ZA854719B - Pyrazole analogs of mevalonolactone and derivatives thereof,processes for their production and their use - Google Patents
Pyrazole analogs of mevalonolactone and derivatives thereof,processes for their production and their useInfo
- Publication number
- ZA854719B ZA854719B ZA854719A ZA854719A ZA854719B ZA 854719 B ZA854719 B ZA 854719B ZA 854719 A ZA854719 A ZA 854719A ZA 854719 A ZA854719 A ZA 854719A ZA 854719 B ZA854719 B ZA 854719B
- Authority
- ZA
- South Africa
- Prior art keywords
- 3alkyl
- phenoxy
- fluoro
- chloro
- trifluoromethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F13/00—Interconnection of, or transfer of information or other signals between, memories, input/output devices or central processing units
- G06F13/38—Information transfer, e.g. on bus
- G06F13/382—Information transfer, e.g. on bus using universal interface adapter
- G06F13/387—Information transfer, e.g. on bus using universal interface adapter for adaptation of different data processing systems to different peripheral devices, e.g. protocol converters for incompatible systems, open system
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F13/00—Interconnection of, or transfer of information or other signals between, memories, input/output devices or central processing units
- G06F13/38—Information transfer, e.g. on bus
- G06F13/40—Bus structure
- G06F13/4004—Coupling between buses
- G06F13/4009—Coupling between buses with data restructuring
- G06F13/4018—Coupling between buses with data restructuring with data-width conversion
Landscapes
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Theoretical Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Computer Hardware Design (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62339384A | 1984-06-22 | 1984-06-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA854719B true ZA854719B (en) | 1987-02-25 |
Family
ID=24497918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA854719A ZA854719B (en) | 1984-06-22 | 1985-06-21 | Pyrazole analogs of mevalonolactone and derivatives thereof,processes for their production and their use |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0200736B1 (fr) |
JP (1) | JPS61502467A (fr) |
KR (1) | KR890001651B1 (fr) |
AT (1) | ATE62906T1 (fr) |
AU (1) | AU573368B2 (fr) |
CA (1) | CA1249283A (fr) |
DE (1) | DE3582674D1 (fr) |
DK (1) | DK157543C (fr) |
ES (1) | ES8703842A1 (fr) |
FI (1) | FI860755A (fr) |
GR (1) | GR851510B (fr) |
HU (1) | HU198711B (fr) |
IL (1) | IL75583A (fr) |
MY (1) | MY101903A (fr) |
NZ (1) | NZ212501A (fr) |
PL (1) | PL151016B1 (fr) |
PT (1) | PT80674B (fr) |
WO (1) | WO1986000307A2 (fr) |
ZA (1) | ZA854719B (fr) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4668794A (en) * | 1985-05-22 | 1987-05-26 | Sandoz Pharm. Corp. | Intermediate imidazole acrolein analogs |
EP0221025A1 (fr) * | 1985-10-25 | 1987-05-06 | Sandoz Ag | Analogues hétérocycliques de la mévalonolactone et dérivés de ceux-ci, leur procédé de préparation et leur application comme médicaments |
EP0244364A3 (fr) * | 1986-04-30 | 1992-04-01 | Sandoz Ag | Préparation de composés oléfiniques |
US4808621A (en) * | 1986-07-07 | 1989-02-28 | Warner-Lambert Company | Trans-6-[2-(N-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl]- or ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
