ZA817597B - Heterocyclic compounds - Google Patents

Heterocyclic compounds

Info

Publication number
ZA817597B
ZA817597B ZA817597A ZA817597A ZA817597B ZA 817597 B ZA817597 B ZA 817597B ZA 817597 A ZA817597 A ZA 817597A ZA 817597 A ZA817597 A ZA 817597A ZA 817597 B ZA817597 B ZA 817597B
Authority
ZA
South Africa
Prior art keywords
heterocyclic compounds
heterocyclic
compounds
Prior art date
Application number
ZA817597A
Other languages
English (en)
Inventor
David Brown
Robert Ian Dowell
Rodney Brian Hargreaves
Brian Geoffrey Main
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Plc filed Critical Ici Plc
Publication of ZA817597B publication Critical patent/ZA817597B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C07D273/04—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/194—Radicals derived from thio- or thiono carboxylic acids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ZA817597A 1980-11-14 1981-11-03 Heterocyclic compounds ZA817597B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8036680 1980-11-14

Publications (1)

Publication Number Publication Date
ZA817597B true ZA817597B (en) 1982-10-27

Family

ID=10517317

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA817597A ZA817597B (en) 1980-11-14 1981-11-03 Heterocyclic compounds

Country Status (20)

Country Link
US (4) US4423045A (fr)
EP (1) EP0052442B1 (fr)
JP (3) JPS57109771A (fr)
KR (1) KR830007624A (fr)
AU (1) AU7709181A (fr)
CA (1) CA1176250A (fr)
DD (1) DD202020A5 (fr)
DE (1) DE3172252D1 (fr)
DK (1) DK498881A (fr)
ES (2) ES507126A0 (fr)
FI (1) FI813566L (fr)
GR (1) GR79554B (fr)
HU (1) HU185979B (fr)
MW (1) MW4881A1 (fr)
NO (1) NO813850L (fr)
NZ (1) NZ198967A (fr)
PL (2) PL233809A1 (fr)
PT (1) PT73995B (fr)
ZA (1) ZA817597B (fr)
ZW (1) ZW26381A1 (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4616014A (en) * 1981-10-22 1986-10-07 Fujisawa Pharmaceutical Co., Ltd. Triazine derivatives, and pharmaceutical compositions comprising the same
US4495185A (en) * 1981-11-12 1985-01-22 Imperial Chemical Industries, Plc 1,2,4-Triazin-3(2H) ones
ZA827641B (en) * 1981-11-12 1983-09-28 Ici Plc Thiadiazine, oxadiazine and triazine derivatives which possess cardiotonic and/or antihypertensive activity
CA1199027A (fr) * 1981-11-12 1986-01-07 Stuart D. Mills Derives heterocycliques de pyridazinone, thiadiazinone, oxadiazinone et triazinone
US4657906A (en) * 1982-06-05 1987-04-14 Smith Kline & French Laboratories Ltd. Heterocyclic compounds having inotropic activity
JPS5962578A (ja) * 1982-10-04 1984-04-10 Mitsui Toatsu Chem Inc オキサジアジン誘導体およびそれを含有する医薬組成物
US4581356A (en) * 1983-03-22 1986-04-08 Fujisawa Pharmaceutical Co., Ltd. Triazine derivatives, and pharmaceutical compositions comprising the same
GB8310435D0 (en) * 1983-04-18 1983-05-25 Fujisawa Pharmaceutical Co Triazine derivatives
JPS59196874A (ja) * 1983-04-22 1984-11-08 Fujisawa Pharmaceut Co Ltd トリアジン誘導体
GB8328907D0 (en) * 1983-10-28 1983-11-30 Smith Kline French Lab Chemical compounds
GB8329784D0 (en) * 1983-11-08 1983-12-14 Smith Kline French Lab Heterocyclic compounds
GB8332313D0 (en) * 1983-12-02 1984-01-11 Smith Kline French Lab Chemical compounds
US4508718A (en) * 1984-01-16 1985-04-02 Warner-Lambert Company Cardiotonic and antihypertensive oxadiazinone compounds
WO1986002074A1 (fr) 1984-10-04 1986-04-10 Zenyaku Kogyo Kabushiki Kaisha Nouveaux derives de 1,4-thiazine, leur procede de preparation et cardiotoniques les contenant
JPS61106574A (ja) * 1984-10-29 1986-05-24 Yoshitomi Pharmaceut Ind Ltd オキサ（またはチア）ジアジン誘導体
DE3531658A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel
FR2592878B1 (fr) * 1986-01-16 1988-12-16 Pf Medicament Monoaryl-5 as triazinones-3 substituees en position 2, leur procede de preparation et leur application en tant que medicaments
US4898862A (en) * 1986-03-20 1990-02-06 Sankyo Company Limited 1,2,4-triazinone derivatives, their preparation and use
US4861773A (en) * 1986-04-28 1989-08-29 Smith Kline & French Laboratories Limited Heterocyclic compounds
GB8610369D0 (en) * 1986-04-28 1986-06-04 Smith Kline French Lab Heterocyclic compounds
DE3706427A1 (de) * 1987-02-27 1988-09-08 Boehringer Mannheim Gmbh Neue substituierte 3h-indole, zwischenprodukte, verfahren zu ihrer herstellung sowie arzneimittel
AU614965B2 (en) * 1987-06-06 1991-09-19 Merck Patent Gesellschaft Mit Beschrankter Haftung Thiadiazinones
GB8903130D0 (en) 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
US5185332A (en) * 1989-02-11 1993-02-09 Orion-Yhtyma Oy Thiadiazines and pharmaceutical compositions thereof as well as method of use
DE3913597A1 (de) * 1989-04-25 1990-11-08 Heumann Pharma Gmbh & Co Diazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4239540A1 (de) * 1992-11-25 1994-05-26 Asta Medica Ag Neue heterocyclische Verbindungen mit antiasthmatischer/antiallergischer, entzündungshemmender, positiv inotroper und blutdrucksenkender Wirkung
TW309520B (fr) * 1994-04-26 1997-07-01 Mitsubishi Chem Corp
USRE39263E1 (en) * 1994-05-04 2006-09-05 Bayer Aktiengesellschaft Substituted aromatic thiocarboxylic acid amides and their use as herbicides
CN1113875C (zh) 1994-05-04 2003-07-09 拜尔公司 取代的芳族硫代羧酰胺及其作为除草剂的用途
AU6320998A (en) 1997-02-21 1998-09-09 Bristol-Myers Squibb Company Benzoic acid derivatives and related compounds as antiarrhythmic agents
DE19929781A1 (de) * 1999-06-29 2001-01-04 Bayer Ag N-[4-(6-Oxotetrahydrotriazinyl)phenyl]amide und ihre Verwendung
BRPI0618609A2 (pt) 2005-11-16 2011-09-06 Novartis Ag biomarcadores para tratamento com anticorpo anti-nogo-a em danos à medula espinhal
US9452978B2 (en) 2010-01-27 2016-09-27 Mitsubishi Rayon Co., Ltd. Chain transfer agent and emulsion polymerization using the same
JOP20200024A1 (ar) 2017-08-04 2020-02-02 Bayer Ag مركبات ثنائي هيدروكساديازينون
CA3071795A1 (fr) 2017-08-04 2019-02-07 Bayer Aktiengesellschaft Derives de 6-phenyl-4,5-dihydropyridazin-3(2h)-one utilises en tant qu'inhibiteurs de pde3a et pde3b pour le traitement du cancer
AR117929A1 (es) 2019-02-01 2021-09-01 Bayer Ag Compuestos de 1,2,4-triazin-3(2h)-ona

