ZA201207727B - Morpholinylquinazolines - Google Patents
MorpholinylquinazolinesInfo
- Publication number
- ZA201207727B ZA201207727B ZA2012/07727A ZA201207727A ZA201207727B ZA 201207727 B ZA201207727 B ZA 201207727B ZA 2012/07727 A ZA2012/07727 A ZA 2012/07727A ZA 201207727 A ZA201207727 A ZA 201207727A ZA 201207727 B ZA201207727 B ZA 201207727B
- Authority
- ZA
- South Africa
- Prior art keywords
- morpholinylquinazolines
- Prior art date
Links
- -1 Morpholinylquinazolines Chemical class 0 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102010011493 | 2010-03-16 | ||
| PCT/EP2011/000767 WO2011113512A1 (en) | 2010-03-16 | 2011-02-17 | Morpholinylquinazolines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201207727B true ZA201207727B (en) | 2013-06-26 |
Family
ID=43828057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2012/07727A ZA201207727B (en) | 2010-03-16 | 2012-10-15 | Morpholinylquinazolines |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9126952B2 (en) |
| EP (1) | EP2547664B1 (en) |
| JP (1) | JP2013522249A (en) |
| KR (1) | KR20130017086A (en) |
| CN (1) | CN102803227B (en) |
| AR (1) | AR080757A1 (en) |
| AU (1) | AU2011229542A1 (en) |
| BR (1) | BR112012022868A2 (en) |
| CA (1) | CA2793299A1 (en) |
| EA (1) | EA201201289A1 (en) |
| ES (1) | ES2586227T3 (en) |
| IL (1) | IL221901A (en) |
| MX (1) | MX2012010557A (en) |
| SG (1) | SG183855A1 (en) |
| WO (1) | WO2011113512A1 (en) |
| ZA (1) | ZA201207727B (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102011118830A1 (en) * | 2011-11-18 | 2013-05-23 | Merck Patent Gmbh | Morpholinylbenzotriazine |
| CA2871471A1 (en) | 2012-04-24 | 2013-10-31 | Vertex Pharmaceuticals Incorporated | Dna-pk inhibitors |
| PT2970218T (en) | 2013-03-12 | 2019-03-01 | Vertex Pharma | Dna-pk inhibitors |
| UY35464A (en) | 2013-03-15 | 2014-10-31 | Araxes Pharma Llc | KRAS G12C covalent inhibitors. |
| DE102013008118A1 (en) | 2013-05-11 | 2014-11-13 | Merck Patent Gmbh | arylchinazoline |
| WO2015054572A1 (en) * | 2013-10-10 | 2015-04-16 | Araxes Pharma Llc | Inhibitors of kras g12c |
| TWI659021B (en) | 2013-10-10 | 2019-05-11 | 亞瑞克西斯製藥公司 | Inhibitors of kras g12c |
| LT3057953T (en) | 2013-10-17 | 2018-11-26 | Vertex Pharmaceuticals Incorporated | Co-crystals of (s)-n-methyl-8-(1-((2`-methyl-[4,5`-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as dna-pk inhibitors |
| TW201625305A (en) | 2014-09-18 | 2016-07-16 | 亞瑞克西斯製藥公司 | Combination therapies for treatment of cancer |
| WO2016049568A1 (en) | 2014-09-25 | 2016-03-31 | Araxes Pharma Llc | Methods and compositions for inhibition of ras |
| CN107849022A (en) | 2015-04-10 | 2018-03-27 | 亚瑞克西斯制药公司 | Substituted quinazoline compound and its application method |
| US10428064B2 (en) | 2015-04-15 | 2019-10-01 | Araxes Pharma Llc | Fused-tricyclic inhibitors of KRAS and methods of use thereof |
| US10144724B2 (en) | 2015-07-22 | 2018-12-04 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
| EP3364977A4 (en) | 2015-10-19 | 2019-09-04 | Araxes Pharma Llc | Method for screening inhibitors of ras |
| US10414757B2 (en) | 2015-11-16 | 2019-09-17 | Araxes Pharma Llc | 2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof |
| US9988357B2 (en) | 2015-12-09 | 2018-06-05 | Araxes Pharma Llc | Methods for preparation of quinazoline derivatives |
| US20190127336A1 (en) * | 2016-03-30 | 2019-05-02 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use |
| CN110036010A (en) | 2016-09-29 | 2019-07-19 | 亚瑞克西斯制药公司 | The inhibitor of KRAS G12C mutain |
| WO2018068017A1 (en) | 2016-10-07 | 2018-04-12 | Araxes Pharma Llc | Heterocyclic compounds as inhibitors of ras and methods of use thereof |
| AU2018357933B2 (en) * | 2017-10-31 | 2019-11-21 | Southern Research Institute | Substituted quinazoline sulfonamides as thioredoxin interacting protein (TXNIP) inhibitors |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0556310B1 (en) | 1990-11-06 | 1995-07-05 | Pfizer Inc. | Quinazolines derivatives for enhancing antitumor activity |
| GB9300059D0 (en) | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
