ZA201207727B - Morpholinylquinazolines - Google Patents

Morpholinylquinazolines

Info

Publication number
ZA201207727B
ZA201207727B ZA2012/07727A ZA201207727A ZA201207727B ZA 201207727 B ZA201207727 B ZA 201207727B ZA 2012/07727 A ZA2012/07727 A ZA 2012/07727A ZA 201207727 A ZA201207727 A ZA 201207727A ZA 201207727 B ZA201207727 B ZA 201207727B
Authority
ZA
South Africa
Prior art keywords
morpholinylquinazolines
Prior art date
Application number
ZA2012/07727A
Inventor
Werner Mederski
Frank Zenke
Thomas Fuchss
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE102010011493 priority Critical
Priority to PCT/EP2011/000767 priority patent/WO2011113512A1/en
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA201207727B publication Critical patent/ZA201207727B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
ZA2012/07727A 2010-03-16 2012-10-15 Morpholinylquinazolines ZA201207727B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE102010011493 2010-03-16
PCT/EP2011/000767 WO2011113512A1 (en) 2010-03-16 2011-02-17 Morpholinylquinazolines

Publications (1)

Publication Number Publication Date
ZA201207727B true ZA201207727B (en) 2013-06-26

Family

ID=43828057

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2012/07727A ZA201207727B (en) 2010-03-16 2012-10-15 Morpholinylquinazolines

Country Status (16)

Country Link
US (1) US9126952B2 (en)
EP (1) EP2547664B1 (en)
JP (1) JP2013522249A (en)
KR (1) KR20130017086A (en)
CN (1) CN102803227B (en)
AR (1) AR080757A1 (en)
AU (1) AU2011229542A1 (en)
BR (1) BR112012022868A2 (en)
CA (1) CA2793299A1 (en)
EA (1) EA201201289A1 (en)
ES (1) ES2586227T3 (en)
IL (1) IL221901A (en)
MX (1) MX2012010557A (en)
SG (1) SG183855A1 (en)
WO (1) WO2011113512A1 (en)
ZA (1) ZA201207727B (en)

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DE102011118830A1 (en) * 2011-11-18 2013-05-23 Merck Patent Gmbh Morpholinylbenzotriazine
CA2871471A1 (en) 2012-04-24 2013-10-31 Vertex Pharmaceuticals Incorporated Dna-pk inhibitors
PT2970218T (en) 2013-03-12 2019-03-01 Vertex Pharma Dna-pk inhibitors
UY35464A (en) 2013-03-15 2014-10-31 Araxes Pharma Llc KRAS G12C covalent inhibitors.
DE102013008118A1 (en) 2013-05-11 2014-11-13 Merck Patent Gmbh arylchinazoline
WO2015054572A1 (en) * 2013-10-10 2015-04-16 Araxes Pharma Llc Inhibitors of kras g12c
TWI659021B (en) 2013-10-10 2019-05-11 亞瑞克西斯製藥公司 Inhibitors of kras g12c
LT3057953T (en) 2013-10-17 2018-11-26 Vertex Pharmaceuticals Incorporated Co-crystals of (s)-n-methyl-8-(1-((2`-methyl-[4,5`-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as dna-pk inhibitors
TW201625305A (en) 2014-09-18 2016-07-16 亞瑞克西斯製藥公司 Combination therapies for treatment of cancer
WO2016049568A1 (en) 2014-09-25 2016-03-31 Araxes Pharma Llc Methods and compositions for inhibition of ras
CN107849022A (en) 2015-04-10 2018-03-27 亚瑞克西斯制药公司 Substituted quinazoline compound and its application method
US10428064B2 (en) 2015-04-15 2019-10-01 Araxes Pharma Llc Fused-tricyclic inhibitors of KRAS and methods of use thereof
US10144724B2 (en) 2015-07-22 2018-12-04 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
EP3364977A4 (en) 2015-10-19 2019-09-04 Araxes Pharma Llc Method for screening inhibitors of ras
US10414757B2 (en) 2015-11-16 2019-09-17 Araxes Pharma Llc 2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof
US9988357B2 (en) 2015-12-09 2018-06-05 Araxes Pharma Llc Methods for preparation of quinazoline derivatives
US20190127336A1 (en) * 2016-03-30 2019-05-02 Araxes Pharma Llc Substituted quinazoline compounds and methods of use
CN110036010A (en) 2016-09-29 2019-07-19 亚瑞克西斯制药公司 The inhibitor of KRAS G12C mutain
WO2018068017A1 (en) 2016-10-07 2018-04-12 Araxes Pharma Llc Heterocyclic compounds as inhibitors of ras and methods of use thereof
AU2018357933B2 (en) * 2017-10-31 2019-11-21 Southern Research Institute Substituted quinazoline sulfonamides as thioredoxin interacting protein (TXNIP) inhibitors