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3314455A (en) * 1964-07-24 1967-04-18 Black Clawson Co Band saw resawing machine
US3377345A (en) * 1966-09-23 1968-04-09 Dow Chemical Co Substituted 3, 4, 5, 6-tetrahydro-2h-1, 3, 4-oxadiazin-2-one compounds and method ofpreparation thereof
FR8169M (fr) * 1967-05-17 1970-08-31
US3946010A (en) * 1975-04-09 1976-03-23 E. R. Squibb & Sons, Inc. 3-Phenyl-2,5-dihydro-as-triazin-6 (1H)-ones
US4097425A (en) * 1975-08-28 1978-06-27 General Electric Company Thermoplastic formable blends, a foaming method and products made thereby
US4097671A (en) * 1975-08-28 1978-06-27 General Electric Company Dihydrooxadiazinones and method for making
US4105848A (en) * 1976-12-27 1978-08-08 General Electric Company Process for the production of dihydrooxadiazinone compounds
ZA827641B (en) * 1981-11-12 1983-09-28 Ici Plc Thiadiazine, oxadiazine and triazine derivatives which possess cardiotonic and/or antihypertensive activity
US4489074A (en) * 1982-11-12 1984-12-18 Imperial Chemical Industries, Plc 1,3,4-Thiadiazin-2-ones
JPH072947B2 (ja) * 1985-06-27 1995-01-18 松下電子工業株式会社 螢光体

Also Published As

Publication number Publication date
EP0052442A1 (fr) 1982-05-26
ES8307231A1 (es) 1983-07-01
KR830007624A (ko) 1983-11-04
ES8401044A1 (es) 1983-11-16
FI813566L (fi) 1982-05-15
HU185979B (en) 1985-04-28
US4423045A (en) 1983-12-27
NZ198967A (en) 1984-12-14
NO813850L (no) 1982-05-18
US4587246A (en) 1986-05-06
JPS57109771A (en) 1982-07-08
PL233809A1 (en) 1983-09-12
JPS6236370A (ja) 1987-02-17
PT73995B (en) 1983-06-20
ZW26381A1 (en) 1983-06-01
PL238802A1 (en) 1983-09-12
US4683232A (en) 1987-07-28
DD202020A5 (de) 1983-08-24
JPS6230771A (ja) 1987-02-09
US4503054A (en) 1985-03-05
CA1176250A (fr) 1984-10-16
EP0052442B1 (fr) 1985-09-11
DK498881A (da) 1982-05-15
GR79554B (fr) 1984-10-30
MW4881A1 (en) 1983-09-14
ES516588A0 (es) 1983-11-16
ES507126A0 (es) 1983-07-01
PT73995A (en) 1981-12-01
JPH0572384B2 (fr) 1993-10-12
DE3172252D1 (en) 1985-10-17
AU7709181A (en) 1982-05-20

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