PT85662B (pt) * | 1986-09-10 | 1990-06-29 | Sandoz Sa | Processo para a preparacao de derivados de aza-indol e de indolizina e de composicoes farmaceuticas que os contem |
US4751235A (en) * | 1986-12-23 | 1988-06-14 | Sandoz Pharm. Corp. | Anti-atherosclerotic indolizine derivatives |
US4735958A (en) * | 1986-12-22 | 1988-04-05 | Warner-Lambert Company | Trans-6-[2-[2-(substituted-phenyl)-3- (or 4-) heteroaryl-5-substituted-1H-pyrrol-1-yl]-ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one inhibitors of cholesterol biosynthesis |
US4898949A (en) * | 1987-02-25 | 1990-02-06 | Bristol-Myers Company | Intermediates for the preparation of antihypercholesterolemic tetrazole compounds |
AT401518B (de) * | 1987-02-25 | 1996-09-25 | Bristol Myers Squibb Co | Neue tetrazol-verbindungen und verfahren zu ihrer herstellung |
US4897490A (en) * | 1987-02-25 | 1990-01-30 | Bristol-Meyers Company | Antihypercholesterolemic tetrazole compounds |
JP2569746B2 (ja) * | 1987-08-20 | 1997-01-08 | 日産化学工業株式会社 | キノリン系メバロノラクトン類 |
CA1336714C (fr) * | 1987-08-20 | 1995-08-15 | Yoshihiro Fujikawa | Mevalonolactone de type quinoleine utilisee comme inhibiteurs de la biosynthese du cholesterol |
US4906624A (en) * | 1987-09-08 | 1990-03-06 | Warner-Lambert Company | 6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
US4997837A (en) * | 1987-09-08 | 1991-03-05 | Warner-Lambert Company | 6-(((substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
DE3800785A1 (de) * | 1988-01-09 | 1989-07-20 | Hoechst Ag | Substituierte 7-(pyridazin-5-yl)-3,5-dihydroxyheptan(en)- saeuren, ihre entsprechenden (delta)-lactone bzw. derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte |
US4822799A (en) * | 1988-01-27 | 1989-04-18 | Sandoz Pharm. Corp. | Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals |
NO890522L (no) * | 1988-02-25 | 1989-08-28 | Bayer Ag | Substituerte imidazolinoner og imidazolinthioner. |
JP2890448B2 (ja) * | 1988-04-26 | 1999-05-17 | 日産化学工業株式会社 | ピラゾロピリジン系メバロノラクトン類 |
US5024999A (en) * | 1988-04-26 | 1991-06-18 | Nissan Chemical Industries Ltd. | Pyrazolopyridine type mevalonolactones useful as pharmaeuticals |
EP0562643A3 (en) * | 1988-10-13 | 1994-05-18 | Sandoz Ag | 7-substituted-hept-6-enoic and -heptanoic acids and derivatives thereof |
JPH04270285A (ja) * | 1988-11-14 | 1992-09-25 | Nissan Chem Ind Ltd | ピラゾロピリミジン系メバロノラクトン類 |
IT1237793B (it) * | 1989-12-21 | 1993-06-17 | Zambon Spa | Composti attivi come inibitori dell'enzima hmg-coa reduttasi |
US5134155A (en) * | 1991-08-08 | 1992-07-28 | Ortho Pharmaceutical Corporation | Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-coA reductase inhibitors |
CA2118795A1 (fr) * | 1991-09-20 | 1993-04-01 | John Crosby | Pyranones |
US5335293A (en) * | 1992-06-16 | 1994-08-02 | Key Technology, Inc. | Product inspection method and apparatus |
AR041867A1 (es) | 2002-11-01 | 2005-06-01 | Takeda Pharmaceutical | Agente para prevenir o tratar neuropatia |
CA2590533C (fr) | 2004-11-23 | 2010-09-07 | Warner-Lambert Company Llc | Derives d'acide 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoique comme inhibiteurs de hmg co-a reductase pour le traitement de l'hyperlipidemie |
