ZA8503440B - Indoline and 2-indolinone derivatives - Google Patents

Indoline and 2-indolinone derivatives

Info

Publication number
ZA8503440B
ZA8503440B ZA853440A ZA8503440A ZA8503440B ZA 8503440 B ZA8503440 B ZA 8503440B ZA 853440 A ZA853440 A ZA 853440A ZA 8503440 A ZA8503440 A ZA 8503440A ZA 8503440 B ZA8503440 B ZA 8503440B
Authority
ZA
South Africa
Prior art keywords
indoline
indolinone derivatives
indolinone
derivatives
Prior art date
Application number
ZA853440A
Inventor
David Wayne Robertson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US61021084A priority Critical
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA8503440B publication Critical patent/ZA8503440B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/34Oxygen atoms in position 2
ZA853440A 1984-05-14 1985-05-07 Indoline and 2-indolinone derivatives ZA8503440B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US61021084A true 1984-05-14 1984-05-14

Publications (1)

Publication Number Publication Date
ZA8503440B true ZA8503440B (en) 1986-12-30

Family

ID=24444125

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA853440A ZA8503440B (en) 1984-05-14 1985-05-07 Indoline and 2-indolinone derivatives

Country Status (18)

Country Link
EP (1) EP0161918B1 (en)
JP (1) JPH0643417B2 (en)
KR (1) KR870000274B1 (en)
AR (1) AR241531A1 (en)
AU (1) AU577372B2 (en)
CA (1) CA1248099A (en)
DE (1) DE3578822D1 (en)
DK (1) DK207785A (en)
EG (1) EG17342A (en)
ES (1) ES8609308A1 (en)
GR (1) GR851121B (en)
HU (1) HU194873B (en)
IL (1) IL75122A (en)
NZ (1) NZ212023A (en)
PH (1) PH21862A (en)
PT (1) PT80414B (en)
SU (1) SU1486060A3 (en)
ZA (1) ZA8503440B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4591591A (en) * 1984-03-08 1986-05-27 Eli Lilly And Company Pyridazinone derivatives as inotropic agents
DE3631085A1 (en) * 1986-09-12 1988-03-24 Boehringer Mannheim Gmbh Heterocyclic-substituted indolinones, processes for their preparation, pharmaceutical compositions and intermediates
DE3706427A1 (en) * 1987-02-27 1988-09-08 Boehringer Mannheim Gmbh New substituted 3h-indoles, intermediates, methods for their production and drug
US5196416A (en) * 1987-08-28 1993-03-23 Eli Lilly And Company Transdermal flux-enhancing pharmaceutical compositions comprising azone, ethanol and water
ZA8806218B (en) * 1987-08-28 1990-04-25 Lilly Co Eli Permeation enhancement compositions
AT110071T (en) * 1988-01-23 1994-09-15 Kyowa Hakko Kogyo Kk Pyridazinone derivatives and pharmaceutical compositions containing them.
GB8816944D0 (en) * 1988-07-15 1988-08-17 Sobio Lab Compounds
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
MX2009013293A (en) 2007-06-04 2010-02-15 Synergy Pharmaceuticals Inc Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2009149279A2 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (en) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer, and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
ES2664873T3 (en) 2011-03-01 2018-04-23 Synergy Pharmaceuticals Inc. Preparation process for guanylate cyclase C agonists
JP6499591B2 (en) 2013-02-25 2019-04-10 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase receptor agonists for use in colon lavage
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP2016522216A (en) 2013-06-05 2016-07-28 シナジー ファーマシューティカルズ インコーポレイテッド Ultra high purity agonist of guanylate cyclase C, method for producing and using the same
AU2014305843B2 (en) 2013-08-09 2019-08-29 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8101067A1 (en) * 1978-08-25 1980-12-01 Thomae Gmbh Dr K Process for preparing new substituted benzimidazole in position 5 or 6 ring pyridazinone
US4258185A (en) * 1978-10-17 1981-03-24 Yoshitomi Pharmaceutical Industries, Ltd. Pyridazinone compounds
DE3124699A1 (en) * 1981-06-24 1983-01-13 Basf Ag New 2-aryl-3,4-diaza-bicyclo (4.n.0.) Alkene (2) -one- (5), processes for their preparation and pharmaceutical compositions containing these compounds
JPS588016A (en) * 1981-07-06 1983-01-18 Mitsubishi Chem Ind Ltd Cardiotonic drug

Also Published As

Publication number Publication date
AU4240585A (en) 1985-11-21
EP0161918A3 (en) 1986-11-20
ES8609308A1 (en) 1986-09-01
EP0161918B1 (en) 1990-07-25
HU194873B (en) 1988-03-28
DE3578822D1 (en) 1990-08-30
PH21862A (en) 1988-03-25
ES543078A0 (en) 1986-09-01
SU1486060A3 (en) 1989-06-07
PT80414B (en) 1987-04-16
DK207785A (en) 1985-11-15
AR241531A1 (en) 1992-08-31
GR851121B (en) 1985-11-25
JPS6122080A (en) 1986-01-30
JPH0643417B2 (en) 1994-06-08
ES543078D0 (en)
KR870000274B1 (en) 1987-02-23
IL75122A (en) 1989-02-28
HUT37783A (en) 1986-02-28
AU577372B2 (en) 1988-09-22
CA1248099A1 (en)
EG17342A (en) 1991-03-30
DK207785D0 (en) 1985-05-10
NZ212023A (en) 1988-04-29
IL75122D0 (en) 1985-09-29
PT80414A (en) 1985-06-01
CA1248099A (en) 1989-01-03
EP0161918A2 (en) 1985-11-21

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