ZA8905058B - 13-alkyl-11 beta-phenyl-gonanes - Google Patents

13-alkyl-11 beta-phenyl-gonanes

Info

Publication number
ZA8905058B
ZA8905058B ZA895058A ZA8905058A ZA8905058B ZA 8905058 B ZA8905058 B ZA 8905058B ZA 895058 A ZA895058 A ZA 895058A ZA 8905058 A ZA8905058 A ZA 8905058A ZA 8905058 B ZA8905058 B ZA 8905058B
Authority
ZA
South Africa
Prior art keywords
gonanes
beta
phenyl
alkyl
Prior art date
Application number
ZA895058A
Inventor
Stefan Scholz
Scholz Stefan
Eckhard Ottow
Ottow Eckhard
Guenter Neef
Neef Guenter
Walter Elger
Elger Walter
Sybille Beier
Beier Sybille
Krzysztof Chwalisz
Chwalisz Krzysztof
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE3822770A priority Critical patent/DE3822770A1/en
Application filed by Schering Ag filed Critical Schering Ag
Publication of ZA8905058B publication Critical patent/ZA8905058B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • C07J71/001Oxiranes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36Antigestagens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051Estrane derivatives
    • C07J1/0081Substituted in position 17 alfa and 17 beta
    • C07J1/0088Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J15/00Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J17/00Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J33/00Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J43/00Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J51/00Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
ZA895058A 1988-07-01 1989-07-03 13-alkyl-11 beta-phenyl-gonanes ZA8905058B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE3822770A DE3822770A1 (en) 1988-07-01 1988-07-01 13-alkyl-11ss-phenylgonane

Publications (1)

Publication Number Publication Date
ZA8905058B true ZA8905058B (en) 1990-04-25

Family

ID=6358021

Family Applications (2)

Application Number Title Priority Date Filing Date
ZA895058A ZA8905058B (en) 1988-07-01 1989-07-03 13-alkyl-11 beta-phenyl-gonanes
ZA895058A ZA895058B (en) 1988-07-01 1989-07-03 13-alkyl-11 beta-phenyl-gonanes

Family Applications After (1)

Application Number Title Priority Date Filing Date
ZA895058A ZA895058B (en) 1988-07-01 1989-07-03 13-alkyl-11 beta-phenyl-gonanes

Country Status (17)

