12-14 |
Elf Sanofi |
N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
|
CN1034934C
(zh)
*
|
1990-06-19 |
1997-05-21 |
明治制果株式会社 |
血管紧张素ii拮抗性吡啶衍生物的制备方法
|
CA2053148A1
(en)
*
|
1990-10-16 |
1992-04-17 |
Karnail Atwal |
Dihydropyrimidine derivatives
|
US5290780A
(en)
*
|
1991-01-30 |
1994-03-01 |
American Cyanamid Co. |
Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
|
IL100917A0
(en)
*
|
1991-02-16 |
1992-11-15 |
Fisons Plc |
Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them
|
FR2673427B1
(fr)
*
|
1991-03-01 |
1993-06-18 |
Sanofi Elf |
Derives heterocycliques diazotes n-substitues par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant.
|
US5202328A
(en)
*
|
1991-03-06 |
1993-04-13 |
Merck & Co., Inc. |
Substituted fused pyrimidinones
|
US5385894A
(en)
*
|
1991-03-06 |
1995-01-31 |
Merck & Co., Inc. |
Disubstituted 6-aminoquinazolinones
|
EP0502575A1
(en)
*
|
1991-03-06 |
1992-09-09 |
Merck & Co. Inc. |
Substituted 1-(2H)-isoquinolinones
|
US5187179A
(en)
*
|
1991-03-22 |
1993-02-16 |
Merck & Co., Inc. |
Angiotensin II antagonists incorporating a substituted imidazo [1,2-b][1,2,4]triazole
|
US5128327A
(en)
*
|
1991-03-25 |
1992-07-07 |
Merck & Co., Inc. |
Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle
|
US5177074A
(en)
*
|
1991-03-26 |
1993-01-05 |
Merck & Co., Inc. |
Angiotensin ii antagonists incorporating a substituted thiophene or furan
|
DE4110019C2
(de)
*
|
1991-03-27 |
2000-04-13 |
Merck Patent Gmbh |
Imidazopyridine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
|
US5157040A
(en)
*
|
1991-04-05 |
1992-10-20 |
Merck & Co., Inc. |
Substituted quinolines as angiotensin ii antagonists
|
US5151435A
(en)
*
|
1991-04-08 |
1992-09-29 |
Merck & Co., Inc. |
Angiotensin ii antagonists incorporating an indole or dihydroindole
|
US5252574A
(en)
*
|
1991-04-26 |
1993-10-12 |
Merck & Co., Inc. |
Angiotensin II antagonists incorporating a substituted thiophene or furan
|
US5162325A
(en)
*
|
1991-05-07 |
1992-11-10 |
Merck & Co., Inc. |
Angiotensin ii antagonists incorporating a substituted benzyl element
|
US5198438A
(en)
*
|
1991-05-07 |
1993-03-30 |
Merck & Co., Inc. |
Angiotensin ii antagonists incorporating a substituted thiophene or furan
|
US5162340A
(en)
*
|
1991-05-10 |
1992-11-10 |
Merck & Co., Inc. |
Substituted 1-(2h)-isoquinolinones bearing acidic functional groups as angiotensin ii antagonists
|
US5238942A
(en)
*
|
1991-05-10 |
1993-08-24 |
Merck & Co., Inc. |
Substituted quinazolinones bearing acidic functional groups as angiotensin ii antagonists
|
NZ242724A
(en)
*
|
1991-05-15 |
1994-09-27 |
Du Pont |
Synergistic composition comprising an angiotensin-ii receptor antagonist and a calcium channel blocker
|
AU1625192A
(en)
*
|
1991-05-31 |
1992-12-03 |
Zeneca Limited |
Heterocyclic derivatives
|
US5175164A
(en)
*
|
1991-06-05 |
1992-12-29 |
Merck & Co., Inc. |
Angiotensin ii antagonists incorporating a substituted indole or dihydroindole
|
GB9113628D0
(en)
*
|
1991-06-25 |
1991-08-14 |
Ici Plc |
Heterocyclic derivatives
|
GB9113626D0
(en)
*
|
1991-06-25 |
1991-08-14 |
Ici Plc |
Heterocyclic compounds
|
TW251288B
(ko)
*
|
1991-06-27 |
1995-07-11 |
Takeda Dharm Industry Co Ltd |
|
IL102183A
(en)
*
|
1991-06-27 |
1999-11-30 |
Takeda Chemical Industries Ltd |
The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them
|
DE4123341A1
(de)
*
|
1991-07-15 |
1993-01-21 |
Thomae Gmbh Dr K |
Phenylalkylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
|
WO1993003040A1
(en)
*
|
1991-08-05 |
1993-02-18 |
Taisho Pharmaceutical Co., Ltd. |
Thienopyrimidin-4-one derivative
|
US5256667A
(en)
*
|
1991-09-25 |
1993-10-26 |
Merck & Co., Inc. |
