ZA200706560B - Process for preparing macrocyclic compounds - Google Patents

Process for preparing macrocyclic compounds

Info

Publication number
ZA200706560B
ZA200706560B ZA200706560A ZA200706560A ZA200706560B ZA 200706560 B ZA200706560 B ZA 200706560B ZA 200706560 A ZA200706560 A ZA 200706560A ZA 200706560 A ZA200706560 A ZA 200706560A ZA 200706560 B ZA200706560 B ZA 200706560B
Authority
ZA
South Africa
Prior art keywords
macrocyclic compounds
preparing macrocyclic
preparing
compounds
macrocyclic
Prior art date
Application number
ZA200706560A
Other languages
English (en)
Inventor
Carl Alan Busacca
Nizar Haddad
Suresh R Kapadia
Chris Hugh Senanayake
Nathan K Yee
Fabrice Gallou
Azad Hossain
Jianxiu Liu
Xudong Wei
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of ZA200706560B publication Critical patent/ZA200706560B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
ZA200706560A 2005-03-08 2007-08-07 Process for preparing macrocyclic compounds ZA200706560B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65969605P 2005-03-08 2005-03-08

Publications (1)

Publication Number Publication Date
ZA200706560B true ZA200706560B (en) 2008-09-25

Family

ID=36570780

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200706560A ZA200706560B (en) 2005-03-08 2007-08-07 Process for preparing macrocyclic compounds

Country Status (17)

Country Link
US (2) US7608614B2 (xx)
EP (2) EP1863833B1 (xx)
JP (2) JP5667745B2 (xx)
KR (2) KR20140059308A (xx)
CN (2) CN103172697A (xx)
AU (1) AU2006220708B9 (xx)
BR (1) BRPI0607817B8 (xx)
CA (1) CA2600367C (xx)
DK (1) DK1863833T3 (xx)
ES (1) ES2439732T3 (xx)
IL (2) IL185779A (xx)
MX (1) MX2007010879A (xx)
NZ (1) NZ562167A (xx)
PL (1) PL1863833T3 (xx)
RU (2) RU2456296C2 (xx)
WO (1) WO2006096652A2 (xx)
ZA (1) ZA200706560B (xx)

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US7592336B2 (en) 2005-05-10 2009-09-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
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CN104557861A (zh) 2007-12-21 2015-04-29 阿维拉制药公司 Hcv蛋白酶抑制剂和其用途
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US8293705B2 (en) 2007-12-21 2012-10-23 Avila Therapeutics, Inc. HCV protease inhibitors and uses thereof
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Also Published As

Publication number Publication date
EP2332963A3 (en) 2011-11-16
AU2006220708A1 (en) 2006-09-14
WO2006096652A3 (en) 2006-11-23
KR20070117664A (ko) 2007-12-12
DK1863833T3 (da) 2013-12-02
KR101514953B1 (ko) 2015-04-24
CN101160317A (zh) 2008-04-09
MX2007010879A (es) 2007-11-23
IL185779A0 (en) 2008-01-06
US7608614B2 (en) 2009-10-27
EP1863833B1 (en) 2013-09-18
US8222369B2 (en) 2012-07-17
CN101160317B (zh) 2013-03-27
RU2456296C2 (ru) 2012-07-20
CA2600367A1 (en) 2006-09-14
CN103172697A (zh) 2013-06-26
IL228977A0 (en) 2013-12-31
RU2012113243A (ru) 2013-10-10
JP2012255030A (ja) 2012-12-27
IL228977A (en) 2015-11-30
AU2006220708B2 (en) 2012-09-27
ES2439732T3 (es) 2014-01-24
JP2008533014A (ja) 2008-08-21
EP2332963A2 (en) 2011-06-15
US20060205638A1 (en) 2006-09-14
WO2006096652A2 (en) 2006-09-14
BRPI0607817B1 (pt) 2019-11-26
CA2600367C (en) 2014-08-12
EP1863833A2 (en) 2007-12-12
US20090326194A1 (en) 2009-12-31
AU2006220708B9 (en) 2013-01-17
JP5667745B2 (ja) 2015-02-12
PL1863833T3 (pl) 2014-03-31
BRPI0607817A2 (pt) 2009-10-06
BRPI0607817B8 (pt) 2021-05-25
IL185779A (en) 2014-02-27
NZ562167A (en) 2011-01-28
KR20140059308A (ko) 2014-05-15
RU2007136964A (ru) 2009-04-20

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