Country Link
US (2) US5273971A (en)
EP (1) EP0349481B1 (en)
JP (1) JP2956776B2 (en)
AT (1) AT129717T (en)
AU (1) AU644060B2 (en)
CA (1) CA1334668C (en)
DD (2) DD287511A5 (en)
DE (1) DE3822770A1 (en)
ES (1) ES2080079T3 (en)
GR (1) GR3018069T3 (en)
HU (1) HU208021B (en)
IE (1) IE70664B1 (en)
IL (1) IL90826A (en)
NO (1) NO180451C (en)
PT (1) PT91031B (en)
WO (1) WO1990000174A1 (en)
ZA (2) ZA8905058B (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3822770A1 (en) * 1988-07-01 1990-01-04 Schering Ag 13-alkyl-11ss-phenylgonane
US5707982A (en) * 1989-02-24 1998-01-13 Roussel Uclaf 19-nor-steroids
US6790971B1 (en) * 1989-02-24 2004-09-14 Aventis Pharma S.A. 19-Nor-steroids
DE4018168A1 (en) * 1990-06-01 1991-12-05 Schering Ag Initial connections for the production of 10ss-h steroids and a method for the production of these output connections
DE4042004A1 (en) * 1990-12-22 1992-06-25 Schering Ag 14 (beta) -h-, 14- & 15-en-11 (beta) -aryl-4-estrene
AT156836T (en) * 1994-05-19 1997-08-15 Akzo Nobel Nv 11,21-bisphenyl-19-nor-pregnan derivatives
DE4434488A1 (en) * 1994-09-14 1996-03-21 Schering Ag Steroid esters and amides, processes for their preparation and their pharmaceutical use
US5929262A (en) * 1995-03-30 1999-07-27 The United States Of America As Represented By The Department Of Health And Human Services Method for preparing 17α-acetoxy-11β-(4-N, N-dimethylaminophyl)-19-Norpregna-4,9-diene-3, 20-dione, intermediates useful in the method, and methods for the preparation of such intermediates
US6900193B1 (en) * 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
JP4260886B2 (en) * 1996-05-01 2009-04-30 アメリカ合衆国 21-Substituted progesterone derivatives as novel anti-progesterone
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en) * 1998-05-29 1999-10-05 Research Triangle Institute 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6262042B1 (en) 1998-05-29 2001-07-17 Research Triangle Institute 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
MXPA03000845A (en) * 2000-07-28 2004-04-05 Akzo Nobel Nv 16alpha-methyl or ethyl substituted estrogens.
US20060111577A1 (en) * 2003-02-28 2006-05-25 Kim Hyun K Method for preparing 17 alpha-acetoxy-11beta-(4-n,n-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, intermediates thereof, and methods for the preparation of such intermediates
TW200531977A (en) * 2004-03-25 2005-10-01 Akzo Nobel Nv Progesterone receptor modulators
US20060196449A1 (en) * 2004-09-17 2006-09-07 Mockry Eldon F Fluid heating system and method
US9517240B2 (en) 2006-09-26 2016-12-13 The Regents Of The University Of California Methods and compositions for cancer prevention and treatment
US20100160275A1 (en) * 2006-09-26 2010-06-24 Lee Eva Y H P Methods and compositions for cancer prevention and treatment
KR20090067198A (en) 2006-10-24 2009-06-24 레프로스 쎄라피우틱스 아이엔씨. Composition and methods for suppressing endometrial proliferation
US7784843B2 (en) * 2008-01-08 2010-08-31 Toyota Motor Engineering & Manufacturing North America, Inc. Vehicle console with sliding panel
US8172293B2 (en) * 2008-01-09 2012-05-08 Toyota Motor Engineering & Manufacturing North America, Inc. Vehicle electronic device support systems
TWI539953B (en) 2008-04-28 2016-07-01 瑞波若斯治療學公司 Compositions and methods for treating breast cancer
JP5894143B2 (en) 2010-03-22 2016-03-23 リプロス セラピューティクス インコーポレイテッド Compositions and methods for non-toxic delivery of antiprogestin
EP2968364A1 (en) 2013-03-12 2016-01-20 Arno Therapeutics Onapristone polymorphic forms and methods of use
US9096641B2 (en) * 2013-06-05 2015-08-04 Evestra, Inc. Imidazolyl progesterone antagonists
AU2016326657B2 (en) 2015-09-25 2019-10-24 Context Biopharma, Inc. Methods of making onapristone intermediates
EP3389632A4 (en) 2015-12-15 2019-11-06 Context Biopharma Inc. Amorphous onapristone compositions and methods of making the same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971772A (en) * 1975-01-06 1976-07-27 E. R. Squibb & Sons, Inc. Steroidal[16α,17-b]1,4-dioxanes and Steroidal[16α,17-b]1,4-dioxins
ZA8200031B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2522328B1 (en) * 1982-03-01 1986-02-14 Roussel Uclaf New products derived from the structure 3-ceto 4,9 19-nor steroids, their preparation process and their application as medicaments
US4780461A (en) * 1983-06-15 1988-10-25 Schering Aktiengesellschaft 13α-alkyl-gonanes, their production, and pharmaceutical preparations containing same
ES533260A0 (en) * 1983-06-15 1985-02-01 Schering Ag Procedure for the preparation of 13a-alquilgonanos
FR2576025B1 (en) * 1985-01-14 1987-01-23 Roussel Uclaf Novel substituted steroids in position 10, their process and the preparation intermediates, their application as medicaments, the pharmaceutical compositions containing them
AU580843B2 (en) * 1985-02-07 1989-02-02 Schering Aktiengesellschaft 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
DE3625315A1 (en) * 1986-07-25 1988-01-28 Schering Ag 11ss- (4-isopropenylphenyl) -estra-4,9-dienes, their production and the pharmaceutical preparations containing them
DE3822770A1 (en) * 1988-07-01 1990-01-04 Schering Ag 13-alkyl-11ss-phenylgonane
DE3832303A1 (en) * 1988-09-20 1990-04-12 Schering Ag 11ss-phenyl-14ssh steroids

Also Published As

Publication number Publication date
US5273971A (en) 1993-12-28
AU644060B2 (en) 1993-12-02
WO1990000174A1 (en) 1990-01-11
PT91031A (en) 1990-02-08
DD287511A5 (en) 1991-02-28
US5446036A (en) 1995-08-29
DD295638A5 (en) 1991-11-07
IL90826A (en) 1994-06-24
ES2080079T3 (en) 1996-02-01
JPH03505727A (en) 1991-12-12
HUT56114A (en) 1991-07-29
NO180451B (en) 1997-01-13
NO180451C (en) 1997-04-23
NO905609L (en) 1991-02-28
AU3856889A (en) 1990-01-23
PT91031B (en) 1994-12-30
AT129717T (en) 1995-11-15
HU894130D0 (en) 1991-06-28
EP0349481A1 (en) 1990-01-03
GR3018069T3 (en) 1996-02-29
IE70664B1 (en) 1996-12-11
HU208021B (en) 1993-07-28
JP2956776B2 (en) 1999-10-04
NO905609D0 (en) 1990-12-27
IL90826D0 (en) 1990-01-18
ZA895058B (en) 1990-04-25
EP0349481B1 (en) 1995-11-02
DE3822770A1 (en) 1990-01-04
IE892141L (en) 1990-01-01
CA1334668C (en) 1995-03-07

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