Quinazolinones and pyridopyrimidinones
|
US5202322A
(en)
*
|
1991-09-25 |
1993-04-13 |
Merck & Co., Inc. |
Quinazolinone and pyridopyrimidine a-II antagonists
|
CA2079982A1
(en)
*
|
1991-10-07 |
1993-04-08 |
Stephen E. De Laszlo |
Substituted pyrazino (2,3-d)-pyrimidinones as angiotensin ii antagonists
|
US5256781A
(en)
*
|
1991-10-24 |
1993-10-26 |
American Home Products Corporation |
Substituted quinazolines as angiotensin II antagonists
|
US5283242A
(en)
*
|
1991-10-24 |
1994-02-01 |
American Home Products Corporation |
Substituted benzimidazoles and quinazolines as antihypertensives
|
US5149699A
(en)
*
|
1991-10-24 |
1992-09-22 |
American Home Products Corporation |
Substituted pyridopyrimidines useful as antgiotensin II antagonists
|
US5236925A
(en)
*
|
1991-10-24 |
1993-08-17 |
American Home Products Corporation |
Fused pyrimidines as angiotensin II antagonists
|
US5234936A
(en)
*
|
1991-10-24 |
1993-08-10 |
American Home Products Corporation |
Pyrimidocycloalkanes as a ii antagonists
|
US5187168A
(en)
*
|
1991-10-24 |
1993-02-16 |
American Home Products Corporation |
Substituted quinazolines as angiotensin II antagonists
|
US5212177A
(en)
*
|
1991-12-16 |
1993-05-18 |
E. R. Squibb & Sons, Inc. |
Indole and benzimidazole-substituted dihydropyrimidine derivatives
|
US5234923A
(en)
*
|
1991-12-16 |
1993-08-10 |
E. R. Squibb & Sons, Inc. |
Substitute indole and benzimidazole derivatives
|
US5350752A
(en)
*
|
1991-12-16 |
1994-09-27 |
E. R. Squibb & Sons, Inc. |
Dihydropyrimidine derivatives
|
GR1001386B
(el)
*
|
1991-12-24 |
1993-10-29 |
Takeda Chemical Industries Ltd |
Ετεροκυκλικές ενώσεις.
|
WO1993014086A1
(en)
*
|
1992-01-17 |
1993-07-22 |
Syntex (U.S.A.) Inc. |
Substituted 1-isoquinolone derivatives as angiotensin ii antagonists
|
US5204354A
(en)
*
|
1992-02-14 |
1993-04-20 |
Merck & Co., Inc. |
Substituted quinazolinones as neurotensin antagonists useful in the treatment of CNS disorders
|
WO1993017682A1
(en)
*
|
1992-03-04 |
1993-09-16 |
Abbott Laboratories |
Angiotensin ii receptor antagonists
|
DE4208304A1
(de)
*
|
1992-03-16 |
1993-09-23 |
Merck Patent Gmbh |
2-oxochinolinderivate
|
US5378704A
(en)
*
|
1992-04-15 |
1995-01-03 |
E. R. Squibb & Sons, Inc. |
Non-peptidic angiotensin-II-receptor-antagonists
|
US5236916A
(en)
*
|
1992-05-26 |
1993-08-17 |
E. R. Squibb & Sons, Inc. |
Oxadiazinone substituted indole and benzimidazole derivatives
|
US5292741A
(en)
*
|
1992-08-18 |
1994-03-08 |
Merck & Co., Inc. |
Macrocycles incorporating quinazolinones
|
IT1263804B
(it)
*
|
1993-01-22 |
1996-09-03 |
Luso Farmaco Inst |
Derivati pirimidinonici fusi con eterocicli azotati ad attivita' a ii antagonista
|
US5420133A
(en)
*
|
1993-03-19 |
1995-05-30 |
Merck & Co., Inc. |
Quinazolinones substituted with phenoxyphenylacetic acid derivatives
|
US5286729A
(en)
*
|
1993-04-23 |
1994-02-15 |
American Cyanamid Company |
Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
|
US5292734A
(en)
*
|
1993-04-23 |
1994-03-08 |
American Cyanamid Company |
Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
|
US5284853A
(en)
*
|
1993-04-23 |
1994-02-08 |
American Cyanamid Company |
Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
|
US5296480A
(en)
*
|
1993-04-23 |
1994-03-22 |
American Cyanamid Company |
Angiotensin II receptor blocking 2,3,6-substituted 5,6,7,8-tetra-hydro-pyrido[4,3]pyrimidin-4(3H)-ones
|
US5294611A
(en)
*
|
1993-04-23 |
1994-03-15 |
American Cyanamid Company |
Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
|
US5288720A
(en)
*
|
1993-04-23 |
1994-02-22 |
American Cyanamid Company |
Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
|
US5281603A
(en)
*
|
