ZA8909960B - Piperazinyl-derivatives - Google Patents

Piperazinyl-derivatives

Info

Publication number
ZA8909960B
ZA8909960B ZA899960A ZA8909960A ZA8909960B ZA 8909960 B ZA8909960 B ZA 8909960B ZA 899960 A ZA899960 A ZA 899960A ZA 8909960 A ZA8909960 A ZA 8909960A ZA 8909960 B ZA8909960 B ZA 8909960B
Authority
ZA
South Africa
Prior art keywords
piperazinyl
derivatives
Prior art date
Application number
ZA899960A
Inventor
Jens Perregaard
Perregaard Jens
John Willie Stenberg
Willie Stenberg John
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB888830312A priority Critical patent/GB8830312D0/en
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of ZA8909960B publication Critical patent/ZA8909960B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
ZA899960A 1988-12-28 1989-12-28 Piperazinyl-derivatives ZA8909960B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB888830312A GB8830312D0 (en) 1988-12-28 1988-12-28 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
ZA8909960B true ZA8909960B (en) 1990-11-28

Family

ID=10649223

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA899960A ZA8909960B (en) 1988-12-28 1989-12-28 Piperazinyl-derivatives

Country Status (17)

Country Link
US (1) US5002948A (en)
EP (1) EP0376607B1 (en)
JP (1) JP2895121B2 (en)
AT (1) AT102184T (en)
AU (1) AU637991B2 (en)
CA (1) CA2006356C (en)
DE (2) DE68913487T2 (en)
DK (1) DK169266B1 (en)
ES (1) ES2062050T3 (en)
FI (1) FI93005C (en)
GB (1) GB8830312D0 (en)
IE (1) IE62668B1 (en)
IL (1) IL92990A (en)
NO (1) NO174772C (en)
NZ (1) NZ231855A (en)
PT (1) PT92728B (en)
ZA (1) ZA8909960B (en)