WO2006087630A2 (fr) * | 2005-02-16 | 2006-08-24 | Warner-Lambert Company Llc | Inhibiteurs oxypyrazole de l'enzyme hmg co-a reductase |
EP1775299A1 (fr) | 2005-10-05 | 2007-04-18 | LEK Pharmaceuticals D.D. | Procédé de préparation de inhibiteurs de la HMG-CoA réductase |
JP5113531B2 (ja) * | 2006-01-16 | 2013-01-09 | 三井化学アグロ株式会社 | (3−硫黄原子置換フェニル)ピラゾール誘導体 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1261124B (de) * | 1961-09-22 | 1968-02-15 | Hoechst Ag | Verfahren zur Herstellung von Pyrazolen |
DE2920933A1 (de) * | 1979-05-23 | 1980-12-04 | Basf Ag | 3-aryl-5-methyl-pyrazol-4-carbonsaeureester enthaltende herbizide |
US4245106A (en) * | 1979-07-05 | 1981-01-13 | Monsanto Company | Process for the preparation of 1-alkyl-3-aryl-4-pyrazolecarboxylates |
-
1985
- 1985-06-18 DE DE8585903248T patent/DE3582674D1/de not_active Expired - Lifetime
- 1985-06-18 HU HU853053A patent/HU198711B/hu not_active IP Right Cessation
- 1985-06-18 JP JP60502997A patent/JPS61502467A/ja active Pending
- 1985-06-18 KR KR1019860700100A patent/KR890001651B1/ko not_active IP Right Cessation
- 1985-06-18 AU AU45466/85A patent/AU573368B2/en not_active Ceased
- 1985-06-18 WO PCT/EP1985/000293 patent/WO1986000307A2/fr active IP Right Grant
- 1985-06-18 EP EP85903248A patent/EP0200736B1/fr not_active Expired - Lifetime
- 1985-06-18 AT AT85903248T patent/ATE62906T1/de not_active IP Right Cessation
- 1985-06-20 GR GR851510A patent/GR851510B/el unknown
- 1985-06-20 NZ NZ212501A patent/NZ212501A/xx unknown
- 1985-06-20 PT PT80674A patent/PT80674B/pt not_active IP Right Cessation
- 1985-06-20 IL IL75583A patent/IL75583A/xx unknown
- 1985-06-21 ES ES544407A patent/ES8703842A1/es not_active Expired
- 1985-06-21 PL PL1985254121A patent/PL151016B1/pl unknown
- 1985-06-21 CA CA000484847A patent/CA1249283A/fr not_active Expired
- 1985-06-21 ZA ZA854719A patent/ZA854719B/xx unknown
-
1986
- 1986-02-20 FI FI860755A patent/FI860755A/fi not_active Application Discontinuation
- 1986-02-21 DK DK083886A patent/DK157543C/da not_active IP Right Cessation
-
1987
- 1987-09-26 MY MYPI87001978A patent/MY101903A/en unknown
Also Published As
Publication number | Publication date |
---|---|
GR851510B (fr) | 1985-11-25 |
DE3582674D1 (de) | 1991-05-29 |
KR890001651B1 (ko) | 1989-05-12 |
ES544407A0 (es) | 1987-03-01 |
DK83886A (da) | 1986-02-21 |
PL151016B1 (en) | 1990-07-31 |
DK83886D0 (da) | 1986-02-21 |
PT80674A (en) | 1985-07-01 |
MY101903A (en) | 1992-02-15 |
AU573368B2 (en) | 1988-06-02 |
PL254121A1 (en) | 1988-07-21 |
PT80674B (en) | 1987-03-17 |
WO1986000307A3 (fr) | 1986-04-10 |
HUT39178A (en) | 1986-08-28 |
IL75583A0 (en) | 1985-10-31 |
EP0200736B1 (fr) | 1991-04-24 |
CA1249283A (fr) | 1989-01-24 |
ATE62906T1 (de) | 1991-05-15 |
AU4546685A (en) | 1986-01-24 |
IL75583A (en) | 1989-09-10 |
HU198711B (en) | 1989-11-28 |
KR860700253A (ko) | 1986-08-01 |
NZ212501A (en) | 1988-06-30 |
EP0200736A1 (fr) | 1986-11-12 |
DK157543C (da) | 1990-06-11 |
FI860755A0 (fi) | 1986-02-20 |
JPS61502467A (ja) | 1986-10-30 |
WO1986000307A2 (fr) | 1986-01-16 |
FI860755A (fi) | 1986-02-20 |
ES8703842A1 (es) | 1987-03-01 |
DK157543B (da) | 1990-01-22 |
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