ZA200808410B - Pyrrolo-and thiazolo-pyridine compounds as hif modulators - Google Patents

Pyrrolo-and thiazolo-pyridine compounds as hif modulators

Info

Publication number
ZA200808410B
ZA200808410B ZA2008/08410A ZA200808410A ZA200808410B ZA 200808410 B ZA200808410 B ZA 200808410B ZA 2008/08410 A ZA2008/08410 A ZA 2008/08410A ZA 200808410 A ZA200808410 A ZA 200808410A ZA 200808410 B ZA200808410 B ZA 200808410B
Authority
ZA
South Africa
Prior art keywords
thiazolo
pyrrolo
pyridine compounds
hif
modulators
Prior art date
Application number
ZA2008/08410A
Inventor
Shaojiang Deng
Wen Bin Ho
Min Wu
Hengmiao Cheng
Eric D Turtle
Lee A Flippin
Michael P Arend
Original Assignee
Fibrogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fibrogen Inc filed Critical Fibrogen Inc
Publication of ZA200808410B publication Critical patent/ZA200808410B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
ZA2008/08410A 2006-04-04 2008-10-02 Pyrrolo-and thiazolo-pyridine compounds as hif modulators ZA200808410B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78931006P 2006-04-04 2006-04-04
PCT/US2007/065987 WO2007115315A2 (en) 2006-04-04 2007-04-04 Pyrrolo- and thiazolo-pyridine compounds as hif modulators

Publications (1)

Publication Number Publication Date
ZA200808410B true ZA200808410B (en) 2009-12-30

Family

ID=38477095

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2008/08410A ZA200808410B (en) 2006-04-04 2008-10-02 Pyrrolo-and thiazolo-pyridine compounds as hif modulators

Country Status (15)

Country Link
US (1) US7696223B2 (en)
EP (2) EP2016078B1 (en)
JP (1) JP5111491B2 (en)
KR (1) KR101084635B1 (en)
CN (2) CN103497184A (en)
AU (1) AU2007234408B2 (en)
BR (1) BRPI0710527B8 (en)
CA (1) CA2647596C (en)
HK (1) HK1127046A1 (en)
IL (1) IL194311A (en)
MX (1) MX2008012734A (en)
NO (1) NO20084627L (en)
RU (1) RU2461557C2 (en)
WO (1) WO2007115315A2 (en)
ZA (1) ZA200808410B (en)

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Publication number Publication date
RU2008143564A (en) 2010-05-10
CN103497184A (en) 2014-01-08
HK1127046A1 (en) 2009-10-02
JP2009532502A (en) 2009-09-10
AU2007234408B2 (en) 2011-05-19
IL194311A0 (en) 2009-08-03
RU2461557C2 (en) 2012-09-20
US7696223B2 (en) 2010-04-13
EP3124489B1 (en) 2020-07-15
EP2016078B1 (en) 2016-06-15
JP5111491B2 (en) 2013-01-09
BRPI0710527B8 (en) 2021-05-25
WO2007115315A2 (en) 2007-10-11
MX2008012734A (en) 2009-01-29
EP2016078A2 (en) 2009-01-21
KR20080112350A (en) 2008-12-24
CN101460497A (en) 2009-06-17
WO2007115315A3 (en) 2007-12-06
BRPI0710527A2 (en) 2012-06-05
NO20084627L (en) 2008-11-26
CA2647596A1 (en) 2007-10-11
US20080004309A1 (en) 2008-01-03
BRPI0710527B1 (en) 2019-09-03
CA2647596C (en) 2012-06-12
EP3124489A1 (en) 2017-02-01
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IL194311A (en) 2015-09-24
AU2007234408A1 (en) 2007-10-11

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