ZA200905229B - 2-aza-bicyclo[3.1.0]hexane derivatives as orexin receptor antagonists - Google Patents
2-aza-bicyclo[3.1.0]hexane derivatives as orexin receptor antagonistsInfo
- Publication number
- ZA200905229B ZA200905229B ZA200905229A ZA200905229A ZA200905229B ZA 200905229 B ZA200905229 B ZA 200905229B ZA 200905229 A ZA200905229 A ZA 200905229A ZA 200905229 A ZA200905229 A ZA 200905229A ZA 200905229 B ZA200905229 B ZA 200905229B
- Authority
- ZA
- South Africa
- Prior art keywords
- aza
- bicyclo
- receptor antagonists
- orexin receptor
- hexane derivatives
- Prior art date
Links
- WSSDGZWSPMAECX-UHFFFAOYSA-N 2-azabicyclo[3.1.0]hexane Chemical class C1CNC2CC21 WSSDGZWSPMAECX-UHFFFAOYSA-N 0.000 title 1
- 229940123730 Orexin receptor antagonist Drugs 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Addiction (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Anesthesiology (AREA)
- Reproductive Health (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB2006055042 | 2006-12-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200905229B true ZA200905229B (en) | 2010-10-27 |
Family
ID=39343649
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200905229A ZA200905229B (en) | 2006-12-28 | 2009-07-27 | 2-aza-bicyclo[3.1.0]hexane derivatives as orexin receptor antagonists |
Country Status (29)
Country | Link |
---|---|
US (1) | US8288435B2 (de) |
EP (1) | EP2094690B1 (de) |
JP (1) | JP2010514751A (de) |
KR (1) | KR20090094168A (de) |
CN (1) | CN101568536B (de) |
AR (1) | AR064561A1 (de) |
AT (1) | ATE505467T1 (de) |
AU (1) | AU2007340944B2 (de) |
BR (1) | BRPI0720876A2 (de) |
CA (1) | CA2669821A1 (de) |
CL (1) | CL2007003827A1 (de) |
CY (1) | CY1111705T1 (de) |
DE (1) | DE602007013937D1 (de) |
DK (1) | DK2094690T3 (de) |
ES (1) | ES2364297T3 (de) |
HK (1) | HK1136554A1 (de) |
HR (1) | HRP20110509T1 (de) |
MA (1) | MA31000B1 (de) |
MX (1) | MX2009006860A (de) |
MY (1) | MY157344A (de) |
NO (1) | NO20092762L (de) |
NZ (1) | NZ578642A (de) |
PL (1) | PL2094690T3 (de) |
PT (1) | PT2094690E (de) |
RU (1) | RU2460732C2 (de) |
SI (1) | SI2094690T1 (de) |
TW (1) | TW200833328A (de) |
WO (1) | WO2008081399A2 (de) |
ZA (1) | ZA200905229B (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE602007009284D1 (de) * | 2006-09-29 | 2010-10-28 | Actelion Pharmaceuticals Ltd | 3-aza-bicycloä3.1.0ühexanderivate |
JP2010511038A (ja) | 2006-12-01 | 2010-04-08 | アクテリオン ファーマシューティカルズ リミテッド | オレキシン受容体阻害剤としての3−ヘテロアリール(アミノ又はアミド)−1−(ビフェニル又はフェニルチアゾリル)カルボニルピペリジン誘導体 |
CL2008000836A1 (es) * | 2007-03-26 | 2008-11-07 | Actelion Pharmaceuticals Ltd | Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras. |
US8030495B2 (en) | 2007-05-23 | 2011-10-04 | Coleman Paul J | Cyclopropyl pyrrolidine orexin receptor antagonists |
US8288411B2 (en) * | 2007-09-24 | 2012-10-16 | Actelion Pharmaceuticals Ltd. | Pyrrolidines and piperidines as orexin receptor antagonists |
JP2011512400A (ja) * | 2008-02-21 | 2011-04-21 | アクテリオン ファーマシューティカルズ リミテッド | 2−アザ−ビシクロ[2.2.1]ヘプタン誘導体 |
JP2011519849A (ja) * | 2008-04-30 | 2011-07-14 | アクテリオン ファーマシューティカルズ リミテッド | ピペリジン及びピロリジン化合物 |
CN102164896A (zh) * | 2008-10-14 | 2011-08-24 | 埃科特莱茵药品有限公司 | 苯乙基酰胺衍生物及其杂环类似物 |
EP2275421A1 (de) * | 2009-07-15 | 2011-01-19 | Rottapharm S.p.A. | Spiro-Amino-Verbindungen geeignet zur Behandlung von unter anderem Schlafstörungen und Drogenabhängigkeit |
MX2012006909A (es) | 2009-12-29 | 2012-07-10 | Suven Life Sciences Ltd | LIGANDOS DEL RECEPTOR NICOTINICO NEURONAL A4ß2 DE ACETILCOLINA. |
JP4944286B1 (ja) * | 2010-09-22 | 2012-05-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | シクロプロパン化合物 |
US9012489B2 (en) * | 2011-08-03 | 2015-04-21 | Boehringer Ingelheim International Gmbh | Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament |
WO2013050938A1 (en) | 2011-10-04 | 2013-04-11 | Actelion Pharmaceuticals Ltd | 3,7-diazabicyclo[3.3.1]nonane and 9-oxa-3,7-diazabicyclo[3.3.1]nonane derivatives |
ITMI20112329A1 (it) * | 2011-12-21 | 2013-06-22 | Rottapharm Spa | Nuovi derivati spiro amminici |
US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
BR112014019426A8 (pt) | 2012-02-07 | 2017-07-11 | Eolas Therapeutics Inc | Prolinas/ piperidinas substituídas como antagonistas do receptor de orexina |
ITMI20120424A1 (it) * | 2012-03-19 | 2013-09-20 | Rottapharm Spa | Composti chimici |
EA029899B1 (ru) | 2012-06-04 | 2018-05-31 | Идорсиа Фармасьютиклз Лтд | Производные бензимидазол-пролина |
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