1993-04-23 |
1994-01-25 |
American Cyanamid Company |
Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
|
US5292742A
(en)
*
|
1993-04-23 |
1994-03-08 |
American Cyanamid Company |
Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
|
US5284852A
(en)
*
|
1993-04-23 |
1994-02-08 |
American Cyanamid Company |
Angiotensin II receptor blocking 2,3,6-substituted quinazolinones
|
US5281604A
(en)
*
|
1993-04-23 |
1994-01-25 |
American Cyanamid Company |
Angiotensin II receptor blocking 2,3,6-substituted quinazolinones
|
US5281602A
(en)
*
|
1993-04-23 |
1994-01-25 |
American Cyanamid Company |
Angiotensin II receptor blocking 2,3,6-substituted 5,6,7,8-tetrahydro-pyrido[4,3-D]pyrimidin-4(3H)-ones
|
US5338740A
(en)
*
|
1993-07-13 |
1994-08-16 |
Pfizer Inc. |
Angiotensin II receptor antagonists
|
US5409926A
(en)
*
|
1993-07-19 |
1995-04-25 |
Merck & Co., Inc. |
AT-2 antagonist inhibition of vascular restenosis
|
US5338736A
(en)
*
|
1993-10-07 |
1994-08-16 |
American Cyanamid Company |
Angiotensin II receptor blocking 2,3,6-substituted quinazolinones
|
GB9404485D0
(en)
*
|
1994-03-09 |
1994-04-20 |
Cancer Res Campaign Tech |
Benzamide analogues
|
KR100300566B1
(ko)
*
|
1994-09-17 |
2001-11-22 |
조생현 |
피리미디논유도체와그의제조방법및용도
|
US6444816B1
(en)
|
1997-10-27 |
2002-09-03 |
Dr. Reddy's Research Foundation |
Fused 7-oxo-pyrimidinyl compounds, preparation, composition and use thereof
|
AU2745199A
(en)
|
1998-03-04 |
1999-09-20 |
Takeda Chemical Industries Ltd. |
Sustained-release preparation for aii antagonist, production and use thereof
|
AU767456B2
(en)
*
|
1998-07-06 |
2003-11-13 |
Bristol-Myers Squibb Company |
Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
|
SE9903028D0
(sv)
|
1999-08-27 |
1999-08-27 |
Astra Ab |
New use
|
FI20010233A0
(fi)
*
|
2001-02-08 |
2001-02-08 |
Orion Corp |
Menetelmä sydämen vajaatoiminnan hoitoon
|
US7812044B2
(en)
|
2001-11-13 |
2010-10-12 |
Takeda Pharmaceutical Company Limited |
Anticancer agents
|
EP1558260A4
(en)
*
|
2002-11-04 |
2006-10-25 |
Nps Pharma Inc |
CHINAZOLINONE COMPOUNDS AS CALCILYTIC
|
EP2952185A1
(en)
*
|
2006-03-20 |
2015-12-09 |
Spinifex Pharmaceuticals Pty Ltd |
Method of treatment or prophylaxis of inflammatory pain
|
MX2009003658A
(es)
|
2006-10-05 |
2009-04-22 |
Cv Therapeutics Inc |
Compuestos heterociclicos que contienen nitrogeno biciclico para utilizarse como inhibidores de desaturasa de estearoilo-coa.
|
US20080255161A1
(en)
*
|
2007-04-11 |
2008-10-16 |
Dmitry Koltun |
3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS
|
DK2170930T3
(da)
|
2007-06-04 |
2012-11-05 |
Synergy Pharmaceuticals Inc |
Agonister af guanylatcyclase, anvendelige til behandlingen af gastrointestinale sygdomme, inflammation, cancer og andre sygdomme
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
JP2011522828A
(ja)
|
2008-06-04 |
2011-08-04 |
シナジー ファーマシューティカルズ インコーポレイテッド |
胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
|
ES2624828T3
(es)
|
2008-07-16 |
2017-07-17 |
Synergy Pharmaceuticals Inc. |
Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
|
CA2740389A1
(en)
*
|
2008-10-15 |
2010-05-20 |
Gilead Sciences, Inc. |
3-hydroquinazolin-4-one derivatives for use as stearoyl coa desaturase inhibitors
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
AU2014235209B2
(en)
|
2013-03-15 |
2018-06-14 |
Bausch Health Ireland Limited |
Guanylate cyclase receptor agonists combined with other drugs
|
US9708367B2
(en)
|
2013-03-15 |
2017-07-18 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase and their uses
|
KR102272746B1
(ko)
|
2013-06-05 |
2021-07-08 |
보슈 헬스 아일랜드 리미티드 |
구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법
|