| JP2994165B2 (en) * | 1992-06-26 | 1999-12-27 | ゼネカ・リミテッド | Quinazoline derivatives, pharmaceutical formulations for obtaining anticancer activity containing their production and the quinazoline derivative |
| GB9707800D0 (en) * | 1996-05-06 | 1997-06-04 | Zeneca Ltd | Chemical compounds |
| WO2000061186A1 (en) | 1999-04-08 | 2000-10-19 | Arch Development Corporation | Use of anti-vegf antibody to enhance radiation in cancer therapy |
| US7179912B2 (en) * | 2000-09-01 | 2007-02-20 | Icos Corporation | Materials and methods to potentiate cancer treatment |
| US7294629B2 (en) * | 2001-02-21 | 2007-11-13 | Mitsubishi Pharma Corporation | Quinazoline derivatives |
| CA2468996A1 (en) * | 2001-12-03 | 2003-06-12 | Schering Corporation | Use of fpt inhibitors and at least two antineoplastic agents in the treatment of cancer |
| PE20060285A1 (en) * | 2004-03-30 | 2006-05-08 | Aventis Pharma Inc | Substituted pyridones as inhibitors of pol (adp-ribose) polymerase (PARP) |
| ES2288359B1 (en) | 2005-07-08 | 2009-07-23 | Consejo Superior Investigaciones Cientificas | Coordinated control system for continuous extraction lines of virgin olive oil. |
| WO2007036734A1 (en) * | 2005-09-29 | 2007-04-05 | Glaxo Group Limited | Pyrazolo[3,4-b]pyridine compound, and its use as a pde4 inhibitor |
| DE102006012251A1 (en) * | 2006-03-15 | 2007-11-08 | Grünenthal GmbH | Substituted 4-aminoquinazoline derivatives and their use for the preparation of medicaments |
| EP1903038A1 (en) * | 2006-09-07 | 2008-03-26 | Bayer Schering Pharma Aktiengesellschaft | N-(1-hetaryl-piperidin-4-yl)-(het)arylamide as EP2 receptor modulators |
| AT461177T (en) * | 2007-03-23 | 2010-04-15 | Icagen Inc | Ion channel inhibitors |
| CN103923072B (en) * | 2007-07-20 | 2017-05-31 | 内尔维阿诺医学科学有限公司 | As the substituted indazole derivative with kinase inhibitory activity |
| WO2009020140A1 (en) * | 2007-08-06 | 2009-02-12 | Dainippon Sumitomo Pharma Co., Ltd. | Adamantylurea derivative |
| AR073354A1 (en) * | 2008-07-31 | 2010-11-03 | Genentech Inc | Pyrimidine compounds, pharmaceutical compositions and their use in treating cancer. |
| US8563539B2 (en) * | 2009-12-23 | 2013-10-22 | Jasco Pharmaceuticals, LLC | Aminopyrimidine kinase inhibitors |
-
2011
- 2011-02-17 ES ES11704552.6T patent/ES2586227T3/en active Active
- 2011-02-17 BR BR112012022868A patent/BR112012022868A2/en not_active IP Right Cessation
- 2011-02-17 EP EP11704552.6A patent/EP2547664B1/en active Active
- 2011-02-17 CN CN201180014341.9A patent/CN102803227B/en not_active IP Right Cessation
- 2011-02-17 EA EA201201289A patent/EA201201289A1/en unknown
- 2011-02-17 CA CA 2793299 patent/CA2793299A1/en not_active Abandoned
- 2011-02-17 SG SG2012064788A patent/SG183855A1/en unknown
- 2011-02-17 MX MX2012010557A patent/MX2012010557A/en not_active Application Discontinuation
- 2011-02-17 KR KR20127026875A patent/KR20130017086A/en not_active Application Discontinuation
- 2011-02-17 JP JP2012557426A patent/JP2013522249A/en active Pending
- 2011-02-17 AU AU2011229542A patent/AU2011229542A1/en not_active Abandoned
- 2011-02-17 WO PCT/EP2011/000767 patent/WO2011113512A1/en active Application Filing
- 2011-02-17 US US13/581,699 patent/US9126952B2/en active Active
- 2011-03-16 AR ARP110100836 patent/AR080757A1/en unknown
-
2012
- 2012-09-11 IL IL221901A patent/IL221901A/en not_active IP Right Cessation
- 2012-10-15 ZA ZA2012/07727A patent/ZA201207727B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013522249A (en) | 2013-06-13 |
| CA2793299A1 (en) | 2011-09-22 |
| AR080757A1 (en) | 2012-05-09 |
| US20130012489A1 (en) | 2013-01-10 |
| EA201201289A1 (en) | 2013-08-30 |
| IL221901D0 (en) | 2012-12-02 |
| CN102803227A (en) | 2012-11-28 |
| EP2547664A1 (en) | 2013-01-23 |
| MX2012010557A (en) | 2012-10-05 |
| US9126952B2 (en) | 2015-09-08 |
| SG183855A1 (en) | 2012-10-30 |
| BR112012022868A2 (en) | 2018-06-05 |
| WO2011113512A1 (en) | 2011-09-22 |
| ES2586227T3 (en) | 2016-10-13 |
| CN102803227B (en) | 2016-01-20 |
| IL221901A (en) | 2016-04-21 |
| KR20130017086A (en) | 2013-02-19 |
| AU2011229542A1 (en) | 2012-11-08 |
| EP2547664B1 (en) | 2016-05-04 |
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