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AR013206A1 (en) * 1997-07-25 2000-12-13 Lundbeck & Co As H Indole derivatives and 2,3-dihydroindole, pharmaceutical compositions containing these compounds and the use of such compounds for preparing a medicament for the treatment of disorders responsive to the inhibition of serotonin reuptake and antagonism of 5-HT1A receptors.
AU736596B2 (en) * 1997-07-25 2001-08-02 H. Lundbeck A/S Indole and 2,3-dihydroindole derivatives, their preparation and use
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AR022303A1 (en) 1999-01-22 2002-09-04 Lundbeck & Co As H Piperidine derivatives, tetrahydropyridine and piperazine, their preparation and use
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BR0016951A (en) * 1999-12-30 2003-02-25 Lundbeck & Co As H Phenylpiperazinyl derivative, compound, pharmaceutical composition, use thereof, method of treatment
CZ20022319A3 (en) * 1999-12-30 2002-10-16 H. Lundbeck A/S Substituted phenylpiperazine compound and pharmaceutical preparation in which the compound is comprised
AR027134A1 (en) * 1999-12-30 2003-03-12 Lundbeck & Co As H Indole derivatives.
US7211594B2 (en) * 2000-07-31 2007-05-01 Signal Pharmaceuticals, Llc Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith
US6897231B2 (en) * 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
AR035521A1 (en) * 2000-12-22 2004-06-02 Lundbeck & Co As H Indoline derivatives of 3-and pharmaceutical composition comprising them
AR032712A1 (en) 2001-02-21 2003-11-19 Solvay Pharm Bv A mesylate phenylpiperazine derivatives and pharmaceutical compositions containing it
US7041683B2 (en) 2001-04-24 2006-05-09 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan
EP1381600A1 (en) * 2001-04-24 2004-01-21 Wyeth, A Corporation of the State of Delaware Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan
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US7183410B2 (en) 2001-08-02 2007-02-27 Bidachem S.P.A. Stable polymorph of flibanserin
US20030060475A1 (en) * 2001-08-10 2003-03-27 Boehringer Ingelheim Pharma Kg Method of using flibanserin for neuroprotection
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US7276603B2 (en) * 2003-05-02 2007-10-02 Wyeth Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
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US20050239798A1 (en) * 2004-04-22 2005-10-27 Boehringer Ingelheim Pharmaceuticals, Inc. Method for the treatment of premenstrual and other female sexual disorders
ES2329388T3 (en) * 2004-05-11 2009-11-25 Egis Gyogyszergyar Nyrt Derivatives of 3 - (((4-phenyl) -piperazin-1-il) -alquil) -3-alquil-1,3-dihidro-2h-indol-2-ona and the corresponding compounds for the treatment of central nervous system.
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AU2005240844A1 (en) * 2004-05-11 2005-11-17 Egis Gyogyszergyar Nyrt. Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders
US20060025420A1 (en) * 2004-07-30 2006-02-02 Boehringer Ingelheimn International GmbH Pharmaceutical compositions for the treatment of female sexual disorders
EP1789048A1 (en) * 2004-09-03 2007-05-30 Boehringer Ingelheim International GmbH Method for the treatment of attention deficit hyperactivity disorder
US7371769B2 (en) 2004-12-07 2008-05-13 Solvay Pharmaceuticals B.V. Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
AT425754T (en) * 2004-12-07 2009-04-15 Solvay Pharm Bv Bezdioxan piperazine derivatives with a combination of affinitate for dopamin d2 receptors and serotonin recovery sites
US20060122247A1 (en) 2004-12-08 2006-06-08 Solvay Pharmaceuticals B.V. Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
CA2599721A1 (en) * 2005-03-04 2006-09-14 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of depression
US20060199805A1 (en) * 2005-03-04 2006-09-07 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of anxiety disorders
WO2006096439A2 (en) * 2005-03-04 2006-09-14 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of schizophrenia and related diseases
US20070004777A1 (en) * 2005-03-23 2007-01-04 Bhagwat Shripad S Methods for treating or preventing acute myelogenous leukemia
WO2006119884A2 (en) * 2005-05-06 2006-11-16 Boehringer Ingelheim International Gmbh Method for the treatment of drug abuse with flibanserin
CA2608713A1 (en) * 2005-05-19 2006-11-23 Boehringer Ingelheim International Gmbh Method for the treatment of sexual dysfunctions due to medical conditions
JP2008540673A (en) * 2005-05-19 2008-11-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Method for treating drug-induced dysfunction
PL1912650T3 (en) 2005-08-03 2018-01-31 Sprout Pharmaceuticals Inc Use of flibanserin in the treatment of obesity
WO2007048803A1 (en) 2005-10-29 2007-05-03 Boehringer Ingelheim International Gmbh Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders
US20070123540A1 (en) * 2005-10-29 2007-05-31 Angelo Ceci Sexual desire enhancing medicaments comprising benzimidazolone derivatives
US20070105869A1 (en) * 2005-11-08 2007-05-10 Stephane Pollentier Use of flibanserin for the treatment of pre-menopausal sexual desire disorders
HUE026156T2 (en) * 2006-05-09 2016-06-28 Sprout Pharmaceuticals Inc Use of flibanserin for the treatment of post-menopausal sexual desire disorders
JP2009541443A (en) * 2006-06-30 2009-11-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Flibanserin for the treatment of urinary incontinence and related diseases
EP2043648A1 (en) * 2006-07-14 2009-04-08 Boehringer Ingelheim International GmbH Use of flibanserin for the treatment of sexual disorders in females
EA200900264A1 (en) 2006-08-14 2009-08-28 Бёрингер Ингельхайм Интернациональ Гмбх Compositions of flibanserin and method of their preparation
CL2007002214A1 (en) 2006-08-14 2008-03-07 Boehringer Ingelheim Int pharmaceutical composition in tablet form, where the least the length of the tablet in the prior application is the least 7/12 of the pyloric diameter of the patient and after ingestion in the fed state, the length of the comp
WO2008022932A2 (en) 2006-08-25 2008-02-28 Boehringer Ingelheim International Gmbh Controlled release system and method for manufacturing the same
PE20091188A1 (en) * 2007-09-12 2009-08-31 Boehringer Ingelheim Int Compound 1- [2- (4- (3-trifluoromethylphenyl) piperazin-1-yl) ethyl] -2,3-dihydro-1H-benzimidazol-2-one (flibanserin), their addition salts and pharmaceutical compositions They contain
SG177628A1 (en) 2009-07-30 2012-03-29 Univ Singapore Small molecule inhibitors of isoprenylcysteine carboxyl methyltransferase with potential anticancer activity
EP2464227A4 (en) * 2009-08-10 2013-02-20 Galenea Corp Compounds and methods of use thereof
CN102993186B (en) * 2012-12-20 2015-11-18 北京海步国际医药科技发展有限公司 A kind of novel bridged piperazine derivatives
US9598401B2 (en) 2013-07-29 2017-03-21 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof
CN104725359B (en) 2013-12-20 2017-05-03 广东东阳光药业有限公司 Substituted piperazine compound as well as application method and application thereof
CN106065018A (en) * 2015-04-23 2016-11-02 广东东阳光药业有限公司 Substituted benzazolyl compounds and using method thereof and purposes
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Also Published As

Publication number Publication date
PT92728B (en) 1995-12-29
IE62668B1 (en) 1995-02-22
NO174772B (en) 1994-03-28
FI896300D0 (en)
CA2006356A1 (en) 1990-06-28
JP2895121B2 (en) 1999-05-24
ES2062050T3 (en) 1994-12-16
NZ231855A (en) 1992-02-25
IL92990D0 (en) 1990-09-17
DK645689D0 (en) 1989-12-19
FI93005B (en) 1994-10-31
IL92990A (en) 1995-01-24
NO174772C (en) 1994-07-06
AU4719889A (en) 1990-07-05
AU637991B2 (en) 1993-06-17
EP0376607B1 (en) 1994-03-02
PT92728A (en) 1990-06-29
DE68913487D1 (en) 1994-04-07
NO895281L (en) 1990-06-29
US5002948A (en) 1991-03-26
FI93005C (en) 1995-02-10
FI896300A0 (en) 1989-12-28
NO895281D0 (en) 1989-12-27
DK645689A (en) 1990-06-29
JPH02225460A (en) 1990-09-07
DE68913487T2 (en) 1994-08-04
GB8830312D0 (en) 1989-02-22
EP0376607A1 (en) 1990-07-04
DK169266B1 (en) 1994-09-26
AT102184T (en) 1994-03-15
CA2006356C (en) 1999-09-14
IE893976L (en) 1990-06-13

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