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EP0556310B1 (en) 1990-11-06 1995-07-05 Pfizer Inc. Quinazolines derivatives for enhancing antitumor activity
GB9300059D0 (en) 1992-01-20 1993-03-03 Zeneca Ltd Quinazoline derivatives
JP2994165B2 (en) * 1992-06-26 1999-12-27 ゼネカ・リミテッド Quinazoline derivatives, pharmaceutical formulations for obtaining anticancer activity containing their production and the quinazoline derivative
GB9707800D0 (en) * 1996-05-06 1997-06-04 Zeneca Ltd Chemical compounds
WO2000061186A1 (en) 1999-04-08 2000-10-19 Arch Development Corporation Use of anti-vegf antibody to enhance radiation in cancer therapy
US7179912B2 (en) * 2000-09-01 2007-02-20 Icos Corporation Materials and methods to potentiate cancer treatment
US7294629B2 (en) * 2001-02-21 2007-11-13 Mitsubishi Pharma Corporation Quinazoline derivatives
CA2468996A1 (en) * 2001-12-03 2003-06-12 Schering Corporation Use of fpt inhibitors and at least two antineoplastic agents in the treatment of cancer
PE20060285A1 (en) * 2004-03-30 2006-05-08 Aventis Pharma Inc Substituted pyridones as inhibitors of pol (adp-ribose) polymerase (PARP)
ES2288359B1 (en) 2005-07-08 2009-07-23 Consejo Superior Investigaciones Cientificas Coordinated control system for continuous extraction lines of virgin olive oil.
WO2007036734A1 (en) * 2005-09-29 2007-04-05 Glaxo Group Limited Pyrazolo[3,4-b]pyridine compound, and its use as a pde4 inhibitor
DE102006012251A1 (en) * 2006-03-15 2007-11-08 Grünenthal GmbH Substituted 4-aminoquinazoline derivatives and their use for the preparation of medicaments
EP1903038A1 (en) * 2006-09-07 2008-03-26 Bayer Schering Pharma Aktiengesellschaft N-(1-hetaryl-piperidin-4-yl)-(het)arylamide as EP2 receptor modulators
AT461177T (en) * 2007-03-23 2010-04-15 Icagen Inc Ion channel inhibitors
CN103923072B (en) * 2007-07-20 2017-05-31 内尔维阿诺医学科学有限公司 As the substituted indazole derivative with kinase inhibitory activity
WO2009020140A1 (en) * 2007-08-06 2009-02-12 Dainippon Sumitomo Pharma Co., Ltd. Adamantylurea derivative
AR073354A1 (en) * 2008-07-31 2010-11-03 Genentech Inc Pyrimidine compounds, pharmaceutical compositions and their use in treating cancer.
US8563539B2 (en) * 2009-12-23 2013-10-22 Jasco Pharmaceuticals, LLC Aminopyrimidine kinase inhibitors

Also Published As

Publication number Publication date
JP2013522249A (en) 2013-06-13
CA2793299A1 (en) 2011-09-22
AR080757A1 (en) 2012-05-09
US20130012489A1 (en) 2013-01-10
EA201201289A1 (en) 2013-08-30
IL221901D0 (en) 2012-12-02
CN102803227A (en) 2012-11-28
EP2547664A1 (en) 2013-01-23
MX2012010557A (en) 2012-10-05
US9126952B2 (en) 2015-09-08
SG183855A1 (en) 2012-10-30
BR112012022868A2 (en) 2018-06-05
WO2011113512A1 (en) 2011-09-22
ES2586227T3 (en) 2016-10-13
CN102803227B (en) 2016-01-20
IL221901A (en) 2016-04-21
KR20130017086A (en) 2013-02-19
AU2011229542A1 (en) 2012-11-08
EP2547664B1 (en) 2016-05-04

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